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Observational studies are often conducted to estimate causal effects of treatments or exposures on event-time outcomes. Since treatments are not randomized in observational studies, techniques from causal inference are required to adjust for confounding. Bayesian approaches to causal estimates are desirable because they provide 1) prior smoothing provides useful regularization of causal effect estimates, 2) flexible models that are robust to misspecification, 3) full inference (i.e. both point and uncertainty estimates) for causal estimands. However, Bayesian causal inference is difficult to implement manually and there is a lack of user-friendly software, presenting a significant barrier to wide-spread use. We address this gap by developing causalBETA (Bayesian Event Time Analysis) - an open-source R package for estimating causal effects on event-time outcomes using Bayesian semiparametric models. The package provides a familiar front-end to users, with syntax identical to existing survival analysis R packages such as survival. At the same time, it back-ends to Stan - a popular platform for Bayesian modeling and high performance statistical computing - for efficient posterior computation. To improve user experience, the package is built using customized S3 class objects and methods to facilitate visualizations and summaries of results using familiar generic functions like plot() and summary(). In this paper, we provide the methodological details of the package, a demonstration using publicly-available data, and computational guidance.

The circular external difference family and its strong version, which themselves are of independent combinatorial interest, were proposed as variants of the difference family to construct new unconditionally secure non-malleable threshold schemes. In this paper, we present new results regarding the construction and non-existence of (strong) circular external difference families, thereby solving several open problems on this topic.

Embodied agents operate in a structured world, often solving tasks with spatial, temporal, and permutation symmetries. Most algorithms for planning and model-based reinforcement learning (MBRL) do not take this rich geometric structure into account, leading to sample inefficiency and poor generalization. We introduce the Equivariant Diffuser for Generating Interactions (EDGI), an algorithm for MBRL and planning that is equivariant with respect to the product of the spatial symmetry group SE(3), the discrete-time translation group Z, and the object permutation group Sn. EDGI follows the Diffuser framework (Janner et al., 2022) in treating both learning a world model and planning in it as a conditional generative modeling problem, training a diffusion model on an offline trajectory dataset. We introduce a new SE(3)xZxSn-equivariant diffusion model that supports multiple representations. We integrate this model in a planning loop, where conditioning and classifier guidance let us softly break the symmetry for specific tasks as needed. On object manipulation and navigation tasks, EDGI is substantially more sample efficient and generalizes better across the symmetry group than non-equivariant models.

Observational studies are often conducted to estimate causal effects of treatments or exposures on event-time outcomes. Since treatments are not randomized in observational studies, techniques from causal inference are required to adjust for confounding. Bayesian approaches to causal estimates are desirable because they provide 1) prior smoothing provides useful regularization of causal effect estimates, 2) flexible models that are robust to misspecification, 3) full inference (i.e. both point and uncertainty estimates) for causal estimands. However, Bayesian causal inference is difficult to implement manually and there is a lack of user-friendly software, presenting a significant barrier to wide-spread use. We address this gap by developing causalBETA (Bayesian Event Time Analysis) - an open-source R package for estimating causal effects on event-time outcomes using Bayesian semiparametric models. The package provides a familiar front-end to users, with syntax identical to existing survival analysis R packages such as survival. At the same time, it back-ends to Stan - a popular platform for Bayesian modeling and high performance statistical computing - for efficient posterior computation. To improve user experience, the package is built using customized S3 class objects and methods to facilitate visualizations and summaries of results using familiar generic functions like plot() and summary(). In this paper, we provide the methodological details of the package, a demonstration using publicly-available data, and computational guidance.

Intent detection and identification from multi-turn dialogue has become a widely explored technique in conversational agents, for example, voice assistants and intelligent customer services. The conventional approaches typically cast the intent mining process as a classification task. Although neural classifiers have proven adept at such classification tasks, the issue of neural network models often impedes their practical deployment in real-world settings. We present a novel graph-based multi-turn dialogue system called , which identifies a user's intent by identifying intent elements and a standard query from a dynamically constructed and extensible intent graph using reinforcement learning. In addition, we provide visualization components to monitor the immediate reasoning path for each turn of a dialogue, which greatly facilitates further improvement of the system.

Data Augmentation through generating pseudo data has been proven effective in mitigating the challenge of data scarcity in the field of Grammatical Error Correction (GEC). Various augmentation strategies have been widely explored, most of which are motivated by two heuristics, i.e., increasing the distribution similarity and diversity of pseudo data. However, the underlying mechanism responsible for the effectiveness of these strategies remains poorly understood. In this paper, we aim to clarify how data augmentation improves GEC models. To this end, we introduce two interpretable and computationally efficient measures: Affinity and Diversity. Our findings indicate that an excellent GEC data augmentation strategy characterized by high Affinity and appropriate Diversity can better improve the performance of GEC models. Based on this observation, we propose MixEdit, a data augmentation approach that strategically and dynamically augments realistic data, without requiring extra monolingual corpora. To verify the correctness of our findings and the effectiveness of the proposed MixEdit, we conduct experiments on mainstream English and Chinese GEC datasets. The results show that MixEdit substantially improves GEC models and is complementary to traditional data augmentation methods.

Recent work has aimed to capture nuances of human behavior by using LLMs to simulate responses from particular demographics in settings like social science experiments and public opinion surveys. However, there are currently no established ways to discuss or evaluate the quality of such LLM simulations. Moreover, there is growing concern that these LLM simulations are flattened caricatures of the personas that they aim to simulate, failing to capture the multidimensionality of people and perpetuating stereotypes. To bridge these gaps, we present CoMPosT, a framework to characterize LLM simulations using four dimensions: Context, Model, Persona, and Topic. We use this framework to measure open-ended LLM simulations' susceptibility to caricature, defined via two criteria: individuation and exaggeration. We evaluate the level of caricature in scenarios from existing work on LLM simulations. We find that for GPT-4, simulations of certain demographics (political and marginalized groups) and topics (general, uncontroversial) are highly susceptible to caricature.

Modeling the interaction between proteins and ligands and accurately predicting their binding structures is a critical yet challenging task in drug discovery. Recent advancements in deep learning have shown promise in addressing this challenge, with sampling-based and regression-based methods emerging as two prominent approaches. However, these methods have notable limitations. Sampling-based methods often suffer from low efficiency due to the need for generating multiple candidate structures for selection. On the other hand, regression-based methods offer fast predictions but may experience decreased accuracy. Additionally, the variation in protein sizes often requires external modules for selecting suitable binding pockets, further impacting efficiency. In this work, we propose $\mathbf{FABind}$, an end-to-end model that combines pocket prediction and docking to achieve accurate and fast protein-ligand binding. $\mathbf{FABind}$ incorporates a unique ligand-informed pocket prediction module, which is also leveraged for docking pose estimation. The model further enhances the docking process by incrementally integrating the predicted pocket to optimize protein-ligand binding, reducing discrepancies between training and inference. Through extensive experiments on benchmark datasets, our proposed $\mathbf{FABind}$ demonstrates strong advantages in terms of effectiveness and efficiency compared to existing methods. Our code is available at $\href{//github.com/QizhiPei/FABind}{Github}$.

Objective: To improve performance of medical entity normalization across many languages, especially when fewer language resources are available compared to English. Materials and Methods: We introduce xMEN, a modular system for cross-lingual medical entity normalization, which performs well in both low- and high-resource scenarios. When synonyms in the target language are scarce for a given terminology, we leverage English aliases via cross-lingual candidate generation. For candidate ranking, we incorporate a trainable cross-encoder model if annotations for the target task are available. We also evaluate cross-encoders trained in a weakly supervised manner based on machine-translated datasets from a high resource domain. Our system is publicly available as an extensible Python toolkit. Results: xMEN improves the state-of-the-art performance across a wide range of multilingual benchmark datasets. Weakly supervised cross-encoders are effective when no training data is available for the target task. Through the compatibility of xMEN with the BigBIO framework, it can be easily used with existing and prospective datasets. Discussion: Our experiments show the importance of balancing the output of general-purpose candidate generators with subsequent trainable re-rankers, which we achieve through a rank regularization term in the loss function of the cross-encoder. However, error analysis reveals that multi-word expressions and other complex entities are still challenging. Conclusion: xMEN exhibits strong performance for medical entity normalization in multiple languages, even when no labeled data and few terminology aliases for the target language are available. Its configuration system and evaluation modules enable reproducible benchmarks. Models and code are available online at the following URL: //github.com/hpi-dhc/xmen

Automatically recognising apparent emotions from face and voice is hard, in part because of various sources of uncertainty, including in the input data and the labels used in a machine learning framework. This paper introduces an uncertainty-aware audiovisual fusion approach that quantifies modality-wise uncertainty towards emotion prediction. To this end, we propose a novel fusion framework in which we first learn latent distributions over audiovisual temporal context vectors separately, and then constrain the variance vectors of unimodal latent distributions so that they represent the amount of information each modality provides w.r.t. emotion recognition. In particular, we impose Calibration and Ordinal Ranking constraints on the variance vectors of audiovisual latent distributions. When well-calibrated, modality-wise uncertainty scores indicate how much their corresponding predictions may differ from the ground truth labels. Well-ranked uncertainty scores allow the ordinal ranking of different frames across the modalities. To jointly impose both these constraints, we propose a softmax distributional matching loss. In both classification and regression settings, we compare our uncertainty-aware fusion model with standard model-agnostic fusion baselines. Our evaluation on two emotion recognition corpora, AVEC 2019 CES and IEMOCAP, shows that audiovisual emotion recognition can considerably benefit from well-calibrated and well-ranked latent uncertainty measures.