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Adaptive subgroup enrichment design is an efficient design framework that allows accelerated development for investigational treatments while also having flexibility in population selection within the course of the trial. The adaptive decision at the interim analysis is commonly made based on the conditional probability of trial success. However, one of the critical challenges for such adaptive designs is immature data for interim decisions, particularly in the targeted subgroup with a limited sample size at the first stage of the trial. In this paper, we improve the interim decision making by incorporating information from surrogate endpoints when estimating conditional power at the interim analysis, by predicting the primary treatment effect based on the observed surrogate endpoint and prior knowledge or historical data about the relationship between endpoints. Modified conditional power is developed for both selecting the patient population to be enrolled after the interim analysis and sample size re-estimation. In the simulation study, our proposed design shows a higher chance to make desirable interim decisions and achieves higher overall power, while controlling the overall type I error. This performance is robust over drift of prior knowledge from the true relationship between two endpoints. We also demonstrate the application of our proposed design in two case studies in oncology and vaccine trials.

Unmanned Aerial Vehicles (UAVs) promise to become an intrinsic part of next generation communications, as they can be deployed to provide wireless connectivity to ground users to supplement existing terrestrial networks. The majority of the existing research into the use of UAV access points for cellular coverage considers rotary-wing UAV designs (i.e. quadcopters). However, we expect fixed-wing UAVs to be more appropriate for connectivity purposes in scenarios where long flight times are necessary (such as for rural coverage), as fixed-wing UAVs rely on a more energy-efficient form of flight when compared to the rotary-wing design. As fixed-wing UAVs are typically incapable of hovering in place, their deployment optimisation involves optimising their individual flight trajectories in a way that allows them to deliver high quality service to the ground users in an energy-efficient manner. In this paper, we propose a multi-agent deep reinforcement learning approach to optimise the energy efficiency of fixed-wing UAV cellular access points while still allowing them to deliver high-quality service to users on the ground. In our decentralized approach, each UAV is equipped with a Dueling Deep Q-Network (DDQN) agent which can adjust the 3D trajectory of the UAV over a series of timesteps. By coordinating with their neighbours, the UAVs adjust their individual flight trajectories in a manner that optimises the total system energy efficiency. We benchmark the performance of our approach against a series of heuristic trajectory planning strategies, and demonstrate that our method can improve the system energy efficiency by as much as 70%.

A simultaneously transmitting and reflecting reconfigurable intelligent surfaces (STAR-RISs) enhanced uplink non-orthogonal multiple access (NOMA) communication system is proposed. A total power consumption minimization problem is formulated by jointly optimizing the transmit-power of users, receive-beamforming vectors at the base station (BS), STAR-beamforming vectors at the STAR-RIS and time slots. Here, the STAR-beamforming introduced by STAR-RIS consists of transmission- and reflection-beamforming. To solve the formulated non-convex problem, an efficient penalty-based alternating optimization (P-AltOp) algorithm is proposed. Simulation results validate the effectiveness of the proposed scheme and reveal the effect of various system parameters on the total power consumption.

This article studies a novel distributed precoding design, coined team minimum mean-square error (TMMSE) precoding, which rigorously generalizes classical centralized MMSE precoding to distributed operations based on transmitter-specific channel state information (CSIT). Building on the so-called theory of teams, we derive a set of necessary and sufficient conditions for optimal TMMSE precoding, in the form of an infinite dimensional linear system of equations. These optimality conditions are further specialized to cell-free massive MIMO networks, and explicitly solved for two important examples, i.e., the classical case of local CSIT and the case of unidirectional CSIT sharing along a serial fronthaul. The latter case is relevant, e.g., for the recently proposed radio stripe concept and the related advances on sequential processing exploiting serial connections. In both cases, our optimal design outperforms the heuristic methods that are known from the previous literature. Duality arguments and numerical simulations validate the effectiveness of the proposed team theoretical approach in terms of ergodic achievable rates under a sum-power constraint.

For mission-critical sensing and control applications such as those to be enabled by 5G Ultra-Reliable, Low-Latency Communications (URLLC), it is critical to ensure the communication quality of individual packets. Prior studies have considered Probabilistic Per-packet Real-time Communications (PPRC) guarantees for single-cell, single-channel networks with implicit deadline constraints, but they have not considered real-world complexities such as inter-cell interference and multiple communication channels. Towards ensuring PPRC in multi-cell, multi-channel wireless networks, we propose a real-time scheduling algorithm based on \emph{local-deadline-partition (LDP)}. The LDP algorithm is suitable for distributed implementation, and it ensures probabilistic per-packet real-time guarantee for multi-cell, multi-channel networks with general deadline constraints. We also address the associated challenge of the schedulability test of PPRC traffic. In particular, we propose the concept of \emph{feasible set} and identify a closed-form sufficient condition for the schedulability of PPRC traffic. We propose a distributed algorithm for the schedulability test, and the algorithm includes a procedure for finding the minimum sum work density of feasible sets which is of interest by itself. We also identify a necessary condition for the schedulability of PPRC traffic, and use numerical studies to understand a lower bound on the approximation ratio of the LDP algorithm. We experimentally study the properties of the LDP algorithm and observe that the PPRC traffic supportable by the LDP algorithm is significantly higher than that of a state-of-the-art algorithm.

This paper provides a theoretical framework for understanding the performance of reconfigurable intelligent surface (RIS)-aided massive multiple-input multiple-output (MIMO) with zero-forcing (ZF) detectors under imperfect channel state information (CSI). We first propose a low-overhead minimum mean square error (MMSE) channel estimator, and then derive and analyze closed-form expressions for the uplink achievable rate. Our analytical results demonstrate that: $1)$ regardless of the RIS phase shift design, the rate of all users scales at least on the order of $\mathcal{O}\left(\log_2\left(MN\right)\right)$, where $M$ and $N$ are the numbers of antennas and reflecting elements, respectively; $2)$ by aligning the RIS phase shifts to one user, the rate of this user can at most scale on the order of $\mathcal{O}\left(\log_2\left(MN^2\right)\right)$; $3)$ either $M$ or the transmit power can be reduced inversely proportional to $N$, while maintaining a given rate. Furthermore, we propose two low-complexity majorization-minimization (MM)-based algorithms to optimize the sum user rate and the minimum user rate, respectively, where closed-form solutions are obtained in each iteration. Finally, simulation results validate all derived analytical results. Our simulation results also show that the maximum sum rate can be closely approached by simply aligning the RIS phase shifts to an arbitrary user.

The existing relay-assisted terahertz (THz) wireless system is limited to dual-hop transmission with pointing errors and short-term fading without considering the shadowing effect. This paper analyzes the performance of a multihop-assisted backhaul communication mixed with an access link under the shadowed fading with antenna misalignment errors. We derive statistical results of the signal-to-noise ratio (SNR) of the multihop link by considering independent but not identically distributed (i.ni.d) $\alpha$-$\mu$ fading channel with pointing errors employing channel-assisted (CA) and fixed-gain (FG) amplify-and-forward (AF) relaying for each hop. We analyze the outage probability, average BER, and ergodic capacity performance of the mixed system considering the generalized-$K$ shadowed fading model with AF and decode-and-forward (DF) protocols employed for the access link. We derive exact expressions of the performance metrics for the CA-multihop system with the DF relaying for the last hop and upper bound of the performance for the FG-multihop system using FG and DF relaying at the last relay. We also develop asymptotic analysis in the high SNR to derive the diversity order of the system and use computer simulations to provide design and deployment aspects of multiple relays in the backhaul link to extend the communication range for THz wireless transmissions.

We propose a joint channel estimation and data detection (JED) algorithm for densely-populated cell-free massive multiuser (MU) multiple-input multiple-output (MIMO) systems, which reduces the channel training overhead caused by the presence of hundreds of simultaneously transmitting user equipments (UEs). Our algorithm iteratively solves a relaxed version of a maximum a-posteriori JED problem and simultaneously exploits the sparsity of cell-free massive MU-MIMO channels as well as the boundedness of QAM constellations. In order to improve the performance and convergence of the algorithm, we propose methods that permute the access point and UE indices to form so-called virtual cells, which leads to better initial solutions. We assess the performance of our algorithm in terms of root-mean-squared-symbol error, bit error rate, and mutual information, and we demonstrate that JED significantly reduces the pilot overhead compared to orthogonal training, which enables reliable communication with short packets to a large number of UEs.

We present an analytical framework for the channel estimation and the data detection in massive multiple-input multiple-output uplink systems with 1-bit analog-to-digital converters (ADCs) and i.i.d. Rayleigh fading. First, we provide closed-form expressions of the mean squared error (MSE) of the channel estimation considering the state-of-the-art linear minimum MSE estimator and the class of scaled least-squares estimators. For the data detection, we provide closed-form expressions of the expected value and the variance of the estimated symbols when maximum ratio combining is adopted, which can be exploited to efficiently implement minimum distance detection and, potentially, to design the set of transmit symbols. Our analytical findings explicitly depend on key system parameters such as the signal-to-noise ratio (SNR), the number of user equipments, and the pilot length, thus enabling a precise characterization of the performance of the channel estimation and the data detection with 1-bit ADCs. The proposed analysis highlights a fundamental SNR trade-off, according to which operating at the right noise level significantly enhances the system performance.

In interactive coding, Alice and Bob wish to compute some function $f$ of their individual private inputs $x$ and $y$. They do this by engaging in a non-adaptive (fixed order, fixed length) protocol to jointly compute $f(x,y)$. The goal is to do this in an error-resilient way, such that even given some fraction of adversarial corruptions, both parties still learn $f(x,y)$. In this work, we study the optimal error resilience of such a protocol in the face of adversarial bit flip or erasures. While the optimal error resilience of such a protocol over a large alphabet is well understood, the situation over the binary alphabet has remained open. In this work, we resolve this problem of determining the optimal error resilience over binary channels. In particular, we construct protocols achieving $\frac16$ error resilience over the binary bit flip channel and $\frac12$ error resilience over the binary erasure channel, for both of which matching upper bounds are known. We remark that the communication complexity of our binary bit flip protocol is polynomial in the size of the inputs, and the communication complexity of our binary erasure protocol is linear in the size of the minimal noiseless protocol computing $f$.