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Bayesian inference and the use of posterior or posterior predictive probabilities for decision making have become increasingly popular in clinical trials. The current approach toward Bayesian clinical trials is, however, a hybrid Bayesian-frequentist approach where the design and decision criteria are assessed with respect to frequentist operating characteristics such as power and type I error rate. These operating characteristics are commonly obtained via simulation studies. In this article we propose methodology to utilize large sample theory of the posterior distribution to define simple parametric models for the sampling distribution of the Bayesian test statistics, i.e., posterior tail probabilities. The parameters of these models are then estimated using a small number of simulation scenarios, thereby refining these models to capture the sampling distribution for small to moderate sample size. The proposed approach toward assessment of operating characteristics and sample size determination can be considered as simulation-assisted rather than simulation-based and significantly reduces the computational burden for design of Bayesian trials.

Humans possess an extraordinary ability to create and utilize tools, allowing them to overcome physical limitations and explore new frontiers. With the advent of foundation models, AI systems have the potential to be equally adept in tool use as humans. This paradigm, i.e., tool learning with foundation models, combines the strengths of specialized tools and foundation models to achieve enhanced accuracy, efficiency, and automation in problem-solving. Despite its immense potential, there is still a lack of a comprehensive understanding of key challenges, opportunities, and future endeavors in this field. To this end, we present a systematic investigation of tool learning in this paper. We first introduce the background of tool learning, including its cognitive origins, the paradigm shift of foundation models, and the complementary roles of tools and models. Then we recapitulate existing tool learning research into tool-augmented and tool-oriented learning. We formulate a general tool learning framework: starting from understanding the user instruction, models should learn to decompose a complex task into several subtasks, dynamically adjust their plan through reasoning, and effectively conquer each sub-task by selecting appropriate tools. We also discuss how to train models for improved tool-use capabilities and facilitate the generalization in tool learning. Considering the lack of a systematic tool learning evaluation in prior works, we experiment with 18 representative tools and show the potential of current foundation models in skillfully utilizing tools. Finally, we discuss several open problems that require further investigation for tool learning. Overall, we hope this paper could inspire future research in integrating tools with foundation models.

A large amount of data and applications are migrated by researchers, stakeholders, academia, and business organizations to the cloud environment due to its large variety of services, which involve the least maintenance cost, maximum flexibility, and on-demand service for storage, computation, and data distribution intentions. Despite the various characteristics the cloud environment supports, it also faces many challenges. However, data users may not completely trust a cloud environment that is engaged by a third party. Every cloud user always has a prime concern, i.e., security. Numerous methods have been designed to solve the issue of data security during data storage, calculation, and sharing across stakeholders and users. Nevertheless, there is a lack of existing methods that tackle the issue of the security of data when it is stored in a cloud environment. This article presents a precise security method that has handled the security of data while it is being shared and stored in the cloud. These methods have been utilized to lessen security assaults and prevent unauthorized parties from accessing the actual data. The article is concluded with some limitations and recommendations for the future in terms of secure data retention and distribution.

Training good representations for items is critical in recommender models. Typically, an item is assigned a unique randomly generated ID, and is commonly represented by learning an embedding corresponding to the value of the random ID. Although widely used, this approach have limitations when the number of items are large and items are power-law distributed -- typical characteristics of real-world recommendation systems. This leads to the item cold-start problem, where the model is unable to make reliable inferences for tail and previously unseen items. Removing these ID features and their learned embeddings altogether to combat cold-start issue severely degrades the recommendation quality. Content-based item embeddings are more reliable, but they are expensive to store and use, particularly for users' past item interaction sequence. In this paper, we use Semantic IDs, a compact discrete item representations learned from content embeddings using RQ-VAE that captures hierarchy of concepts in items. We showcase how we use them as a replacement of item IDs in a resource-constrained ranking model used in an industrial-scale video sharing platform. Moreover, we show how Semantic IDs improves the generalization ability of our system, without sacrificing top-level metrics.

The design of particle simulation methods for collisional plasma physics has always represented a challenge due to the unbounded total collisional cross section, which prevents a natural extension of the classical Direct Simulation Monte Carlo (DSMC) method devised for the Boltzmann equation. One way to overcome this problem is to consider the design of Monte Carlo algorithms that are robust in the so-called grazing collision limit. In the first part of this manuscript, we will focus on the construction of collision algorithms for the Landau-Fokker-Planck equation based on the grazing collision asymptotics and which avoids the use of iterative solvers. Subsequently, we discuss problems involving uncertainties and show how to develop a stochastic Galerkin projection of the particle dynamics which permits to recover spectral accuracy for smooth solutions in the random space. Several classical numerical tests are reported to validate the present approach.

Big data programming frameworks have become increasingly important for the development of applications for which performance and scalability are critical. In those complex frameworks, optimizing code by hand is hard and time-consuming, making automated optimization particularly necessary. In order to automate optimization, a prerequisite is to find suitable abstractions to represent programs; for instance, algebras based on monads or monoids to represent distributed data collections. Currently, however, such algebras do not represent recursive programs in a way which allows for analyzing or rewriting them. In this paper, we extend a monoid algebra with a fixpoint operator for representing recursion as a first class citizen and show how it enables new optimizations. Experiments with the Spark platform illustrate performance gains brought by these systematic optimizations.

Minwise hashing (MinHash) is a standard algorithm widely used in the industry, for large-scale search and learning applications with the binary (0/1) Jaccard similarity. One common use of MinHash is for processing massive n-gram text representations so that practitioners do not have to materialize the original data (which would be prohibitive). Another popular use of MinHash is for building hash tables to enable sub-linear time approximate near neighbor (ANN) search. MinHash has also been used as a tool for building large-scale machine learning systems. The standard implementation of MinHash requires applying $K$ random permutations. In comparison, the method of one permutation hashing (OPH), is an efficient alternative of MinHash which splits the data vectors into $K$ bins and generates hash values within each bin. OPH is substantially more efficient and also more convenient to use. In this paper, we combine the differential privacy (DP) with OPH (as well as MinHash), to propose the DP-OPH framework with three variants: DP-OPH-fix, DP-OPH-re and DP-OPH-rand, depending on which densification strategy is adopted to deal with empty bins in OPH. A detailed roadmap to the algorithm design is presented along with the privacy analysis. An analytical comparison of our proposed DP-OPH methods with the DP minwise hashing (DP-MH) is provided to justify the advantage of DP-OPH. Experiments on similarity search confirm the merits of DP-OPH, and guide the choice of the proper variant in different practical scenarios. Our technique is also extended to bin-wise consistent weighted sampling (BCWS) to develop a new DP algorithm called DP-BCWS for non-binary data. Experiments on classification tasks demonstrate that DP-BCWS is able to achieve excellent utility at around $\epsilon = 5\sim 10$, where $\epsilon$ is the standard parameter in the language of $(\epsilon, \delta)$-DP.

Diffusion models are a class of probabilistic generative models that have been widely used as a prior for image processing tasks like text conditional generation and inpainting. We demonstrate that these models can be adapted to make predictions and provide uncertainty quantification for chaotic dynamical systems. In these applications, diffusion models can implicitly represent knowledge about outliers and extreme events; however, querying that knowledge through conditional sampling or measuring probabilities is surprisingly difficult. Existing methods for conditional sampling at inference time seek mainly to enforce the constraints, which is insufficient to match the statistics of the distribution or compute the probability of the chosen events. To achieve these ends, optimally one would use the conditional score function, but its computation is typically intractable. In this work, we develop a probabilistic approximation scheme for the conditional score function which provably converges to the true distribution as the noise level decreases. With this scheme we are able to sample conditionally on nonlinear userdefined events at inference time, and matches data statistics even when sampling from the tails of the distribution.

AI is undergoing a paradigm shift with the rise of models (e.g., BERT, DALL-E, GPT-3) that are trained on broad data at scale and are adaptable to a wide range of downstream tasks. We call these models foundation models to underscore their critically central yet incomplete character. This report provides a thorough account of the opportunities and risks of foundation models, ranging from their capabilities (e.g., language, vision, robotics, reasoning, human interaction) and technical principles(e.g., model architectures, training procedures, data, systems, security, evaluation, theory) to their applications (e.g., law, healthcare, education) and societal impact (e.g., inequity, misuse, economic and environmental impact, legal and ethical considerations). Though foundation models are based on standard deep learning and transfer learning, their scale results in new emergent capabilities,and their effectiveness across so many tasks incentivizes homogenization. Homogenization provides powerful leverage but demands caution, as the defects of the foundation model are inherited by all the adapted models downstream. Despite the impending widespread deployment of foundation models, we currently lack a clear understanding of how they work, when they fail, and what they are even capable of due to their emergent properties. To tackle these questions, we believe much of the critical research on foundation models will require deep interdisciplinary collaboration commensurate with their fundamentally sociotechnical nature.