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Following the increasing trends of malicious applications or cyber threats in general, program analysis has become a ubiquitous technique in extracting relevant features. The current state-of-the-art solutions seem to fall behind new techniques. For instance, dynamic binary instrumentation (DBI) provides some promising results, but falls short when it comes to ease of use and overcoming analysis evasion. In this regard, we propose a two-fold contribution. First, we introduce COBAI (Complex Orchestrator for Binary Analysis and Instrumentation), a DBI framework designed for malware analysis, prioritizing ease-of-use and analysis transparency, without imposing a significant overhead. Second, we introduce an aggregated test suite intended to stand as a benchmark in determining the quality of an analysis solution regarding the protection against evasion mechanisms. The efficiency of our solution is validated by a careful evaluation taking into consideration other DBI frameworks, analysis environments, and the proposed benchmark.

With the implementation of the new EU regulation 2022/1426 regarding the type-approval of the automated driving system (ADS) of fully automated vehicles, scenario-based testing has gained significant importance in evaluating the performance and safety of advanced driver assistance systems and automated driving systems. However, the exploration and generation of concrete scenarios from a single logical scenario can often lead to a number of similar or redundant scenarios, which may not contribute to the testing goals. This paper focuses on the the goal to reduce the scenario set by clustering concrete scenarios from a single logical scenario. By employing clustering techniques, redundant and uninteresting scenarios can be identified and eliminated, resulting in a representative scenario set. This reduction allows for a more focused and efficient testing process, enabling the allocation of resources to the most relevant and critical scenarios. Furthermore, the identified clusters can provide valuable insights into the scenario space, revealing patterns and potential problems with the system's behavior.

Rare diseases (RDs) are collectively common and affect 300 million people worldwide. Accurate phenotyping is critical for informing diagnosis and treatment, but RD phenotypes are often embedded in unstructured text and time-consuming to extract manually. While natural language processing (NLP) models can perform named entity recognition (NER) to automate extraction, a major bottleneck is the development of a large, annotated corpus for model training. Recently, prompt learning emerged as an NLP paradigm that can lead to more generalizable results without any (zero-shot) or few labeled samples (few-shot). Despite growing interest in ChatGPT, a revolutionary large language model capable of following complex human prompts and generating high-quality responses, none have studied its NER performance for RDs in the zero- and few-shot settings. To this end, we engineered novel prompts aimed at extracting RD phenotypes and, to the best of our knowledge, are the first the establish a benchmark for evaluating ChatGPT's performance in these settings. We compared its performance to the traditional fine-tuning approach and conducted an in-depth error analysis. Overall, fine-tuning BioClinicalBERT resulted in higher performance (F1 of 0.689) than ChatGPT (F1 of 0.472 and 0.591 in the zero- and few-shot settings, respectively). Despite this, ChatGPT achieved similar or higher accuracy for certain entities (i.e., rare diseases and signs) in the one-shot setting (F1 of 0.776 and 0.725). This suggests that with appropriate prompt engineering, ChatGPT has the potential to match or outperform fine-tuned language models for certain entity types with just one labeled sample. While the proliferation of large language models may provide opportunities for supporting RD diagnosis and treatment, researchers and clinicians should critically evaluate model outputs and be well-informed of their limitations.

Transition path theory (TPT) is a mathematical framework for quantifying rare transition events between a pair of selected metastable states $A$ and $B$. Central to TPT is the committor function, which describes the probability to hit the metastable state $B$ prior to $A$ from any given starting point of the phase space. Once the committor is computed, the transition channels and the transition rate can be readily found. The committor is the solution to the backward Kolmogorov equation with appropriate boundary conditions. However, solving it is a challenging task in high dimensions due to the need to mesh a whole region of the ambient space. In this work, we explore the finite expression method (FEX, Liang and Yang (2022)) as a tool for computing the committor. FEX approximates the committor by an algebraic expression involving a fixed finite number of nonlinear functions and binary arithmetic operations. The optimal nonlinear functions, the binary operations, and the numerical coefficients in the expression template are found via reinforcement learning. The FEX-based committor solver is tested on several high-dimensional benchmark problems. It gives comparable or better results than neural network-based solvers. Most importantly, FEX is capable of correctly identifying the algebraic structure of the solution which allows one to reduce the committor problem to a low-dimensional one and find the committor with any desired accuracy.

Large multimodal language models (LMMs) have achieved significant success in general domains. However, due to the significant differences between medical images and text and general web content, the performance of LMMs in medical scenarios is limited. In ophthalmology, clinical diagnosis relies on multiple modalities of medical images, but unfortunately, multimodal ophthalmic large language models have not been explored to date. In this paper, we study and construct an ophthalmic large multimodal model. Firstly, we use fundus images as an entry point to build a disease assessment and diagnosis pipeline to achieve common ophthalmic disease diagnosis and lesion segmentation. Then, we establish a new ophthalmic multimodal instruction-following and dialogue fine-tuning dataset based on disease-related knowledge data and publicly available real-world medical dialogue. We introduce visual ability into the large language model to complete the ophthalmic large language and vision assistant (OphGLM). Our experimental results demonstrate that the OphGLM model performs exceptionally well, and it has the potential to revolutionize clinical applications in ophthalmology. The dataset, code, and models will be made publicly available at //github.com/ML-AILab/OphGLM.

In today's world, many technologically advanced countries have realized that real power lies not in physical strength but in educated minds. As a result, every country has embarked on restructuring its education system to meet the demands of technology. As a country in the midst of these developments, we cannot remain indifferent to this transformation in education. In the Information Age of the 21st century, rapid access to information is crucial for the development of individuals and societies. To take our place among the knowledge societies in a world moving rapidly towards globalization, we must closely follow technological innovations and meet the requirements of technology. This can be achieved by providing learning opportunities to anyone interested in acquiring education in their area of interest. This study focuses on the advantages and disadvantages of internet-based learning compared to traditional teaching methods, the importance of computer usage in internet-based learning, negative factors affecting internet-based learning, and the necessary recommendations for addressing these issues. In today's world, it is impossible to talk about education without technology or technology without education.

Over the past few years, the rapid development of deep learning technologies for computer vision has greatly promoted the performance of medical image segmentation (MedISeg). However, the recent MedISeg publications usually focus on presentations of the major contributions (e.g., network architectures, training strategies, and loss functions) while unwittingly ignoring some marginal implementation details (also known as "tricks"), leading to a potential problem of the unfair experimental result comparisons. In this paper, we collect a series of MedISeg tricks for different model implementation phases (i.e., pre-training model, data pre-processing, data augmentation, model implementation, model inference, and result post-processing), and experimentally explore the effectiveness of these tricks on the consistent baseline models. Compared to paper-driven surveys that only blandly focus on the advantages and limitation analyses of segmentation models, our work provides a large number of solid experiments and is more technically operable. With the extensive experimental results on both the representative 2D and 3D medical image datasets, we explicitly clarify the effect of these tricks. Moreover, based on the surveyed tricks, we also open-sourced a strong MedISeg repository, where each of its components has the advantage of plug-and-play. We believe that this milestone work not only completes a comprehensive and complementary survey of the state-of-the-art MedISeg approaches, but also offers a practical guide for addressing the future medical image processing challenges including but not limited to small dataset learning, class imbalance learning, multi-modality learning, and domain adaptation. The code has been released at: //github.com/hust-linyi/MedISeg

Automated Driving Systems (ADS) have made great achievements in recent years thanks to the efforts from both academia and industry. A typical ADS is composed of multiple modules, including sensing, perception, planning and control, which brings together the latest advances in multiple domains. Despite these achievements, safety assurance of the systems is still of great significance, since the unsafe behavior of ADS can bring catastrophic consequences and unacceptable economic and social losses. Testing is an important approach to system validation for the deployment in practice; in the context of ADS, it is extremely challenging, due to the system complexity and multidisciplinarity. There has been a great deal of literature that focuses on the testing of ADS, and a number of surveys have also emerged to summarize the technical advances. However, most of these surveys focus on the system-level testing that is performed within software simulators, and thereby ignore the distinct features of individual modules. In this paper, we provide a comprehensive survey on the existing ADS testing literature, which takes into account both module-level and system-level testing. Specifically, we make the following contributions: (1) we build a threat model that reveals the potential safety threats for each module of an ADS; (2) we survey the module-level testing techniques for ADS and highlight the technical differences affected by the properties of the modules; (3) we also survey the system-level testing techniques, but we focus on empirical studies that take a bird's-eye view on the system, the problems due to the collaborations between modules, and the gaps between ADS testing in simulators and real world; (4) we identify the challenges and opportunities in ADS testing, which facilitates the future research in this field.

With the advent of 5G commercialization, the need for more reliable, faster, and intelligent telecommunication systems are envisaged for the next generation beyond 5G (B5G) radio access technologies. Artificial Intelligence (AI) and Machine Learning (ML) are not just immensely popular in the service layer applications but also have been proposed as essential enablers in many aspects of B5G networks, from IoT devices and edge computing to cloud-based infrastructures. However, most of the existing surveys in B5G security focus on the performance of AI/ML models and their accuracy, but they often overlook the accountability and trustworthiness of the models' decisions. Explainable AI (XAI) methods are promising techniques that would allow system developers to identify the internal workings of AI/ML black-box models. The goal of using XAI in the security domain of B5G is to allow the decision-making processes of the security of systems to be transparent and comprehensible to stakeholders making the systems accountable for automated actions. In every facet of the forthcoming B5G era, including B5G technologies such as RAN, zero-touch network management, E2E slicing, this survey emphasizes the role of XAI in them and the use cases that the general users would ultimately enjoy. Furthermore, we presented the lessons learned from recent efforts and future research directions on top of the currently conducted projects involving XAI.

Games and simulators can be a valuable platform to execute complex multi-agent, multiplayer, imperfect information scenarios with significant parallels to military applications: multiple participants manage resources and make decisions that command assets to secure specific areas of a map or neutralize opposing forces. These characteristics have attracted the artificial intelligence (AI) community by supporting development of algorithms with complex benchmarks and the capability to rapidly iterate over new ideas. The success of artificial intelligence algorithms in real-time strategy games such as StarCraft II have also attracted the attention of the military research community aiming to explore similar techniques in military counterpart scenarios. Aiming to bridge the connection between games and military applications, this work discusses past and current efforts on how games and simulators, together with the artificial intelligence algorithms, have been adapted to simulate certain aspects of military missions and how they might impact the future battlefield. This paper also investigates how advances in virtual reality and visual augmentation systems open new possibilities in human interfaces with gaming platforms and their military parallels.