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Optimal estimation and inference for both the minimizer and minimum of a convex regression function under the white noise and nonparametric regression models are studied in a non-asymptotic local minimax framework, where the performance of a procedure is evaluated at individual functions. Fully adaptive and computationally efficient algorithms are proposed and sharp minimax lower bounds are given for both the estimation accuracy and expected length of confidence intervals for the minimizer and minimum. The non-asymptotic local minimax framework brings out new phenomena in simultaneous estimation and inference for the minimizer and minimum. We establish a novel Uncertainty Principle that provides a fundamental limit on how well the minimizer and minimum can be estimated simultaneously for any convex regression function. A similar result holds for the expected length of the confidence intervals for the minimizer and minimum.

Assessing causal effects in the presence of unmeasured confounding is a challenging problem. Although auxiliary variables, such as instrumental variables, are commonly used to identify causal effects, they are often unavailable in practice due to stringent and untestable conditions. To address this issue, previous researches have utilized linear structural equation models to show that the causal effect can be identifiable when noise variables of the treatment and outcome are both non-Gaussian. In this paper, we investigate the problem of identifying the causal effect using auxiliary covariates and non-Gaussianity from the treatment. Our key idea is to characterize the impact of unmeasured confounders using an observed covariate, assuming they are all Gaussian. The auxiliary covariate can be an invalid instrument or an invalid proxy variable. We demonstrate that the causal effect can be identified using this measured covariate, even when the only source of non-Gaussianity comes from the treatment. We then extend the identification results to the multi-treatment setting and provide sufficient conditions for identification. Based on our identification results, we propose a simple and efficient procedure for calculating causal effects and show the $\sqrt{n}$-consistency of the proposed estimator. Finally, we evaluate the performance of our estimator through simulation studies and an application.

We consider a cellular network, where the uplink transmissions to a base station (BS) are interferenced by other devices, a condition that may occur, e.g., in cell-free networks or when using non-orthogonal multiple access (NOMA) techniques. Assuming that the BS treats this interference as additional noise, we focus on the problem of estimating the interference correlation matrix from received signal samples. We consider a BS equipped with multiple antennas and operating in the millimeter-wave (mmWave) bands and propose techniques exploiting the fact that channels comprise only a few reflections at these frequencies. This yields a specific structure of the interference correlation matrix that can be decomposed into three matrices, two rectangular depending on the angle of arrival (AoA) of the interference and the third square with smaller dimensions. We resort to gridless approaches to estimate the AoAs and then project the least square estimate of the interference correlation matrix into a subspace with a smaller dimension, thus reducing the estimation error. Moreover, we derive two simplified estimators, still based on the gridless angle estimation that turns out to be convenient when estimating the interference over a larger number of samples.

Besov priors are nonparametric priors that model spatially inhomogeneous functions. They are routinely used in inverse problems and imaging, where they exhibit attractive sparsity-promoting and edge-preserving features. A recent line of work has initiated the study of their asymptotic frequentist convergence properties. In the present paper, we consider the theoretical recovery performance of the posterior distributions associated to Besov-Laplace priors in the density estimation model, under the assumption that the observations are generated by a possibly spatially inhomogeneous true density belonging to a Besov space. We improve on existing results and show that carefully tuned Besov-Laplace priors attain optimal posterior contraction rates. Furthermore, we show that hierarchical procedures involving a hyper-prior on the regularity parameter lead to adaptation to any smoothness level.

We study numerical integration over bounded regions in $\mathbb{R}^s, s\ge1$ with respect to some probability measure. We replace random sampling with quasi-Monte Carlo methods, where the underlying point set is derived from deterministic constructions that aim to fill the space more evenly than random points. Such quasi-Monte Carlo point sets are ordinarily designed for the uniform measure, and the theory only works for product measures when a coordinate-wise transformation is applied. Going beyond this setting, we first consider the case where the target density is a mixture distribution where each term in the mixture comes from a product distribution. Next we consider target densities which can be approximated with such mixture distributions. We require the approximation to be a sum of coordinate-wise products and the approximation to be positive everywhere (so that they can be re-scaled to probability density functions). We use tensor product hat function approximations for this purpose here, since a hat function approximation of a positive function is itself positive. We also study more complex algorithms, where we first approximate the target density with a general Gaussian mixture distribution and approximate the mixtures with an adaptive hat function approximation on rotated intervals. The Gaussian mixture approximation allows us to locate the essential parts of the target density, whereas the adaptive hat function approximation allows us to approximate the finer structure of the target density. We prove convergence rates for each of the integration techniques based on quasi-Monte Carlo sampling for integrands with bounded partial mixed derivatives. The employed algorithms are based on digital $(t,s)$-sequences over the finite field $\mathbb{F}_2$ and an inversion method. Numerical examples illustrate the performance of the algorithms for some target densities and integrands.

According to ICH Q8 guidelines, the biopharmaceutical manufacturer submits a design space (DS) definition as part of the regulatory approval application, in which case process parameter (PP) deviations within this space are not considered a change and do not trigger a regulatory post approval procedure. A DS can be described by non-linear PP ranges, i.e., the range of one PP conditioned on specific values of another. However, independent PP ranges (linear combinations) are often preferred in biopharmaceutical manufacturing due to their operation simplicity. While some statistical software supports the calculation of a DS comprised of linear combinations, such methods are generally based on discretizing the parameter space - an approach that scales poorly as the number of PPs increases. Here, we introduce a novel method for finding linear PP combinations using a numeric optimizer to calculate the largest design space within the parameter space that results in critical quality attribute (CQA) boundaries within acceptance criteria, predicted by a regression model. A precomputed approximation of tolerance intervals is used in inequality constraints to facilitate fast evaluations of this boundary using a single matrix multiplication. Correctness of the method was validated against different ground truths with known design spaces. Compared to stateof-the-art, grid-based approaches, the optimizer-based procedure is more accurate, generally yields a larger DS and enables the calculation in higher dimensions. Furthermore, a proposed weighting scheme can be used to favor certain PPs over others and therefore enabling a more dynamic approach to DS definition and exploration. The increased PP ranges of the larger DS provide greater operational flexibility for biopharmaceutical manufacturers.

Generalized and Simulated Method of Moments are often used to estimate structural Economic models. Yet, it is commonly reported that optimization is challenging because the corresponding objective function is non-convex. For smooth problems, this paper shows that convexity is not required: under a global rank condition involving the Jacobian of the sample moments, certain algorithms are globally convergent. These include a gradient-descent and a Gauss-Newton algorithm with appropriate choice of tuning parameters. The results are robust to 1) non-convexity, 2) one-to-one non-linear reparameterizations, and 3) moderate misspecification. In contrast, Newton-Raphson and quasi-Newton methods can fail to converge for the same estimation because of non-convexity. A simple example illustrates a non-convex GMM estimation problem that satisfies the aforementioned rank condition. Empirical applications to random coefficient demand estimation and impulse response matching further illustrate the results.

Experimental data is often comprised of variables measured independently, at different sampling rates (non-uniform ${\Delta}$t between successive measurements); and at a specific time point only a subset of all variables may be sampled. Approaches to identifying dynamical systems from such data typically use interpolation, imputation or subsampling to reorganize or modify the training data $\textit{prior}$ to learning. Partial physical knowledge may also be available $\textit{a priori}$ (accurately or approximately), and data-driven techniques can complement this knowledge. Here we exploit neural network architectures based on numerical integration methods and $\textit{a priori}$ physical knowledge to identify the right-hand side of the underlying governing differential equations. Iterates of such neural-network models allow for learning from data sampled at arbitrary time points $\textit{without}$ data modification. Importantly, we integrate the network with available partial physical knowledge in "physics informed gray-boxes"; this enables learning unknown kinetic rates or microbial growth functions while simultaneously estimating experimental parameters.

We introduce a new computational framework for estimating parameters in generalized generalized linear models (GGLM), a class of models that extends the popular generalized linear models (GLM) to account for dependencies among observations in spatio-temporal data. The proposed approach uses a monotone operator-based variational inequality method to overcome non-convexity in parameter estimation and provide guarantees for parameter recovery. The results can be applied to GLM and GGLM, focusing on spatio-temporal models. We also present online instance-based bounds using martingale concentrations inequalities. Finally, we demonstrate the performance of the algorithm using numerical simulations and a real data example for wildfire incidents.

Autonomous Nano Aerial Vehicles have been increasingly popular in surveillance and monitoring operations due to their efficiency and maneuverability. Once a target location has been reached, drones do not have to remain active during the mission. It is possible for the vehicle to perch and stop its motors in such situations to conserve energy, as well as maintain a static position in unfavorable flying conditions. In the perching target estimation phase, the steady and accuracy of a visual camera with markers is a significant challenge. It is rapidly detectable from afar when using a large marker, but when the drone approaches, it quickly disappears as out of camera view. In this paper, a vision-based target poses estimation method using multiple markers is proposed to deal with the above-mentioned problems. First, a perching target with a small marker inside a larger one is designed to improve detection capability at wide and close ranges. Second, the relative poses of the flying vehicle are calculated from detected markers using a monocular camera. Next, a Kalman filter is applied to provide a more stable and reliable pose estimation, especially when the measurement data is missing due to unexpected reasons. Finally, we introduced an algorithm for merging the poses data from multi markers. The poses are then sent to the position controller to align the drone and the marker's center and steer it to perch on the target. The experimental results demonstrated the effectiveness and feasibility of the adopted approach. The drone can perch successfully onto the center of the markers with the attached 25mm-diameter rounded magnet.