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In this paper, we present ML-Quadrat, an open-source research prototype that is based on the Eclipse Modeling Framework (EMF) and the state of the art in the literature of Model-Driven Software Engineering (MDSE) for smart Cyber-Physical Systems (CPS) and the Internet of Things (IoT). Its envisioned users are mostly software developers who might not have deep knowledge and skills in the heterogeneous IoT platforms and the diverse Artificial Intelligence (AI) technologies, specifically regarding Machine Learning (ML). ML-Quadrat is released under the terms of the Apache 2.0 license on Github. Additionally, we demonstrate an early tool prototype of DriotData, a web-based Low-Code platform targeting citizen data scientists and citizen/end-user software developers. DriotData exploits and adopts ML-Quadrat in the industry by offering an extended version of it as a subscription-based service to companies, mainly Small- and Medium-Sized Enterprises (SME). The current preliminary version of DriotData has three web-based model editors: text-based, tree-/form-based and diagram-based. The latter is designed for domain experts in the problem or use case domains (namely the IoT vertical domains) who might not have knowledge and skills in the field of IT. Finally, a short video demonstrating the tools is available on YouTube: //youtu.be/VAuz25w0a5k

The world has been experiencing a mind-blowing expansion of blockchain technology since it was first introduced as an emerging means of cryptocurrency called bitcoin. Currently, it has been regarded as a pervasive frame of reference across almost all research domains, ranging from virtual cash to agriculture or even supply-chain to the Internet of Things. The ability to have a self-administering register with legitimate immutability makes blockchain appealing for the Internet of Things (IoT). As billions of IoT devices are now online in distributed fashion, the huge challenges and questions require to addressed in pursuit of urgently needed solutions. The present paper has been motivated by the aim of facilitating such efforts. The contribution of this work is to figure out those trade-offs the IoT ecosystem usually encounters because of the wrong choice of blockchain technology. Unlike a survey or review, the critical findings of this paper target sorting out specific security challenges of blockchain-IoT Infrastructure. The contribution includes how to direct developers and researchers in this domain to pick out the unblemished combinations of Blockchain enabled IoT applications. In addition, the paper promises to bring a deep insight on Ethereum, Hyperledger blockchain and IOTA technology to show their limitations and prospects in terms of performance and scalability.

Securing safe-driving for connected and autonomous vehicles (CAVs) continues to be a widespread concern despite various sophisticated functions delivered by artificial intelligence for in-vehicle devices. Besides, diverse malicious network attacks become ubiquitous along with the worldwide implementation of the Internet of Vehicles, which exposes a range of reliability and privacy threats for managing data in CAV networks. Combined with the fact that the capability of existing CAVs in handling intensive computation tasks is limited, this implies a need for designing an efficient assessment system to guarantee autonomous driving safety without compromising data security. Motivated by this, in this article, we propose a novel framework, namely Blockchain-enabled intElligent Safe-driving assessmenT (BEST), that offers a smart and reliable approach for conducting safe driving supervision while protecting vehicular information. Specifically, a promising solution that exploits a long short-term memory model is introduced to assess the safety level of the moving CAVs. Then, we investigate how a distributed blockchain obtains adequate trustworthiness and robustness for CAV data by adopting a byzantine fault tolerance-based delegated proof-of-stake consensus mechanism. Simulation results demonstrate that our presented BEST gains better data credibility with a higher prediction accuracy for vehicular safety assessment when compared with existing schemes. Finally, we discuss several open challenges that need to be addressed in future CAV networks.

Human genomic data carry unique information about an individual and offer unprecedented opportunities for healthcare. The clinical interpretations derived from large genomic datasets can greatly improve healthcare and pave the way for personalized medicine. Sharing genomic datasets, however, pose major challenges, as genomic data is different from traditional medical data, indirectly revealing information about descendants and relatives of the data owner and carrying valid information even after the owner passes away. Therefore, stringent data ownership and control measures are required when dealing with genomic data. In order to provide secure and accountable infrastructure, blockchain technologies offer a promising alternative to traditional distributed systems. Indeed, the research on blockchain-based infrastructures tailored to genomics is on the rise. However, there is a lack of a comprehensive literature review that summarizes the current state-of-the-art methods in the applications of blockchain in genomics. In this paper, we systematically look at the existing work both commercial and academic, and discuss the major opportunities and challenges. Our study is driven by five research questions that we aim to answer in our review. We also present our projections of future research directions which we hope the researchers interested in the area can benefit from.

Blockchain technologies have been boosting the development of data-driven decentralized services in a wide range of fields. However, with the spirit of full transparency, many public blockchains expose all types of data to the public such as Ethereum. Besides, the on-chain persistence of large data is significantly expensive technically and economically. These issues lead to the difficulty of sharing fairly large private data while preserving attractive properties of public blockchains. Although direct encryption for on-chain data persistence can introduce confidentiality, new challenges such as key sharing, access control, and legal rights proving are still open. Meanwhile, cross-chain collaboration still requires secure and effective protocols, though decentralized storage systems such as IPFS bring the possibility for fairly large data persistence. In this paper, we propose Sunspot, a decentralized framework for privacy-preserving data sharing with access control on transparent public blockchains, to solve these issues. We also show the practicality and applicability of Sunspot by MyPub, a decentralized privacy-preserving publishing platform based on Sunspot. Furthermore, we evaluate the security, privacy, and performance of Sunspot through theoretical analysis and experiments.

Artificial intelligence (AI) provides a promising substitution for streamlining COVID-19 diagnoses. However, concerns surrounding security and trustworthiness impede the collection of large-scale representative medical data, posing a considerable challenge for training a well-generalised model in clinical practices. To address this, we launch the Unified CT-COVID AI Diagnostic Initiative (UCADI), where the AI model can be distributedly trained and independently executed at each host institution under a federated learning framework (FL) without data sharing. Here we show that our FL model outperformed all the local models by a large yield (test sensitivity /specificity in China: 0.973/0.951, in the UK: 0.730/0.942), achieving comparable performance with a panel of professional radiologists. We further evaluated the model on the hold-out (collected from another two hospitals leaving out the FL) and heterogeneous (acquired with contrast materials) data, provided visual explanations for decisions made by the model, and analysed the trade-offs between the model performance and the communication costs in the federated training process. Our study is based on 9,573 chest computed tomography scans (CTs) from 3,336 patients collected from 23 hospitals located in China and the UK. Collectively, our work advanced the prospects of utilising federated learning for privacy-preserving AI in digital health.

It is well understood that an individual's health trajectory is influenced by choices made in each moment, such as from lifestyle or medical decisions. With the advent of modern sensing technologies, individuals have more data and information about themselves than any other time in history. How can we use this data to make the best decisions to keep the health state optimal? We propose a generalized Personal Health Navigation (PHN) framework. PHN takes individuals towards their personal health goals through a system which perpetually digests data streams, estimates current health status, computes the best route through intermediate states utilizing personal models, and guides the best inputs that carry a user towards their goal. In addition to describing the general framework, we test the PHN system in two experiments within the field of cardiology. First, we prospectively test a knowledge-infused cardiovascular PHN system with a pilot clinical trial of 41 users. Second, we build a data-driven personalized model on cardiovascular exercise response variability on a smartwatch data-set of 33,269 real-world users. We conclude with critical challenges in health computing for PHN systems that require deep future investigation.

Federated learning has been showing as a promising approach in paving the last mile of artificial intelligence, due to its great potential of solving the data isolation problem in large scale machine learning. Particularly, with consideration of the heterogeneity in practical edge computing systems, asynchronous edge-cloud collaboration based federated learning can further improve the learning efficiency by significantly reducing the straggler effect. Despite no raw data sharing, the open architecture and extensive collaborations of asynchronous federated learning (AFL) still give some malicious participants great opportunities to infer other parties' training data, thus leading to serious concerns of privacy. To achieve a rigorous privacy guarantee with high utility, we investigate to secure asynchronous edge-cloud collaborative federated learning with differential privacy, focusing on the impacts of differential privacy on model convergence of AFL. Formally, we give the first analysis on the model convergence of AFL under DP and propose a multi-stage adjustable private algorithm (MAPA) to improve the trade-off between model utility and privacy by dynamically adjusting both the noise scale and the learning rate. Through extensive simulations and real-world experiments with an edge-could testbed, we demonstrate that MAPA significantly improves both the model accuracy and convergence speed with sufficient privacy guarantee.

Nowadays, recommender systems are present in many daily activities such as online shopping, browsing social networks, etc. Given the rising demand for reinvigoration of the tourist industry through information technology, recommenders have been included into tourism websites such as Expedia, Booking or Tripadvisor, among others. Furthermore, the amount of scientific papers related to recommender systems for tourism is on solid and continuous growth since 2004. Much of this growth is due to social networks that, besides to offer researchers the possibility of using a great mass of available and constantly updated data, they also enable the recommendation systems to become more personalised, effective and natural. This paper reviews and analyses many research publications focusing on tourism recommender systems that use social networks in their projects. We detail their main characteristics, like which social networks are exploited, which data is extracted, the applied recommendation techniques, the methods of evaluation, etc. Through a comprehensive literature review, we aim to collaborate with the future recommender systems, by giving some clear classifications and descriptions of the current tourism recommender systems.

Privacy is a major good for users of personalized services such as recommender systems. When applied to the field of health informatics, privacy concerns of users may be amplified, but the possible utility of such services is also high. Despite availability of technologies such as k-anonymity, differential privacy, privacy-aware recommendation, and personalized privacy trade-offs, little research has been conducted on the users' willingness to share health data for usage in such systems. In two conjoint-decision studies (sample size n=521), we investigate importance and utility of privacy-preserving techniques related to sharing of personal health data for k-anonymity and differential privacy. Users were asked to pick a preferred sharing scenario depending on the recipient of the data, the benefit of sharing data, the type of data, and the parameterized privacy. Users disagreed with sharing data for commercial purposes regarding mental illnesses and with high de-anonymization risks but showed little concern when data is used for scientific purposes and is related to physical illnesses. Suggestions for health recommender system development are derived from the findings.