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Epilepsy is a clinical neurological disorder characterized by recurrent and spontaneous seizures consisting of abnormal high-frequency electrical activity in the brain. In this condition, the transmembrane potential dynamics are characterized by rapid and sharp wavefronts traveling along the heterogeneous and anisotropic conduction pathways of the brain. This work employs the monodomain model, coupled with specific neuronal ionic models characterizing ion concentration dynamics, to mathematically describe brain tissue electrophysiology in grey and white matter at the organ scale. This multiscale model is discretized in space with the high-order discontinuous Galerkin method on polygonal and polyhedral grids (PolyDG) and advanced in time with a Crank-Nicolson scheme. This ensures, on the one hand, efficient and accurate simulations of the high-frequency electrical activity that is responsible for epileptic seizure and, on the other hand, keeps reasonably low the computational costs by a suitable combination of high-order approximations and agglomerated polytopal meshes. We numerically investigate synthetic test cases on a two-dimensional heterogeneous squared domain discretized with a polygonal grid, and on a two-dimensional brainstem in a sagittal plane with an agglomerated polygonal grid that takes full advantage of the flexibility of the PolyDG approximation of the semidiscrete formulation. Finally, we provide a theoretical analysis of stability and an a-priori convergence analysis for a simplified mathematical problem.

Physics-informed neural networks (PINNs), rooted in deep learning, have emerged as a promising approach for solving partial differential equations (PDEs). By embedding the physical information described by PDEs into feedforward neural networks, PINNs are trained as surrogate models to approximate solutions without the need for label data. Nevertheless, even though PINNs have shown remarkable performance, they can face difficulties, especially when dealing with equations featuring rapidly changing solutions. These difficulties encompass slow convergence, susceptibility to becoming trapped in local minima, and reduced solution accuracy. To address these issues, we propose a binary structured physics-informed neural network (BsPINN) framework, which employs binary structured neural network (BsNN) as the neural network component. By leveraging a binary structure that reduces inter-neuron connections compared to fully connected neural networks, BsPINNs excel in capturing the local features of solutions more effectively and efficiently. These features are particularly crucial for learning the rapidly changing in the nature of solutions. In a series of numerical experiments solving Burgers equation, Euler equation, Helmholtz equation, and high-dimension Poisson equation, BsPINNs exhibit superior convergence speed and heightened accuracy compared to PINNs. From these experiments, we discover that BsPINNs resolve the issues caused by increased hidden layers in PINNs resulting in over-smoothing, and prevent the decline in accuracy due to non-smoothness of PDEs solutions.

We present a novel combination of dynamic embedded topic models and change-point detection to explore diachronic change of lexical semantic modality in classical and early Christian Latin. We demonstrate several methods for finding and characterizing patterns in the output, and relating them to traditional scholarship in Comparative Literature and Classics. This simple approach to unsupervised models of semantic change can be applied to any suitable corpus, and we conclude with future directions and refinements aiming to allow noisier, less-curated materials to meet that threshold.

The Sinkhorn algorithm is a numerical method for the solution of optimal transport problems. Here, I give a brief survey of this algorithm, with a strong emphasis on its geometric origin: it is natural to view it as a discretization, by standard methods, of a non-linear integral equation. In the appendix, I also provide a short summary of an early result of Beurling on product measures, directly related to the Sinkhorn algorithm.

Most existing neural network-based approaches for solving stochastic optimal control problems using the associated backward dynamic programming principle rely on the ability to simulate the underlying state variables. However, in some problems, this simulation is infeasible, leading to the discretization of state variable space and the need to train one neural network for each data point. This approach becomes computationally inefficient when dealing with large state variable spaces. In this paper, we consider a class of this type of stochastic optimal control problems and introduce an effective solution employing multitask neural networks. To train our multitask neural network, we introduce a novel scheme that dynamically balances the learning across tasks. Through numerical experiments on real-world derivatives pricing problems, we prove that our method outperforms state-of-the-art approaches.

In Koopman operator theory, a finite-dimensional nonlinear system is transformed into an infinite but linear system using a set of observable functions. However, manually selecting observable functions that span the invariant subspace of the Koopman operator based on prior knowledge is inefficient and challenging, particularly when little or no information is available about the underlying systems. Furthermore, current methodologies tend to disregard the importance of the invertibility of observable functions, which leads to inaccurate results. To address these challenges, we propose the so-called FlowDMD, aka Flow-based Dynamic Mode Decomposition, that utilizes the Coupling Flow Invertible Neural Network (CF-INN) framework. FlowDMD leverages the intrinsically invertible characteristics of the CF-INN to learn the invariant subspaces of the Koopman operator and accurately reconstruct state variables. Numerical experiments demonstrate the superior performance of our algorithm compared to state-of-the-art methodologies.

It is well known that for singular inconsistent range-symmetric linear systems, the generalized minimal residual (GMRES) method determines a least squares solution without breakdown. The reached least squares solution may be or not be the pseudoinverse solution. We show that a lift strategy can be used to obtain the pseudoinverse solution. In addition, we propose a new iterative method named RSMAR (minimum $\mathbf A$-residual) for range-symmetric linear systems $\mathbf A\mathbf x=\mathbf b$. At step $k$ RSMAR minimizes $\|\mathbf A\mathbf r_k\|$ in the $k$th Krylov subspace generated with $\{\mathbf A, \mathbf r_0\}$ rather than $\|\mathbf r_k\|$, where $\mathbf r_k$ is the $k$th residual vector and $\|\cdot\|$ denotes the Euclidean vector norm. We show that RSMAR and GMRES terminate with the same least squares solution when applied to range-symmetric linear systems. We provide two implementations for RSMAR. Our numerical experiments show that RSMAR is the most suitable method among GMRES-type methods for singular inconsistent range-symmetric linear systems.

Recently, addressing spatial confounding has become a major topic in spatial statistics. However, the literature has provided conflicting definitions, and many proposed definitions do not address the issue of confounding as it is understood in causal inference. We define spatial confounding as the existence of an unmeasured causal confounder with a spatial structure. We present a causal inference framework for nonparametric identification of the causal effect of a continuous exposure on an outcome in the presence of spatial confounding. We propose double machine learning (DML), a procedure in which flexible models are used to regress both the exposure and outcome variables on confounders to arrive at a causal estimator with favorable robustness properties and convergence rates, and we prove that this approach is consistent and asymptotically normal under spatial dependence. As far as we are aware, this is the first approach to spatial confounding that does not rely on restrictive parametric assumptions (such as linearity, effect homogeneity, or Gaussianity) for both identification and estimation. We demonstrate the advantages of the DML approach analytically and in simulations. We apply our methods and reasoning to a study of the effect of fine particulate matter exposure during pregnancy on birthweight in California.

We hypothesize that due to the greedy nature of learning in multi-modal deep neural networks, these models tend to rely on just one modality while under-fitting the other modalities. Such behavior is counter-intuitive and hurts the models' generalization, as we observe empirically. To estimate the model's dependence on each modality, we compute the gain on the accuracy when the model has access to it in addition to another modality. We refer to this gain as the conditional utilization rate. In the experiments, we consistently observe an imbalance in conditional utilization rates between modalities, across multiple tasks and architectures. Since conditional utilization rate cannot be computed efficiently during training, we introduce a proxy for it based on the pace at which the model learns from each modality, which we refer to as the conditional learning speed. We propose an algorithm to balance the conditional learning speeds between modalities during training and demonstrate that it indeed addresses the issue of greedy learning. The proposed algorithm improves the model's generalization on three datasets: Colored MNIST, Princeton ModelNet40, and NVIDIA Dynamic Hand Gesture.

Graph representation learning for hypergraphs can be used to extract patterns among higher-order interactions that are critically important in many real world problems. Current approaches designed for hypergraphs, however, are unable to handle different types of hypergraphs and are typically not generic for various learning tasks. Indeed, models that can predict variable-sized heterogeneous hyperedges have not been available. Here we develop a new self-attention based graph neural network called Hyper-SAGNN applicable to homogeneous and heterogeneous hypergraphs with variable hyperedge sizes. We perform extensive evaluations on multiple datasets, including four benchmark network datasets and two single-cell Hi-C datasets in genomics. We demonstrate that Hyper-SAGNN significantly outperforms the state-of-the-art methods on traditional tasks while also achieving great performance on a new task called outsider identification. Hyper-SAGNN will be useful for graph representation learning to uncover complex higher-order interactions in different applications.