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Large language models (LLMs) have initiated a paradigm shift in transfer learning. In contrast to the classic pretraining-then-finetuning procedure, in order to use LLMs for downstream prediction tasks, one only needs to provide a few demonstrations, known as in-context examples, without adding more or updating existing model parameters. This in-context learning (ICL) capabilities of LLMs is intriguing, and it is not yet fully understood how pretrained LLMs acquire such capabilities. In this paper, we investigate the reason why a transformer-based language model can accomplish in-context learning after pre-training on a general language corpus by proposing one hypothesis that LLMs can simulate kernel regression algorithms when faced with in-context examples. More concretely, we first prove that Bayesian inference on in-context prompts can be asymptotically understood as kernel regression $\hat y = \frac{\sum_i y_i K(x, x_i)}{\sum_i K(x, x_i)}$ as the number of in-context demonstrations grows. Then, we empirically investigate the in-context behaviors of language models. We find that during ICL, the attentions and hidden features in LLMs match the behaviors of a kernel regression. Finally, our theory provides insights on multiple phenomena observed in ICL field: why retrieving demonstrative samples similar to test sample can help, why ICL performance is sensitive to the output formats, and why ICL accuracy benefits from selecting in-distribution and representative samples. We will make our code available to the research community following publication.

The recent release of large language model (LLM) based chatbots, such as ChatGPT, has attracted significant attention on foundation models. It is widely believed that foundation models will serve as the fundamental building blocks for future AI systems. As foundation models are in their early stages, the design of foundation model based systems has not yet been systematically explored. There is little understanding about the impact of introducing foundation models in software architecture. Therefore, in this paper, we propose a taxonomy of foundation model based systems, which classifies and compares the characteristics of foundation models and design options of foundation model based systems. Our taxonomy comprises three categories: foundation model pretraining and fine-tuning, architecture design of foundation model based systems, and responsible-AI-by-design. This taxonomy provides concrete guidance for making major design decisions when designing foundation model based systems and highlights trade-offs arising from design decisions.

Information retrieval (IR) plays a crucial role in locating relevant resources from vast amounts of data, and its applications have evolved from traditional knowledge bases to modern search engines (SEs). The emergence of large language models (LLMs) has further revolutionized the IR field by enabling users to interact with search systems in natural language. In this paper, we explore the advantages and disadvantages of LLMs and SEs, highlighting their respective strengths in understanding user-issued queries and retrieving up-to-date information. To leverage the benefits of both paradigms while circumventing their limitations, we propose InteR, a novel framework that facilitates knowledge refinement through interaction between SEs and LLMs. InteR allows SEs to expand knowledge in queries using LLM-generated knowledge collections and enables LLMs to enhance prompt formulation using SE-retrieved documents. This iterative refinement process augments the inputs of SEs and LLMs, leading to more accurate retrieval. Experiments on large-scale retrieval benchmarks involving web search and low-resource retrieval tasks demonstrate that InteR achieves overall superior zero-shot retrieval performance compared to state-of-the-art methods, even those using relevance judgment. Source code is available at //github.com/Cyril-JZ/InteR

The Segment Anything Model (SAM) is the first foundation model for general image segmentation. It designed a novel promotable segmentation task, ensuring zero-shot image segmentation using the pre-trained model via two main modes including automatic everything and manual prompt. SAM has achieved impressive results on various natural image segmentation tasks. However, medical image segmentation (MIS) is more challenging due to the complex modalities, fine anatomical structures, uncertain and complex object boundaries, and wide-range object scales. Meanwhile, zero-shot and efficient MIS can well reduce the annotation time and boost the development of medical image analysis. Hence, SAM seems to be a potential tool and its performance on large medical datasets should be further validated. We collected and sorted 52 open-source datasets, and built a large medical segmentation dataset with 16 modalities, 68 objects, and 553K slices. We conducted a comprehensive analysis of different SAM testing strategies on the so-called COSMOS 553K dataset. Extensive experiments validate that SAM performs better with manual hints like points and boxes for object perception in medical images, leading to better performance in prompt mode compared to everything mode. Additionally, SAM shows remarkable performance in some specific objects and modalities, but is imperfect or even totally fails in other situations. Finally, we analyze the influence of different factors (e.g., the Fourier-based boundary complexity and size of the segmented objects) on SAM's segmentation performance. Extensive experiments validate that SAM's zero-shot segmentation capability is not sufficient to ensure its direct application to the MIS.

Recent artificial intelligence (AI) systems have reached milestones in "grand challenges" ranging from Go to protein-folding. The capability to retrieve medical knowledge, reason over it, and answer medical questions comparably to physicians has long been viewed as one such grand challenge. Large language models (LLMs) have catalyzed significant progress in medical question answering; Med-PaLM was the first model to exceed a "passing" score in US Medical Licensing Examination (USMLE) style questions with a score of 67.2% on the MedQA dataset. However, this and other prior work suggested significant room for improvement, especially when models' answers were compared to clinicians' answers. Here we present Med-PaLM 2, which bridges these gaps by leveraging a combination of base LLM improvements (PaLM 2), medical domain finetuning, and prompting strategies including a novel ensemble refinement approach. Med-PaLM 2 scored up to 86.5% on the MedQA dataset, improving upon Med-PaLM by over 19% and setting a new state-of-the-art. We also observed performance approaching or exceeding state-of-the-art across MedMCQA, PubMedQA, and MMLU clinical topics datasets. We performed detailed human evaluations on long-form questions along multiple axes relevant to clinical applications. In pairwise comparative ranking of 1066 consumer medical questions, physicians preferred Med-PaLM 2 answers to those produced by physicians on eight of nine axes pertaining to clinical utility (p < 0.001). We also observed significant improvements compared to Med-PaLM on every evaluation axis (p < 0.001) on newly introduced datasets of 240 long-form "adversarial" questions to probe LLM limitations. While further studies are necessary to validate the efficacy of these models in real-world settings, these results highlight rapid progress towards physician-level performance in medical question answering.

Prognostics and health management (PHM) technology plays a critical role in industrial production and equipment maintenance by identifying and predicting possible equipment failures and damages, thereby allowing necessary maintenance measures to be taken to enhance equipment service life and reliability while reducing production costs and downtime. In recent years, PHM technology based on artificial intelligence (AI) has made remarkable achievements in the context of the industrial IoT and big data, and it is widely used in various industries, such as railway, energy, and aviation, for condition monitoring, fault prediction, and health management. The emergence of large-scale foundation models (LSF-Models) such as ChatGPT and DALLE-E marks the entry of AI into a new era of AI-2.0 from AI-1.0, where deep models have rapidly evolved from a research paradigm of single-modal, single-task, and limited-data to a multi-modal, multi-task, massive data, and super-large model paradigm. ChatGPT represents a landmark achievement in this research paradigm, offering hope for general artificial intelligence due to its highly intelligent natural language understanding ability. However, the PHM field lacks a consensus on how to respond to this significant change in the AI field, and a systematic review and roadmap is required to elucidate future development directions. To fill this gap, this paper systematically expounds on the key components and latest developments of LSF-Models. Then, we systematically answered how to build the LSF-Model applicable to PHM tasks and outlined the challenges and future development roadmaps for this research paradigm.

Knowledge plays a critical role in artificial intelligence. Recently, the extensive success of pre-trained language models (PLMs) has raised significant attention about how knowledge can be acquired, maintained, updated and used by language models. Despite the enormous amount of related studies, there still lacks a unified view of how knowledge circulates within language models throughout the learning, tuning, and application processes, which may prevent us from further understanding the connections between current progress or realizing existing limitations. In this survey, we revisit PLMs as knowledge-based systems by dividing the life circle of knowledge in PLMs into five critical periods, and investigating how knowledge circulates when it is built, maintained and used. To this end, we systematically review existing studies of each period of the knowledge life cycle, summarize the main challenges and current limitations, and discuss future directions.

Reasoning is a fundamental aspect of human intelligence that plays a crucial role in activities such as problem solving, decision making, and critical thinking. In recent years, large language models (LLMs) have made significant progress in natural language processing, and there is observation that these models may exhibit reasoning abilities when they are sufficiently large. However, it is not yet clear to what extent LLMs are capable of reasoning. This paper provides a comprehensive overview of the current state of knowledge on reasoning in LLMs, including techniques for improving and eliciting reasoning in these models, methods and benchmarks for evaluating reasoning abilities, findings and implications of previous research in this field, and suggestions on future directions. Our aim is to provide a detailed and up-to-date review of this topic and stimulate meaningful discussion and future work.

In practically every industry today, artificial intelligence is one of the most effective ways for machines to assist humans. Since its inception, a large number of researchers throughout the globe have been pioneering the application of artificial intelligence in medicine. Although artificial intelligence may seem to be a 21st-century concept, Alan Turing pioneered the first foundation concept in the 1940s. Artificial intelligence in medicine has a huge variety of applications that researchers are continually exploring. The tremendous increase in computer and human resources has hastened progress in the 21st century, and it will continue to do so for many years to come. This review of the literature will highlight the emerging field of artificial intelligence in medicine and its current level of development.

AI is undergoing a paradigm shift with the rise of models (e.g., BERT, DALL-E, GPT-3) that are trained on broad data at scale and are adaptable to a wide range of downstream tasks. We call these models foundation models to underscore their critically central yet incomplete character. This report provides a thorough account of the opportunities and risks of foundation models, ranging from their capabilities (e.g., language, vision, robotics, reasoning, human interaction) and technical principles(e.g., model architectures, training procedures, data, systems, security, evaluation, theory) to their applications (e.g., law, healthcare, education) and societal impact (e.g., inequity, misuse, economic and environmental impact, legal and ethical considerations). Though foundation models are based on standard deep learning and transfer learning, their scale results in new emergent capabilities,and their effectiveness across so many tasks incentivizes homogenization. Homogenization provides powerful leverage but demands caution, as the defects of the foundation model are inherited by all the adapted models downstream. Despite the impending widespread deployment of foundation models, we currently lack a clear understanding of how they work, when they fail, and what they are even capable of due to their emergent properties. To tackle these questions, we believe much of the critical research on foundation models will require deep interdisciplinary collaboration commensurate with their fundamentally sociotechnical nature.