Large language models (LLMs) are gaining increasing interests to improve clinical efficiency for medical diagnosis, owing to their unprecedented performance in modelling natural language. Ensuring the safe and reliable clinical applications, the evaluation of LLMs indeed becomes critical for better mitigating the potential risks, e.g., hallucinations. However, current evaluation methods heavily rely on labor-intensive human participation to achieve human-preferred judgements. To overcome this challenge, we propose an automatic evaluation paradigm tailored to assess the LLMs' capabilities in delivering clinical services, e.g., disease diagnosis and treatment. The evaluation paradigm contains three basic elements: metric, data, and algorithm. Specifically, inspired by professional clinical practice pathways, we formulate a LLM-specific clinical pathway (LCP) to define the clinical capabilities that a doctor agent should possess. Then, Standardized Patients (SPs) from the medical education are introduced as the guideline for collecting medical data for evaluation, which can well ensure the completeness of the evaluation procedure. Leveraging these steps, we develop a multi-agent framework to simulate the interactive environment between SPs and a doctor agent, which is equipped with a Retrieval-Augmented Evaluation (RAE) to determine whether the behaviors of a doctor agent are in accordance with LCP. The above paradigm can be extended to any similar clinical scenarios to automatically evaluate the LLMs' medical capabilities. Applying such paradigm, we construct an evaluation benchmark in the field of urology, including a LCP, a SPs dataset, and an automated RAE. Extensive experiments are conducted to demonstrate the effectiveness of the proposed approach, providing more insights for LLMs' safe and reliable deployments in clinical practice.
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Over the past two decades, machine analysis of medical imaging has advanced rapidly, opening up significant potential for several important medical applications. As complicated diseases increase and the number of cases rises, the role of machine-based imaging analysis has become indispensable. It serves as both a tool and an assistant to medical experts, providing valuable insights and guidance. A particularly challenging task in this area is lesion segmentation, a task that is challenging even for experienced radiologists. The complexity of this task highlights the urgent need for robust machine learning approaches to support medical staff. In response, we present our novel solution: the D-TrAttUnet architecture. This framework is based on the observation that different diseases often target specific organs. Our architecture includes an encoder-decoder structure with a composite Transformer-CNN encoder and dual decoders. The encoder includes two paths: the Transformer path and the Encoders Fusion Module path. The Dual-Decoder configuration uses two identical decoders, each with attention gates. This allows the model to simultaneously segment lesions and organs and integrate their segmentation losses. To validate our approach, we performed evaluations on the Covid-19 and Bone Metastasis segmentation tasks. We also investigated the adaptability of the model by testing it without the second decoder in the segmentation of glands and nuclei. The results confirmed the superiority of our approach, especially in Covid-19 infections and the segmentation of bone metastases. In addition, the hybrid encoder showed exceptional performance in the segmentation of glands and nuclei, solidifying its role in modern medical image analysis.
Large language models (LLMs) have rapidly evolved as the foundation of various natural language processing (NLP) applications. Despite their wide use cases, their understanding of culturally-related concepts and reasoning remains limited. Meantime, there is a significant need to enhance these models' cultural reasoning capabilities, especially concerning underrepresented regions. This paper introduces a novel pipeline for extracting high-quality, culturally-related instruction tuning datasets from vast unstructured corpora. We utilize a self-instruction generation pipeline to identify cultural concepts and trigger instruction. By integrating with a general-purpose instruction tuning dataset, our model demonstrates enhanced capabilities in recognizing and understanding regional cultural nuances, thereby enhancing its reasoning capabilities. We conduct experiments across three regions: Singapore, the Philippines, and the United States, achieving performance improvement of up to 6%. Our research opens new avenues for extracting cultural instruction tuning sets directly from unstructured data, setting a precedent for future innovations in the field.
Despite their improved capabilities in generation and reasoning, adapting large language models (LLMs) to the biomedical domain remains challenging due to their immense size and corporate privacy. In this work, we propose MedAdapter, a unified post-hoc adapter for test-time adaptation of LLMs towards biomedical applications. Instead of fine-tuning the entire LLM, MedAdapter effectively adapts the original model by fine-tuning only a small BERT-sized adapter to rank candidate solutions generated by LLMs. Experiments demonstrate that MedAdapter effectively adapts both white-box and black-box LLMs in biomedical reasoning, achieving average performance improvements of 25.48% and 11.31%, respectively, without requiring extensive computational resources or sharing data with third parties. MedAdapter also yields superior performance when combined with train-time adaptation, highlighting a flexible and complementary solution to existing adaptation methods. Faced with the challenges of balancing model performance, computational resources, and data privacy, MedAdapter provides an efficient, privacy-preserving, cost-effective, and transparent solution for adapting LLMs to the biomedical domain.
Large language models (LLMs) have revolutionized numerous domains with their impressive performance but still face their challenges. A predominant issue is the propensity for these models to generate non-existent facts, a concern termed hallucination. Our research is motivated by the observation that previous instruction tuning methods force the model to complete a sentence no matter whether the model knows the knowledge or not. When the question is out of the parametric knowledge, it will try to make up something and fail to indicate when it lacks knowledge. In this paper, we present a new approach called Refusal-Aware Instruction Tuning (R-Tuning). This approach is formalized by first identifying the disparity in knowledge encompassed by pre-trained parameters compared to that of instruction tuning data. Then, we construct the refusal-aware data based on the knowledge intersection, to tune LLMs to refrain from responding to questions beyond its parametric knowledge. Experimental results demonstrate R-Tuning effectively improves a model's ability to answer known questions and refrain from answering unknown questions. Furthermore, when tested on out-of-domain datasets, the refusal ability was found to be a meta-skill that could be generalized to other tasks. Further analysis surprisingly finds that learning the uncertainty results in better calibration and an improved ability to estimate the uncertainty than uncertainty-based testing. Our code is available at //github.com/shizhediao/R-Tuning.
In the fast-evolving domain of artificial intelligence, large language models (LLMs) such as GPT-3 and GPT-4 are revolutionizing the landscapes of finance, healthcare, and law: domains characterized by their reliance on professional expertise, challenging data acquisition, high-stakes, and stringent regulatory compliance. This survey offers a detailed exploration of the methodologies, applications, challenges, and forward-looking opportunities of LLMs within these high-stakes sectors. We highlight the instrumental role of LLMs in enhancing diagnostic and treatment methodologies in healthcare, innovating financial analytics, and refining legal interpretation and compliance strategies. Moreover, we critically examine the ethics for LLM applications in these fields, pointing out the existing ethical concerns and the need for transparent, fair, and robust AI systems that respect regulatory norms. By presenting a thorough review of current literature and practical applications, we showcase the transformative impact of LLMs, and outline the imperative for interdisciplinary cooperation, methodological advancements, and ethical vigilance. Through this lens, we aim to spark dialogue and inspire future research dedicated to maximizing the benefits of LLMs while mitigating their risks in these precision-dependent sectors. To facilitate future research on LLMs in these critical societal domains, we also initiate a reading list that tracks the latest advancements under this topic, which will be continually updated: \url{//github.com/czyssrs/LLM_X_papers}.
The emergence of large language models (LLMs) has marked a significant breakthrough in natural language processing (NLP), leading to remarkable advancements in text understanding and generation. Nevertheless, alongside these strides, LLMs exhibit a critical tendency to produce hallucinations, resulting in content that is inconsistent with real-world facts or user inputs. This phenomenon poses substantial challenges to their practical deployment and raises concerns over the reliability of LLMs in real-world scenarios, which attracts increasing attention to detect and mitigate these hallucinations. In this survey, we aim to provide a thorough and in-depth overview of recent advances in the field of LLM hallucinations. We begin with an innovative taxonomy of LLM hallucinations, then delve into the factors contributing to hallucinations. Subsequently, we present a comprehensive overview of hallucination detection methods and benchmarks. Additionally, representative approaches designed to mitigate hallucinations are introduced accordingly. Finally, we analyze the challenges that highlight the current limitations and formulate open questions, aiming to delineate pathways for future research on hallucinations in LLMs.
Ensuring alignment, which refers to making models behave in accordance with human intentions [1,2], has become a critical task before deploying large language models (LLMs) in real-world applications. For instance, OpenAI devoted six months to iteratively aligning GPT-4 before its release [3]. However, a major challenge faced by practitioners is the lack of clear guidance on evaluating whether LLM outputs align with social norms, values, and regulations. This obstacle hinders systematic iteration and deployment of LLMs. To address this issue, this paper presents a comprehensive survey of key dimensions that are crucial to consider when assessing LLM trustworthiness. The survey covers seven major categories of LLM trustworthiness: reliability, safety, fairness, resistance to misuse, explainability and reasoning, adherence to social norms, and robustness. Each major category is further divided into several sub-categories, resulting in a total of 29 sub-categories. Additionally, a subset of 8 sub-categories is selected for further investigation, where corresponding measurement studies are designed and conducted on several widely-used LLMs. The measurement results indicate that, in general, more aligned models tend to perform better in terms of overall trustworthiness. However, the effectiveness of alignment varies across the different trustworthiness categories considered. This highlights the importance of conducting more fine-grained analyses, testing, and making continuous improvements on LLM alignment. By shedding light on these key dimensions of LLM trustworthiness, this paper aims to provide valuable insights and guidance to practitioners in the field. Understanding and addressing these concerns will be crucial in achieving reliable and ethically sound deployment of LLMs in various applications.
The emergence of large language models (LLMs) has substantially influenced natural language processing, demonstrating exceptional results across various tasks. In this study, we employ ``Introspective Tips" to facilitate LLMs in self-optimizing their decision-making. By introspectively examining trajectories, LLM refines its policy by generating succinct and valuable tips. Our method enhances the agent's performance in both few-shot and zero-shot learning situations by considering three essential scenarios: learning from the agent's past experiences, integrating expert demonstrations, and generalizing across diverse games. Importantly, we accomplish these improvements without fine-tuning the LLM parameters; rather, we adjust the prompt to generalize insights from the three aforementioned situations. Our framework not only supports but also emphasizes the advantage of employing LLM in in-contxt decision-making. Experiments involving over 100 games in TextWorld illustrate the superior performance of our approach.
Deep neural networks (DNNs) have achieved unprecedented success in the field of artificial intelligence (AI), including computer vision, natural language processing and speech recognition. However, their superior performance comes at the considerable cost of computational complexity, which greatly hinders their applications in many resource-constrained devices, such as mobile phones and Internet of Things (IoT) devices. Therefore, methods and techniques that are able to lift the efficiency bottleneck while preserving the high accuracy of DNNs are in great demand in order to enable numerous edge AI applications. This paper provides an overview of efficient deep learning methods, systems and applications. We start from introducing popular model compression methods, including pruning, factorization, quantization as well as compact model design. To reduce the large design cost of these manual solutions, we discuss the AutoML framework for each of them, such as neural architecture search (NAS) and automated pruning and quantization. We then cover efficient on-device training to enable user customization based on the local data on mobile devices. Apart from general acceleration techniques, we also showcase several task-specific accelerations for point cloud, video and natural language processing by exploiting their spatial sparsity and temporal/token redundancy. Finally, to support all these algorithmic advancements, we introduce the efficient deep learning system design from both software and hardware perspectives.
Deep Learning has revolutionized the fields of computer vision, natural language understanding, speech recognition, information retrieval and more. However, with the progressive improvements in deep learning models, their number of parameters, latency, resources required to train, etc. have all have increased significantly. Consequently, it has become important to pay attention to these footprint metrics of a model as well, not just its quality. We present and motivate the problem of efficiency in deep learning, followed by a thorough survey of the five core areas of model efficiency (spanning modeling techniques, infrastructure, and hardware) and the seminal work there. We also present an experiment-based guide along with code, for practitioners to optimize their model training and deployment. We believe this is the first comprehensive survey in the efficient deep learning space that covers the landscape of model efficiency from modeling techniques to hardware support. Our hope is that this survey would provide the reader with the mental model and the necessary understanding of the field to apply generic efficiency techniques to immediately get significant improvements, and also equip them with ideas for further research and experimentation to achieve additional gains.
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