Integrating data from different platforms, such as bulk and single-cell RNA sequencing, is crucial for improving the accuracy and interpretability of complex biological analyses like cell type deconvolution. However, this task is complicated by measurement and biological heterogeneity between target and reference datasets. For the problem of cell type deconvolution, existing methods often neglect the correlation and uncertainty in cell type proportion estimates, possibly leading to an additional concern of false positives in downstream comparisons across multiple individuals. We introduce MEAD, a comprehensive statistical framework that not only estimates cell type proportions but also provides asymptotically valid statistical inference on the estimates. One of our key contributions is the identifiability result, which rigorously establishes the conditions under which cell type proportions are identifiable despite arbitrary heterogeneity of measurement biases between platforms. MEAD also supports the comparison of cell type proportions across individuals after deconvolution, accounting for gene-gene correlations and biological variability. Through simulations and real-data analysis, MEAD demonstrates superior reliability for inferring cell type compositions in complex biological systems.
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Emotion recognition based on body movements is vital in human-computer interaction. However, existing emotion recognition methods predominantly focus on enhancing classification accuracy, often neglecting the provision of textual explanations to justify their classifications. In this paper, we propose an Emotion-Action Interpreter powered by Large Language Model (EAI-LLM), which not only recognizes emotions but also generates textual explanations by treating 3D body movement data as unique input tokens within large language models (LLMs). Specifically, we propose a multi-granularity skeleton tokenizer designed for LLMs, which separately extracts spatio-temporal tokens and semantic tokens from the skeleton data. This approach allows LLMs to generate more nuanced classification descriptions while maintaining robust classification performance. Furthermore, we treat the skeleton sequence as a specific language and propose a unified skeleton token module. This module leverages the extensive background knowledge and language processing capabilities of LLMs to address the challenges of joint training on heterogeneous datasets, thereby significantly enhancing recognition accuracy on individual datasets. Experimental results demonstrate that our model achieves recognition accuracy comparable to existing methods. More importantly, with the support of background knowledge from LLMs, our model can generate detailed emotion descriptions based on classification results, even when trained on a limited amount of labeled skeleton data.
We establish that a non-Gaussian nonparametric regression model is asymptotically equivalent to a regression model with Gaussian noise. The approximation is in the sense of Le Cam's deficiency distance $\Delta $; the models are then asymptotically equivalent for all purposes of statistical decision with bounded loss. Our result concerns a sequence of independent but not identically distributed observations with each distribution in the same real-indexed exponential family. The canonical parameter is a value $f(t_i)$ of a regression function $f$ at a grid point $t_i$ (nonparametric GLM). When $f$ is in a H\"{o}lder ball with exponent $\beta >\frac 12 ,$ we establish global asymptotic equivalence to observations of a signal $\Gamma (f(t))$ in Gaussian white noise, where $\Gamma $ is related to a variance stabilizing transformation in the exponential family. The result is a regression analog of the recently established Gaussian approximation for the i.i.d. model. The proof is based on a functional version of the Hungarian construction for the partial sum process.
Previous research has shown that constraining the gradient of loss function with respect to model-predicted probabilities can enhance the model robustness against noisy labels. These methods typically specify a fixed optimal threshold for gradient clipping through validation data to obtain the desired robustness against noise. However, this common practice overlooks the dynamic distribution of gradients from both clean and noisy-labeled samples at different stages of training, significantly limiting the model capability to adapt to the variable nature of gradients throughout the training process. To address this issue, we propose a simple yet effective approach called Optimized Gradient Clipping (OGC), which dynamically adjusts the clipping threshold based on the ratio of noise gradients to clean gradients after clipping, estimated by modeling the distributions of clean and noisy samples. This approach allows us to modify the clipping threshold at each training step, effectively controlling the influence of noise gradients. Additionally, we provide statistical analysis to certify the noise-tolerance ability of OGC. Our extensive experiments across various types of label noise, including symmetric, asymmetric, instance-dependent, and real-world noise, demonstrate the effectiveness of our approach.
Conventional cardiac cine MRI methods rely on retrospective gating, which limits temporal resolution and the ability to capture continuous cardiac dynamics, particularly in patients with arrhythmias and beat-to-beat variations. To address these challenges, we propose a reconstruction framework based on subspace implicit neural representations for real-time cardiac cine MRI of continuously sampled radial data. This approach employs two multilayer perceptrons to learn spatial and temporal subspace bases, leveraging the low-rank properties of cardiac cine MRI. Initialized with low-resolution reconstructions, the networks are fine-tuned using spoke-specific loss functions to recover spatial details and temporal fidelity. Our method directly utilizes the continuously sampled radial k-space spokes during training, thereby eliminating the need for binning and non-uniform FFT. This approach achieves superior spatial and temporal image quality compared to conventional binned methods at the acceleration rate of 10 and 20, demonstrating potential for high-resolution imaging of dynamic cardiac events and enhancing diagnostic capability.
It is widely recognised that semiparametric efficient estimation can be hard to achieve in practice: estimators that are in theory efficient may require unattainable levels of accuracy for the estimation of complex nuisance functions. As a consequence, estimators deployed on real datasets are often chosen in a somewhat ad hoc fashion, and may suffer high variance. We study this gap between theory and practice in the context of a broad collection of semiparametric regression models that includes the generalised partially linear model. We advocate using estimators that are robust in the sense that they enjoy $\sqrt{n}$-consistent uniformly over a sufficiently rich class of distributions characterised by certain conditional expectations being estimable by user-chosen machine learning methods. We show that even asking for locally uniform estimation within such a class narrows down possible estimators to those parametrised by certain weight functions. Conversely, we show that such estimators do provide the desired uniform consistency and introduce a novel random forest-based procedure for estimating the optimal weights. We prove that the resulting estimator recovers a notion of $\textbf{ro}$bust $\textbf{s}$emiparametric $\textbf{e}$fficiency (ROSE) and provides a practical alternative to semiparametric efficient estimators. We demonstrate the effectiveness of our ROSE random forest estimator in a variety of semiparametric settings on simulated and real-world data.
Data rebalancing techniques, including oversampling and undersampling, are a common approach to addressing the challenges of imbalanced data. To tackle unresolved problems related to both oversampling and undersampling, we propose a new undersampling approach that: (i) avoids the pitfalls of noise and overlap caused by synthetic data and (ii) avoids the pitfall of under-fitting caused by random undersampling. Instead of undersampling majority data randomly, our method undersamples datapoints based on their ability to improve model loss. Using improved model loss as a proxy measurement for classification performance, our technique assesses a datapoint's impact on loss and rejects those unable to improve it. In so doing, our approach rejects majority datapoints redundant to datapoints already accepted and, thereby, finds an optimal subset of majority training data for classification. The accept/reject component of our algorithm is motivated by a bilevel optimization problem uniquely formulated to identify the optimal training set we seek. Experimental results show our proposed technique with F1 scores up to 10% higher than state-of-the-art methods.
Quadratic programming (QP) forms a crucial foundation in optimization, encompassing a broad spectrum of domains and serving as the basis for more advanced algorithms. Consequently, as the scale and complexity of modern applications continue to grow, the development of efficient and reliable QP algorithms is becoming increasingly vital. In this context, this paper introduces a novel deep learning-aided distributed optimization architecture designed for tackling large-scale QP problems. First, we combine the state-of-the-art Operator Splitting QP (OSQP) method with a consensus approach to derive DistributedQP, a new method tailored for network-structured problems, with convergence guarantees to optimality. Subsequently, we unfold this optimizer into a deep learning framework, leading to DeepDistributedQP, which leverages learned policies to accelerate reaching to desired accuracy within a restricted amount of iterations. Our approach is also theoretically grounded through Probably Approximately Correct (PAC)-Bayes theory, providing generalization bounds on the expected optimality gap for unseen problems. The proposed framework, as well as its centralized version DeepQP, significantly outperform their standard optimization counterparts on a variety of tasks such as randomly generated problems, optimal control, linear regression, transportation networks and others. Notably, DeepDistributedQP demonstrates strong generalization by training on small problems and scaling to solve much larger ones (up to 50K variables and 150K constraints) using the same policy. Moreover, it achieves orders-of-magnitude improvements in wall-clock time compared to OSQP. The certifiable performance guarantees of our approach are also demonstrated, ensuring higher-quality solutions over traditional optimizers.
Transformer is a type of deep neural network mainly based on self-attention mechanism which is originally applied in natural language processing field. Inspired by the strong representation ability of transformer, researchers propose to extend transformer for computer vision tasks. Transformer-based models show competitive and even better performance on various visual benchmarks compared to other network types such as convolutional networks and recurrent networks. In this paper we provide a literature review of these visual transformer models by categorizing them in different tasks and analyze the advantages and disadvantages of these methods. In particular, the main categories include the basic image classification, high-level vision, low-level vision and video processing. Self-attention in computer vision is also briefly revisited as self-attention is the base component in transformer. Efficient transformer methods are included for pushing transformer into real applications. Finally, we give a discussion about the further research directions for visual transformer.
Data augmentation has been widely used to improve generalizability of machine learning models. However, comparatively little work studies data augmentation for graphs. This is largely due to the complex, non-Euclidean structure of graphs, which limits possible manipulation operations. Augmentation operations commonly used in vision and language have no analogs for graphs. Our work studies graph data augmentation for graph neural networks (GNNs) in the context of improving semi-supervised node-classification. We discuss practical and theoretical motivations, considerations and strategies for graph data augmentation. Our work shows that neural edge predictors can effectively encode class-homophilic structure to promote intra-class edges and demote inter-class edges in given graph structure, and our main contribution introduces the GAug graph data augmentation framework, which leverages these insights to improve performance in GNN-based node classification via edge prediction. Extensive experiments on multiple benchmarks show that augmentation via GAug improves performance across GNN architectures and datasets.
Benefit from the quick development of deep learning techniques, salient object detection has achieved remarkable progresses recently. However, there still exists following two major challenges that hinder its application in embedded devices, low resolution output and heavy model weight. To this end, this paper presents an accurate yet compact deep network for efficient salient object detection. More specifically, given a coarse saliency prediction in the deepest layer, we first employ residual learning to learn side-output residual features for saliency refinement, which can be achieved with very limited convolutional parameters while keep accuracy. Secondly, we further propose reverse attention to guide such side-output residual learning in a top-down manner. By erasing the current predicted salient regions from side-output features, the network can eventually explore the missing object parts and details which results in high resolution and accuracy. Experiments on six benchmark datasets demonstrate that the proposed approach compares favorably against state-of-the-art methods, and with advantages in terms of simplicity, efficiency (45 FPS) and model size (81 MB).
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