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The introduction of computerized medical records in hospitals has reduced burdensome operations like manual writing and information fetching. However, the data contained in medical records are still far underutilized, primarily because extracting them from unstructured textual medical records takes time and effort. Information Extraction, a subfield of Natural Language Processing, can help clinical practitioners overcome this limitation, using automated text-mining pipelines. In this work, we created the first Italian neuropsychiatric Named Entity Recognition dataset, PsyNIT, and used it to develop a Large Language Model for this task. Moreover, we conducted several experiments with three external independent datasets to implement an effective multicenter model, with overall F1-score 84.77%, Precision 83.16%, Recall 86.44%. The lessons learned are: (i) the crucial role of a consistent annotation process and (ii) a fine-tuning strategy that combines classical methods with a "few-shot" approach. This allowed us to establish methodological guidelines that pave the way for future implementations in this field and allow Italian hospitals to tap into important research opportunities.

The use of a hypothetical generative model was been suggested for causal analysis of observational data. The very assumption of a particular model is a commitment to a certain set of variables and therefore to a certain set of possible causes. Estimating the joint probability distribution of can be useful for predicting values of variables in view of the observed values of others, but it is not sufficient for inferring causal relationships. The model describes a single observable distribution and cannot a chain of effects of intervention that deviate from the observed distribution.

Large Language Models (LLMs) have made remarkable advancements in the field of artificial intelligence, significantly reshaping the human-computer interaction. We not only focus on the performance of LLMs, but also explore their features from a psychological perspective, acknowledging the importance of understanding their behavioral characteristics. Our study examines the behavioral patterns displayed by LLMs by employing trait theory, a psychological framework. We first focus on evaluating the consistency of personality types exhibited by ChatGPT. Furthermore, experiments include cross-lingual effects on seven additional languages, and the investigation of six other LLMs. Moreover, the study investigates whether ChatGPT can exhibit personality changes in response to instructions or contextual cues. The findings show that ChatGPT consistently maintains its ENFJ personality regardless of instructions or contexts. By shedding light on the personalization of LLMs, we anticipate that our study will serve as a catalyst for further research in this field.

Automating dysarthria assessments offers the opportunity to develop effective, low-cost tools that address the current limitations of manual and subjective assessments. Nonetheless, it is unclear whether current approaches rely on dysarthria-related speech patterns or external factors. We aim toward obtaining a clearer understanding of dysarthria patterns. To this extent, we study the effects of noise in recordings, both through addition and reduction. We design and implement a new method for visualizing and comparing feature extractors and models, at a patient level, in a more interpretable way. We use the UA-Speech dataset with a speaker-based split of the dataset. Results reported in the literature appear to have been done irrespective of such split, leading to models that may be overconfident due to data-leakage. We hope that these results raise awareness in the research community regarding the requirements for establishing reliable automatic dysarthria assessment systems.

ChatGPT has piqued the interest of many fields, particularly in the academic community. GPT-4, the latest version, starts supporting multimodal input and output. This study examines social media posts to analyze how the Chinese public perceives the potential of ChatGPT for educational and general purposes. The study also serves as the first effort to investigate the changes in public opinion since the release of GPT-4. According to the analysis results, prior to GPT-4, although some social media users believed that AI advancements would benefit education and society, some believed that advanced AI, such as ChatGPT, would make humans feel inferior and lead to problems such as cheating and a decline in moral principles, while the majority remain neutral. Interestingly, public attitudes have tended to shift in a positive direction since the release of GPT-4. We present a thorough analysis of the trending shift and a roadmap to ensure the ethical application of ChatGPT-like models in education and beyond.

Vulnerabilities of Ethereum smart contracts often cause serious financial damage. Whereas the Solidity compiler has been updated to prevent vulnerabilities, its effectiveness has not been revealed so far, to the best of our knowledge. In this paper, we shed light on the impact of compiler versions of vulnerabilities of Ethereum smart contracts. To this end, we collected 503,572 contracts with Solidity source codes in the Ethereum blockchain and then analyzed their vulnerabilities. For three vulnerabilities with high severity, i.e., Locked Money, Using tx.origin, and Unchecked Call, we show that their appearance rates are decreased by virtue of major updates of the Solidity compiler. We then found the following four key insights. First, after the release of version 0.6, the appearance rate for Locked Money has decreased. Second, regardless of compiler updates, the appearance rate for Using tx.origin is significantly low. Third, although the appearance rate for Unchecked Call has decreased in version 0.8, it still remains high due to various factors, including code clones. Fourth, through analysis of code clones, our promising results show that the appearance rate for Unchecked Call can be further decreased by removing the code clones.

U-statistics play central roles in many statistical learning tools but face the haunting issue of scalability. Significant efforts have been devoted into accelerating computation by U-statistic reduction. However, existing results almost exclusively focus on power analysis, while little work addresses risk control accuracy -- comparatively, the latter requires distinct and much more challenging techniques. In this paper, we establish the first statistical inference procedure with provably higher-order accurate risk control for incomplete U-statistics. The sharpness of our new result enables us to reveal how risk control accuracy also trades off with speed for the first time in literature, which complements the well-known variance-speed trade-off. Our proposed general framework converts the long-standing challenge of formulating accurate statistical inference procedures for many different designs into a surprisingly routine task. This paper covers non-degenerate and degenerate U-statistics, and network moments. We conducted comprehensive numerical studies and observed results that validate our theory's sharpness. Our method also demonstrates effectiveness on real-world data applications.

Software is vital for the advancement of biology and medicine. Analysis of usage and impact metrics can help developers determine user and community engagement, justify additional funding, encourage additional use, identify unanticipated use cases, and help define improvement areas. However, there are challenges associated with these analyses including distorted or misleading metrics, as well as ethical and security concerns. More attention to the nuances involved in capturing impact across the spectrum of biological software is needed. Furthermore, some tools may be especially beneficial to a small audience, yet may not have compelling typical usage metrics. We propose more general guidelines, as well as strategies for more specific types of software. We highlight outstanding issues regarding how communities measure or evaluate software impact. To get a deeper understanding of current practices for software evaluations, we performed a survey of participants in the Informatics Technology for Cancer Research (ITCR) program funded by the National Cancer Institute (NCI). We also investigated software among this community and others to assess how often infrastructure that supports such evaluations is implemented and how this impacts rates of papers describing usage of the software. We find that developers recognize the utility of analyzing software usage, but struggle to find the time or funding for such analyses. We also find that infrastructure such as social media presence, more in-depth documentation, the presence of software health metrics, and clear information on how to contact developers seem to be associated with increased usage rates. Our findings can help scientific software developers make the most out of evaluations of their software.

In this work we make progress in understanding the relationship between learning models with access to entangled, separable and statistical measurements in the quantum statistical query (QSQ) model. To this end, we show the following results. $\textbf{Entangled versus separable measurements.}$ The goal here is to learn an unknown $f$ from the concept class $C\subseteq \{f:\{0,1\}^n\rightarrow [k]\}$ given copies of $\frac{1}{\sqrt{2^n}}\sum_x \vert x,f(x)\rangle$. We show that, if $T$ copies suffice to learn $f$ using entangled measurements, then $O(nT^2)$ copies suffice to learn $f$ using just separable measurements. $\textbf{Entangled versus statistical measurements}$ The goal here is to learn a function $f \in C$ given access to separable measurements and statistical measurements. We exhibit a class $C$ that gives an exponential separation between QSQ learning and quantum learning with entangled measurements (even in the presence of noise). This proves the "quantum analogue" of the seminal result of Blum et al. [BKW'03]. that separates classical SQ and PAC learning with classification noise. $\textbf{QSQ lower bounds for learning states.}$ We introduce a quantum statistical query dimension (QSD), which we use to give lower bounds on the QSQ learning. With this we prove superpolynomial QSQ lower bounds for testing purity, shadow tomography, Abelian hidden subgroup problem, degree-$2$ functions, planted bi-clique states and output states of Clifford circuits of depth $\textsf{polylog}(n)$. $\textbf{Further applications.}$ We give and $\textit{unconditional}$ separation between weak and strong error mitigation and prove lower bounds for learning distributions in the QSQ model. Prior works by Quek et al. [QFK+'22], Hinsche et al. [HIN+'22], and Nietner et al. [NIS+'23] proved the analogous results $\textit{assuming}$ diagonal measurements and our work removes this assumption.

The notion of uncertainty is of major importance in machine learning and constitutes a key element of machine learning methodology. In line with the statistical tradition, uncertainty has long been perceived as almost synonymous with standard probability and probabilistic predictions. Yet, due to the steadily increasing relevance of machine learning for practical applications and related issues such as safety requirements, new problems and challenges have recently been identified by machine learning scholars, and these problems may call for new methodological developments. In particular, this includes the importance of distinguishing between (at least) two different types of uncertainty, often refereed to as aleatoric and epistemic. In this paper, we provide an introduction to the topic of uncertainty in machine learning as well as an overview of hitherto attempts at handling uncertainty in general and formalizing this distinction in particular.