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Autism spectrum disorder (ASD) is a developmental disorder characterized by significant social communication impairments and difficulties perceiving and presenting communication cues. Machine learning techniques have been broadly adopted to facilitate autism studies and assessments. However, computational models are primarily concentrated on specific analysis and validated on private datasets in the autism community, which limits comparisons across models due to privacy-preserving data sharing complications. This work presents a novel privacy-preserving open-source dataset, MMASD as a MultiModal ASD benchmark dataset, collected from play therapy interventions of children with Autism. MMASD includes data from 32 children with ASD, and 1,315 data samples segmented from over 100 hours of intervention recordings. To promote public access, each data sample consists of four privacy-preserving modalities of data; some of which are derived from original videos: (1) optical flow, (2) 2D skeleton, (3) 3D skeleton, and (4) clinician ASD evaluation scores of children, e.g., ADOS scores. MMASD aims to assist researchers and therapists in understanding children's cognitive status, monitoring their progress during therapy, and customizing the treatment plan accordingly. It also has inspiration for downstream tasks such as action quality assessment and interpersonal synchrony estimation. MMASD dataset can be easily accessed at //github.com/Li-Jicheng/MMASD-A-Multimodal-Dataset-for-Autism-Intervention-Analysis.

Quantifying the causal effects of continuous exposures on outcomes of interest is critical for social, economic, health, and medical research. However, most existing software packages focus on binary exposures. We develop the CausalGPS R package that implements a collection of algorithms to provide algorithmic solutions for causal inference with continuous exposures. CausalGPS implements a causal inference workflow, with algorithms based on generalized propensity scores (GPS) as the core, extending propensity scores (the probability of a unit being exposed given pre-exposure covariates) from binary to continuous exposures. As the first step, the package implements efficient and flexible estimations of the GPS, allowing multiple user-specified modeling options. As the second step, the package provides two ways to adjust for confounding: weighting and matching, generating weighted and matched data sets, respectively. Lastly, the package provides built-in functions to fit flexible parametric, semi-parametric, or non-parametric regression models on the weighted or matched data to estimate the exposure-response function relating the outcome with the exposures. The computationally intensive tasks are implemented in C++, and efficient shared-memory parallelization is achieved by OpenMP API. This paper outlines the main components of the CausalGPS R package and demonstrates its application to assess the effect of long-term exposure to PM2.5 on educational attainment using zip code-level data from the contiguous United States from 2000-2016.

Behavioral health interventions, delivered through digital platforms, have the potential to significantly improve health outcomes, through education, motivation, reminders, and outreach. We study the problem of optimizing personalized interventions for patients to maximize a long-term outcome, where interventions are costly and capacity-constrained. We assume there exists a dataset collected from an initial pilot study that we can leverage. We present a new approach for this problem that we dub DecompPI, which approximates one step of policy iteration. Implementing DecompPI simply consists of a prediction task using the dataset, alleviating the need for online experimentation. DecompPI is a generic model-free algorithm that can be used irrespective of the underlying patient behavior model. We derive theoretical guarantees on a simple, special case of the model that is representative of our problem setting. We establish an approximation ratio for DecompPI with respect to the improvement beyond a null policy that does not allocate interventions. Specifically, when the initial policy used to collect the data is randomized, the approximation ratio of the improvement approaches 1/2 as the intervention capacity of the initial policy decreases. We show that this guarantee is robust to estimation errors. We conduct a rigorous empirical case study using real-world data from a mobile health platform for improving treatment adherence for tuberculosis. Using a validated simulation model, we demonstrate that DecompPI can provide the same efficacy as the status quo approach with approximately half the capacity of interventions. DecompPI is simple and easy to implement for organizations aiming to improve long-term behavior through targeted interventions, and this paper demonstrates its strong performance both theoretically and empirically.

Deployable Large Language Models (LLMs) must conform to the criterion of helpfulness and harmlessness, thereby achieving consistency between LLMs outputs and human values. Red-teaming techniques constitute a critical way towards this criterion. Existing work rely solely on manual red team designs and heuristic adversarial prompts for vulnerability detection and optimization. These approaches lack rigorous mathematical formulation, thus limiting the exploration of diverse attack strategy within quantifiable measure and optimization of LLMs under convergence guarantees. In this paper, we present Red-teaming Game (RTG), a general game-theoretic framework without manual annotation. RTG is designed for analyzing the multi-turn attack and defense interactions between Red-team language Models (RLMs) and Blue-team Language Model (BLM). Within the RTG, we propose Gamified Red-teaming Solver (GRTS) with diversity measure of the semantic space. GRTS is an automated red teaming technique to solve RTG towards Nash equilibrium through meta-game analysis, which corresponds to the theoretically guaranteed optimization direction of both RLMs and BLM. Empirical results in multi-turn attacks with RLMs show that GRTS autonomously discovered diverse attack strategies and effectively improved security of LLMs, outperforming existing heuristic red-team designs. Overall, RTG has established a foundational framework for red teaming tasks and constructed a new scalable oversight technique for alignment.

Clinical predictive models often rely on patients' electronic health records (EHR), but integrating medical knowledge to enhance predictions and decision-making is challenging. This is because personalized predictions require personalized knowledge graphs (KGs), which are difficult to generate from patient EHR data. To address this, we propose \textsc{GraphCare}, an open-world framework that uses external KGs to improve EHR-based predictions. Our method extracts knowledge from large language models (LLMs) and external biomedical KGs to build patient-specific KGs, which are then used to train our proposed Bi-attention AugmenTed (BAT) graph neural network (GNN) for healthcare predictions. On two public datasets, MIMIC-III and MIMIC-IV, \textsc{GraphCare} surpasses baselines in four vital healthcare prediction tasks: mortality, readmission, length of stay (LOS), and drug recommendation. On MIMIC-III, it boosts AUROC by 17.6\% and 6.6\% for mortality and readmission, and F1-score by 7.9\% and 10.8\% for LOS and drug recommendation, respectively. Notably, \textsc{GraphCare} demonstrates a substantial edge in scenarios with limited data availability. Our findings highlight the potential of using external KGs in healthcare prediction tasks and demonstrate the promise of \textsc{GraphCare} in generating personalized KGs for promoting personalized medicine.

Anticipating the motion of all humans in dynamic environments such as homes and offices is critical to enable safe and effective robot navigation. Such spaces remain challenging as humans do not follow strict rules of motion and there are often multiple occluded entry points such as corners and doors that create opportunities for sudden encounters. In this work, we present a Transformer based architecture to predict human future trajectories in human-centric environments from input features including human positions, head orientations, and 3D skeletal keypoints from onboard in-the-wild sensory information. The resulting model captures the inherent uncertainty for future human trajectory prediction and achieves state-of-the-art performance on common prediction benchmarks and a human tracking dataset captured from a mobile robot adapted for the prediction task. Furthermore, we identify new agents with limited historical data as a major contributor to error and demonstrate the complementary nature of 3D skeletal poses in reducing prediction error in such challenging scenarios.

Due to data privacy constraints, data sharing among multiple clinical centers is restricted, which impedes the development of high performance deep learning models from multicenter collaboration. Naive weight transfer methods share intermediate model weights without raw data and hence can bypass data privacy restrictions. However, performance drops are typically observed when the model is transferred from one center to the next because of the forgetting problem. Incremental transfer learning, which combines peer-to-peer federated learning and domain incremental learning, can overcome the data privacy issue and meanwhile preserve model performance by using continual learning techniques. In this work, a conventional domain/task incremental learning framework is adapted for incremental transfer learning. A comprehensive survey on the efficacy of different regularization-based continual learning methods for multicenter collaboration is performed. The influences of data heterogeneity, classifier head setting, network optimizer, model initialization, center order, and weight transfer type have been investigated thoroughly. Our framework is publicly accessible to the research community for further development.

Sensitive personal information of individuals and non-personal information of organizations or communities often needs to be legitimately exchanged among different stakeholders, to provide services, maintain public health, law and order, and so on. While such exchanges are necessary, they also impose enormous privacy and security challenges. Data protection laws like GDPR for personal data and Indian Non-personal data protection draft specify conditions and the \textit{legal capacity} in which personal and non-personal information can be solicited and disseminated further. But there is a dearth of formalisms for specifying legal capacities and jurisdictional boundaries, so that open-ended exchange of such data can be implemented. This paper proposes an extensible framework for consent management in Data Trusts in which data can flow across a network through "role tunnels" established based on corresponding legal capacities.

Computer-based decision systems are widely used to automate decisions in many aspects of everyday life, which include sensitive areas like hiring, loaning and even criminal sentencing. A decision pipeline heavily relies on large volumes of historical real-world data for training its models. However, historical training data often contains gender, racial or other biases which are propagated to the trained models influencing computer-based decisions. In this work, we propose a robust methodology that guarantees the removal of unwanted biases while maximally preserving classification utility. Our approach can always achieve this in a model-independent way by deriving from real-world data the asymptotic dataset that uniquely encodes demographic parity and realism. As a proof-of-principle, we deduce from public census records such an asymptotic dataset from which synthetic samples can be generated to train well-established classifiers. Benchmarking the generalization capability of these classifiers trained on our synthetic data, we confirm the absence of any explicit or implicit bias in the computer-aided decision.