The description of gene interactions that constantly occur in the cellular environment is an extremely challenging task due to an immense number of degrees of freedom and incomplete knowledge about microscopic details. Hence, a coarse-grained and rather powerful modeling of such dynamics is provided by Boolean Networks (BNs). BNs are dynamical systems composed of Boolean agents and a record of their possible interactions over time. Stable states in these systems are called attractors which are closely related to the cellular expression of biological phenotypes. Identifying the full set of attractors is, therefore, of substantial biological interest. However, for conventional high-performance computing, this problem is plagued by an exponential growth of the dynamic state space. Here, we demonstrate a novel quantum search algorithm inspired by Grover's algorithm to be implemented on quantum computing platforms. The algorithm performs an iterative suppression of states belonging to basins of previously discovered attractors from a uniform superposition, thus increasing the amplitudes of states in basins of yet unknown attractors. This approach guarantees that a new attractor state is measured with each iteration of the algorithm, an optimization not currently achieved by any other algorithm in the literature. Tests of its resistance to noise have also shown promising performance on devices from the current Noise Intermediate Scale Quantum Computing (NISQ) era.
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Hyperspectral super-resolution is commonly accomplished by the fusing of a hyperspectral imaging of low spatial resolution with a multispectral image of high spatial resolution, and many tensor-based approaches to this task have been recently proposed. Yet, it is assumed in such tensor-based methods that the spatial-blurring operation that creates the observed hyperspectral image from the desired super-resolved image is separable into independent horizontal and vertical blurring. Recent work has argued that such separable spatial degradation is ill-equipped to model the operation of real sensors which may exhibit, for example, anisotropic blurring. To accommodate this fact, a generalized tensor formulation based on a Kronecker decomposition is proposed to handle any general spatial-degradation matrix, including those that are not separable as previously assumed. Analysis of the generalized formulation reveals conditions under which exact recovery of the desired super-resolved image is guaranteed, and a practical algorithm for such recovery, driven by a blockwise-group-sparsity regularization, is proposed. Extensive experimental results demonstrate that the proposed generalized tensor approach outperforms not only traditional matrix-based techniques but also state-of-the-art tensor-based methods; the gains with respect to the latter are especially significant in cases of anisotropic spatial blurring.
As the use of autonomous robots expands in tasks that are complex and challenging to model, the demand for robust data-driven control methods that can certify safety and stability in uncertain conditions is increasing. However, the practical implementation of these methods often faces scalability issues due to the growing amount of data points with system complexity, and a significant reliance on high-quality training data. In response to these challenges, this study presents a scalable data-driven controller that efficiently identifies and infers from the most informative data points for implementing data-driven safety filters. Our approach is grounded in the integration of a model-based certificate function-based method and Gaussian Process (GP) regression, reinforced by a novel online data selection algorithm that reduces time complexity from quadratic to linear relative to dataset size. Empirical evidence, gathered from successful real-world cart-pole swing-up experiments and simulated locomotion of a five-link bipedal robot, demonstrates the efficacy of our approach. Our findings reveal that our efficient online data selection algorithm, which strategically selects key data points, enhances the practicality and efficiency of data-driven certifying filters in complex robotic systems, significantly mitigating scalability concerns inherent in nonparametric learning-based control methods.
With the rapid development of artificial intelligence technology, especially the increasingly widespread application of question-and-answer systems, high-quality question generation has become a key component in supporting the development of these systems. This article focuses on knowledge-based question generation technology, which aims to enable computers to simulate the human questioning process based on understanding specific texts or knowledge bases. In light of the issues of hallucination and knowledge gaps present in large-scale language models when applied to knowledge-intensive tasks, this paper proposes an enhanced question generation method that incorporates contrastive learning. This method utilizes multiple models to jointly mine domain knowledge and uses contrastive learning to guide the model in reducing noise and hallucinations in generation. Experimental results show that by designing prompts containing contrasting examples, the model's performance in question generation improves considerably, particularly when contrasting instructions and examples are used simultaneously, leading to the highest quality of generated questions and improved accuracy. These results demonstrate that the method proposed in this study, which combines contrasting context and chain-of-thought prompts, can effectively improve both the quality and the practicality of question generation.
An important goal of environmental epidemiology is to quantify the complex health risks posed by a wide array of environmental exposures. In analyses focusing on a smaller number of exposures within a mixture, flexible models like Bayesian kernel machine regression (BKMR) are appealing because they allow for non-linear and non-additive associations among mixture components. However, this flexibility comes at the cost of low power and difficult interpretation, particularly in exposomic analyses when the number of exposures is large. We propose a flexible framework that allows for separate selection of additive and non-additive effects, unifying additive models and kernel machine regression. The proposed approach yields increased power and simpler interpretation when there is little evidence of interaction. Further, it allows users to specify separate priors for additive and non-additive effects, and allows for tests of non-additive interaction. We extend the approach to the class of multiple index models, in which the special case of kernel machine-distributed lag models are nested. We apply the method to motivating data from a subcohort of the Human Early Life Exposome (HELIX) study containing 65 mixture components grouped into 13 distinct exposure classes.
Volatile memristors have recently gained popularity as promising devices for neuromorphic circuits, capable of mimicking the leaky function of neurons and offering advantages over capacitor-based circuits in terms of power dissipation and area. Additionally, volatile memristors are useful as selector devices and for hardware security circuits such as physical unclonable functions. To facilitate the design and simulation of circuits, a compact behavioral model is essential. This paper proposes V-VTEAM, a compact, simple, general, and flexible behavioral model for volatile memristors, inspired by the VTEAM nonvolatile memristor model and developed in MATLAB. The validity of the model is demonstrated by fitting it to an ion drift/diffusion-based Ag/SiOx/C/W volatile memristor, achieving a relative root mean error square of 4.5%.
Embedding-based neural retrieval is a prevalent approach to address the semantic gap problem which often arises in product search on tail queries. In contrast, popular queries typically lack context and have a broad intent where additional context from users historical interaction can be helpful. In this paper, we share our novel approach to address both: the semantic gap problem followed by an end to end trained model for personalized semantic retrieval. We propose learning a unified embedding model incorporating graph, transformer and term-based embeddings end to end and share our design choices for optimal tradeoff between performance and efficiency. We share our learnings in feature engineering, hard negative sampling strategy, and application of transformer model, including a novel pre-training strategy and other tricks for improving search relevance and deploying such a model at industry scale. Our personalized retrieval model significantly improves the overall search experience, as measured by a 5.58% increase in search purchase rate and a 2.63% increase in site-wide conversion rate, aggregated across multiple A/B tests - on live traffic.
In contemporary healthcare, to protect patient data, electronic health records have become invaluable repositories, creating vast opportunities to leverage deep learning techniques for predictive analysis. Retinal fundus images, cirrhosis stages, and heart disease diagnostic predictions have shown promising results through the integration of deep learning techniques for classifying diverse datasets. This study proposes a novel deep learning predictive analysis framework for classifying multiple datasets by pre-processing data from three distinct sources. A hybrid deep learning model combining Residual Networks and Artificial Neural Networks is proposed to detect acute and chronic diseases such as heart diseases, cirrhosis, and retinal conditions, outperforming existing models. Dataset preparation involves aspects such as categorical data transformation, dimensionality reduction, and missing data synthesis. Feature extraction is effectively performed using scaler transformation for categorical datasets and ResNet architecture for image datasets. The resulting features are integrated into a unified classification model. Rigorous experimentation and evaluation resulted in high accuracies of 93%, 99%, and 95% for retinal fundus images, cirrhosis stages, and heart disease diagnostic predictions, respectively. The efficacy of the proposed method is demonstrated through a detailed analysis of F1-score, precision, and recall metrics. This study offers a comprehensive exploration of methodologies and experiments, providing in-depth knowledge of deep learning predictive analysis in electronic health records.
Understanding causality helps to structure interventions to achieve specific goals and enables predictions under interventions. With the growing importance of learning causal relationships, causal discovery tasks have transitioned from using traditional methods to infer potential causal structures from observational data to the field of pattern recognition involved in deep learning. The rapid accumulation of massive data promotes the emergence of causal search methods with brilliant scalability. Existing summaries of causal discovery methods mainly focus on traditional methods based on constraints, scores and FCMs, there is a lack of perfect sorting and elaboration for deep learning-based methods, also lacking some considers and exploration of causal discovery methods from the perspective of variable paradigms. Therefore, we divide the possible causal discovery tasks into three types according to the variable paradigm and give the definitions of the three tasks respectively, define and instantiate the relevant datasets for each task and the final causal model constructed at the same time, then reviews the main existing causal discovery methods for different tasks. Finally, we propose some roadmaps from different perspectives for the current research gaps in the field of causal discovery and point out future research directions.
Analyzing observational data from multiple sources can be useful for increasing statistical power to detect a treatment effect; however, practical constraints such as privacy considerations may restrict individual-level information sharing across data sets. This paper develops federated methods that only utilize summary-level information from heterogeneous data sets. Our federated methods provide doubly-robust point estimates of treatment effects as well as variance estimates. We derive the asymptotic distributions of our federated estimators, which are shown to be asymptotically equivalent to the corresponding estimators from the combined, individual-level data. We show that to achieve these properties, federated methods should be adjusted based on conditions such as whether models are correctly specified and stable across heterogeneous data sets.
Human doctors with well-structured medical knowledge can diagnose a disease merely via a few conversations with patients about symptoms. In contrast, existing knowledge-grounded dialogue systems often require a large number of dialogue instances to learn as they fail to capture the correlations between different diseases and neglect the diagnostic experience shared among them. To address this issue, we propose a more natural and practical paradigm, i.e., low-resource medical dialogue generation, which can transfer the diagnostic experience from source diseases to target ones with a handful of data for adaptation. It is capitalized on a commonsense knowledge graph to characterize the prior disease-symptom relations. Besides, we develop a Graph-Evolving Meta-Learning (GEML) framework that learns to evolve the commonsense graph for reasoning disease-symptom correlations in a new disease, which effectively alleviates the needs of a large number of dialogues. More importantly, by dynamically evolving disease-symptom graphs, GEML also well addresses the real-world challenges that the disease-symptom correlations of each disease may vary or evolve along with more diagnostic cases. Extensive experiment results on the CMDD dataset and our newly-collected Chunyu dataset testify the superiority of our approach over state-of-the-art approaches. Besides, our GEML can generate an enriched dialogue-sensitive knowledge graph in an online manner, which could benefit other tasks grounded on knowledge graph.
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