Background: A critical step in effective care and treatment planning for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of the COVID-19 pandemic, is the assessment of the severity of disease progression. Chest x-rays (CXRs) are often used to assess SARS-CoV-2 severity, with two important assessment metrics being extent of lung involvement and degree of opacity. In this proof-of-concept study, we assess the feasibility of computer-aided scoring of CXRs of SARS-CoV-2 lung disease severity using a deep learning system. Materials and Methods: Data consisted of 396 CXRs from SARS-CoV-2 positive patient cases. Geographic extent and opacity extent were scored by two board-certified expert chest radiologists (with 20+ years of experience) and a 2nd-year radiology resident. The deep neural networks used in this study, which we name COVID-Net S, are based on a COVID-Net network architecture. 100 versions of the network were independently learned (50 to perform geographic extent scoring and 50 to perform opacity extent scoring) using random subsets of CXRs from the study, and we evaluated the networks using stratified Monte Carlo cross-validation experiments. Findings: The COVID-Net S deep neural networks yielded R$^2$ of 0.664 $\pm$ 0.032 and 0.635 $\pm$ 0.044 between predicted scores and radiologist scores for geographic extent and opacity extent, respectively, in stratified Monte Carlo cross-validation experiments. The best performing networks achieved R$^2$ of 0.739 and 0.741 between predicted scores and radiologist scores for geographic extent and opacity extent, respectively. Interpretation: The results are promising and suggest that the use of deep neural networks on CXRs could be an effective tool for computer-aided assessment of SARS-CoV-2 lung disease severity, although additional studies are needed before adoption for routine clinical use.
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Temporal evolution of the coronavirus literature over the last thirty years (N=43,769) is analyzed along with its subdomain of SARS-CoV-2 articles (N=27,460) and the subdomain of reviews and meta-analytic studies (N=1,027). (i) The analyses on the subset of SARS-CoV-2 literature identified studies published prior to 2020 that have now proven highly instrumental in the development of various clusters of publications linked to SARS-CoV-2. In particular, the so-called sleeping beauties of the coronavirus literature with an awakening in 2020 were identified, i.e., previously published studies of this literature that had remained relatively unnoticed for several years but gained sudden traction in 2020 in the wake of the SARS-CoV-2 outbreak. (ii) The subset of 2020 SARS-CoV-2 articles is bibliographically distant from the rest of this literature published prior to 2020. Individual articles of the SARS-CoV-2 segment with a bridging role between the two bodies of articles (i.e., before and after 2020) are identifiable. (iii) Furthermore, the degree of bibliographic coupling within the 2020 SARS-CoV-2 cluster is much poorer compared to the cluster of articles published prior to 2020. This could, in part, be explained by the higher diversity of topics that are studied in relation to SARS-CoV-2 compared to the literature of coronaviruses published prior to the SARS-CoV-2 disease. This work demonstrates how scholarly efforts undertaken during peace time or prior to a disease outbreak could suddenly play a critical role in prevention and mitigation of health disasters caused by new diseases.
Coronavirus disease (COVID-19) pandemic has changed various aspects of people's lives and behaviors. At this stage, there are no other ways to control the natural progression of the disease than adopting mitigation strategies such as wearing masks, watching distance, and washing hands. Moreover, at this time of social distancing, social media plays a key role in connecting people and providing a platform for expressing their feelings. In this study, we tap into social media to surveil the uptake of mitigation and detection strategies, and capture issues and concerns about the pandemic. In particular, we explore the research question, "how much can be learned regarding the public uptake of mitigation strategies and concerns about COVID-19 pandemic by using natural language processing on Reddit posts?" After extracting COVID-related posts from the four largest subreddit communities of North Carolina over six months, we performed NLP-based preprocessing to clean the noisy data. We employed a custom Named-entity Recognition (NER) system and a Latent Dirichlet Allocation (LDA) method for topic modeling on a Reddit corpus. We observed that 'mask', 'flu', and 'testing' are the most prevalent named-entities for "Personal Protective Equipment", "symptoms", and "testing" categories, respectively. We also observed that the most discussed topics are related to testing, masks, and employment. The mitigation measures are the most prevalent theme of discussion across all subreddits.
Traditional reactive approach of blacklisting botnets fails to adapt to the rapidly evolving landscape of cyberattacks. An automated and proactive approach to detect and block botnet hosts will immensely benefit the industry. Behavioral analysis of botnet is shown to be effective against a wide variety of attack types. Current works, however, focus solely on analyzing network traffic from and to the bots. In this work we take a different approach of analyzing the chain of commands input by attackers in a compromised host. We have deployed several honeypots to simulate Linux shells and allowed attackers access to the shells to collect a large dataset of commands. We have further developed an automated mechanism to analyze these data. For the automation we have developed a system called CYbersecurity information Exchange with Privacy (CYBEX-P). Finally, we have done a sequential analysis on the dataset to show that we can successfully predict attacker behavior from the shell commands without analyzing network traffic like previous works.
A smart home is grounded on the sensors that endure automation, safety, and structural integration. The security mechanism in digital setup possesses vibrant prominence and the biometric facial recognition system is novel addition to accrue the smart home features. Understanding the implementation of such technology is the outcome of user behavior modeling. However, there is the paucity of empirical research that explains the role of cognitive, functional, and social aspects of end-users acceptance behavior towards biometric facial recognition systems at homes. Therefore, a causal research survey was conducted to comprehend the behavioral intention towards the use of a biometric facial recognition system. Technology Acceptance Model (TAM)was implied with Perceived System Quality (PSQ) and Social Influence (SI)to hypothesize the conceptual framework. Data was collected from 475respondents through online questionnaires. Structural Equation Modeling(SEM) and Artificial Neural Network (ANN) were employed to analyze the surveyed data. The results showed that all the variables of the proposed framework significantly affected the behavioral intention to use the system. The PSQ appeared as the noteworthy predictor towards biometric facial recognition system usability through regression and sensitivity analyses. A multi-analytical approach towards understanding the technology user behavior will support the efficient decision-making process in Human-centric computing.
Machine Learning Approaches for Binary Classification to Discover Liver Diseases using Clinical Data
For a medical diagnosis, health professionals use different kinds of pathological ways to make a decision for medical reports in terms of patients medical condition. In the modern era, because of the advantage of computers and technologies, one can collect data and visualize many hidden outcomes from them. Statistical machine learning algorithms based on specific problems can assist one to make decisions. Machine learning data driven algorithms can be used to validate existing methods and help researchers to suggest potential new decisions. In this paper, multiple imputation by chained equations was applied to deal with missing data, and Principal Component Analysis to reduce the dimensionality. To reveal significant findings, data visualizations were implemented. We presented and compared many binary classifier machine learning algorithms (Artificial Neural Network, Random Forest, Support Vector Machine) which were used to classify blood donors and non-blood donors with hepatitis, fibrosis and cirrhosis diseases. From the data published in UCI-MLR [1], all mentioned techniques were applied to find one better method to classify blood donors and non-blood donors (hepatitis, fibrosis, and cirrhosis) that can help health professionals in a laboratory to make better decisions. Our proposed ML-method showed better accuracy score (e.g. 98.23% for SVM). Thus, it improved the quality of classification.
Prostate cancer (PCa) is one of the leading causes of death for men worldwide. Multi-parametric magnetic resonance (mpMR) imaging has emerged as a non-invasive diagnostic tool for detecting and localising prostate tumours by specialised radiologists. These radiological examinations, for example, for differentiating malignant lesions from benign prostatic hyperplasia in transition zones and for defining the boundaries of clinically significant cancer, remain challenging and highly skill-and-experience-dependent. We first investigate experimental results in developing object detection neural networks that are trained to predict the radiological assessment, using these high-variance labels. We further argue that such a computer-assisted diagnosis (CAD) system needs to have the ability to control the false-positive rate (FPR) or false-negative rate (FNR), in order to be usefully deployed in a clinical workflow, informing clinical decisions without further human intervention. This work proposes a novel PCa detection network that incorporates a lesion-level cost-sensitive loss and an additional slice-level loss based on a lesion-to-slice mapping function, to manage the lesion- and slice-level costs, respectively. Our experiments based on 290 clinical patients concludes that 1) The lesion-level FNR was effectively reduced from 0.19 to 0.10 and the lesion-level FPR was reduced from 1.03 to 0.66 by changing the lesion-level cost; 2) The slice-level FNR was reduced from 0.19 to 0.00 by taking into account the slice-level cost; (3) Both lesion-level and slice-level FNRs were reduced with lower FP/FPR by changing the lesion-level or slice-level costs, compared with post-training threshold adjustment using networks without the proposed cost-aware training.
The COVID-19 pandemic continues to have a devastating effect on the health and well-being of the global population. A critical step in the fight against COVID-19 is effective screening of infected patients, with one of the key screening approaches being radiological imaging using chest radiography. Motivated by this, a number of artificial intelligence (AI) systems based on deep learning have been proposed and results have been shown to be quite promising in terms of accuracy in detecting patients infected with COVID-19 using chest radiography images. However, to the best of the authors' knowledge, these developed AI systems have been closed source and unavailable to the research community for deeper understanding and extension, and unavailable for public access and use. Therefore, in this study we introduce COVID-Net, a deep convolutional neural network design tailored for the detection of COVID-19 cases from chest radiography images that is open source and available to the general public. We also describe the chest radiography dataset leveraged to train COVID-Net, which we will refer to as COVIDx and is comprised of 5941 posteroanterior chest radiography images across 2839 patient cases from two open access data repositories. Furthermore, we investigate how COVID-Net makes predictions using an explainability method in an attempt to gain deeper insights into critical factors associated with COVID cases, which can aid clinicians in improved screening. By no means a production-ready solution, the hope is that the open access COVID-Net, along with the description on constructing the open source COVIDx dataset, will be leveraged and build upon by both researchers and citizen data scientists alike to accelerate the development of highly accurate yet practical deep learning solutions for detecting COVID-19 cases and accelerate treatment of those who need it the most.
It is becoming increasingly easy to automatically replace a face of one person in a video with the face of another person by using a pre-trained generative adversarial network (GAN). Recent public scandals, e.g., the faces of celebrities being swapped onto pornographic videos, call for automated ways to detect these Deepfake videos. To help developing such methods, in this paper, we present the first publicly available set of Deepfake videos generated from videos of VidTIMIT database. We used open source software based on GANs to create the Deepfakes, and we emphasize that training and blending parameters can significantly impact the quality of the resulted videos. To demonstrate this impact, we generated videos with low and high visual quality (320 videos each) using differently tuned parameter sets. We showed that the state of the art face recognition systems based on VGG and Facenet neural networks are vulnerable to Deepfake videos, with 85.62% and 95.00% false acceptance rates respectively, which means methods for detecting Deepfake videos are necessary. By considering several baseline approaches, we found that audio-visual approach based on lip-sync inconsistency detection was not able to distinguish Deepfake videos. The best performing method, which is based on visual quality metrics and is often used in presentation attack detection domain, resulted in 8.97% equal error rate on high quality Deepfakes. Our experiments demonstrate that GAN-generated Deepfake videos are challenging for both face recognition systems and existing detection methods, and the further development of face swapping technology will make it even more so.
In this study, we investigate the limits of the current state of the art AI system for detecting buffer overflows and compare it with current static analysis tools. To do so, we developed a code generator, s-bAbI, capable of producing an arbitrarily large number of code samples of controlled complexity. We found that the static analysis engines we examined have good precision, but poor recall on this dataset, except for a sound static analyzer that has good precision and recall. We found that the state of the art AI system, a memory network modeled after Choi et al. [1], can achieve similar performance to the static analysis engines, but requires an exhaustive amount of training data in order to do so. Our work points towards future approaches that may solve these problems; namely, using representations of code that can capture appropriate scope information and using deep learning methods that are able to perform arithmetic operations.
Voice conversion (VC) aims at conversion of speaker characteristic without altering content. Due to training data limitations and modeling imperfections, it is difficult to achieve believable speaker mimicry without introducing processing artifacts; performance assessment of VC, therefore, usually involves both speaker similarity and quality evaluation by a human panel. As a time-consuming, expensive, and non-reproducible process, it hinders rapid prototyping of new VC technology. We address artifact assessment using an alternative, objective approach leveraging from prior work on spoofing countermeasures (CMs) for automatic speaker verification. Therein, CMs are used for rejecting `fake' inputs such as replayed, synthetic or converted speech but their potential for automatic speech artifact assessment remains unknown. This study serves to fill that gap. As a supplement to subjective results for the 2018 Voice Conversion Challenge (VCC'18) data, we configure a standard constant-Q cepstral coefficient CM to quantify the extent of processing artifacts. Equal error rate (EER) of the CM, a confusability index of VC samples with real human speech, serves as our artifact measure. Two clusters of VCC'18 entries are identified: low-quality ones with detectable artifacts (low EERs), and higher quality ones with less artifacts. None of the VCC'18 systems, however, is perfect: all EERs are < 30 % (the `ideal' value would be 50 %). Our preliminary findings suggest potential of CMs outside of their original application, as a supplemental optimization and benchmarking tool to enhance VC technology.
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