State-of-the-art brain tumor segmentation is based on deep learning models applied to multi-modal MRIs. Currently, these models are trained on images after a preprocessing stage that involves registration, interpolation, brain extraction (BE, also known as skull-stripping) and manual correction by an expert. However, for clinical practice, this last step is tedious and time-consuming and, therefore, not always feasible, resulting in skull-stripping faults that can negatively impact the tumor segmentation quality. Still, the extent of this impact has never been measured for any of the many different BE methods available. In this work, we propose an automatic brain tumor segmentation pipeline and evaluate its performance with multiple BE methods. Our experiments show that the choice of a BE method can compromise up to 15.7% of the tumor segmentation performance. Moreover, we propose training and testing tumor segmentation models on non-skull-stripped images, effectively discarding the BE step from the pipeline. Our results show that this approach leads to a competitive performance at a fraction of the time. We conclude that, in contrast to the current paradigm, training tumor segmentation models on non-skull-stripped images can be the best option when high performance in clinical practice is desired.
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Reliability of machine learning evaluation -- the consistency of observed evaluation scores across replicated model training runs -- is affected by several sources of nondeterminism which can be regarded as measurement noise. Current tendencies to remove noise in order to enforce reproducibility of research results neglect inherent nondeterminism at the implementation level and disregard crucial interaction effects between algorithmic noise factors and data properties. This limits the scope of conclusions that can be drawn from such experiments. Instead of removing noise, we propose to incorporate several sources of variance, including their interaction with data properties, into an analysis of significance and reliability of machine learning evaluation, with the aim to draw inferences beyond particular instances of trained models. We show how to use linear mixed effects models (LMEMs) to analyze performance evaluation scores, and to conduct statistical inference with a generalized likelihood ratio test (GLRT). This allows us to incorporate arbitrary sources of noise like meta-parameter variations into statistical significance testing, and to assess performance differences conditional on data properties. Furthermore, a variance component analysis (VCA) enables the analysis of the contribution of noise sources to overall variance and the computation of a reliability coefficient by the ratio of substantial to total variance.
Emotional support conversation (ESC) task can utilize various support strategies to help people relieve emotional distress and overcome the problem they face, which has attracted much attention in these years. However, most state-of-the-art works rely heavily on external commonsense knowledge to infer the mental state of the user in every dialogue round. Although effective, they may suffer from significant human effort, knowledge update and domain change in a long run. Therefore, in this article, we focus on exploring the task itself without using any external knowledge. We find all existing works ignore two significant characteristics of ESC. (a) Abundant prior knowledge exists in historical conversations, such as the responses to similar cases and the general order of support strategies, which has a great reference value for current conversation. (b) There is a one-to-many mapping relationship between context and support strategy, i.e.multiple strategies are reasonable for a single context. It lays a better foundation for the diversity of generations. Taking into account these two key factors, we propose Prior Knowledge Enhanced emotional support model with latent variable, PoKE. The proposed model fully taps the potential of prior knowledge in terms of exemplars and strategy sequence and then utilizes a latent variable to model the one-to-many relationship of strategy. Furthermore, we introduce a memory schema to incorporate the encoded knowledge into decoder. Experiment results on benchmark dataset show that our PoKE outperforms existing baselines on both automatic evaluation and human evaluation. Compared with the model using external knowledge, PoKE still can make a slight improvement in some metrics. Further experiments prove that abundant prior knowledge is conducive to high-quality emotional support, and a well-learned latent variable is critical to the diversity of generations.
Segmenting visual stimuli into distinct groups of features and visual objects is central to visual function. Classical psychophysical methods have helped uncover many rules of human perceptual segmentation, and recent progress in machine learning has produced successful algorithms. Yet, the computational logic of human segmentation remains unclear, partially because we lack well-controlled paradigms to measure perceptual segmentation maps and compare models quantitatively. Here we propose a new, integrated approach: given an image, we measure multiple pixel-based same--different judgments and perform model--based reconstruction of the underlying segmentation map. The reconstruction is robust to several experimental manipulations and captures the variability of individual participants. We demonstrate the validity of the approach on human segmentation of natural images and composite textures. We show that image uncertainty affects measured human variability, and it influences how participants weigh different visual features. Because any putative segmentation algorithm can be inserted to perform the reconstruction, our paradigm affords quantitative tests of theories of perception as well as new benchmarks for segmentation algorithms.
The goal of this paper is to make a strong point for the usage of dynamical models when using reinforcement learning (RL) for feedback control of dynamical systems governed by partial differential equations (PDEs). To breach the gap between the immense promises we see in RL and the applicability in complex engineering systems, the main challenges are the massive requirements in terms of the training data, as well as the lack of performance guarantees. We present a solution for the first issue using a data-driven surrogate model in the form of a convolutional LSTM with actuation. We demonstrate that learning an actuated model in parallel to training the RL agent significantly reduces the total amount of required data sampled from the real system. Furthermore, we show that iteratively updating the model is of major importance to avoid biases in the RL training. Detailed ablation studies reveal the most important ingredients of the modeling process. We use the chaotic Kuramoto-Sivashinsky equation do demonstarte our findings.
The Gaia Data Release 3 (DR3), published in June 2022, delivers a diverse set of astrometric, photometric, and spectroscopic measurements for more than a billion stars. The wealth and complexity of the data makes traditional approaches for estimating stellar parameters for the full Gaia dataset almost prohibitive. We have explored different supervised learning methods for extracting basic stellar parameters as well as distances and line-of-sight extinctions, given spectro-photo-astrometric data (including also the new Gaia XP spectra). For training we use an enhanced high-quality dataset compiled from Gaia DR3 and ground-based spectroscopic survey data covering the whole sky and all Galactic components. We show that even with a simple neural-network architecture or tree-based algorithm (and in the absence of Gaia XP spectra), we succeed in predicting competitive results (compared to Bayesian isochrone fitting) down to faint magnitudes. We will present a new Gaia DR3 stellar-parameter catalogue obtained using the currently best-performing machine-learning algorithm for tabular data, XGBoost, in the near future.
Semantic segmentation is a crucial step to extract quantitative information from medical (and, specifically, radiological) images to aid the diagnostic process, clinical follow-up. and to generate biomarkers for clinical research. In recent years, machine learning algorithms have become the primary tool for this task. However, its real-world performance is heavily reliant on the comprehensiveness of training data. Dafne is the first decentralized, collaborative solution that implements continuously evolving deep learning models exploiting the collective knowledge of the users of the system. In the Dafne workflow, the result of each automated segmentation is refined by the user through an integrated interface, so that the new information is used to continuously expand the training pool via federated incremental learning. The models deployed through Dafne are able to improve their performance over time and to generalize to data types not seen in the training sets, thus becoming a viable and practical solution for real-life medical segmentation tasks.
In this paper we develop a novel neural network model for predicting implied volatility surface. Prior financial domain knowledge is taken into account. A new activation function that incorporates volatility smile is proposed, which is used for the hidden nodes that process the underlying asset price. In addition, financial conditions, such as the absence of arbitrage, the boundaries and the asymptotic slope, are embedded into the loss function. This is one of the very first studies which discuss a methodological framework that incorporates prior financial domain knowledge into neural network architecture design and model training. The proposed model outperforms the benchmarked models with the option data on the S&P 500 index over 20 years. More importantly, the domain knowledge is satisfied empirically, showing the model is consistent with the existing financial theories and conditions related to implied volatility surface.
The canonical approach to video-and-language learning (e.g., video question answering) dictates a neural model to learn from offline-extracted dense video features from vision models and text features from language models. These feature extractors are trained independently and usually on tasks different from the target domains, rendering these fixed features sub-optimal for downstream tasks. Moreover, due to the high computational overload of dense video features, it is often difficult (or infeasible) to plug feature extractors directly into existing approaches for easy finetuning. To provide a remedy to this dilemma, we propose a generic framework ClipBERT that enables affordable end-to-end learning for video-and-language tasks, by employing sparse sampling, where only a single or a few sparsely sampled short clips from a video are used at each training step. Experiments on text-to-video retrieval and video question answering on six datasets demonstrate that ClipBERT outperforms (or is on par with) existing methods that exploit full-length videos, suggesting that end-to-end learning with just a few sparsely sampled clips is often more accurate than using densely extracted offline features from full-length videos, proving the proverbial less-is-more principle. Videos in the datasets are from considerably different domains and lengths, ranging from 3-second generic domain GIF videos to 180-second YouTube human activity videos, showing the generalization ability of our approach. Comprehensive ablation studies and thorough analyses are provided to dissect what factors lead to this success. Our code is publicly available at //github.com/jayleicn/ClipBERT
This paper reports Deep LOGISMOS approach to 3D tumor segmentation by incorporating boundary information derived from deep contextual learning to LOGISMOS - layered optimal graph image segmentation of multiple objects and surfaces. Accurate and reliable tumor segmentation is essential to tumor growth analysis and treatment selection. A fully convolutional network (FCN), UNet, is first trained using three adjacent 2D patches centered at the tumor, providing contextual UNet segmentation and probability map for each 2D patch. The UNet segmentation is then refined by Gaussian Mixture Model (GMM) and morphological operations. The refined UNet segmentation is used to provide the initial shape boundary to build a segmentation graph. The cost for each node of the graph is determined by the UNet probability maps. Finally, a max-flow algorithm is employed to find the globally optimal solution thus obtaining the final segmentation. For evaluation, we applied the method to pancreatic tumor segmentation on a dataset of 51 CT scans, among which 30 scans were used for training and 21 for testing. With Deep LOGISMOS, DICE Similarity Coefficient (DSC) and Relative Volume Difference (RVD) reached 83.2+-7.8% and 18.6+-17.4% respectively, both are significantly improved (p<0.05) compared with contextual UNet and/or LOGISMOS alone.
Image segmentation is considered to be one of the critical tasks in hyperspectral remote sensing image processing. Recently, convolutional neural network (CNN) has established itself as a powerful model in segmentation and classification by demonstrating excellent performances. The use of a graphical model such as a conditional random field (CRF) contributes further in capturing contextual information and thus improving the segmentation performance. In this paper, we propose a method to segment hyperspectral images by considering both spectral and spatial information via a combined framework consisting of CNN and CRF. We use multiple spectral cubes to learn deep features using CNN, and then formulate deep CRF with CNN-based unary and pairwise potential functions to effectively extract the semantic correlations between patches consisting of three-dimensional data cubes. Effective piecewise training is applied in order to avoid the computationally expensive iterative CRF inference. Furthermore, we introduce a deep deconvolution network that improves the segmentation masks. We also introduce a new dataset and experimented our proposed method on it along with several widely adopted benchmark datasets to evaluate the effectiveness of our method. By comparing our results with those from several state-of-the-art models, we show the promising potential of our method.
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