The Internet of Things (IoT) has grown significantly in popularity, accompanied by increased capacity and lower cost of communications, and overwhelming development of technologies. At the same time, big data and real-time data analysis have taken on great importance and have been accompanied by unprecedented interest in sharing data among citizens, public administrations and other organisms, giving rise to what is known as the Collaborative Internet of Things. This growth in data and infrastructure must be accompanied by a software architecture that allows its exploitation. Although there are various proposals focused on the exploitation of the IoT at edge, fog and/or cloud levels, it is not easy to find a software solution that exploits the three tiers together, taking maximum advantage not only of the analysis of contextual and situational data at each tier, but also of two-way communications between adjacent ones. In this paper, we propose an architecture that solves these deficiencies by proposing novel technologies which are appropriate for managing the resources of each tier: edge, fog and cloud. In addition, the fact that two-way communications along the three tiers of the architecture is allowed considerably enriches the contextual and situational information in each layer, and substantially assists decision making in real time. The paper illustrates the proposed software architecture through a case study of respiratory disease surveillance in hospitals. As a result, the proposed architecture permits efficient communications between the different tiers responding to the needs of these types of IoT scenarios.
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Varimax factor rotations, while popular among practitioners in psychology and statistics since being introduced by H. Kaiser, have historically been viewed with skepticism and suspicion by some theoreticians and mathematical statisticians. Now, work by K. Rohe and M. Zeng provides new, fundamental insight: varimax rotations provably perform statistical estimation in certain classes of latent variable models when paired with spectral-based matrix truncations for dimensionality reduction. We build on this newfound understanding of varimax rotations by developing further connections to network analysis and spectral methods rooted in entrywise matrix perturbation analysis. Concretely, this paper establishes the asymptotic multivariate normality of vectors in varimax-transformed Euclidean point clouds that represent low-dimensional node embeddings in certain latent space random graph models. We address related concepts including network sparsity, data denoising, and the role of matrix rank in latent variable parameterizations. Collectively, these findings, at the confluence of classical and contemporary multivariate analysis, reinforce methodology and inference procedures grounded in matrix factorization-based techniques. Numerical examples illustrate our findings and supplement our discussion.
Efficient and accurate algorithms are necessary to reconstruct particles in the highly granular detectors anticipated at the High-Luminosity Large Hadron Collider and the Future Circular Collider. We study scalable machine learning models for event reconstruction in electron-positron collisions based on a full detector simulation. Particle-flow reconstruction can be formulated as a supervised learning task using tracks and calorimeter clusters. We compare a graph neural network and kernel-based transformer and demonstrate that we can avoid quadratic operations while achieving realistic reconstruction. We show that hyperparameter tuning significantly improves the performance of the models. The best graph neural network model shows improvement in the jet transverse momentum resolution by up to 50% compared to the rule-based algorithm. The resulting model is portable across Nvidia, AMD and Habana hardware. Accurate and fast machine-learning based reconstruction can significantly improve future measurements at colliders.
Mendelian randomization is an instrumental variable method that utilizes genetic information to investigate the causal effect of a modifiable exposure on an outcome. In most cases, the exposure changes over time. Understanding the time-varying causal effect of the exposure can yield detailed insights into mechanistic effects and the potential impact of public health interventions. Recently, a growing number of Mendelian randomization studies have attempted to explore time-varying causal effects. However, the proposed approaches oversimplify temporal information and rely on overly restrictive structural assumptions, limiting their reliability in addressing time-varying causal problems. This paper considers a novel approach to estimate time-varying effects through continuous-time modelling by combining functional principal component analysis and weak-instrument-robust techniques. Our method effectively utilizes available data without making strong structural assumptions and can be applied in general settings where the exposure measurements occur at different timepoints for different individuals. We demonstrate through simulations that our proposed method performs well in estimating time-varying effects and provides reliable inference results when the time-varying effect form is correctly specified. The method could theoretically be used to estimate arbitrarily complex time-varying effects. However, there is a trade-off between model complexity and instrument strength. Estimating complex time-varying effects requires instruments that are unrealistically strong. We illustrate the application of this method in a case study examining the time-varying effects of systolic blood pressure on urea levels.
Multi-contrast (MC) Magnetic Resonance Imaging (MRI) reconstruction aims to incorporate a reference image of auxiliary modality to guide the reconstruction process of the target modality. Known MC reconstruction methods perform well with a fully sampled reference image, but usually exhibit inferior performance, compared to single-contrast (SC) methods, when the reference image is missing or of low quality. To address this issue, we propose DuDoUniNeXt, a unified dual-domain MRI reconstruction network that can accommodate to scenarios involving absent, low-quality, and high-quality reference images. DuDoUniNeXt adopts a hybrid backbone that combines CNN and ViT, enabling specific adjustment of image domain and k-space reconstruction. Specifically, an adaptive coarse-to-fine feature fusion module (AdaC2F) is devised to dynamically process the information from reference images of varying qualities. Besides, a partially shared shallow feature extractor (PaSS) is proposed, which uses shared and distinct parameters to handle consistent and discrepancy information among contrasts. Experimental results demonstrate that the proposed model surpasses state-of-the-art SC and MC models significantly. Ablation studies show the effectiveness of the proposed hybrid backbone, AdaC2F, PaSS, and the dual-domain unified learning scheme.
Deep neural networks are widely deployed in many fields. Due to the in-situ computation (known as processing in memory) capacity of the Resistive Random Access Memory (ReRAM) crossbar, ReRAM-based accelerator shows potential in accelerating DNN with low power and high performance. However, despite power advantage, such kind of accelerators suffer from the high power consumption of peripheral circuits, especially Analog-to-Digital Converter (ADC), which account for over 60 percent of total power consumption. This problem hinders the ReRAM-based accelerator to achieve higher efficiency. Some redundant Analog-to-Digital conversion operations have no contribution to maintaining inference accuracy, and such operations can be eliminated by modifying the ADC searching logic. Based on such observations, we propose an algorithm-hardware co-design method and explore the co-design approach in both hardware design and quantization algorithms. Firstly, we focus on the distribution output along the crossbar's bit-lines and identify the fine-grained redundant ADC sampling bits. % of weight and To further compress ADC bits, we propose a hardware-friendly quantization method and coding scheme, in which different quantization strategy was applied to the partial results in different intervals. To support the two features above, we propose a lightweight architectural design based on SAR-ADC\@. It's worth mentioning that our method is not only more energy efficient but also retains the flexibility of the algorithm. Experiments demonstrate that our method can reduce about $1.6 \sim 2.3 \times$ ADC power reduction.
Robust Markov Decision Processes (RMDPs) are a widely used framework for sequential decision-making under parameter uncertainty. RMDPs have been extensively studied when the objective is to maximize the discounted return, but little is known for average optimality (optimizing the long-run average of the rewards obtained over time) and Blackwell optimality (remaining discount optimal for all discount factors sufficiently close to 1). In this paper, we prove several foundational results for RMDPs beyond the discounted return. We show that average optimal policies can be chosen stationary and deterministic for sa-rectangular RMDPs but, perhaps surprisingly, that history-dependent (Markovian) policies strictly outperform stationary policies for average optimality in s-rectangular RMDPs. We also study Blackwell optimality for sa-rectangular RMDPs, where we show that {\em approximate} Blackwell optimal policies always exist, although Blackwell optimal policies may not exist. We also provide a sufficient condition for their existence, which encompasses virtually any examples from the literature. We then discuss the connection between average and Blackwell optimality, and we describe several algorithms to compute the optimal average return. Interestingly, our approach leverages the connections between RMDPs and stochastic games.
One of the main challenges for interpreting black-box models is the ability to uniquely decompose square-integrable functions of non-independent random inputs into a sum of functions of every possible subset of variables. However, dealing with dependencies among inputs can be complicated. We propose a novel framework to study this problem, linking three domains of mathematics: probability theory, functional analysis, and combinatorics. We show that, under two reasonable assumptions on the inputs (non-perfect functional dependence and non-degenerate stochastic dependence), it is always possible to decompose such a function uniquely. This generalizes the well-known Hoeffding decomposition. The elements of this decomposition can be expressed using oblique projections and allow for novel interpretability indices for evaluation and variance decomposition purposes. The properties of these novel indices are studied and discussed. This generalization offers a path towards a more precise uncertainty quantification, which can benefit sensitivity analysis and interpretability studies whenever the inputs are dependent. This decomposition is illustrated analytically, and the challenges for adopting these results in practice are discussed.
The minimum covariance determinant (MCD) estimator is a popular method for robustly estimating the mean and covariance of multivariate data. We extend the MCD to the setting where the observations are matrices rather than vectors and introduce the matrix minimum covariance determinant (MMCD) estimators for robust parameter estimation. These estimators hold equivariance properties, achieve a high breakdown point, and are consistent under elliptical matrix-variate distributions. We have also developed an efficient algorithm with convergence guarantees to compute the MMCD estimators. Using the MMCD estimators, we can compute robust Mahalanobis distances that can be used for outlier detection. Those distances can be decomposed into outlyingness contributions from each cell, row, or column of a matrix-variate observation using Shapley values, a concept for outlier explanation recently introduced in the multivariate setting. Simulations and examples reveal the excellent properties and usefulness of the robust estimators.
With the increasing availability of large scale datasets, computational power and tools like automatic differentiation and expressive neural network architectures, sequential data are now often treated in a data-driven way, with a dynamical model trained from the observation data. While neural networks are often seen as uninterpretable black-box architectures, they can still benefit from physical priors on the data and from mathematical knowledge. In this paper, we use a neural network architecture which leverages the long-known Koopman operator theory to embed dynamical systems in latent spaces where their dynamics can be described linearly, enabling a number of appealing features. We introduce methods that enable to train such a model for long-term continuous reconstruction, even in difficult contexts where the data comes in irregularly-sampled time series. The potential for self-supervised learning is also demonstrated, as we show the promising use of trained dynamical models as priors for variational data assimilation techniques, with applications to e.g. time series interpolation and forecasting.
Recent advances in 3D fully convolutional networks (FCN) have made it feasible to produce dense voxel-wise predictions of volumetric images. In this work, we show that a multi-class 3D FCN trained on manually labeled CT scans of several anatomical structures (ranging from the large organs to thin vessels) can achieve competitive segmentation results, while avoiding the need for handcrafting features or training class-specific models. To this end, we propose a two-stage, coarse-to-fine approach that will first use a 3D FCN to roughly define a candidate region, which will then be used as input to a second 3D FCN. This reduces the number of voxels the second FCN has to classify to ~10% and allows it to focus on more detailed segmentation of the organs and vessels. We utilize training and validation sets consisting of 331 clinical CT images and test our models on a completely unseen data collection acquired at a different hospital that includes 150 CT scans, targeting three anatomical organs (liver, spleen, and pancreas). In challenging organs such as the pancreas, our cascaded approach improves the mean Dice score from 68.5 to 82.2%, achieving the highest reported average score on this dataset. We compare with a 2D FCN method on a separate dataset of 240 CT scans with 18 classes and achieve a significantly higher performance in small organs and vessels. Furthermore, we explore fine-tuning our models to different datasets. Our experiments illustrate the promise and robustness of current 3D FCN based semantic segmentation of medical images, achieving state-of-the-art results. Our code and trained models are available for download: //github.com/holgerroth/3Dunet_abdomen_cascade.
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