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Deep learning models have obtained state-of-the-art results for medical image analysis. However, when these models are tested on an unseen domain there is a significant performance degradation. In this work, we present an unsupervised Cross-Modality Adversarial Domain Adaptation (C-MADA) framework for medical image segmentation. C-MADA implements an image- and feature-level adaptation method in a sequential manner. First, images from the source domain are translated to the target domain through an un-paired image-to-image adversarial translation with cycle-consistency loss. Then, a U-Net network is trained with the mapped source domain images and target domain images in an adversarial manner to learn domain-invariant feature representations. Furthermore, to improve the networks segmentation performance, information about the shape, texture, and con-tour of the predicted segmentation is included during the adversarial train-ing. C-MADA is tested on the task of brain MRI segmentation, obtaining competitive results.

In semi-supervised domain adaptation, a few labeled samples per class in the target domain guide features of the remaining target samples to aggregate around them. However, the trained model cannot produce a highly discriminative feature representation for the target domain because the training data is dominated by labeled samples from the source domain. This could lead to disconnection between the labeled and unlabeled target samples as well as misalignment between unlabeled target samples and the source domain. In this paper, we propose a novel approach called Cross-domain Adaptive Clustering to address this problem. To achieve both inter-domain and intra-domain adaptation, we first introduce an adversarial adaptive clustering loss to group features of unlabeled target data into clusters and perform cluster-wise feature alignment across the source and target domains. We further apply pseudo labeling to unlabeled samples in the target domain and retain pseudo-labels with high confidence. Pseudo labeling expands the number of ``labeled" samples in each class in the target domain, and thus produces a more robust and powerful cluster core for each class to facilitate adversarial learning. Extensive experiments on benchmark datasets, including DomainNet, Office-Home and Office, demonstrate that our proposed approach achieves the state-of-the-art performance in semi-supervised domain adaptation.

We aim at the problem named One-Shot Unsupervised Domain Adaptation. Unlike traditional Unsupervised Domain Adaptation, it assumes that only one unlabeled target sample can be available when learning to adapt. This setting is realistic but more challenging, in which conventional adaptation approaches are prone to failure due to the scarce of unlabeled target data. To this end, we propose a novel Adversarial Style Mining approach, which combines the style transfer module and task-specific module into an adversarial manner. Specifically, the style transfer module iteratively searches for harder stylized images around the one-shot target sample according to the current learning state, leading the task model to explore the potential styles that are difficult to solve in the almost unseen target domain, thus boosting the adaptation performance in a data-scarce scenario. The adversarial learning framework makes the style transfer module and task-specific module benefit each other during the competition. Extensive experiments on both cross-domain classification and segmentation benchmarks verify that ASM achieves state-of-the-art adaptation performance under the challenging one-shot setting.

We address the problem of segmenting 3D multi-modal medical images in scenarios where very few labeled examples are available for training. Leveraging the recent success of adversarial learning for semi-supervised segmentation, we propose a novel method based on Generative Adversarial Networks (GANs) to train a segmentation model with both labeled and unlabeled images. The proposed method prevents over-fitting by learning to discriminate between true and fake patches obtained by a generator network. Our work extends current adversarial learning approaches, which focus on 2D single-modality images, to the more challenging context of 3D volumes of multiple modalities. The proposed method is evaluated on the problem of segmenting brain MRI from the iSEG-2017 and MRBrainS 2013 datasets. Significant performance improvement is reported, compared to state-of-art segmentation networks trained in a fully-supervised manner. In addition, our work presents a comprehensive analysis of different GAN architectures for semi-supervised segmentation, showing recent techniques like feature matching to yield a higher performance than conventional adversarial training approaches. Our code is publicly available at //github.com/arnab39/FewShot_GAN-Unet3D

We present a new method that learns to segment and cluster images without labels of any kind. A simple loss based on information theory is used to extract meaningful representations directly from raw images. This is achieved by maximising mutual information of images known to be related by spatial proximity or randomized transformations, which distills their shared abstract content. Unlike much of the work in unsupervised deep learning, our learned function outputs segmentation heatmaps and discrete classifications labels directly, rather than embeddings that need further processing to be usable. The loss can be formulated as a convolution, making it the first end-to-end unsupervised learning method that learns densely and efficiently for semantic segmentation. Implemented using realistic settings on generic deep neural network architectures, our method attains superior performance on COCO-Stuff and ISPRS-Potsdam for segmentation and STL for clustering, beating state-of-the-art baselines.

Deep Convolutional Neural Networks have pushed the state-of-the art for semantic segmentation provided that a large amount of images together with pixel-wise annotations is available. Data collection is expensive and a solution to alleviate it is to use transfer learning. This reduces the amount of annotated data required for the network training but it does not get rid of this heavy processing step. We propose a method of transfer learning without annotations on the target task for datasets with redundant content and distinct pixel distributions. Our method takes advantage of the approximate content alignment of the images between two datasets when the approximation error prevents the reuse of annotation from one dataset to another. Given the annotations for only one dataset, we train a first network in a supervised manner. This network autonomously learns to generate deep data representations relevant to the semantic segmentation. Then the images in the new dataset, we train a new network to generate a deep data representation that matches the one from the first network on the previous dataset. The training consists in a regression between feature maps and does not require any annotations on the new dataset. We show that this method reaches performances similar to a classic transfer learning on the PASCAL VOC dataset with synthetic transformations.

Recent works showed that Generative Adversarial Networks (GANs) can be successfully applied in unsupervised domain adaptation, where, given a labeled source dataset and an unlabeled target dataset, the goal is to train powerful classifiers for the target samples. In particular, it was shown that a GAN objective function can be used to learn target features indistinguishable from the source ones. In this work, we extend this framework by (i) forcing the learned feature extractor to be domain-invariant, and (ii) training it through data augmentation in the feature space, namely performing feature augmentation. While data augmentation in the image space is a well established technique in deep learning, feature augmentation has not yet received the same level of attention. We accomplish it by means of a feature generator trained by playing the GAN minimax game against source features. Results show that both enforcing domain-invariance and performing feature augmentation lead to superior or comparable performance to state-of-the-art results in several unsupervised domain adaptation benchmarks.

Convolutional networks (ConvNets) have achieved great successes in various challenging vision tasks. However, the performance of ConvNets would degrade when encountering the domain shift. The domain adaptation is more significant while challenging in the field of biomedical image analysis, where cross-modality data have largely different distributions. Given that annotating the medical data is especially expensive, the supervised transfer learning approaches are not quite optimal. In this paper, we propose an unsupervised domain adaptation framework with adversarial learning for cross-modality biomedical image segmentations. Specifically, our model is based on a dilated fully convolutional network for pixel-wise prediction. Moreover, we build a plug-and-play domain adaptation module (DAM) to map the target input to features which are aligned with source domain feature space. A domain critic module (DCM) is set up for discriminating the feature space of both domains. We optimize the DAM and DCM via an adversarial loss without using any target domain label. Our proposed method is validated by adapting a ConvNet trained with MRI images to unpaired CT data for cardiac structures segmentations, and achieved very promising results.

Most existing person re-identification (re-id) methods require supervised model learning from a separate large set of pairwise labelled training data for every single camera pair. This significantly limits their scalability and usability in real-world large scale deployments with the need for performing re-id across many camera views. To address this scalability problem, we develop a novel deep learning method for transferring the labelled information of an existing dataset to a new unseen (unlabelled) target domain for person re-id without any supervised learning in the target domain. Specifically, we introduce an Transferable Joint Attribute-Identity Deep Learning (TJ-AIDL) for simultaneously learning an attribute-semantic and identitydiscriminative feature representation space transferrable to any new (unseen) target domain for re-id tasks without the need for collecting new labelled training data from the target domain (i.e. unsupervised learning in the target domain). Extensive comparative evaluations validate the superiority of this new TJ-AIDL model for unsupervised person re-id over a wide range of state-of-the-art methods on four challenging benchmarks including VIPeR, PRID, Market-1501, and DukeMTMC-ReID.

We introduce an adversarial learning framework, which we named KBGAN, to improve the performances of a wide range of existing knowledge graph embedding models. Because knowledge graph datasets typically only contain positive facts, sampling useful negative training examples is a non-trivial task. Replacing the head or tail entity of a fact with a uniformly randomly selected entity is a conventional method for generating negative facts used by many previous works, but the majority of negative facts generated in this way can be easily discriminated from positive facts, and will contribute little towards the training. Inspired by generative adversarial networks (GANs), we use one knowledge graph embedding model as a negative sample generator to assist the training of our desired model, which acts as the discriminator in GANs. The objective of the generator is to generate difficult negative samples that can maximize their likeliness determined by the discriminator, while the discriminator minimizes its training loss. This framework is independent of the concrete form of generator and discriminator, and therefore can utilize a wide variety of knowledge graph embedding models as its building blocks. In experiments, we adversarially train two translation-based models, TransE and TransD, each with assistance from one of the two probability-based models, DistMult and ComplEx. We evaluate the performances of KBGAN on the link prediction task, using three knowledge base completion datasets: FB15k-237, WN18 and WN18RR. Experimental results show that adversarial training substantially improves the performances of target embedding models under various settings.