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Thyroid nodule segmentation is a crucial step in the diagnostic procedure of physicians and computer-aided diagnosis systems. Mostly, current studies treat segmentation and diagnosis as independent tasks without considering the correlation between these tasks. The sequence steps of these independent tasks in computer-aided diagnosis systems may lead to the accumulation of errors. Therefore, it is worth combining them as a whole through exploring the relationship between thyroid nodule segmentation and diagnosis. According to the thyroid imaging reporting and data system (TI-RADS), the assessment of shape and margin characteristics is the prerequisite for the discrimination of benign and malignant thyroid nodules. These characteristics can be observed in the thyroid nodule segmentation masks. Inspired by the diagnostic procedure of TI-RADS, this paper proposes a shape-margin knowledge augmented network (SkaNet) for simultaneously thyroid nodule segmentation and diagnosis. Due to the similarity in visual features between segmentation and diagnosis, SkaNet shares visual features in the feature extraction stage and then utilizes a dual-branch architecture to perform thyroid nodule segmentation and diagnosis tasks simultaneously. To enhance effective discriminative features, an exponential mixture module is devised, which incorporates convolutional feature maps and self-attention maps by exponential weighting. Then, SkaNet is jointly optimized by a knowledge augmented multi-task loss function with a constraint penalty term. It embeds shape and margin characteristics through numerical computation and models the relationship between the thyroid nodule diagnosis results and segmentation masks.

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The development of closed-loop systems for glycemia control in type I diabetes relies heavily on simulated patients. Improving the performances and adaptability of these close-loops raises the risk of over-fitting the simulator. This may have dire consequences, especially in unusual cases which were not faithfully-if at all-captured by the simulator. To address this, we propose to use offline RL agents, trained on real patient data, to perform the glycemia control. To further improve the performances, we propose an end-to-end personalization pipeline, which leverages offline-policy evaluation methods to remove altogether the need of a simulator, while still enabling an estimation of clinically relevant metrics for diabetes.

Realistic physics engines play a crucial role for learning to manipulate deformable objects such as garments in simulation. By doing so, researchers can circumvent challenges such as sensing the deformation of the object in the real-world. In spite of the extensive use of simulations for this task, few works have evaluated the reality gap between deformable object simulators and real-world data. We present a benchmark dataset to evaluate the sim-to-real gap in cloth manipulation. The dataset is collected by performing a dynamic cloth manipulation task involving contact with a rigid table. We use the dataset to evaluate the reality gap, computational time, and simulation stability of four popular deformable object simulators: MuJoCo, Bullet, Flex, and SOFA. Additionally, we discuss the benefits and drawbacks of each simulator. The benchmark dataset is open-source. Supplementary material, videos, and code, can be found at //sites.google.com/view/cloth-sim2real-benchmark.

Ensuring the correctness of critical real-time systems, involving concurrent behaviors and timing requirements, is crucial. Timed automata extend finite-state automata with clocks, compared in guards and invariants with integer constants. Parametric timed automata (PTAs) extend timed automata with timing parameters. Parameter synthesis aims at computing dense sets of valuations for the timing parameters, guaranteeing a good behavior. However, in most cases, the emptiness problem for reachability (i.e., whether the emptiness of the parameter valuations set for which some location is reachable) is undecidable for PTAs and, as a consequence, synthesis procedures do not terminate in general, even for bounded parameters. In this paper, we introduce a parametric extrapolation, that allows us to derive an underapproximation in the form of linear constraints containing not only all the integer points ensuring reachability, but also all the (non-necessarily integer) convex combinations of these integer points, for general PTAs with a bounded parameter domain. We also propose two further algorithms synthesizing parameter valuations guaranteeing unavoidability, and preservation of the untimed behavior w.r.t. a reference parameter valuation, respectively. Our algorithms terminate and can output constraints arbitrarily close to the complete result. We demonstrate their applicability and efficiency using the tool Rom\'eo on two classical benchmarks.

Can transformers generalize efficiently on problems that require dealing with examples with different levels of difficulty? We introduce a new task tailored to assess generalization over different complexities and present results that indicate that standard transformers face challenges in solving these tasks. These tasks are variations of pointer value retrieval previously introduced by Zhang et al. (2021). We investigate how the use of a mechanism for adaptive and modular computation in transformers facilitates the learning of tasks that demand generalization over the number of sequential computation steps (i.e., the depth of the computation graph). Based on our observations, we propose a transformer-based architecture called Hyper-UT, which combines dynamic function generation from hyper networks with adaptive depth from Universal Transformers. This model demonstrates higher accuracy and a fairer allocation of computational resources when generalizing to higher numbers of computation steps. We conclude that mechanisms for adaptive depth and modularity complement each other in improving efficient generalization concerning example complexity. Additionally, to emphasize the broad applicability of our findings, we illustrate that in a standard image recognition task, Hyper- UT's performance matches that of a ViT model but with considerably reduced computational demands (achieving over 70\% average savings by effectively using fewer layers).

Case-based reasoning (CBR) as a methodology for problem-solving can use any appropriate computational technique. This position paper argues that CBR researchers have somewhat overlooked recent developments in deep learning and large language models (LLMs). The underlying technical developments that have enabled the recent breakthroughs in AI have strong synergies with CBR and could be used to provide a persistent memory for LLMs to make progress towards Artificial General Intelligence.

Safe autonomous driving critically depends on how well the ego-vehicle can predict the trajectories of neighboring vehicles. To this end, several trajectory prediction algorithms have been presented in the existing literature. Many of these approaches output a multi-modal distribution of obstacle trajectories instead of a single deterministic prediction to account for the underlying uncertainty. However, existing planners cannot handle the multi-modality based on just sample-level information of the predictions. With this motivation, this paper proposes a trajectory optimizer that can leverage the distributional aspects of the prediction in a computationally tractable and sample-efficient manner. Our optimizer can work with arbitrarily complex distributions and thus can be used with output distribution represented as a deep neural network. The core of our approach is built on embedding distribution in Reproducing Kernel Hilbert Space (RKHS), which we leverage in two ways. First, we propose an RKHS embedding approach to select probable samples from the obstacle trajectory distribution. Second, we rephrase chance-constrained optimization as distribution matching in RKHS and propose a novel sampling-based optimizer for its solution. We validate our approach with hand-crafted and neural network-based predictors trained on real-world datasets and show improvement over the existing stochastic optimization approaches in safety metrics.

Graph partitioning is a common solution to scale up the graph algorithms, and shortest path (SP) computation is one of them. However, the existing solutions typically have a fixed partition method with a fixed path index and fixed partition structure, so it is unclear how the partition method and path index influence the pathfinding performance. Moreover, few studies have explored the index maintenance of partitioned SP (PSP) on dynamic graphs. To provide a deeper insight into the dynamic PSP indexes, we systematically deliberate on the existing works and propose a universal scheme to analyze this problem theoretically. Specifically, we first propose two novel partitioned index strategies and one optimization to improve index construction, query answering, or index maintenance of PSP index. Then we propose a path-oriented graph partitioning classification criteria for easier partition method selection. After that, we re-couple the dimensions in our scheme (partitioned index strategy, path index, and partition structure) to propose five new partitioned SP indexes that are more efficient either in the query or update on different networks. Finally, we demonstrate the effectiveness of our new indexes by comparing them with state-of-the-art PSP indexes through comprehensive evaluations.

We propose to use a simulation driven inverse inference approach to model the dynamics of tree branches under manipulation. Learning branch dynamics and gaining the ability to manipulate deformable vegetation can help with occlusion-prone tasks, such as fruit picking in dense foliage, as well as moving overhanging vines and branches for navigation in dense vegetation. The underlying deformable tree geometry is encapsulated as coarse spring abstractions executed on parallel, non-differentiable simulators. The implicit statistical model defined by the simulator, reference trajectories obtained by actively probing the ground truth, and the Bayesian formalism, together guide the spring parameter posterior density estimation. Our non-parametric inference algorithm, based on Stein Variational Gradient Descent, incorporates biologically motivated assumptions into the inference process as neural network driven learnt joint priors; moreover, it leverages the finite difference scheme for gradient approximations. Real and simulated experiments confirm that our model can predict deformation trajectories, quantify the estimation uncertainty, and it can perform better when base-lined against other inference algorithms, particularly from the Monte Carlo family. The model displays strong robustness properties in the presence of heteroscedastic sensor noise; furthermore, it can generalise to unseen grasp locations.

Knowledge graph completion aims to predict missing relations between entities in a knowledge graph. While many different methods have been proposed, there is a lack of a unifying framework that would lead to state-of-the-art results. Here we develop PathCon, a knowledge graph completion method that harnesses four novel insights to outperform existing methods. PathCon predicts relations between a pair of entities by: (1) Considering the Relational Context of each entity by capturing the relation types adjacent to the entity and modeled through a novel edge-based message passing scheme; (2) Considering the Relational Paths capturing all paths between the two entities; And, (3) adaptively integrating the Relational Context and Relational Path through a learnable attention mechanism. Importantly, (4) in contrast to conventional node-based representations, PathCon represents context and path only using the relation types, which makes it applicable in an inductive setting. Experimental results on knowledge graph benchmarks as well as our newly proposed dataset show that PathCon outperforms state-of-the-art knowledge graph completion methods by a large margin. Finally, PathCon is able to provide interpretable explanations by identifying relations that provide the context and paths that are important for a given predicted relation.

Aspect level sentiment classification aims to identify the sentiment expressed towards an aspect given a context sentence. Previous neural network based methods largely ignore the syntax structure in one sentence. In this paper, we propose a novel target-dependent graph attention network (TD-GAT) for aspect level sentiment classification, which explicitly utilizes the dependency relationship among words. Using the dependency graph, it propagates sentiment features directly from the syntactic context of an aspect target. In our experiments, we show our method outperforms multiple baselines with GloVe embeddings. We also demonstrate that using BERT representations further substantially boosts the performance.

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