In standard hospital blood tests, the traditional process requires doctors to manually isolate leukocytes from microscopic images of patients' blood using microscopes. These isolated leukocytes are then categorized via automatic leukocyte classifiers to determine the proportion and volume of different types of leukocytes present in the blood samples, aiding disease diagnosis. This methodology is not only time-consuming and labor-intensive, but it also has a high propensity for errors due to factors such as image quality and environmental conditions, which could potentially lead to incorrect subsequent classifications and misdiagnosis. To address these issues, this paper proposes an innovative method of leukocyte detection: the Multi-level Feature Fusion and Deformable Self-attention DETR (MFDS-DETR). To tackle the issue of leukocyte scale disparity, we designed the High-level Screening-feature Fusion Pyramid (HS-FPN), enabling multi-level fusion. This model uses high-level features as weights to filter low-level feature information via a channel attention module and then merges the screened information with the high-level features, thus enhancing the model's feature expression capability. Further, we address the issue of leukocyte feature scarcity by incorporating a multi-scale deformable self-attention module in the encoder and using the self-attention and cross-deformable attention mechanisms in the decoder, which aids in the extraction of the global features of the leukocyte feature maps. The effectiveness, superiority, and generalizability of the proposed MFDS-DETR method are confirmed through comparisons with other cutting-edge leukocyte detection models using the private WBCDD, public LISC and BCCD datasets. Our source code and private WBCCD dataset are available at //github.com/JustlfC03/MFDS-DETR.
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The value of text classification's future research has encountered challenges and uncertainties, due to the extraordinary efficacy demonstrated by large language models (LLMs) across numerous downstream NLP tasks. In this era of open-ended language modeling, where task boundaries are gradually fading, an urgent question emerges: have we made significant advances in text classification under the full benefit of LLMs? To answer this question, we propose RGPT, an adaptive boosting framework tailored to produce a specialized text classification LLM by recurrently ensembling a pool of strong base learners. The base learners are constructed by adaptively adjusting the distribution of training samples and iteratively fine-tuning LLMs with them. Such base learners are then ensembled to be a specialized text classification LLM, by recurrently incorporating the historical predictions from the previous learners. Through a comprehensive empirical comparison, we show that RGPT significantly outperforms 8 SOTA PLMs and 7 SOTA LLMs on four benchmarks by 1.36% on average. Further evaluation experiments show a clear surpassing of RGPT over human classification.
Entity and relationship extraction is a crucial component in natural language processing tasks such as knowledge graph construction, question answering system design, and semantic analysis. Most of the information of the Yishui school of traditional Chinese Medicine (TCM) is stored in the form of unstructured classical Chinese text. The key information extraction of TCM texts plays an important role in mining and studying the academic schools of TCM. In order to solve these problems efficiently using artificial intelligence methods, this study constructs a word segmentation and entity relationship extraction model based on conditional random fields under the framework of natural language processing technology to identify and extract the entity relationship of traditional Chinese medicine texts, and uses the common weighting technology of TF-IDF information retrieval and data mining to extract important key entity information in different ancient books. The dependency syntactic parser based on neural network is used to analyze the grammatical relationship between entities in each ancient book article, and it is represented as a tree structure visualization, which lays the foundation for the next construction of the knowledge graph of Yishui school and the use of artificial intelligence methods to carry out the research of TCM academic schools.
We discuss guidelines for evaluating the performance of parameterized stochastic solvers for optimization problems, with particular attention to systems that employ novel hardware, such as digital quantum processors running variational algorithms, analog processors performing quantum annealing, or coherent Ising Machines. We illustrate through an example a benchmarking procedure grounded in the statistical analysis of the expectation of a given performance metric measured in a test environment. In particular, we discuss the necessity and cost of setting parameters that affect the algorithm's performance. The optimal value of these parameters could vary significantly between instances of the same target problem. We present an open-source software package that facilitates the design, evaluation, and visualization of practical parameter tuning strategies for complex use of the heterogeneous components of the solver. We examine in detail an example using parallel tempering and a simulator of a photonic Coherent Ising Machine computing and display the scoring of an illustrative baseline family of parameter-setting strategies that feature an exploration-exploitation trade-off.
Traditional rigid endoscopes have challenges in flexibly treating tumors located deep in the brain, and low operability and fixed viewing angles limit its development. This study introduces a novel dual-segment flexible robotic endoscope MicroNeuro, designed to perform biopsies with dexterous surgical manipulation deep in the brain. Taking into account the uncertainty of the control model, an image-based visual servoing with online robot Jacobian estimation has been implemented to enhance motion accuracy. Furthermore, the application of model predictive control with constraints significantly bolsters the flexible robot's ability to adaptively track mobile objects and resist external interference. Experimental results underscore that the proposed control system enhances motion stability and precision. Phantom testing substantiates its considerable potential for deployment in neurosurgery.
With the widespread adoption of large language models (LLMs) in numerous applications, the challenge of factuality and the propensity for hallucinations raises significant concerns. To address this issue, particularly in retrieval-augmented in-context learning, we introduce the hierarchical graph of thoughts (HGOT), a structured, multi-layered graph approach designed to enhance the retrieval of pertinent passages during in-context learning. The framework utilizes the emergent planning capabilities of LLMs, employing the divide-and-conquer strategy to break down complex queries into manageable sub-queries. It refines self-consistency majority voting for answer selection, which incorporates the recently proposed citation recall and precision metrics to assess the quality of thoughts, linking an answer's credibility intrinsically to the thought's quality. This methodology introduces a weighted system in majority voting, prioritizing answers based on the citation quality of their thoughts. Additionally, we propose a scoring mechanism for evaluating retrieved passages, considering factors such as citation frequency and quality, self-consistency confidence, and the retrieval module's ranking. Experiments reveal that HGOT outperforms other retrieval-augmented in-context learning methods, including Demonstrate-Search-Predict (DSP), ReAct, Self-Ask, and Retrieve-then-Read on different datasets by as much as $7\%$, demonstrating its efficacy in enhancing the factuality of LLMs.
Eulerian Formulation of the Tensor-Based Morphology Equations for Strain-Based Blood Damage Modeling
The development of blood-handling medical devices, such as ventricular assist devices, requires the analysis of their biocompatibility. Among other aspects, this includes hemolysis, i.e., red blood cell damage. For this purpose, computational fluid dynamics (CFD) methods are employed to predict blood flow in prototypes. The most basic hemolysis models directly estimate red blood cell damage from fluid stress in the resulting flow field. More advanced models explicitly resolve cell deformation. On the downside, these models are typically written in a Lagrangian formulation, i.e., they require pathline tracking. We present a new Eulerian description of cell deformation, enabling the evaluation of the solution across the whole domain. The resulting hemolysis model can be applied to any converged CFD simulation due to one-way coupling with the fluid velocity field. We discuss the efficient numerical treatment of the model equations in a stabilized finite element context. We validate the model by comparison to the original Lagrangian formulation in selected benchmark flows. Two more complex test cases demonstrate the method's capabilities in real-world applications. The results highlight the advantages over previous hemolysis models. In conclusion, the model holds great potential for the design process of future generations of medical devices.
As 6G emerges, cellular systems are envisioned to integrate sensing with communication capabilities, leading to multi-faceted communication and sensing (JCAS). This paper presents a comprehensive cross-layer overview of the Hexa-X-II project's endeavors in JCAS, aligning 6G use cases with service requirements and pinpointing distinct scenarios that bridge communication and sensing. This work relates to these scenarios through the lens of the cross-layer physical and networking domains, covering models, deployments, resource allocation, storage challenges, computational constraints, interfaces, and innovative functions.
For a class of biped robots with impulsive dynamics and a non-empty set of passive gaits (unactuated, periodic motions of the biped model), we present a method for computing continuous families of locally optimal gaits with respect to a class of commonly used energetic cost functions (e.g., the integral of torque-squared). We compute these families using only the passive gaits of the biped, which are globally optimal gaits with respect to these cost functions. Our approach fills in an important gap in the literature when computing a library of locally optimal gaits, which often do not make use of these globally optimal solutions as seed values. We demonstrate our approach on a well-studied two-link biped model.
Understanding causality helps to structure interventions to achieve specific goals and enables predictions under interventions. With the growing importance of learning causal relationships, causal discovery tasks have transitioned from using traditional methods to infer potential causal structures from observational data to the field of pattern recognition involved in deep learning. The rapid accumulation of massive data promotes the emergence of causal search methods with brilliant scalability. Existing summaries of causal discovery methods mainly focus on traditional methods based on constraints, scores and FCMs, there is a lack of perfect sorting and elaboration for deep learning-based methods, also lacking some considers and exploration of causal discovery methods from the perspective of variable paradigms. Therefore, we divide the possible causal discovery tasks into three types according to the variable paradigm and give the definitions of the three tasks respectively, define and instantiate the relevant datasets for each task and the final causal model constructed at the same time, then reviews the main existing causal discovery methods for different tasks. Finally, we propose some roadmaps from different perspectives for the current research gaps in the field of causal discovery and point out future research directions.
Object detection typically assumes that training and test data are drawn from an identical distribution, which, however, does not always hold in practice. Such a distribution mismatch will lead to a significant performance drop. In this work, we aim to improve the cross-domain robustness of object detection. We tackle the domain shift on two levels: 1) the image-level shift, such as image style, illumination, etc, and 2) the instance-level shift, such as object appearance, size, etc. We build our approach based on the recent state-of-the-art Faster R-CNN model, and design two domain adaptation components, on image level and instance level, to reduce the domain discrepancy. The two domain adaptation components are based on H-divergence theory, and are implemented by learning a domain classifier in adversarial training manner. The domain classifiers on different levels are further reinforced with a consistency regularization to learn a domain-invariant region proposal network (RPN) in the Faster R-CNN model. We evaluate our newly proposed approach using multiple datasets including Cityscapes, KITTI, SIM10K, etc. The results demonstrate the effectiveness of our proposed approach for robust object detection in various domain shift scenarios.
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