The significant advancements in applying Artificial Intelligence (AI) to healthcare decision-making, medical diagnosis, and other domains have simultaneously raised concerns about the fairness and bias of AI systems. This is particularly critical in areas like healthcare, employment, criminal justice, credit scoring, and increasingly, in generative AI models (GenAI) that produce synthetic media. Such systems can lead to unfair outcomes and perpetuate existing inequalities, including generative biases that affect the representation of individuals in synthetic data. This survey paper offers a succinct, comprehensive overview of fairness and bias in AI, addressing their sources, impacts, and mitigation strategies. We review sources of bias, such as data, algorithm, and human decision biases - highlighting the emergent issue of generative AI bias where models may reproduce and amplify societal stereotypes. We assess the societal impact of biased AI systems, focusing on the perpetuation of inequalities and the reinforcement of harmful stereotypes, especially as generative AI becomes more prevalent in creating content that influences public perception. We explore various proposed mitigation strategies, discussing the ethical considerations of their implementation and emphasizing the need for interdisciplinary collaboration to ensure effectiveness. Through a systematic literature review spanning multiple academic disciplines, we present definitions of AI bias and its different types, including a detailed look at generative AI bias. We discuss the negative impacts of AI bias on individuals and society and provide an overview of current approaches to mitigate AI bias, including data pre-processing, model selection, and post-processing. We emphasize the unique challenges presented by generative AI models and the importance of strategies specifically tailored to address these.
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Analyzing the health status of patients based on Electronic Health Records (EHR) is a fundamental research problem in medical informatics. The presence of extensive missing values in EHR makes it challenging for deep neural networks to directly model the patient's health status based on EHR. Existing deep learning training protocols require the use of statistical information or imputation models to reconstruct missing values; however, the protocols inject non-realistic data into downstream EHR analysis models, significantly limiting model performance. This paper introduces Learnable Prompt as Pseudo Imputation (PAI) as a new training protocol. PAI no longer introduces any imputed data but constructs a learnable prompt to model the implicit preferences of the downstream model for missing values, resulting in a significant performance improvement for all EHR analysis models. Additionally, our experiments show that PAI exhibits higher robustness in situations of data insufficiency and high missing rates. More importantly, in a real-world application involving cross-institutional data with zero-shot evaluation, PAI demonstrates stronger model generalization capabilities for non-overlapping features.
Numerous applications in the field of molecular communications (MC) such as healthcare systems are often event-driven. The conventional Shannon capacity may not be the appropriate metric for assessing performance in such cases. We propose the identification (ID) capacity as an alternative metric. Particularly, we consider randomized identification (RI) over the discrete-time Poisson channel (DTPC), which is typically used as a model for MC systems that utilize molecule-counting receivers. In the ID paradigm, the receiver's focus is not on decoding the message sent. However, he wants to determine whether a message of particular significance to him has been sent or not. In contrast to Shannon transmission codes, the size of ID codes for a Discrete Memoryless Channel (DMC) grows doubly exponentially fast with the blocklength, if randomized encoding is used. In this paper, we derive the capacity formula for RI over the DTPC subject to some peak and average power constraints. Furthermore, we analyze the case of state-dependent DTPC.
Digital circuits, despite having been studied for nearly a century and used at scale for about half that time, have until recently evaded a fully compositional theoretical understanding, in which arbitrary circuits may be freely composed together without consulting their internals. Recent work remedied this theoretical shortcoming by showing how digital circuits can be presented compositionally as morphisms in a freely generated symmetric traced category. However, this was done informally; in this paper we refine and expand the previous work in several ways, culminating in the presentation of three sound and complete semantics for digital circuits: denotational, operational and algebraic. For the denotational semantics, we establish a correspondence between stream functions with certain properties and circuits constructed syntactically. For the operational semantics, we present the reductions required to model how a circuit processes a value, including the addition of a new reduction for eliminating non-delay-guarded feedback; this leads to an adequate notion of observational equivalence for digital circuits. Finally, we define a new family of equations for translating circuits into bisimilar circuits of a 'normal form', leading to a complete algebraic semantics for sequential circuits
Glyphosate contamination in waters is becoming a major health problem that needs to be urgently addressed, as accidental spraying, drift or leakage of this highly water-soluble herbicide can impact aquatic ecosystems. Researchers are increasingly concerned about exposure to glyphosate and the risks its poses to human health, since it may cause substantial damage, even in small doses. The detection of glyphosate residues in waters is not a simple task, as it requires complex and expensive equipment and qualified personnel. New technological tools need to be designed and developed, based on proven, but also cost-efficient, agile and user-friendly, analytical techniques, which can be used in the field and in the lab, enabled by connectivity and multi-platform software applications. This paper presents the design, development and testing of an innovative low-cost VIS-NIR (Visible and Near-Infrared) spectrometer (called SpectroGLY), based on IoT (Internet of Things) technologies, which allows potential glyphosate contamination in waters to be detected. SpectroGLY combines the functional concept of a traditional lab spectrometer with the IoT technological concept, enabling the integration of several connectivity options for rural and urban settings and digital visualization and monitoring platforms (Mobile App and Dashboard Web). Thanks to its portability, it can be used in any context and provides results in 10 minutes. Additionally, it is unnecessary to transfer the sample to a laboratory (optimizing time, costs and the capacity for corrective actions by the authorities). In short, this paper proposes an innovative, low-cost, agile and highly promising solution to avoid potential intoxications that may occur due to ingestion of water contaminated by this herbicide.
A primary concern of public health researchers involves identifying and quantifying heterogeneous exposure effects across population subgroups. Understanding the magnitude and direction of these effects on a given scale provides researchers the ability to recommend policy prescriptions and assess the external validity of findings. Furthermore, increasing popularity in fields such as precision medicine that rely on accurate estimation of high-dimensional interaction effects has highlighted the importance of understanding effect modification. Traditional methods for effect measure modification analyses include parametric regression modeling with either stratified analyses and corresponding heterogeneity tests or including an interaction term in a multivariable model. However, these methods require manual model specification and are often impractical or not feasible to conduct by hand in high-dimensional settings. Recent developments in machine learning aim to solve this issue by automating heterogeneous subgroup identification and effect estimation. In this paper, we summarize and provide the intuition behind modern machine learning methods for effect measure modification analyses to serve as a reference for public health researchers. We discuss their implementation in R, provide annotated syntax and review available supplemental analysis tools by assessing the heterogeneous effects of drought on stunting among children in the Demographic and Health Survey data set as a case study.
Background: Cognitive biases in clinical decision-making significantly contribute to errors in diagnosis and suboptimal patient outcomes. Addressing these biases presents a formidable challenge in the medical field. This study explores the role of large language models (LLMs) in mitigating these biases through the utilization of a multi-agent framework. We simulate the clinical decision-making processes through multi-agent conversation and evaluate its efficacy in improving diagnostic accuracy. Methods: A total of 16 published and unpublished case reports where cognitive biases have resulted in misdiagnoses were identified from the literature. In the multi-agent system, we leveraged GPT-4 Turbo to facilitate interactions among four simulated agents to replicate clinical team dynamics. Each agent has a distinct role: 1) To make the initial and final diagnosis after considering the discussions, 2) The devil's advocate and correct confirmation and anchoring bias, 3) The tutor and facilitator of the discussion to reduce premature closure bias, and 4) To record and summarize the findings. A total of 80 simulations were evaluated for the accuracy of initial diagnosis, top differential diagnosis and final two differential diagnoses. Findings: In a total of 80 responses evaluating both initial and final diagnoses, the initial diagnosis had an accuracy of 0% (0/80), but following multi-agent discussions, the accuracy for the top differential diagnosis increased to 71.3% (57/80), and for the final two differential diagnoses, to 80.0% (64/80). The system demonstrated an ability to reevaluate and correct misconceptions, even in scenarios with misleading initial investigations. Interpretation: The LLM-driven multi-agent conversation system shows promise in enhancing diagnostic accuracy in diagnostically challenging medical scenarios.
Background: Recent advancements in large language models (LLMs) offer potential benefits in healthcare, particularly in processing extensive patient records. However, existing benchmarks do not fully assess LLMs' capability in handling real-world, lengthy clinical data. Methods: We present the LongHealth benchmark, comprising 20 detailed fictional patient cases across various diseases, with each case containing 5,090 to 6,754 words. The benchmark challenges LLMs with 400 multiple-choice questions in three categories: information extraction, negation, and sorting, challenging LLMs to extract and interpret information from large clinical documents. Results: We evaluated nine open-source LLMs with a minimum of 16,000 tokens and also included OpenAI's proprietary and cost-efficient GPT-3.5 Turbo for comparison. The highest accuracy was observed for Mixtral-8x7B-Instruct-v0.1, particularly in tasks focused on information retrieval from single and multiple patient documents. However, all models struggled significantly in tasks requiring the identification of missing information, highlighting a critical area for improvement in clinical data interpretation. Conclusion: While LLMs show considerable potential for processing long clinical documents, their current accuracy levels are insufficient for reliable clinical use, especially in scenarios requiring the identification of missing information. The LongHealth benchmark provides a more realistic assessment of LLMs in a healthcare setting and highlights the need for further model refinement for safe and effective clinical application. We make the benchmark and evaluation code publicly available.
In pace with developments in the research field of artificial intelligence, knowledge graphs (KGs) have attracted a surge of interest from both academia and industry. As a representation of semantic relations between entities, KGs have proven to be particularly relevant for natural language processing (NLP), experiencing a rapid spread and wide adoption within recent years. Given the increasing amount of research work in this area, several KG-related approaches have been surveyed in the NLP research community. However, a comprehensive study that categorizes established topics and reviews the maturity of individual research streams remains absent to this day. Contributing to closing this gap, we systematically analyzed 507 papers from the literature on KGs in NLP. Our survey encompasses a multifaceted review of tasks, research types, and contributions. As a result, we present a structured overview of the research landscape, provide a taxonomy of tasks, summarize our findings, and highlight directions for future work.
Maritime activities represent a major domain of economic growth with several emerging maritime Internet of Things use cases, such as smart ports, autonomous navigation, and ocean monitoring systems. The major enabler for this exciting ecosystem is the provision of broadband, low-delay, and reliable wireless coverage to the ever-increasing number of vessels, buoys, platforms, sensors, and actuators. Towards this end, the integration of unmanned aerial vehicles (UAVs) in maritime communications introduces an aerial dimension to wireless connectivity going above and beyond current deployments, which are mainly relying on shore-based base stations with limited coverage and satellite links with high latency. Considering the potential of UAV-aided wireless communications, this survey presents the state-of-the-art in UAV-aided maritime communications, which, in general, are based on both conventional optimization and machine-learning-aided approaches. More specifically, relevant UAV-based network architectures are discussed together with the role of their building blocks. Then, physical-layer, resource management, and cloud/edge computing and caching UAV-aided solutions in maritime environments are discussed and grouped based on their performance targets. Moreover, as UAVs are characterized by flexible deployment with high re-positioning capabilities, studies on UAV trajectory optimization for maritime applications are thoroughly discussed. In addition, aiming at shedding light on the current status of real-world deployments, experimental studies on UAV-aided maritime communications are presented and implementation details are given. Finally, several important open issues in the area of UAV-aided maritime communications are given, related to the integration of sixth generation (6G) advancements.
Small data challenges have emerged in many learning problems, since the success of deep neural networks often relies on the availability of a huge amount of labeled data that is expensive to collect. To address it, many efforts have been made on training complex models with small data in an unsupervised and semi-supervised fashion. In this paper, we will review the recent progresses on these two major categories of methods. A wide spectrum of small data models will be categorized in a big picture, where we will show how they interplay with each other to motivate explorations of new ideas. We will review the criteria of learning the transformation equivariant, disentangled, self-supervised and semi-supervised representations, which underpin the foundations of recent developments. Many instantiations of unsupervised and semi-supervised generative models have been developed on the basis of these criteria, greatly expanding the territory of existing autoencoders, generative adversarial nets (GANs) and other deep networks by exploring the distribution of unlabeled data for more powerful representations. While we focus on the unsupervised and semi-supervised methods, we will also provide a broader review of other emerging topics, from unsupervised and semi-supervised domain adaptation to the fundamental roles of transformation equivariance and invariance in training a wide spectrum of deep networks. It is impossible for us to write an exclusive encyclopedia to include all related works. Instead, we aim at exploring the main ideas, principles and methods in this area to reveal where we are heading on the journey towards addressing the small data challenges in this big data era.
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