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The success of deep learning is partly attributed to the availability of massive data downloaded freely from the Internet. However, it also means that users' private data may be collected by commercial organizations without consent and used to train their models. Therefore, it's important and necessary to develop a method or tool to prevent unauthorized data exploitation. In this paper, we propose ConfounderGAN, a generative adversarial network (GAN) that can make personal image data unlearnable to protect the data privacy of its owners. Specifically, the noise produced by the generator for each image has the confounder property. It can build spurious correlations between images and labels, so that the model cannot learn the correct mapping from images to labels in this noise-added dataset. Meanwhile, the discriminator is used to ensure that the generated noise is small and imperceptible, thereby remaining the normal utility of the encrypted image for humans. The experiments are conducted in six image classification datasets, consisting of three natural object datasets and three medical datasets. The results demonstrate that our method not only outperforms state-of-the-art methods in standard settings, but can also be applied to fast encryption scenarios. Moreover, we show a series of transferability and stability experiments to further illustrate the effectiveness and superiority of our method.

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Text-to-image models, which can generate high-quality images based on textual input, have recently enabled various content-creation tools. Despite significantly affecting a wide range of downstream applications, the distributions of these generated images are still not fully understood, especially when it comes to the potential stereotypical attributes of different genders. In this work, we propose a paradigm (Gender Presentation Differences) that utilizes fine-grained self-presentation attributes to study how gender is presented differently in text-to-image models. By probing gender indicators in the input text (e.g., "a woman" or "a man"), we quantify the frequency differences of presentation-centric attributes (e.g., "a shirt" and "a dress") through human annotation and introduce a novel metric: GEP. Furthermore, we propose an automatic method to estimate such differences. The automatic GEP metric based on our approach yields a higher correlation with human annotations than that based on existing CLIP scores, consistently across three state-of-the-art text-to-image models. Finally, we demonstrate the generalization ability of our metrics in the context of gender stereotypes related to occupations.

We analyze to what extent final users can infer information about the level of protection of their data when the data obfuscation mechanism is a priori unknown to them (the so-called ''black-box'' scenario). In particular, we delve into the investigation of two notions of local differential privacy (LDP), namely {\epsilon}-LDP and R\'enyi LDP. On one hand, we prove that, without any assumption on the underlying distributions, it is not possible to have an algorithm able to infer the level of data protection with provable guarantees; this result also holds for the central versions of the two notions of DP considered. On the other hand, we demonstrate that, under reasonable assumptions (namely, Lipschitzness of the involved densities on a closed interval), such guarantees exist and can be achieved by a simple histogram-based estimator. We validate our results experimentally and we note that, on a particularly well-behaved distribution (namely, the Laplace noise), our method gives even better results than expected, in the sense that in practice the number of samples needed to achieve the desired confidence is smaller than the theoretical bound, and the estimation of {\epsilon} is more precise than predicted.

The large-scale pre-trained vision language models (VLM) have shown remarkable domain transfer capability on natural images. However, it remains unknown whether this capability can also apply to the medical image domain. This paper thoroughly studies the knowledge transferability of pre-trained VLMs to the medical domain, where we show that well-designed medical prompts are the key to elicit knowledge from pre-trained VLMs. We demonstrate that by prompting with expressive attributes that are shared between domains, the VLM can carry the knowledge across domains and improve its generalization. This mechanism empowers VLMs to recognize novel objects with fewer or without image samples. Furthermore, to avoid the laborious manual designing process, we develop three approaches for automatic generation of medical prompts, which can inject expert-level medical knowledge and image-specific information into the prompts for fine-grained grounding. We conduct extensive experiments on thirteen different medical datasets across various modalities, showing that our well-designed prompts greatly improve the zero-shot performance compared to the default prompts, and our fine-tuned models surpass the supervised models by a significant margin.

Differential privacy is typically ensured by perturbation with additive noise that is sampled from a known distribution. Conventionally, independent and identically distributed (i.i.d.) noise samples are added to each coordinate. In this work, propose to add noise which is independent, but not identically distributed (i.n.i.d.) across the coordinates. In particular, we study the i.n.i.d. Gaussian and Laplace mechanisms and obtain the conditions under which these mechanisms guarantee privacy. The optimal choice of parameters that ensure these conditions are derived theoretically. Theoretical analyses and numerical simulations show that the i.n.i.d. mechanisms achieve higher utility for the given privacy requirements compared to their i.i.d. counterparts.

This article introduces a causal discovery method to learn nonlinear relationships in a directed acyclic graph with correlated Gaussian errors due to confounding. First, we derive model identifiability under the sublinear growth assumption. Then, we propose a novel method, named the Deconfounded Functional Structure Estimation (DeFuSE), consisting of a deconfounding adjustment to remove the confounding effects and a sequential procedure to estimate the causal order of variables. We implement DeFuSE via feedforward neural networks for scalable computation. Moreover, we establish the consistency of DeFuSE under an assumption called the strong causal minimality. In simulations, DeFuSE compares favorably against state-of-the-art competitors that ignore confounding or nonlinearity. Finally, we demonstrate the utility and effectiveness of the proposed approach with an application to gene regulatory network analysis. The Python implementation is available at //github.com/chunlinli/defuse.

Privacy auditing techniques for differentially private (DP) algorithms are useful for estimating the privacy loss to compare against analytical bounds, or empirically measure privacy in settings where known analytical bounds on the DP loss are not tight. However, existing privacy auditing techniques usually make strong assumptions on the adversary (e.g., knowledge of intermediate model iterates or the training data distribution), are tailored to specific tasks and model architectures, and require retraining the model many times (typically on the order of thousands). These shortcomings make deploying such techniques at scale difficult in practice, especially in federated settings where model training can take days or weeks. In this work, we present a novel "one-shot" approach that can systematically address these challenges, allowing efficient auditing or estimation of the privacy loss of a model during the same, single training run used to fit model parameters. Our privacy auditing method for federated learning does not require a priori knowledge about the model architecture or task. We show that our method provides provably correct estimates for privacy loss under the Gaussian mechanism, and we demonstrate its performance on a well-established FL benchmark dataset under several adversarial models.

Large-scale text-to-image generative models have shown their remarkable ability to synthesize diverse and high-quality images. However, it is still challenging to directly apply these models for editing real images for two reasons. First, it is hard for users to come up with a perfect text prompt that accurately describes every visual detail in the input image. Second, while existing models can introduce desirable changes in certain regions, they often dramatically alter the input content and introduce unexpected changes in unwanted regions. In this work, we propose pix2pix-zero, an image-to-image translation method that can preserve the content of the original image without manual prompting. We first automatically discover editing directions that reflect desired edits in the text embedding space. To preserve the general content structure after editing, we further propose cross-attention guidance, which aims to retain the cross-attention maps of the input image throughout the diffusion process. In addition, our method does not need additional training for these edits and can directly use the existing pre-trained text-to-image diffusion model. We conduct extensive experiments and show that our method outperforms existing and concurrent works for both real and synthetic image editing.

Recent works have shown that selecting an optimal model architecture suited to the differential privacy setting is necessary to achieve the best possible utility for a given privacy budget using differentially private stochastic gradient descent (DP-SGD)(Tramer and Boneh 2020; Cheng et al. 2022). In light of these findings, we empirically analyse how different fairness notions, belonging to distinct classes of statistical fairness criteria (independence, separation and sufficiency), are impacted when one selects a model architecture suitable for DP-SGD, optimized for utility. Using standard datasets from ML fairness literature, we show using a rigorous experimental protocol, that by selecting the optimal model architecture for DP-SGD, the differences across groups concerning the relevant fairness metrics (demographic parity, equalized odds and predictive parity) more often decrease or are negligibly impacted, compared to the non-private baseline, for which optimal model architecture has also been selected to maximize utility. These findings challenge the understanding that differential privacy will necessarily exacerbate unfairness in deep learning models trained on biased datasets.

For medical image segmentation, contrastive learning is the dominant practice to improve the quality of visual representations by contrasting semantically similar and dissimilar pairs of samples. This is enabled by the observation that without accessing ground truth label, negative examples with truly dissimilar anatomical features, if sampled, can significantly improve the performance. In reality, however, these samples may come from similar anatomical features and the models may struggle to distinguish the minority tail-class samples, making the tail classes more prone to misclassification, both of which typically lead to model collapse. In this paper, we propose ARCO, a semi-supervised contrastive learning (CL) framework with stratified group sampling theory in medical image segmentation. In particular, we first propose building ARCO through the concept of variance-reduced estimation, and show that certain variance-reduction techniques are particularly beneficial in medical image segmentation tasks with extremely limited labels. Furthermore, we theoretically prove these sampling techniques are universal in variance reduction. Finally, we experimentally validate our approaches on three benchmark datasets with different label settings, and our methods consistently outperform state-of-the-art semi- and fully-supervised methods. Additionally, we augment the CL frameworks with these sampling techniques and demonstrate significant gains over previous methods. We believe our work is an important step towards semi-supervised medical image segmentation by quantifying the limitation of current self-supervision objectives for accomplishing medical image analysis tasks.

With continuous outcomes, the average causal effect is typically defined using a contrast of expected potential outcomes. However, in the presence of skewed outcome data, the expectation may no longer be meaningful. In practice the typical approach is to either "ignore or transform" - ignore the skewness altogether or transform the outcome to obtain a more symmetric distribution, although neither approach is entirely satisfactory. Alternatively the causal effect can be redefined as a contrast of median potential outcomes, yet discussion of confounding-adjustment methods to estimate this parameter is limited. In this study we described and compared confounding-adjustment methods to address this gap. The methods considered were multivariable quantile regression, an inverse probability weighted (IPW) estimator, weighted quantile regression and two little-known implementations of g-computation for this problem. Motivated by a cohort investigation in the Longitudinal Study of Australian Children, we conducted a simulation study that found the IPW estimator, weighted quantile regression and g-computation implementations minimised bias when the relevant models were correctly specified, with g-computation additionally minimising the variance. These methods provide appealing alternatives to the common "ignore or transform" approach and multivariable quantile regression, enhancing our capability to obtain meaningful causal effect estimates with skewed outcome data.

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