Semi-supervised learning has made significant strides in the medical domain since it alleviates the heavy burden of collecting abundant pixel-wise annotated data for semantic segmentation tasks. Existing semi-supervised approaches enhance the ability to extract features from unlabeled data with prior knowledge obtained from limited labeled data. However, due to the scarcity of labeled data, the features extracted by the models are limited in supervised learning, and the quality of predictions for unlabeled data also cannot be guaranteed. Both will impede consistency training. To this end, we proposed a novel uncertainty-aware scheme to make models learn regions purposefully. Specifically, we employ Monte Carlo Sampling as an estimation method to attain an uncertainty map, which can serve as a weight for losses to force the models to focus on the valuable region according to the characteristics of supervised learning and unsupervised learning. Simultaneously, in the backward process, we joint unsupervised and supervised losses to accelerate the convergence of the network via enhancing the gradient flow between different tasks. Quantitatively, we conduct extensive experiments on three challenging medical datasets. Experimental results show desirable improvements to state-of-the-art counterparts.
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A fundamental limitation of applying semi-supervised learning in real-world settings is the assumption that unlabeled test data contains only classes previously encountered in the labeled training data. However, this assumption rarely holds for data in-the-wild, where instances belonging to novel classes may appear at testing time. Here, we introduce a novel open-world semi-supervised learning setting that formalizes the notion that novel classes may appear in the unlabeled test data. In this novel setting, the goal is to solve the class distribution mismatch between labeled and unlabeled data, where at the test time every input instance either needs to be classified into one of the existing classes or a new unseen class needs to be initialized. To tackle this challenging problem, we propose ORCA, an end-to-end deep learning approach that introduces uncertainty adaptive margin mechanism to circumvent the bias towards seen classes caused by learning discriminative features for seen classes faster than for the novel classes. In this way, ORCA reduces the gap between intra-class variance of seen with respect to novel classes. Experiments on image classification datasets and a single-cell annotation dataset demonstrate that ORCA consistently outperforms alternative baselines, achieving 25% improvement on seen and 96% improvement on novel classes of the ImageNet dataset.
Unsupervised domain adaptation (UDA) becomes more and more popular in tackling real-world problems without ground truth of the target domain. Though tedious annotation work is not required, UDA unavoidably faces two problems: 1) how to narrow the domain discrepancy to boost the transferring performance; 2) how to improve pseudo annotation producing mechanism for self-supervised learning (SSL). In this paper, we focus on UDA for semantic segmentation task. Firstly, we introduce adversarial learning into style gap bridging mechanism to keep the style information from two domains in the similar space. Secondly, to keep the balance of pseudo labels on each category, we propose a category-adaptive threshold mechanism to choose category-wise pseudo labels for SSL. The experiments are conducted using GTA5 as the source domain, Cityscapes as the target domain. The results show that our model outperforms the state-of-the-arts with a noticeable gain on cross-domain adaptation tasks.
In this paper, we tackle the unsupervised domain adaptation (UDA) for semantic segmentation, which aims to segment the unlabeled real data using labeled synthetic data. The main problem of UDA for semantic segmentation relies on reducing the domain gap between the real image and synthetic image. To solve this problem, we focused on separating information in an image into content and style. Here, only the content has cues for semantic segmentation, and the style makes the domain gap. Thus, precise separation of content and style in an image leads to effect as supervision of real data even when learning with synthetic data. To make the best of this effect, we propose a zero-style loss. Even though we perfectly extract content for semantic segmentation in the real domain, another main challenge, the class imbalance problem, still exists in UDA for semantic segmentation. We address this problem by transferring the contents of tail classes from synthetic to real domain. Experimental results show that the proposed method achieves the state-of-the-art performance in semantic segmentation on the major two UDA settings.
Acquiring sufficient ground-truth supervision to train deep visual models has been a bottleneck over the years due to the data-hungry nature of deep learning. This is exacerbated in some structured prediction tasks, such as semantic segmentation, which requires pixel-level annotations. This work addresses weakly supervised semantic segmentation (WSSS), with the goal of bridging the gap between image-level annotations and pixel-level segmentation. We formulate WSSS as a novel group-wise learning task that explicitly models semantic dependencies in a group of images to estimate more reliable pseudo ground-truths, which can be used for training more accurate segmentation models. In particular, we devise a graph neural network (GNN) for group-wise semantic mining, wherein input images are represented as graph nodes, and the underlying relations between a pair of images are characterized by an efficient co-attention mechanism. Moreover, in order to prevent the model from paying excessive attention to common semantics only, we further propose a graph dropout layer, encouraging the model to learn more accurate and complete object responses. The whole network is end-to-end trainable by iterative message passing, which propagates interaction cues over the images to progressively improve the performance. We conduct experiments on the popular PASCAL VOC 2012 and COCO benchmarks, and our model yields state-of-the-art performance. Our code is available at: //github.com/Lixy1997/Group-WSSS.
In this paper, we aim to improve the performance of semantic image segmentation in a semi-supervised setting in which training is effectuated with a reduced set of annotated images and additional non-annotated images. We present a method based on an ensemble of deep segmentation models. Each model is trained on a subset of the annotated data, and uses the non-annotated images to exchange information with the other models, similar to co-training. Even if each model learns on the same non-annotated images, diversity is preserved with the use of adversarial samples. Our results show that this ability to simultaneously train models, which exchange knowledge while preserving diversity, leads to state-of-the-art results on two challenging medical image datasets.
3D image segmentation plays an important role in biomedical image analysis. Many 2D and 3D deep learning models have achieved state-of-the-art segmentation performance on 3D biomedical image datasets. Yet, 2D and 3D models have their own strengths and weaknesses, and by unifying them together, one may be able to achieve more accurate results. In this paper, we propose a new ensemble learning framework for 3D biomedical image segmentation that combines the merits of 2D and 3D models. First, we develop a fully convolutional network based meta-learner to learn how to improve the results from 2D and 3D models (base-learners). Then, to minimize over-fitting for our sophisticated meta-learner, we devise a new training method that uses the results of the base-learners as multiple versions of "ground truths". Furthermore, since our new meta-learner training scheme does not depend on manual annotation, it can utilize abundant unlabeled 3D image data to further improve the model. Extensive experiments on two public datasets (the HVSMR 2016 Challenge dataset and the mouse piriform cortex dataset) show that our approach is effective under fully-supervised, semi-supervised, and transductive settings, and attains superior performance over state-of-the-art image segmentation methods.
Medical image segmentation requires consensus ground truth segmentations to be derived from multiple expert annotations. A novel approach is proposed that obtains consensus segmentations from experts using graph cuts (GC) and semi supervised learning (SSL). Popular approaches use iterative Expectation Maximization (EM) to estimate the final annotation and quantify annotator's performance. Such techniques pose the risk of getting trapped in local minima. We propose a self consistency (SC) score to quantify annotator consistency using low level image features. SSL is used to predict missing annotations by considering global features and local image consistency. The SC score also serves as the penalty cost in a second order Markov random field (MRF) cost function optimized using graph cuts to derive the final consensus label. Graph cut obtains a global maximum without an iterative procedure. Experimental results on synthetic images, real data of Crohn's disease patients and retinal images show our final segmentation to be accurate and more consistent than competing methods.
In multi-organ segmentation of abdominal CT scans, most existing fully supervised deep learning algorithms require lots of voxel-wise annotations, which are usually difficult, expensive, and slow to obtain. In comparison, massive unlabeled 3D CT volumes are usually easily accessible. Current mainstream works to address the semi-supervised biomedical image segmentation problem are mostly graph-based. By contrast, deep network based semi-supervised learning methods have not drawn much attention in this field. In this work, we propose Deep Multi-Planar Co-Training (DMPCT), whose contributions can be divided into two folds: 1) The deep model is learned in a co-training style which can mine consensus information from multiple planes like the sagittal, coronal, and axial planes; 2) Multi-planar fusion is applied to generate more reliable pseudo-labels, which alleviates the errors occurring in the pseudo-labels and thus can help to train better segmentation networks. Experiments are done on our newly collected large dataset with 100 unlabeled cases as well as 210 labeled cases where 16 anatomical structures are manually annotated by four radiologists and confirmed by a senior expert. The results suggest that DMPCT significantly outperforms the fully supervised method by more than 4% especially when only a small set of annotations is used.
Deep Convolutional Neural Networks have pushed the state-of-the art for semantic segmentation provided that a large amount of images together with pixel-wise annotations is available. Data collection is expensive and a solution to alleviate it is to use transfer learning. This reduces the amount of annotated data required for the network training but it does not get rid of this heavy processing step. We propose a method of transfer learning without annotations on the target task for datasets with redundant content and distinct pixel distributions. Our method takes advantage of the approximate content alignment of the images between two datasets when the approximation error prevents the reuse of annotation from one dataset to another. Given the annotations for only one dataset, we train a first network in a supervised manner. This network autonomously learns to generate deep data representations relevant to the semantic segmentation. Then the images in the new dataset, we train a new network to generate a deep data representation that matches the one from the first network on the previous dataset. The training consists in a regression between feature maps and does not require any annotations on the new dataset. We show that this method reaches performances similar to a classic transfer learning on the PASCAL VOC dataset with synthetic transformations.
We propose a novel locally adaptive learning estimator for enhancing the inter- and intra- discriminative capabilities of Deep Neural Networks, which can be used as improved loss layer for semantic image segmentation tasks. Most loss layers compute pixel-wise cost between feature maps and ground truths, ignoring spatial layouts and interactions between neighboring pixels with same object category, and thus networks cannot be effectively sensitive to intra-class connections. Stride by stride, our method firstly conducts adaptive pooling filter operating over predicted feature maps, aiming to merge predicted distributions over a small group of neighboring pixels with same category, and then it computes cost between the merged distribution vector and their category label. Such design can make groups of neighboring predictions from same category involved into estimations on predicting correctness with respect to their category, and hence train networks to be more sensitive to regional connections between adjacent pixels based on their categories. In the experiments on Pascal VOC 2012 segmentation datasets, the consistently improved results show that our proposed approach achieves better segmentation masks against previous counterparts.
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