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Context: Cybersecurity vendors often publish cyber threat intelligence (CTI) reports, referring to the written artifacts on technical and forensic analysis of the techniques used by the malware in APT attacks. Objective: The goal of this research is to inform cybersecurity practitioners about how adversaries form cyberattacks through an analysis of adversarial techniques documented in cyberthreat intelligence reports. Dataset: We use 594 adversarial techniques cataloged in MITRE ATT\&CK. We systematically construct a set of 667 CTI reports that MITRE ATT\&CK used as citations in the descriptions of the cataloged adversarial techniques. Methodology: We analyze the frequency and trend of adversarial techniques, followed by a qualitative analysis of the implementation of techniques. Next, we perform association rule mining to identify pairs of techniques recurring in APT attacks. We then perform qualitative analysis to identify the underlying relations among the techniques in the recurring pairs. Findings: The set of 667 CTI reports documents 10,370 techniques in total, and we identify 19 prevalent techniques accounting for 37.3\% of documented techniques. We also identify 425 statistically significant recurring pairs and seven types of relations among the techniques in these pairs. The top three among the seven relationships suggest that techniques used by the malware inter-relate with one another in terms of (a) abusing or affecting the same system assets, (b) executing in sequences, and (c) overlapping in their implementations. Overall, the study quantifies how adversaries leverage techniques through malware in APT attacks based on publicly reported documents. We advocate organizations prioritize their defense against the identified prevalent techniques and actively hunt for potential malicious intrusion based on the identified pairs of techniques.

We introduce ensembles of stochastic neural networks to approximate the Bayesian posterior, combining stochastic methods such as dropout with deep ensembles. The stochastic ensembles are formulated as families of distributions and trained to approximate the Bayesian posterior with variational inference. We implement stochastic ensembles based on Monte Carlo dropout, DropConnect and a novel non-parametric version of dropout and evaluate them on a toy problem and CIFAR image classification. For both tasks, we test the quality of the posteriors directly against Hamiltonian Monte Carlo simulations. Our results show that stochastic ensembles provide more accurate posterior estimates than other popular baselines for Bayesian inference.

We analyze the prediction error of principal component regression (PCR) and prove high probability bounds for the corresponding squared risk conditional on the design. Our first main result shows that PCR performs comparably to the oracle method obtained by replacing empirical principal components by their population counterparts, provided that an effective rank condition holds. On the other hand, if the latter condition is violated, then empirical eigenvalues start to have a significant upward bias, resulting in a self-induced regularization of PCR. Our approach relies on the behavior of empirical eigenvalues, empirical eigenvectors and the excess risk of principal component analysis in high-dimensional regimes.

Skin lesions are classified in benign or malignant. Among the malignant, melanoma is a very aggressive cancer and the major cause of deaths. So, early diagnosis of skin cancer is very desired. In the last few years, there is a growing interest in computer aided diagnostic (CAD) using most image and clinical data of the lesion. These sources of information present limitations due to their inability to provide information of the molecular structure of the lesion. NIR spectroscopy may provide an alternative source of information to automated CAD of skin lesions. The most commonly used techniques and classification algorithms used in spectroscopy are Principal Component Analysis (PCA), Partial Least Squares - Discriminant Analysis (PLS-DA), and Support Vector Machines (SVM). Nonetheless, there is a growing interest in applying the modern techniques of machine and deep learning (MDL) to spectroscopy. One of the main limitations to apply MDL to spectroscopy is the lack of public datasets. Since there is no public dataset of NIR spectral data to skin lesions, as far as we know, an effort has been made and a new dataset named NIR-SC-UFES, has been collected, annotated and analyzed generating the gold-standard for classification of NIR spectral data to skin cancer. Next, the machine learning algorithms XGBoost, CatBoost, LightGBM, 1D-convolutional neural network (1D-CNN) were investigated to classify cancer and non-cancer skin lesions. Experimental results indicate the best performance obtained by LightGBM with pre-processing using standard normal variate (SNV), feature extraction providing values of 0.839 for balanced accuracy, 0.851 for recall, 0.852 for precision, and 0.850 for F-score. The obtained results indicate the first steps in CAD of skin lesions aiming the automated triage of patients with skin lesions in vivo using NIR spectral data.

Physics-informed neural networks (PINNs) and their variants have recently emerged as alternatives to traditional partial differential equation (PDE) solvers, but little literature has focused on devising accurate numerical integration methods for neural networks (NNs), which is essential for getting accurate solutions. In this work, we propose adaptive quadratures for the accurate integration of neural networks and apply them to loss functions appearing in low-dimensional PDE discretisations. We show that at opposite ends of the spectrum, continuous piecewise linear (CPWL) activation functions enable one to bound the integration error, while smooth activations ease the convergence of the optimisation problem. We strike a balance by considering a CPWL approximation of a smooth activation function. The CPWL activation is used to obtain an adaptive decomposition of the domain into regions where the network is almost linear, and we derive an adaptive global quadrature from this mesh. The loss function is then obtained by evaluating the smooth network (together with other quantities, e.g., the forcing term) at the quadrature points. We propose a method to approximate a class of smooth activations by CPWL functions and show that it has a quadratic convergence rate. We then derive an upper bound for the overall integration error of our proposed adaptive quadrature. The benefits of our quadrature are evaluated on a strong and weak formulation of the Poisson equation in dimensions one and two. Our numerical experiments suggest that compared to Monte-Carlo integration, our adaptive quadrature makes the convergence of NNs quicker and more robust to parameter initialisation while needing significantly fewer integration points and keeping similar training times.

Sperm whales (Physeter macrocephalus) navigate underwater with a series of impulsive, click-like sounds known as echolocation clicks. These clicks are characterized by a multipulse structure (MPS) that serves as a distinctive pattern. In this work, we use the stability of the MPS as a detection metric for recognizing and classifying the presence of clicks in noisy environments. To distinguish between noise transients and to handle simultaneous emissions from multiple sperm whales, our approach clusters a time series of MPS measures while removing potential clicks that do not fulfil the limits of inter-click interval, duration and spectrum. As a result, our approach can handle high noise transients and low signal-to-noise ratio. The performance of our detection approach is examined using three datasets: seven months of recordings from the Mediterranean Sea containing manually verified ambient noise; several days of manually labelled data collected from the Dominica Island containing approximately 40,000 clicks from multiple sperm whales; and a dataset from the Bahamas containing 1,203 labelled clicks from a single sperm whale. Comparing with the results of two benchmark detectors, a better trade-off between precision and recall is observed as well as a significant reduction in false detection rates, especially in noisy environments. To ensure reproducibility, we provide our database of labelled clicks along with our implementation code.

In healthcare, patient data is often collected as multivariate time series, providing a comprehensive view of a patient's health status over time. While this data can be sparse, connected devices may enhance its frequency. The goal is to create patient profiles from these time series. In the absence of labels, a predictive model can be used to predict future values while forming a latent cluster space, evaluated based on predictive performance. We compare two models on Withing's datasets, M AGMAC LUST which clusters entire time series and DGM${}^2$ which allows the group affiliation of an individual to change over time (dynamic clustering).

Natural Medicinal Materials (NMMs) have a long history of global clinical applications, accompanied by extensive informational records. Despite their significant impact on healthcare, the field faces a major challenge: the non-standardization of NMM knowledge, stemming from historical complexities and causing limitations in broader applications. To address this, we introduce a Systematic Nomenclature for NMMs, underpinned by ShennongAlpha, an AI-driven platform designed for intelligent knowledge acquisition. This nomenclature system enables precise identification and differentiation of NMMs. ShennongAlpha, cataloging over ten thousand NMMs with standardized bilingual information, enhances knowledge management and application capabilities, thereby overcoming traditional barriers. Furthermore, it pioneers AI-empowered conversational knowledge acquisition and standardized machine translation. These synergistic innovations mark the first major advance in integrating domain-specific NMM knowledge with AI, propelling research and applications across both NMM and AI fields while establishing a groundbreaking precedent in this crucial area.

Objective: This study aims to use artificial intelligence to realize the automatic planning of laminectomy, and verify the method. Methods: We propose a two-stage approach for automatic laminectomy cutting plane planning. The first stage was the identification of key points. 7 key points were manually marked on each CT image. The Spatial Pyramid Upsampling Network (SPU-Net) algorithm developed by us was used to accurately locate the 7 key points. In the second stage, based on the identification of key points, a personalized coordinate system was generated for each vertebra. Finally, the transverse and longitudinal cutting planes of laminectomy were generated under the coordinate system. The overall effect of planning was evaluated. Results: In the first stage, the average localization error of the SPU-Net algorithm for the seven key points was 0.65mm. In the second stage, a total of 320 transverse cutting planes and 640 longitudinal cutting planes were planned by the algorithm. Among them, the number of horizontal plane planning effects of grade A, B, and C were 318(99.38%), 1(0.31%), and 1(0.31%), respectively. The longitudinal planning effects of grade A, B, and C were 622(97.18%), 1(0.16%), and 17(2.66%), respectively. Conclusions: In this study, we propose a method for automatic surgical path planning of laminectomy based on the localization of key points in CT images. The results showed that the method achieved satisfactory results. More studies are needed to confirm the reliability of this approach in the future.

Breast cancer remains a global challenge, causing over 1 million deaths globally in 2018. To achieve earlier breast cancer detection, screening x-ray mammography is recommended by health organizations worldwide and has been estimated to decrease breast cancer mortality by 20-40%. Nevertheless, significant false positive and false negative rates, as well as high interpretation costs, leave opportunities for improving quality and access. To address these limitations, there has been much recent interest in applying deep learning to mammography; however, obtaining large amounts of annotated data poses a challenge for training deep learning models for this purpose, as does ensuring generalization beyond the populations represented in the training dataset. Here, we present an annotation-efficient deep learning approach that 1) achieves state-of-the-art performance in mammogram classification, 2) successfully extends to digital breast tomosynthesis (DBT; "3D mammography"), 3) detects cancers in clinically-negative prior mammograms of cancer patients, 4) generalizes well to a population with low screening rates, and 5) outperforms five-out-of-five full-time breast imaging specialists by improving absolute sensitivity by an average of 14%. Our results demonstrate promise towards software that can improve the accuracy of and access to screening mammography worldwide.