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The growing utilization of synthetic medical data (SMD) in training and testing AI-driven tools in healthcare necessitates a systematic framework for assessing SMD quality. The current lack of a standardized methodology to evaluate SMD, particularly in terms of its applicability in various medical scenarios, is a significant hindrance to its broader acceptance and utilization in healthcare applications. Here, we outline an evaluation framework designed to meet the unique requirements of medical applications, and introduce the concept of SMD scorecards, which can serve as comprehensive reports that accompany artificially generated datasets. This can help standardize evaluation and enable SMD developers to assess and further enhance the quality of SMDs by identifying areas in need of attention and ensuring that the synthetic data more accurately approximate patient data.

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Adapting foundation models for medical image analysis requires finetuning them on a considerable amount of data because of extreme distribution shifts between natural (source) data used for pretraining and medical (target) data. However, collecting task-specific medical data for such finetuning at a central location raises many privacy concerns. Although Federated learning (FL) provides an effective means for training on private decentralized data, communication costs in federating large foundation models can quickly become a significant bottleneck, impacting the solution's scalability. In this work, we address this problem of efficient communication while ensuring effective learning in FL by combining the strengths of Parameter-Efficient Fine-tuning (PEFT) with FL. Specifically, we study plug-and-play Low-Rank Adapters (LoRA) in a federated manner to adapt the Segment Anything Model (SAM) for 3D medical image segmentation. Unlike prior works that utilize LoRA and finetune the entire decoder, we critically analyze the contribution of each granular component of SAM on finetuning performance. Thus, we identify specific layers to be federated that are very efficient in terms of communication cost while producing on-par accuracy. Our experiments show that retaining the parameters of the SAM model (including most of the decoder) in their original state during adaptation is beneficial because fine-tuning on small datasets tends to distort the inherent capabilities of the underlying foundation model. On Fed-KiTS, our approach decreases communication cost (~48x) compared to full fine-tuning while increasing performance (~6% Dice score) in 3D segmentation tasks. Our approach performs similar to SAMed while achieving ~2.8x reduction in communication and parameters to be finetuned. We further validate our approach with experiments on Fed-IXI and Prostate MRI datasets.

Automation of medical image interpretation could alleviate bottlenecks in diagnostic workflows, and has become of particular interest in recent years due to advancements in natural language processing. Great strides have been made towards automated radiology report generation via AI, yet ensuring clinical accuracy in generated reports is a significant challenge, hindering deployment of such methods in clinical practice. In this work we propose a quality control framework for assessing the reliability of AI-generated radiology reports with respect to semantics of diagnostic importance using modular auxiliary auditing components (AC). Evaluating our pipeline on the MIMIC-CXR dataset, our findings show that incorporating ACs in the form of disease-classifiers can enable auditing that identifies more reliable reports, resulting in higher F1 scores compared to unfiltered generated reports. Additionally, leveraging the confidence of the AC labels further improves the audit's effectiveness.

We develop a novel generative model to simulate vehicle health and forecast faults, conditioned on practical operational considerations. The model, trained on data from the US Army's Predictive Logistics program, aims to support predictive maintenance. It forecasts faults far enough in advance to execute a maintenance intervention before a breakdown occurs. The model incorporates real-world factors that affect vehicle health. It also allows us to understand the vehicle's condition by analyzing operating data, and characterizing each vehicle into discrete states. Importantly, the model predicts the time to first fault with high accuracy. We compare its performance to other models and demonstrate its successful training.

Background: The reproducibility of machine-learning models in prostate cancer detection across different MRI vendors remains a significant challenge. Methods: This study investigates Support Vector Machines (SVM) and Random Forest (RF) models trained on radiomic features extracted from T2-weighted MRI images using Pyradiomics and MRCradiomics libraries. Feature selection was performed using the maximum relevance minimum redundancy (MRMR) technique. We aimed to enhance clinical decision support through multimodal learning and feature fusion. Results: Our SVM model, utilizing combined features from Pyradiomics and MRCradiomics, achieved an AUC of 0.74 on the Multi-Improd dataset (Siemens scanner) but decreased to 0.60 on the Philips test set. The RF model showed similar trends, with notable robustness for models using Pyradiomics features alone (AUC of 0.78 on Philips). Conclusions: These findings demonstrate the potential of multimodal feature integration to improve the robustness and generalizability of machine-learning models for clinical decision support in prostate cancer detection. This study marks a significant step towards developing reliable AI-driven diagnostic tools that maintain efficacy across various imaging platforms.

Federated Learning (FL) offers a privacy-preserving approach to train models on decentralized data. Its potential in healthcare is significant, but challenges arise due to cross-client variations in medical image data, exacerbated by limited annotations. This paper introduces Cross-Client Variations Adaptive Federated Learning (CCVA-FL) to address these issues. CCVA-FL aims to minimize cross-client variations by transforming images into a common feature space. It involves expert annotation of a subset of images from each client, followed by the selection of a client with the least data complexity as the target. Synthetic medical images are then generated using Scalable Diffusion Models with Transformers (DiT) based on the target client's annotated images. These synthetic images, capturing diversity and representing the original data, are shared with other clients. Each client then translates its local images into the target image space using image-to-image translation. The translated images are subsequently used in a federated learning setting to develop a server model. Our results demonstrate that CCVA-FL outperforms Vanilla Federated Averaging by effectively addressing data distribution differences across clients without compromising privacy.

We develop a novel generative model to simulate vehicle health and forecast faults, conditioned on practical operational considerations. The model, trained on data from the US Army's Predictive Logistics program, aims to support predictive maintenance. It forecasts faults far enough in advance to execute a maintenance intervention before a breakdown occurs. The model incorporates real-world factors that affect vehicle health. It also allows us to understand the vehicle's condition by analyzing operating data, and characterizing each vehicle into discrete states. Importantly, the model predicts the time to first fault with high accuracy. We compare its performance to other models and demonstrate its successful training.

This research explores the integration of language models and unsupervised anomaly detection in medical imaging, addressing two key questions: (1) Can language models enhance the interpretability of anomaly detection maps? and (2) Can anomaly maps improve the generalizability of language models in open-set anomaly detection tasks? To investigate these questions, we introduce a new dataset for multi-image visual question-answering on brain magnetic resonance images encompassing multiple conditions. We propose KQ-Former (Knowledge Querying Transformer), which is designed to optimally align visual and textual information in limited-sample contexts. Our model achieves a 60.81% accuracy on closed questions, covering disease classification and severity across 15 different classes. For open questions, KQ-Former demonstrates a 70% improvement over the baseline with a BLEU-4 score of 0.41, and achieves the highest entailment ratios (up to 71.9%) and lowest contradiction ratios (down to 10.0%) among various natural language inference models. Furthermore, integrating anomaly maps results in an 18% accuracy increase in detecting open-set anomalies, thereby enhancing the language model's generalizability to previously unseen medical conditions. The code and dataset are available at //github.com/compai-lab/miccai-2024-junli?tab=readme-ov-file

Virtual scenario-based testing methods to validate autonomous driving systems are predominantly centred around collision avoidance, and lack a comprehensive approach to evaluate optimal driving behaviour holistically. Furthermore, current validation approaches do not align with authorisation and monitoring requirements put forth by regulatory bodies. We address these validation gaps by outlining a universal evaluation framework that: incorporates the notion of careful and competent driving, unifies behavioural competencies and evaluation criteria, and is amenable at a scenario-specific and aggregate behaviour level. This framework can be leveraged to evaluate optimal driving in scenario-based testing, and for post-deployment monitoring to ensure continual compliance with regulation and safety standards.

Graph Neural Networks (GNNs) have received considerable attention on graph-structured data learning for a wide variety of tasks. The well-designed propagation mechanism which has been demonstrated effective is the most fundamental part of GNNs. Although most of GNNs basically follow a message passing manner, litter effort has been made to discover and analyze their essential relations. In this paper, we establish a surprising connection between different propagation mechanisms with a unified optimization problem, showing that despite the proliferation of various GNNs, in fact, their proposed propagation mechanisms are the optimal solution optimizing a feature fitting function over a wide class of graph kernels with a graph regularization term. Our proposed unified optimization framework, summarizing the commonalities between several of the most representative GNNs, not only provides a macroscopic view on surveying the relations between different GNNs, but also further opens up new opportunities for flexibly designing new GNNs. With the proposed framework, we discover that existing works usually utilize naive graph convolutional kernels for feature fitting function, and we further develop two novel objective functions considering adjustable graph kernels showing low-pass or high-pass filtering capabilities respectively. Moreover, we provide the convergence proofs and expressive power comparisons for the proposed models. Extensive experiments on benchmark datasets clearly show that the proposed GNNs not only outperform the state-of-the-art methods but also have good ability to alleviate over-smoothing, and further verify the feasibility for designing GNNs with our unified optimization framework.

Ensembles over neural network weights trained from different random initialization, known as deep ensembles, achieve state-of-the-art accuracy and calibration. The recently introduced batch ensembles provide a drop-in replacement that is more parameter efficient. In this paper, we design ensembles not only over weights, but over hyperparameters to improve the state of the art in both settings. For best performance independent of budget, we propose hyper-deep ensembles, a simple procedure that involves a random search over different hyperparameters, themselves stratified across multiple random initializations. Its strong performance highlights the benefit of combining models with both weight and hyperparameter diversity. We further propose a parameter efficient version, hyper-batch ensembles, which builds on the layer structure of batch ensembles and self-tuning networks. The computational and memory costs of our method are notably lower than typical ensembles. On image classification tasks, with MLP, LeNet, and Wide ResNet 28-10 architectures, our methodology improves upon both deep and batch ensembles.

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