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A comprehensive understanding of the organizational principles in the human brain requires, among other factors, well-quantifiable descriptors of nerve fiber architecture. Three-dimensional polarized light imaging (3D-PLI) is a microscopic imaging technique that enables insights into the fine-grained organization of myelinated nerve fibers with high resolution. Descriptors characterizing the fiber architecture observed in 3D-PLI would enable downstream analysis tasks such as multimodal correlation studies, clustering, and mapping. However, best practices for observer-independent characterization of fiber architecture in 3D-PLI are not yet available. To this end, we propose the application of a fully data-driven approach to characterize nerve fiber architecture in 3D-PLI images using self-supervised representation learning. We introduce a 3D-Context Contrastive Learning (CL-3D) objective that utilizes the spatial neighborhood of texture examples across histological brain sections of a 3D reconstructed volume to sample positive pairs for contrastive learning. We combine this sampling strategy with specifically designed image augmentations to gain robustness to typical variations in 3D-PLI parameter maps. The approach is demonstrated for the 3D reconstructed occipital lobe of a vervet monkey brain. We show that extracted features are highly sensitive to different configurations of nerve fibers, yet robust to variations between consecutive brain sections arising from histological processing. We demonstrate their practical applicability for retrieving clusters of homogeneous fiber architecture and performing data mining for interactively selected templates of specific components of fiber architecture such as U-fibers.

A robust multichannel speaker diarization and separation system is proposed by exploiting the spatio-temporal activity of the speakers. The system is realized in a hybrid architecture that combines the array signal processing units and the deep learning units. For speaker diarization, a spatial coherence matrix across time frames is computed based on the whitened relative transfer functions (wRTFs) of the microphone array. This serves as a robust feature for subsequent machine learning without the need for prior knowledge of the array configuration. A computationally efficient Spatial Activity-driven Speaker Diarization network (SASDnet) is constructed to estimate the speaker activity directly from the spatial coherence matrix. For speaker separation, we propose the Global and Local Activity-driven Speaker Extraction network (GLASEnet) to separate speaker signals via speaker-specific global and local spatial activity functions. The local spatial activity functions depend on the coherence between the wRTFs of each time-frequency bin and the target speaker-dominant bins. The global spatial activity functions are computed from the global spatial coherence functions based on frequency-averaged local spatial activity functions. Experimental results have demonstrated superior speaker, diarization, counting, and separation performance achieved by the proposed system with low computational complexity compared to the pre-selected baselines.

Semantic communications have emerged as a new paradigm for improving communication efficiency by transmitting the semantic information of a source message that is most relevant to a desired task at the receiver. Most existing approaches typically utilize neural networks (NNs) to design end-to-end semantic communication systems, where NN-based semantic encoders output continuously distributed signals to be sent directly to the channel in an analog fashion. In this work, we propose a joint coding-modulation (JCM) framework for digital semantic communications by using variational autoencoder (VAE). Our approach learns the transition probability from source data to discrete constellation symbols, thereby avoiding the non-differentiability problem of digital modulation. Meanwhile, by jointly designing the coding and modulation process together, we can match the obtained modulation strategy with the operating channel condition. We also derive a matching loss function with information-theoretic meaning for end-to-end training. Experiments on image semantic communication validate the superiority of our proposed JCM framework over the state-of-the-art quantization-based digital semantic coding-modulation methods across a wide range of channel conditions, transmission rates, and modulation orders. Furthermore, its performance gap to analog semantic communication reduces as the modulation order increases while enjoying the hardware implementation convenience.

Previous theoretical results pertaining to meta-learning on sequences build on contrived assumptions and are somewhat convoluted. We introduce new information-theoretic tools that lead to an elegant and very general decomposition of error into three components: irreducible error, meta-learning error, and intra-task error. These tools unify analyses across many meta-learning challenges. To illustrate, we apply them to establish new results about in-context learning with transformers. Our theoretical results characterizes how error decays in both the number of training sequences and sequence lengths. Our results are very general; for example, they avoid contrived mixing time assumptions made by all prior results that establish decay of error with sequence length.

Because of their excellent asymptotic and finite-length performance, spatially-coupled (SC) codes are a class of low-density parity-check codes that is gaining increasing attention. Multi-dimensional (MD) SC codes are constructed by connecting copies of an SC code via relocations in order to mitigate various sources of non-uniformity and improve performance in many data storage and data transmission systems. As the number of degrees of freedom in the MD-SC code design increases, appropriately exploiting them becomes more difficult because of the complexity growth of the design process. In this paper, we propose a probabilistic framework for the MD-SC code design, which is based on the gradient-descent (GD) algorithm, to design better MD codes and address this challenge. In particular, we express the expected number of short cycles, which we seek to minimize, in the graph representation of the code in terms of entries of a probability-distribution matrix that characterizes the MD-SC code design. We then find a locally-optimal probability distribution, which serves as the starting point of a finite-length algorithmic optimizer that produces the final MD-SC code. We offer the theoretical analysis as well as the algorithms, and we present experimental results demonstrating that our MD codes, conveniently called GD-MD codes, have notably lower short cycle numbers compared with the available state-of-the-art. Moreover, our algorithms converge on solutions in few iterations, which confirms the complexity reduction as a result of limiting the search space via the locally-optimal GD-MD distributions.

Causal effect estimation from observational data is a fundamental task in empirical sciences. It becomes particularly challenging when unobserved confounders are involved in a system. This paper focuses on front-door adjustment -- a classic technique which, using observed mediators allows to identify causal effects even in the presence of unobserved confounding. While the statistical properties of the front-door estimation are quite well understood, its algorithmic aspects remained unexplored for a long time. In 2022, Jeong, Tian, and Bareinboim presented the first polynomial-time algorithm for finding sets satisfying the front-door criterion in a given directed acyclic graph (DAG), with an $O(n^3(n+m))$ run time, where $n$ denotes the number of variables and $m$ the number of edges of the causal graph. In our work, we give the first linear-time, i.e., $O(n+m)$, algorithm for this task, which thus reaches the asymptotically optimal time complexity. This result implies an $O(n(n+m))$ delay enumeration algorithm of all front-door adjustment sets, again improving previous work by a factor of $n^3$. Moreover, we provide the first linear-time algorithm for finding a minimal front-door adjustment set. We offer implementations of our algorithms in multiple programming languages to facilitate practical usage and empirically validate their feasibility, even for large graphs.

Although continuous advances in theoretical modelling of Molecular Communications (MC) are observed, there is still an insuperable gap between theory and experimental testbeds, especially at the microscale. In this paper, the development of the first testbed incorporating engineered yeast cells is reported. Different from the existing literature, eukaryotic yeast cells are considered for both the sender and the receiver, with {\alpha}-factor molecules facilitating the information transfer. The use of such cells is motivated mainly by the well understood biological mechanism of yeast mating, together with their genetic amenability. In addition, recent advances in yeast biosensing establish yeast as a suitable detector and a neat interface to in-body sensor networks. The system under consideration is presented first, and the mathematical models of the underlying biological processes leading to an end-to-end (E2E) system are given. The experimental setup is then described and used to obtain experimental results which validate the developed mathematical models. Beyond that, the ability of the system to effectively generate output pulses in response to repeated stimuli is demonstrated, reporting one event per two hours. However, fast RNA fluctuations indicate cell responses in less than three minutes, demonstrating the potential for much higher rates in the future.

In recent years, large-scale pre-trained multimodal models (LMM) generally emerge to integrate the vision and language modalities, achieving considerable success in various natural language processing and computer vision tasks. The growing size of LMMs, however, results in a significant computational cost for fine-tuning these models for downstream tasks. Hence, prompt-based interaction strategy is studied to align modalities more efficiently. In this contex, we propose a novel prompt-based multimodal interaction strategy inspired by human memory strategy, namely Memory-Inspired Temporal Prompt Interaction (MITP). Our proposed method involves in two stages as in human memory strategy: the acquiring stage, and the consolidation and activation stage. We utilize temporal prompts on intermediate layers to imitate the acquiring stage, leverage similarity-based prompt interaction to imitate memory consolidation, and employ prompt generation strategy to imitate memory activation. The main strength of our paper is that we interact the prompt vectors on intermediate layers to leverage sufficient information exchange between modalities, with compressed trainable parameters and memory usage. We achieve competitive results on several datasets with relatively small memory usage and 2.0M of trainable parameters (about 1% of the pre-trained foundation model).

Conventional methods for object detection typically require a substantial amount of training data and preparing such high-quality training data is very labor-intensive. In this paper, we propose a novel few-shot object detection network that aims at detecting objects of unseen categories with only a few annotated examples. Central to our method are our Attention-RPN, Multi-Relation Detector and Contrastive Training strategy, which exploit the similarity between the few shot support set and query set to detect novel objects while suppressing false detection in the background. To train our network, we contribute a new dataset that contains 1000 categories of various objects with high-quality annotations. To the best of our knowledge, this is one of the first datasets specifically designed for few-shot object detection. Once our few-shot network is trained, it can detect objects of unseen categories without further training or fine-tuning. Our method is general and has a wide range of potential applications. We produce a new state-of-the-art performance on different datasets in the few-shot setting. The dataset link is //github.com/fanq15/Few-Shot-Object-Detection-Dataset.

Multi-relation Question Answering is a challenging task, due to the requirement of elaborated analysis on questions and reasoning over multiple fact triples in knowledge base. In this paper, we present a novel model called Interpretable Reasoning Network that employs an interpretable, hop-by-hop reasoning process for question answering. The model dynamically decides which part of an input question should be analyzed at each hop; predicts a relation that corresponds to the current parsed results; utilizes the predicted relation to update the question representation and the state of the reasoning process; and then drives the next-hop reasoning. Experiments show that our model yields state-of-the-art results on two datasets. More interestingly, the model can offer traceable and observable intermediate predictions for reasoning analysis and failure diagnosis, thereby allowing manual manipulation in predicting the final answer.