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Mental health conditions, prevalent across various demographics, necessitate efficient monitoring to mitigate their adverse impacts on life quality. The surge in data-driven methodologies for mental health monitoring has underscored the importance of privacy-preserving techniques in handling sensitive health data. Despite strides in federated learning for mental health monitoring, existing approaches struggle with vulnerabilities to certain cyber-attacks and data insufficiency in real-world applications. In this paper, we introduce a differential private federated transfer learning framework for mental health monitoring to enhance data privacy and enrich data sufficiency. To accomplish this, we integrate federated learning with two pivotal elements: (1) differential privacy, achieved by introducing noise into the updates, and (2) transfer learning, employing a pre-trained universal model to adeptly address issues of data imbalance and insufficiency. We evaluate the framework by a case study on stress detection, employing a dataset of physiological and contextual data from a longitudinal study. Our finding show that the proposed approach can attain a 10% boost in accuracy and a 21% enhancement in recall, while ensuring privacy protection.

The use of hyperspectral imaging for medical applications is becoming more common in recent years. One of the main obstacles that researchers find when developing hyperspectral algorithms for medical applications is the lack of specific, publicly available, and hyperspectral medical data. The work described in this paper was developed within the framework of the European project HELICoiD (HypErspectraL Imaging Cancer Detection), which had as a main goal the application of hyperspectral imaging to the delineation of brain tumors in real-time during neurosurgical operations. In this paper, the methodology followed to generate the first hyperspectral database of in-vivo human brain tissues is presented. Data was acquired employing a customized hyperspectral acquisition system capable of capturing information in the Visual and Near InfraRed (VNIR) range from 400 to 1000 nm. Repeatability was assessed for the cases where two images of the same scene were captured consecutively. The analysis reveals that the system works more efficiently in the spectral range between 450 and 900 nm. A total of 36 hyperspectral images from 22 different patients were obtained. From these data, more than 300 000 spectral signatures were labeled employing a semi-automatic methodology based on the spectral angle mapper algorithm. Four different classes were defined: normal tissue, tumor tissue, blood vessel, and background elements. All the hyperspectral data has been made available in a public repository.

Comparative diagnostic in brain tumor evaluation makes possible to use the available information of a medical center to compare similar cases when a new patient is evaluated. By leveraging Artificial Intelligence models, the proposed system is able of retrieving the most similar cases of brain tumors for a given query. The primary objective is to enhance the diagnostic process by generating more accurate representations of medical images, with a particular focus on patient-specific normal features and pathologies. A key distinction from previous models lies in its ability to produce enriched image descriptors solely from binary information, eliminating the need for costly and difficult to obtain tumor segmentation. The proposed model uses Artificial Intelligence to detect patient features to recommend the most similar cases from a database. The system not only suggests similar cases but also balances the representation of healthy and abnormal features in its design. This not only encourages the generalization of its use but also aids clinicians in their decision-making processes. This generalization makes possible for future research in different medical diagnosis areas with almost not any change in the system. We conducted a comparative analysis of our approach in relation to similar studies. The proposed architecture obtains a Dice coefficient of 0.474 in both tumoral and healthy regions of the patients, which outperforms previous literature. Our proposed model excels at extracting and combining anatomical and pathological features from brain scans, achieving state-of-the-art results while relying on less expensive label information. This substantially reduces the overall cost of the training process. Our findings highlight the significant potential for improving the efficiency and accuracy of comparative diagnostics and the treatment of tumoral pathologies.

The rising global prevalence of skin conditions, some of which can escalate to life-threatening stages if not timely diagnosed and treated, presents a significant healthcare challenge. This issue is particularly acute in remote areas where limited access to healthcare often results in delayed treatment, allowing skin diseases to advance to more critical stages. One of the primary challenges in diagnosing skin diseases is their low inter-class variations, as many exhibit similar visual characteristics, making accurate classification challenging. This research introduces a novel multimodal method for classifying skin lesions, integrating smartphone-captured images with essential clinical and demographic information. This approach mimics the diagnostic process employed by medical professionals. A distinctive aspect of this method is the integration of an auxiliary task focused on super-resolution image prediction. This component plays a crucial role in refining visual details and enhancing feature extraction, leading to improved differentiation between classes and, consequently, elevating the overall effectiveness of the model. The experimental evaluations have been conducted using the PAD-UFES20 dataset, applying various deep-learning architectures. The results of these experiments not only demonstrate the effectiveness of the proposed method but also its potential applicability under-resourced healthcare environments.

Anomaly detection is a critical challenge across various research domains, aiming to identify instances that deviate from normal data distributions. This paper explores the application of Generative Adversarial Networks (GANs) in fraud detection, comparing their advantages with traditional methods. GANs, a type of Artificial Neural Network (ANN), have shown promise in modeling complex data distributions, making them effective tools for anomaly detection. The paper systematically describes the principles of GANs and their derivative models, emphasizing their application in fraud detection across different datasets. And by building a collection of adversarial verification graphs, we will effectively prevent fraud caused by bots or automated systems and ensure that the users in the transaction are real. The objective of the experiment is to design and implement a fake face verification code and fraud detection system based on Generative Adversarial network (GANs) algorithm to enhance the security of the transaction process.The study demonstrates the potential of GANs in enhancing transaction security through deep learning techniques.

The development of blood-handling medical devices, such as ventricular assist devices, requires the analysis of their biocompatibility. Among other aspects, this includes hemolysis, i.e., red blood cell damage. For this purpose, computational fluid dynamics (CFD) methods are employed to predict blood flow in prototypes. The most basic hemolysis models directly estimate red blood cell damage from fluid stress in the resulting flow field. More advanced models explicitly resolve cell deformation. On the downside, these models are typically written in a Lagrangian formulation, i.e., they require pathline tracking. We present a new Eulerian description of cell deformation, enabling the evaluation of the solution across the whole domain. The resulting hemolysis model can be applied to any converged CFD simulation due to one-way coupling with the fluid velocity field. We discuss the efficient numerical treatment of the model equations in a stabilized finite element context. We validate the model by comparison to the original Lagrangian formulation in selected benchmark flows. Two more complex test cases demonstrate the method's capabilities in real-world applications. The results highlight the advantages over previous hemolysis models. In conclusion, the model holds great potential for the design process of future generations of medical devices.

In medical and epidemiological studies, one of the most common settings is studying the effect of a treatment on a time-to-event outcome, where the time-to-event might be censored before end of study. A common parameter of interest in such a setting is the marginal hazard ratio (MHR). When a study is based on observational data, propensity score (PS) based methods are often used, in an attempt to make the treatment groups comparable despite having a non-randomized treatment. Previous studies have shown censoring to be a factor that induces bias when using PS based estimators. In this paper we study the magnitude of the bias under different rates of non-informative censoring when estimating MHR using PS weighting or PS matching. A bias correction involving the probability of event is suggested and compared to conventional PS based methods.

Addressing the critical shortage of mental health resources for effective screening, diagnosis, and treatment remains a significant challenge. This scarcity underscores the need for innovative solutions, particularly in enhancing the accessibility and efficacy of therapeutic support. Embodied agents with advanced interactive capabilities emerge as a promising and cost-effective supplement to traditional caregiving methods. Crucial to these agents' effectiveness is their ability to simulate non-verbal behaviors, like backchannels, that are pivotal in establishing rapport and understanding in therapeutic contexts but remain under-explored. To improve the rapport-building capabilities of embodied agents we annotated backchannel smiles in videos of intimate face-to-face conversations over topics such as mental health, illness, and relationships. We hypothesized that both speaker and listener behaviors affect the duration and intensity of backchannel smiles. Using cues from speech prosody and language along with the demographics of the speaker and listener, we found them to contain significant predictors of the intensity of backchannel smiles. Based on our findings, we introduce backchannel smile production in embodied agents as a generation problem. Our attention-based generative model suggests that listener information offers performance improvements over the baseline speaker-centric generation approach. Conditioned generation using the significant predictors of smile intensity provides statistically significant improvements in empirical measures of generation quality. Our user study by transferring generated smiles to an embodied agent suggests that agent with backchannel smiles is perceived to be more human-like and is an attractive alternative for non-personal conversations over agent without backchannel smiles.

Matching problems have been widely studied in the research community, especially Ad-Auctions with many applications ranging from network design to advertising. Following the various advancements in machine learning, one natural question is whether classical algorithms can benefit from machine learning and obtain better-quality solutions. Even a small percentage of performance improvement in matching problems could result in significant gains for the studied use cases. For example, the network throughput or the revenue of Ad-Auctions can increase remarkably. This paper presents algorithms with machine learning predictions for the Online Bounded Allocation and the Online Ad-Auctions problems. We constructed primal-dual algorithms that achieve competitive performance depending on the quality of the predictions. When the predictions are accurate, the algorithms' performance surpasses previous performance bounds, while when the predictions are misleading, the algorithms maintain standard worst-case performance guarantees. We provide supporting experiments on generated data for our theoretical findings.

Human doctors with well-structured medical knowledge can diagnose a disease merely via a few conversations with patients about symptoms. In contrast, existing knowledge-grounded dialogue systems often require a large number of dialogue instances to learn as they fail to capture the correlations between different diseases and neglect the diagnostic experience shared among them. To address this issue, we propose a more natural and practical paradigm, i.e., low-resource medical dialogue generation, which can transfer the diagnostic experience from source diseases to target ones with a handful of data for adaptation. It is capitalized on a commonsense knowledge graph to characterize the prior disease-symptom relations. Besides, we develop a Graph-Evolving Meta-Learning (GEML) framework that learns to evolve the commonsense graph for reasoning disease-symptom correlations in a new disease, which effectively alleviates the needs of a large number of dialogues. More importantly, by dynamically evolving disease-symptom graphs, GEML also well addresses the real-world challenges that the disease-symptom correlations of each disease may vary or evolve along with more diagnostic cases. Extensive experiment results on the CMDD dataset and our newly-collected Chunyu dataset testify the superiority of our approach over state-of-the-art approaches. Besides, our GEML can generate an enriched dialogue-sensitive knowledge graph in an online manner, which could benefit other tasks grounded on knowledge graph.