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One of the challenges in virtual environments is the difficulty users have in interacting with these increasingly complex systems. Ultimately, endowing machines with the ability to perceive users emotions will enable a more intuitive and reliable interaction. Consequently, using the electroencephalogram as a bio-signal sensor, the affective state of a user can be modelled and subsequently utilised in order to achieve a system that can recognise and react to the user's emotions. This paper investigates features extracted from electroencephalogram signals for the purpose of affective state modelling based on Russell's Circumplex Model. Investigations are presented that aim to provide the foundation for future work in modelling user affect to enhance interaction experience in virtual environments. The DEAP dataset was used within this work, along with a Support Vector Machine and Random Forest, which yielded reasonable classification accuracies for Valence and Arousal using feature vectors based on statistical measurements and band power from the \'z, \b{eta}, \'z, and \'z\'z waves and High Order Crossing of the EEG signal.

Optical coherence tomography angiography (OCTA) is a novel imaging modality that has been widely utilized in ophthalmology and neuroscience studies to observe retinal vessels and microvascular systems. However, publicly available OCTA datasets remain scarce. In this paper, we introduce the largest and most comprehensive OCTA dataset dubbed OCTA-500, which contains OCTA imaging under two fields of view (FOVs) from 500 subjects. The dataset provides rich images and annotations including two modalities (OCT/OCTA volumes), six types of projections, four types of text labels (age / gender / eye / disease) and seven types of segmentation labels (large vessel/capillary/artery/vein/2D FAZ/3D FAZ/retinal layers). Then, we propose a multi-object segmentation task called CAVF, which integrates capillary segmentation, artery segmentation, vein segmentation, and FAZ segmentation under a unified framework. In addition, we optimize the 3D-to-2D image projection network (IPN) to IPN-V2 to serve as one of the segmentation baselines. Experimental results demonstrate that IPN-V2 achieves an ~10% mIoU improvement over IPN on CAVF task. Finally, we further study the impact of several dataset characteristics: the training set size, the model input (OCT/OCTA, 3D volume/2D projection), the baseline networks, and the diseases. The dataset and code are publicly available at: //ieee-dataport.org/open-access/octa-500.

Semi-competing risks refers to the survival analysis setting where the occurrence of a non-terminal event is subject to whether a terminal event has occurred, but not vice versa. Semi-competing risks arise in a broad range of clinical contexts, with a novel example being the pregnancy condition preeclampsia, which can only occur before the `terminal' event of giving birth. Models that acknowledge semi-competing risks enable investigation of relationships between covariates and the joint timing of the outcomes, but methods for model selection and prediction of semi-competing risks in high dimensions are lacking. Instead, researchers commonly analyze only a single or composite outcome, losing valuable information and limiting clinical utility -- in the obstetric setting, this means ignoring valuable insight into timing of delivery after preeclampsia has onset. To address this gap we propose a novel penalized estimation framework for frailty-based illness-death multi-state modeling of semi-competing risks. Our approach combines non-convex and structured fusion penalization, inducing global sparsity as well as parsimony across submodels. We perform estimation and model selection via a pathwise routine for non-convex optimization, and prove the first statistical error bound results in this setting. We present a simulation study investigating estimation error and model selection performance, and a comprehensive application of the method to joint risk modeling of preeclampsia and timing of delivery using pregnancy data from an electronic health record.

Deep neural networks have shown excellent prospects in speech separation tasks. However, obtaining good results while keeping a low model complexity remains challenging in real-world applications. In this paper, we provide a bio-inspired efficient encoder-decoder architecture by mimicking the brain's top-down attention, called TDANet, with decreased model complexity without sacrificing performance. The top-down attention in TDANet is extracted by the global attention (GA) module and the cascaded local attention (LA) layers. The GA module takes multi-scale acoustic features as input to extract global attention signal, which then modulates features of different scales by direct top-down connections. The LA layers use features of adjacent layers as input to extract the local attention signal, which is used to modulate the lateral input in a top-down manner. On three benchmark datasets, TDANet consistently achieved competitive separation performance to previous state-of-the-art (SOTA) methods with higher efficiency. Specifically, TDANet's multiply-accumulate operations (MACs) are only 5\% of Sepformer, one of the previous SOTA models, and CPU inference time is only 10\% of Sepformer. In addition, a large-size version of TDANet obtained SOTA results on three datasets, with MACs still only 10\% of Sepformer and the CPU inference time only 24\% of Sepformer. Our study suggests that top-down attention can be a more efficient strategy for speech separation.

Image reconstruction of low-count positron emission tomography (PET) data is challenging. Kernel methods address the challenge by incorporating image prior information in the forward model of iterative PET image reconstruction. The kernelized expectation-maximization (KEM) algorithm has been developed and demonstrated to be effective and easy to implement. A common approach for a further improvement of the kernel method would be adding an explicit regularization, which however leads to a complex optimization problem. In this paper, we propose an implicit regularization for the kernel method by using a deep coefficient prior, which represents the kernel coefficient image in the PET forward model using a convolutional neural-network. To solve the maximum-likelihood neural network-based reconstruction problem, we apply the principle of optimization transfer to derive a neural KEM algorithm. Each iteration of the algorithm consists of two separate steps: a KEM step for image update from the projection data and a deep-learning step in the image domain for updating the kernel coefficient image using the neural network. This optimization algorithm is guaranteed to monotonically increase the data likelihood. The results from computer simulations and real patient data have demonstrated that the neural KEM can outperform existing KEM and deep image prior methods.

Reinforcement learning has been demonstrated as a flexible and effective approach for learning a range of continuous control tasks, such as those used by robots to manipulate objects in their environment. But in robotics particularly, real-world rollouts are costly, and sample efficiency can be a major limiting factor when learning a new skill. In game environments, the use of world models has been shown to improve sample efficiency while still achieving good performance, especially when images or other rich observations are provided. In this project, we explore the use of a world model in a deformable robotic manipulation task, evaluating its effect on sample efficiency when learning to fold a cloth in simulation. We compare the use of RGB image observation with a feature space leveraging built-in structure (keypoints representing the cloth configuration), a common approach in robot skill learning, and compare the impact on task performance and learning efficiency with and without the world model. Our experiments showed that the usage of keypoints increased the performance of the best model on the task by 50%, and in general, the use of a learned or constructed reduced feature space improved task performance and sample efficiency. The use of a state transition predictor(MDN-RNN) in our world models did not have a notable effect on task performance.

A fundamental task in science is to design experiments that yield valuable insights about the system under study. Mathematically, these insights can be represented as a utility or risk function that shapes the value of conducting each experiment. We present PDBAL, a targeted active learning method that adaptively designs experiments to maximize scientific utility. PDBAL takes a user-specified risk function and combines it with a probabilistic model of the experimental outcomes to choose designs that rapidly converge on a high-utility model. We prove theoretical bounds on the label complexity of PDBAL and provide fast closed-form solutions for designing experiments with common exponential family likelihoods. In simulation studies, PDBAL consistently outperforms standard untargeted approaches that focus on maximizing expected information gain over the design space. Finally, we demonstrate the scientific potential of PDBAL through a study on a large cancer drug screen dataset where PDBAL quickly recovers the most efficacious drugs with a small fraction of the total number of experiments.

Autonomous suturing has been a long-sought-after goal for surgical robotics. Outside of staged environments, accurate localization of suture needles is a critical foundation for automating various suture needle manipulation tasks in the real world. When localizing a needle held by a gripper, previous work usually tracks them separately without considering their relationship. Because of the significant errors that can arise in the stereo-triangulation of objects and instruments, their reconstructions may often not be consistent. This can lead to unrealistic tool-needle grasp reconstructions that are infeasible. Instead, an obvious strategy to improve localization would be to leverage constraints that arise from contact, thereby constraining reconstructions of objects and instruments into a jointly feasible space. In this work, we consider feasible grasping constraints when tracking the 6D pose of an in-hand suture needle. We propose a reparameterization trick to define a new state space for describing a needle pose, where grasp constraints can be easily defined and satisfied. Our proposed state space and feasible grasping constraints are then incorporated into Bayesian filters for real-time needle localization. In the experiments, we show that our constrained methods outperform previous unconstrained/constrained tracking approaches and demonstrate the importance of incorporating feasible grasping constraints into automating suture needle manipulation tasks.

The state-of-the-art for monocular 3D human pose estimation in videos is dominated by the paradigm of 2D-to-3D pose uplifting. While the uplifting methods themselves are rather efficient, the true computational complexity depends on the per-frame 2D pose estimation. In this paper, we present a Transformer-based pose uplifting scheme that can operate on temporally sparse 2D pose sequences but still produce temporally dense 3D pose estimates. We show how masked token modeling can be utilized for temporal upsampling within Transformer blocks. This allows to decouple the sampling rate of input 2D poses and the target frame rate of the video and drastically decreases the total computational complexity. Additionally, we explore the option of pre-training on large motion capture archives, which has been largely neglected so far. We evaluate our method on two popular benchmark datasets: Human3.6M and MPI-INF-3DHP. With an MPJPE of 45.0 mm and 46.9 mm, respectively, our proposed method can compete with the state-of-the-art while reducing inference time by a factor of 12. This enables real-time throughput with variable consumer hardware in stationary and mobile applications. We release our code and models at //github.com/goldbricklemon/uplift-upsample-3dhpe

With the rapid increase of large-scale, real-world datasets, it becomes critical to address the problem of long-tailed data distribution (i.e., a few classes account for most of the data, while most classes are under-represented). Existing solutions typically adopt class re-balancing strategies such as re-sampling and re-weighting based on the number of observations for each class. In this work, we argue that as the number of samples increases, the additional benefit of a newly added data point will diminish. We introduce a novel theoretical framework to measure data overlap by associating with each sample a small neighboring region rather than a single point. The effective number of samples is defined as the volume of samples and can be calculated by a simple formula $(1-\beta^{n})/(1-\beta)$, where $n$ is the number of samples and $\beta \in [0,1)$ is a hyperparameter. We design a re-weighting scheme that uses the effective number of samples for each class to re-balance the loss, thereby yielding a class-balanced loss. Comprehensive experiments are conducted on artificially induced long-tailed CIFAR datasets and large-scale datasets including ImageNet and iNaturalist. Our results show that when trained with the proposed class-balanced loss, the network is able to achieve significant performance gains on long-tailed datasets.