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We collect robust proposals given in the field of regression models with heteroscedastic errors. Our motivation stems from the fact that the practitioner frequently faces the confluence of two phenomena in the context of data analysis: non--linearity and heteroscedasticity. The impact of heteroscedasticity on the precision of the estimators is well--known, however the conjunction of these two phenomena makes handling outliers more difficult. An iterative procedure to estimate the parameters of a heteroscedastic non--linear model is considered. The studied estimators combine weighted $MM-$regression estimators, to control the impact of high leverage points, and a robust method to estimate the parameters of the variance function.

Modern high-throughput sequencing assays efficiently capture not only gene expression and different levels of gene regulation but also a multitude of genome variants. Focused analysis of alternative alleles of variable sites at homologous chromosomes of the human genome reveals allele-specific gene expression and allele-specific gene regulation by assessing allelic imbalance of read counts at individual sites. Here we formally describe an advanced statistical framework for detecting the allelic imbalance in allelic read counts at single-nucleotide variants detected in diverse omics studies (ChIP-Seq, ATAC-Seq, DNase-Seq, CAGE-Seq, and others). MIXALIME accounts for copy-number variants and aneuploidy, reference read mapping bias, and provides several scoring models to balance between sensitivity and specificity when scoring data with varying levels of experimental noise-caused overdispersion.

By universal formulas we understand parameterized analytic expressions that have a fixed complexity, but nevertheless can approximate any continuous function on a compact set. There exist various examples of such formulas, including some in the form of neural networks. In this paper we analyze the essential structural elements of these highly expressive models. We introduce a hierarchy of expressiveness classes connecting the global approximability property to the weaker property of infinite VC dimension, and prove a series of classification results for several increasingly complex functional families. In particular, we introduce a general family of polynomially-exponentially-algebraic functions that, as we prove, is subject to polynomial constraints. As a consequence, we show that fixed-size neural networks with not more than one layer of neurons having transcendental activations (e.g., sine or standard sigmoid) cannot in general approximate functions on arbitrary finite sets. On the other hand, we give examples of functional families, including two-hidden-layer neural networks, that approximate functions on arbitrary finite sets, but fail to do that on the whole domain of definition.

We propose a data-driven approach to explicitly learn the progressive encoding of a continuous source, which is successively decoded with increasing levels of quality and with the aid of correlated side information. This setup refers to the successive refinement of the Wyner-Ziv coding problem. Assuming ideal Slepian-Wolf coding, our approach employs recurrent neural networks (RNNs) to learn layered encoders and decoders for the quadratic Gaussian case. The models are trained by minimizing a variational bound on the rate-distortion function of the successively refined Wyner-Ziv coding problem. We demonstrate that RNNs can explicitly retrieve layered binning solutions akin to scalable nested quantization. Moreover, the rate-distortion performance of the scheme is on par with the corresponding monolithic Wyner-Ziv coding approach and is close to the rate-distortion bound.

We give a broad survey of inequalities for the number of linear extensions of finite posets. We review many examples, discuss open problems, and present recent results on the subject. We emphasize the bounds, the equality conditions of the inequalities, and the computational complexity aspects of the results.

We prove the linear orbital stability of spectrally stable stationary discrete shock profiles for conservative finite difference schemes applied to systems of conservation laws. The proof relies on a precise description of the pointwise asymptotic behavior of the Green's function associated with those discrete shock profiles, improving on the result of Godillon [God03]. The main novelty of this stability result is that it applies for a fairly large family of schemes that introduce some artificial viscosity and most importantly, that we do not impose any weakness assumption on the shock.

Functionality is a graph complexity measure that extends a variety of parameters, such as vertex degree, degeneracy, clique-width, or twin-width. In the present paper, we show that functionality is bounded for box intersection graphs in $\mathbb{R}^1$, i.e. for interval graphs, and unbounded for box intersection graphs in $\mathbb{R}^3$. We also study a parameter known as symmetric difference, which is intermediate between twin-width and functionality, and show that this parameter is unbounded both for interval graphs and for unit box intersection graphs in $\mathbb{R}^2$.

Quantum computing has recently emerged as a transformative technology. Yet, its promised advantages rely on efficiently translating quantum operations into viable physical realizations. In this work, we use generative machine learning models, specifically denoising diffusion models (DMs), to facilitate this transformation. Leveraging text-conditioning, we steer the model to produce desired quantum operations within gate-based quantum circuits. Notably, DMs allow to sidestep during training the exponential overhead inherent in the classical simulation of quantum dynamics -- a consistent bottleneck in preceding ML techniques. We demonstrate the model's capabilities across two tasks: entanglement generation and unitary compilation. The model excels at generating new circuits and supports typical DM extensions such as masking and editing to, for instance, align the circuit generation to the constraints of the targeted quantum device. Given their flexibility and generalization abilities, we envision DMs as pivotal in quantum circuit synthesis, enhancing both practical applications but also insights into theoretical quantum computation.

We establish conditions under which latent causal graphs are nonparametrically identifiable and can be reconstructed from unknown interventions in the latent space. Our primary focus is the identification of the latent structure in measurement models without parametric assumptions such as linearity or Gaussianity. Moreover, we do not assume the number of hidden variables is known, and we show that at most one unknown intervention per hidden variable is needed. This extends a recent line of work on learning causal representations from observations and interventions. The proofs are constructive and introduce two new graphical concepts -- imaginary subsets and isolated edges -- that may be useful in their own right. As a matter of independent interest, the proofs also involve a novel characterization of the limits of edge orientations within the equivalence class of DAGs induced by unknown interventions. These are the first results to characterize the conditions under which causal representations are identifiable without making any parametric assumptions in a general setting with unknown interventions and without faithfulness.

To improve the predictability of complex computational models in the experimentally-unknown domains, we propose a Bayesian statistical machine learning framework utilizing the Dirichlet distribution that combines results of several imperfect models. This framework can be viewed as an extension of Bayesian stacking. To illustrate the method, we study the ability of Bayesian model averaging and mixing techniques to mine nuclear masses. We show that the global and local mixtures of models reach excellent performance on both prediction accuracy and uncertainty quantification and are preferable to classical Bayesian model averaging. Additionally, our statistical analysis indicates that improving model predictions through mixing rather than mixing of corrected models leads to more robust extrapolations.