Large language models (LLMs), such as ChatGPT, have received substantial attention due to their capabilities for understanding and generating human language. LLMs in medicine to assist physicians for patient care are emerging as a promising research direction in both artificial intelligence and clinical medicine. This review provides a comprehensive overview of the principles, applications, and challenges faced by LLMs in medicine. We address the following specific questions: 1) How should medical LLMs be built? 2) What are the measures for the downstream performance of medical LLMs? 3) How should medical LLMs be utilized in real-world clinical practice? 4) What challenges arise from the use of medical LLMs? and 5) How should we better construct and utilize medical LLMs? This review aims to provide insights into the opportunities and challenges of LLMs in medicine, and serve as a practical resource for constructing effective medical LLMs. We also maintain and regularly updated list of practical guides on medical LLMs at //github.com/AI-in-Health/MedLLMsPracticalGuide.
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The advent of the Transformer architecture has propelled the growth of natural language processing (NLP) models, leading to remarkable achievements in numerous NLP tasks. Yet, the absence of specialized hardware like expansive GPU memory and high-speed interconnects poses challenges for training large-scale models. This makes it daunting for many users to experiment with pre-training and fine-tuning large language models (LLMs). In this study, we introduce \atom, a resilient distributed training framework designed for asynchronous training of vast models in a decentralized setting using cost-effective hardware, including consumer-grade GPUs and Ethernet. Unlike conventional model partitioning methods that distribute sub-models across GPUs, \atom aims to accommodate a complete LLM on one host (peer) through seamlessly model swapping and concurrently trains multiple copies across various peers to optimize training throughput. Through static analysis, \atom identifies the best model partitioning strategy and flawlessly merges model execution with swapping. Key benefits of \atom include: Avoiding the central point of failure found in pipeline parallelism methods. Demonstrating superior performance and scalability compared to closely-integrated pipeline parallelism in slower networks. Our experiments using different GPT-3 model configurations reveal that, in scenarios with suboptimal network connections, \atom can enhance training efficiency up to $20 \times$ when juxtaposed with the state-of-the-art decentralized pipeline parallelism approaches.
Despite the rapid development of large language models (LLMs) for the Korean language, there remains an obvious lack of benchmark datasets that test the requisite Korean cultural and linguistic knowledge. Because many existing Korean benchmark datasets are derived from the English counterparts through translation, they often overlook the different cultural contexts. For the few benchmark datasets that are sourced from Korean data capturing cultural knowledge, only narrow tasks such as bias and hate speech detection are offered. To address this gap, we introduce a benchmark of Cultural and Linguistic Intelligence in Korean (CLIcK), a dataset comprising 1,995 QA pairs. CLIcK sources its data from official Korean exams and textbooks, partitioning the questions into eleven categories under the two main categories of language and culture. For each instance in CLIcK, we provide fine-grained annotation of which cultural and linguistic knowledge is required to answer the question correctly. Using CLIcK, we test 13 language models to assess their performance. Our evaluation uncovers insights into their performances across the categories, as well as the diverse factors affecting their comprehension. CLIcK offers the first large-scale comprehensive Korean-centric analysis of LLMs' proficiency in Korean culture and language.
Large Language Models (LLMs) are demonstrating outstanding potential for tasks such as text generation, summarization, and classification. Given that such models are trained on a humongous amount of online knowledge, we hypothesize that LLMs can assess whether driving scenarios generated by autonomous driving testing techniques are realistic, i.e., being aligned with real-world driving conditions. To test this hypothesis, we conducted an empirical evaluation to assess whether LLMs are effective and robust in performing the task. This reality check is an important step towards devising LLM-based autonomous driving testing techniques. For our empirical evaluation, we selected 64 realistic scenarios from \deepscenario--an open driving scenario dataset. Next, by introducing minor changes to them, we created 512 additional realistic scenarios, to form an overall dataset of 576 scenarios. With this dataset, we evaluated three LLMs (\gpt, \llama, and \mistral) to assess their robustness in assessing the realism of driving scenarios. Our results show that: (1) Overall, \gpt achieved the highest robustness compared to \llama and \mistral, consistently throughout almost all scenarios, roads, and weather conditions; (2) \mistral performed the worst consistently; (3) \llama achieved good results under certain conditions; and (4) roads and weather conditions do influence the robustness of the LLMs.
Multimodal large language models (MLLMs) have shown impressive reasoning abilities, which, however, are also more vulnerable to jailbreak attacks than their LLM predecessors. Although still capable of detecting unsafe responses, we observe that safety mechanisms of the pre-aligned LLMs in MLLMs can be easily bypassed due to the introduction of image features. To construct robust MLLMs, we propose ECSO(Eyes Closed, Safety On), a novel training-free protecting approach that exploits the inherent safety awareness of MLLMs, and generates safer responses via adaptively transforming unsafe images into texts to activate intrinsic safety mechanism of pre-aligned LLMs in MLLMs. Experiments on five state-of-the-art (SoTA) MLLMs demonstrate that our ECSO enhances model safety significantly (e.g., a 37.6% improvement on the MM-SafetyBench (SD+OCR), and 71.3% on VLSafe for the LLaVA-1.5-7B), while consistently maintaining utility results on common MLLM benchmarks. Furthermore, we show that ECSO can be used as a data engine to generate supervised-finetuning (SFT) data for MLLM alignment without extra human intervention.
Large language models (LLMs) are complex artificial intelligence systems capable of understanding, generating and translating human language. They learn language patterns by analyzing large amounts of text data, allowing them to perform writing, conversation, summarizing and other language tasks. When LLMs process and generate large amounts of data, there is a risk of leaking sensitive information, which may threaten data privacy. This paper concentrates on elucidating the data privacy concerns associated with LLMs to foster a comprehensive understanding. Specifically, a thorough investigation is undertaken to delineate the spectrum of data privacy threats, encompassing both passive privacy leakage and active privacy attacks within LLMs. Subsequently, we conduct an assessment of the privacy protection mechanisms employed by LLMs at various stages, followed by a detailed examination of their efficacy and constraints. Finally, the discourse extends to delineate the challenges encountered and outline prospective directions for advancement in the realm of LLM privacy protection.
Large language models (LLMs) have achieved remarkable performance in various evaluation benchmarks. However, concerns are raised about potential data contamination in their considerable volume of training corpus. Moreover, the static nature and fixed complexity of current benchmarks may inadequately gauge the advancing capabilities of LLMs. In this paper, we introduce DyVal, a general and flexible protocol for dynamic evaluation of LLMs. Based on our framework, we build graph-informed DyVal by leveraging the structural advantage of directed acyclic graphs to dynamically generate evaluation samples with controllable complexities. DyVal generates challenging evaluation sets on reasoning tasks including mathematics, logical reasoning, and algorithm problems. We evaluate various LLMs ranging from Flan-T5-large to GPT-3.5-Turbo and GPT-4. Experiments show that LLMs perform worse in DyVal-generated evaluation samples with different complexities, highlighting the significance of dynamic evaluation. We also analyze the failure cases and results of different prompting methods. Moreover, DyVal-generated samples are not only evaluation sets, but also helpful data for fine-tuning to improve the performance of LLMs on existing benchmarks. We hope that DyVal can shed light on future evaluation research of LLMs. Code is available at: //github.com/microsoft/promptbench.
Although large language models (LLMs) have demonstrated impressive text generation capabilities, they are easily misled by the untruthful context provided by users or knowledge augmentation tools, thereby producing hallucinations. To alleviate the LLMs from being misled by untruthful information and take advantage of knowledge augmentation, we propose Truth-Aware Context Selection (TACS), a lightweight method to shield untruthful context from the inputs. TACS begins by performing truth detection on the input context, leveraging the parameterized knowledge within the LLM. Subsequently, it constructs a corresponding attention mask based on the truthfulness of each position, selecting the truthful context and discarding the untruthful context. Additionally, we introduce a new evaluation metric, Disturbance Adaption Rate, to further study the LLMs' ability to accept truthful information and resist untruthful information. Experimental results show that TACS can effectively filter information in context and significantly improve the overall quality of LLMs' responses when presented with misleading information.
Large language models (LLMs) exhibit superior performance on various natural language tasks, but they are susceptible to issues stemming from outdated data and domain-specific limitations. In order to address these challenges, researchers have pursued two primary strategies, knowledge editing and retrieval augmentation, to enhance LLMs by incorporating external information from different aspects. Nevertheless, there is still a notable absence of a comprehensive survey. In this paper, we propose a review to discuss the trends in integration of knowledge and large language models, including taxonomy of methods, benchmarks, and applications. In addition, we conduct an in-depth analysis of different methods and point out potential research directions in the future. We hope this survey offers the community quick access and a comprehensive overview of this research area, with the intention of inspiring future research endeavors.
The emergence of large language models (LLMs) has marked a significant breakthrough in natural language processing (NLP), leading to remarkable advancements in text understanding and generation. Nevertheless, alongside these strides, LLMs exhibit a critical tendency to produce hallucinations, resulting in content that is inconsistent with real-world facts or user inputs. This phenomenon poses substantial challenges to their practical deployment and raises concerns over the reliability of LLMs in real-world scenarios, which attracts increasing attention to detect and mitigate these hallucinations. In this survey, we aim to provide a thorough and in-depth overview of recent advances in the field of LLM hallucinations. We begin with an innovative taxonomy of LLM hallucinations, then delve into the factors contributing to hallucinations. Subsequently, we present a comprehensive overview of hallucination detection methods and benchmarks. Additionally, representative approaches designed to mitigate hallucinations are introduced accordingly. Finally, we analyze the challenges that highlight the current limitations and formulate open questions, aiming to delineate pathways for future research on hallucinations in LLMs.
Machine reading comprehension (MRC) aims to teach machines to read and comprehend human languages, which is a long-standing goal of natural language processing (NLP). With the burst of deep neural networks and the evolution of contextualized language models (CLMs), the research of MRC has experienced two significant breakthroughs. MRC and CLM, as a phenomenon, have a great impact on the NLP community. In this survey, we provide a comprehensive and comparative review on MRC covering overall research topics about 1) the origin and development of MRC and CLM, with a particular focus on the role of CLMs; 2) the impact of MRC and CLM to the NLP community; 3) the definition, datasets, and evaluation of MRC; 4) general MRC architecture and technical methods in the view of two-stage Encoder-Decoder solving architecture from the insights of the cognitive process of humans; 5) previous highlights, emerging topics, and our empirical analysis, among which we especially focus on what works in different periods of MRC researches. We propose a full-view categorization and new taxonomies on these topics. The primary views we have arrived at are that 1) MRC boosts the progress from language processing to understanding; 2) the rapid improvement of MRC systems greatly benefits from the development of CLMs; 3) the theme of MRC is gradually moving from shallow text matching to cognitive reasoning.
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