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Inferring causal effects on long-term outcomes using short-term surrogates is crucial to rapid innovation. However, even when treatments are randomized and surrogates fully mediate their effect on outcomes, it's possible that we get the direction of causal effects wrong due to confounding between surrogates and outcomes -- a situation famously known as the surrogate paradox. The availability of many historical experiments offer the opportunity to instrument for the surrogate and bypass this confounding. However, even as the number of experiments grows, two-stage least squares has non-vanishing bias if each experiment has a bounded size, and this bias is exacerbated when most experiments barely move metrics, as occurs in practice. We show how to eliminate this bias using cross-fold procedures, JIVE being one example, and construct valid confidence intervals for the long-term effect in new experiments where long-term outcome has not yet been observed. Our methodology further allows to proxy for effects not perfectly mediated by the surrogates, allowing us to handle both confounding and effect leakage as violations of standard statistical surrogacy conditions.

Large language models with instruction-following abilities have revolutionized the field of artificial intelligence. These models show exceptional generalizability to tackle various real-world tasks through their natural language interfaces. However, their performance heavily relies on high-quality exemplar data, which is often difficult to obtain. This challenge is further exacerbated when it comes to multimodal instruction following. We introduce TextBind, an almost annotation-free framework for empowering larger language models with the multi-turn interleaved multimodal instruction-following capabilities. Our approach requires only image-caption pairs and generates multi-turn multimodal instruction-response conversations from a language model. To accommodate interleaved image-text inputs and outputs, we devise MIM, a language model-centric architecture that seamlessly integrates image encoder and decoder models. We release our dataset, model, and demo to foster future research in the area of multimodal instruction following.

Data augmentation (DA) has been widely leveraged in the realm of computer vision to alleviate the data shortage, whereas the DA in medical image analysis (MIA) faces multiple challenges. The prevalent DA approaches in MIA encompass conventional DA, synthetic DA, and automatic DA. However, the utilization of these approaches poses various challenges such as experience-driven design and intensive computation cost. Here, we propose an efficient and effective automatic DA method termed MedAugment. We propose the pixel augmentation space and spatial augmentation space and exclude the operations that can break the details and features within medical images. Besides, we propose a novel sampling strategy by sampling a limited number of operations from the two spaces. Moreover, we present a hyperparameter mapping relationship to produce a rational augmentation level and make the MedAugment fully controllable using a single hyperparameter. These revisions address the differences between natural and medical images. Extensive experimental results on four classification and three segmentation datasets demonstrate the superiority of MedAugment. We posit that the plug-and-use and training-free MedAugment holds the potential to make a valuable contribution to the medical field, particularly benefiting medical experts lacking foundational expertise in deep learning. Code is available at //github.com/NUS-Tim/MedAugment.

Latent diffusion models have proven to be state-of-the-art in the creation and manipulation of visual outputs. However, as far as we know, the generation of depth maps jointly with RGB is still limited. We introduce LDM3D-VR, a suite of diffusion models targeting virtual reality development that includes LDM3D-pano and LDM3D-SR. These models enable the generation of panoramic RGBD based on textual prompts and the upscaling of low-resolution inputs to high-resolution RGBD, respectively. Our models are fine-tuned from existing pretrained models on datasets containing panoramic/high-resolution RGB images, depth maps and captions. Both models are evaluated in comparison to existing related methods.

Multi-modal image fusion (MMIF) integrates valuable information from different modality images into a fused one. However, the fusion of multiple visible images with different focal regions and infrared images is a unprecedented challenge in real MMIF applications. This is because of the limited depth of the focus of visible optical lenses, which impedes the simultaneous capture of the focal information within the same scene. To address this issue, in this paper, we propose a MMIF framework for joint focused integration and modalities information extraction. Specifically, a semi-sparsity-based smoothing filter is introduced to decompose the images into structure and texture components. Subsequently, a novel multi-scale operator is proposed to fuse the texture components, capable of detecting significant information by considering the pixel focus attributes and relevant data from various modal images. Additionally, to achieve an effective capture of scene luminance and reasonable contrast maintenance, we consider the distribution of energy information in the structural components in terms of multi-directional frequency variance and information entropy. Extensive experiments on existing MMIF datasets, as well as the object detection and depth estimation tasks, consistently demonstrate that the proposed algorithm can surpass the state-of-the-art methods in visual perception and quantitative evaluation. The code is available at //github.com/ixilai/MFIF-MMIF.

In many real-world systems, such as adaptive robotics, achieving a single, optimised solution may be insufficient. Instead, a diverse set of high-performing solutions is often required to adapt to varying contexts and requirements. This is the realm of Quality-Diversity (QD), which aims to discover a collection of high-performing solutions, each with their own unique characteristics. QD methods have recently seen success in many domains, including robotics, where they have been used to discover damage-adaptive locomotion controllers. However, most existing work has focused on single-agent settings, despite many tasks of interest being multi-agent. To this end, we introduce Mix-ME, a novel multi-agent variant of the popular MAP-Elites algorithm that forms new solutions using a crossover-like operator by mixing together agents from different teams. We evaluate the proposed methods on a variety of partially observable continuous control tasks. Our evaluation shows that these multi-agent variants obtained by Mix-ME not only compete with single-agent baselines but also often outperform them in multi-agent settings under partial observability.

Restricting the variance of a policy's return is a popular choice in risk-averse Reinforcement Learning (RL) due to its clear mathematical definition and easy interpretability. Traditional methods directly restrict the total return variance. Recent methods restrict the per-step reward variance as a proxy. We thoroughly examine the limitations of these variance-based methods, such as sensitivity to numerical scale and hindering of policy learning, and propose to use an alternative risk measure, Gini deviation, as a substitute. We study various properties of this new risk measure and derive a policy gradient algorithm to minimize it. Empirical evaluation in domains where risk-aversion can be clearly defined, shows that our algorithm can mitigate the limitations of variance-based risk measures and achieves high return with low risk in terms of variance and Gini deviation when others fail to learn a reasonable policy.

The widespread use of ChatGPT and other emerging technology powered by generative artificial intelligence (AI) has drawn much attention to potential ethical issues, especially in high-stakes applications such as healthcare. However, less clear is how to resolve such issues beyond following guidelines and regulations that are still under discussion and development. On the other hand, other types of generative AI have been used to synthesize images and other types of data for research and practical purposes, which have resolved some ethical issues and exposed other ethical issues, but such technology is less often the focus of ongoing ethical discussions. Here we highlight gaps in current ethical discussions of generative AI via a systematic scoping review of relevant existing research in healthcare, and reduce the gaps by proposing an ethics checklist for comprehensive assessment and transparent documentation of ethical discussions in generative AI development. While the checklist can be readily integrated into the current peer review and publication system to enhance generative AI research, it may also be used in broader settings to disclose ethics-related considerations in generative AI-powered products (or real-life applications of such products) to help users establish reasonable trust in their capabilities.

With the advances of data-driven machine learning research, a wide variety of prediction problems have been tackled. It has become critical to explore how machine learning and specifically deep learning methods can be exploited to analyse healthcare data. A major limitation of existing methods has been the focus on grid-like data; however, the structure of physiological recordings are often irregular and unordered which makes it difficult to conceptualise them as a matrix. As such, graph neural networks have attracted significant attention by exploiting implicit information that resides in a biological system, with interactive nodes connected by edges whose weights can be either temporal associations or anatomical junctions. In this survey, we thoroughly review the different types of graph architectures and their applications in healthcare. We provide an overview of these methods in a systematic manner, organized by their domain of application including functional connectivity, anatomical structure and electrical-based analysis. We also outline the limitations of existing techniques and discuss potential directions for future research.

Knowledge graphs are important resources for many artificial intelligence tasks but often suffer from incompleteness. In this work, we propose to use pre-trained language models for knowledge graph completion. We treat triples in knowledge graphs as textual sequences and propose a novel framework named Knowledge Graph Bidirectional Encoder Representations from Transformer (KG-BERT) to model these triples. Our method takes entity and relation descriptions of a triple as input and computes scoring function of the triple with the KG-BERT language model. Experimental results on multiple benchmark knowledge graphs show that our method can achieve state-of-the-art performance in triple classification, link prediction and relation prediction tasks.