Large language models (LLMs), such as ChatGPT, have received substantial attention due to their impressive human language understanding and generation capabilities. Therefore, the application of LLMs in medicine to assist physicians and patient care emerges as a promising research direction in both artificial intelligence and clinical medicine. To reflect this trend, this survey provides a comprehensive overview of the principles, applications, and challenges faced by LLMs in medicine. Specifically, we aim to address the following questions: 1) How can medical LLMs be built? 2) What are the downstream performances of medical LLMs? 3) How can medical LLMs be utilized in real-world clinical practice? 4) What challenges arise from the use of medical LLMs? and 5) How can we better construct and utilize medical LLMs? As a result, this survey aims to provide insights into the opportunities and challenges of LLMs in medicine and serve as a valuable resource for constructing practical and effective medical LLMs. A regularly updated list of practical guides on medical LLMs can be found at //github.com/AI-in-Health/MedLLMsPracticalGuide.
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大語言模型是基于海量文本數據訓練的深度學習模型。它不僅能夠生成自然語言文本，還能夠深入理解文本含義，處理各種自然語言任務，如文本摘要、問答、翻譯等。2023年，大語言模型及其在人工智能領域的應用已成為全球科技研究的熱點，其在規模上的增長尤為引人注目，參數量已從最初的十幾億躍升到如今的一萬億。參數量的提升使得模型能夠更加精細地捕捉人類語言微妙之處，更加深入地理解人類語言的復雜性。在過去的一年里，大語言模型在吸納新知識、分解復雜任務以及圖文對齊等多方面都有顯著提升。隨著技術的不斷成熟，它將不斷拓展其應用范圍，為人類提供更加智能化和個性化的服務，進一步改善人們的生活和生產方式。
Multi-modal large language models (MLLMs) have demonstrated remarkable vision-language capabilities, primarily due to the exceptional in-context understanding and multi-task learning strengths of large language models (LLMs). The advent of visual instruction tuning has further enhanced MLLMs' performance in vision-language understanding. However, while existing MLLMs adeptly recognize \textit{what} objects are in an image, they still face challenges in effectively discerning \textit{where} these objects are, particularly along the distance (scene depth) axis. To overcome this limitation in MLLMs, we introduce Proximity Question Answering (Proximity QA), a novel framework designed to enable MLLMs to infer the proximity relationship between objects in images. The framework operates in two phases: the first phase focuses on guiding the models to understand the relative depth of objects, and the second phase further encourages the models to infer the proximity relationships between objects based on their depth perceptions. We also propose a VQA dataset called Proximity-110K, containing additional instructions that incorporate depth information and the proximity relationships of objects. We have conducted extensive experiments to validate Proximity QA's superior ability in depth perception and proximity analysis, outperforming other state-of-the-art MLLMs. Code and dataset will be released at \textcolor{magenta}{//github.com/NorthSummer/ProximityQA.git}.
While "instruction-tuned" generative large language models (LLMs) have demonstrated an impressive ability to generalize to new tasks, the training phases heavily rely on large amounts of diverse and high-quality instruction data (such as ChatGPT and GPT-4). Unfortunately, acquiring high-quality data, especially when it comes to human-written data, can pose significant challenges both in terms of cost and accessibility. Moreover, concerns related to privacy can further limit access to such data, making the process of obtaining it a complex and nuanced undertaking. Consequently, this hinders the generality of the tuned models and may restrict their effectiveness in certain contexts. To tackle this issue, our study introduces a new approach called Federated Instruction Tuning (FedIT), which leverages federated learning (FL) as the learning framework for the instruction tuning of LLMs. This marks the first exploration of FL-based instruction tuning for LLMs. This is especially important since text data is predominantly generated by end users. Therefore, it is imperative to design and adapt FL approaches to effectively leverage these users' diverse instructions stored on local devices, while preserving privacy and ensuring data security. In the current paper, by conducting widely used GPT-4 auto-evaluation, we demonstrate that by exploiting the heterogeneous and diverse sets of instructions on the client's end with the proposed framework FedIT, we improved the performance of LLMs compared to centralized training with only limited local instructions. Further, in this paper, we developed a Github repository named Shepherd. This repository offers a foundational framework for exploring federated fine-tuning of LLMs using heterogeneous instructions across diverse categories.
We provide an overview of three different query languages whose objective is to specify properties on the highly popular formalisms of fault trees (FTs) and attack trees (ATs). These are BFL, a Boolean Logic for FTs, PFL, a probabilistic extension of BFL and ATM, a logic for security metrics on ATs. We validate the framework composed by these three logics by applying them to the case study of a water distribution network. We extend the FT for this network - found in the literature - and we propose to model the system under analysis with the Fault Trees/Attack Trees (FT/ATs) formalism, combining both FTs and ATs in a unique model. Furthermore, we propose a novel combination of the showcased logics to account for queries that jointly consider both the FT and the AT of the model, integrating influences of attacks on failure probabilities of different components. Finally, we extend the domain specific language for PFL with novel constructs to capture the interplay between metrics of attacks - e.g., "cost", success probabilities - and failure probabilities in the system.
Recent multilingual pretrained language models (mPLMs) have been shown to encode strong language-specific signals, which are not explicitly provided during pretraining. It remains an open question whether it is feasible to employ mPLMs to measure language similarity, and subsequently use the similarity results to select source languages for boosting cross-lingual transfer. To investigate this, we propose mPLMSim, a language similarity measure that induces the similarities across languages from mPLMs using multi-parallel corpora. Our study shows that mPLM-Sim exhibits moderately high correlations with linguistic similarity measures, such as lexicostatistics, genealogical language family, and geographical sprachbund. We also conduct a case study on languages with low correlation and observe that mPLM-Sim yields more accurate similarity results. Additionally, we find that similarity results vary across different mPLMs and different layers within an mPLM. We further investigate whether mPLMSim is effective for zero-shot cross-lingual transfer by conducting experiments on both low-level syntactic tasks and high-level semantic tasks. The experimental results demonstrate that mPLM-Sim is capable of selecting better source languages than linguistic measures, resulting in a 1%-2% improvement in zero-shot cross-lingual transfer performance.
Recently, the large language models (LLMs) have shown extraordinary ability in understanding natural language and generating programming code. It has been a common practice of software engineers to consult LLMs when encountering coding questions. Although efforts have been made to avoid syntax errors and align the code with the intended semantics, the reliability and robustness of the code generationfrom LLMs have not yet been thoroughly studied. The executable code is not equivalent to the reliable and robust code, especially in the context of real-world software development. The misuse of APIs in the generated code could lead to severe problem, such as resource leaks, program crashes. To make things worse, the users of LLM code generation services are actually the developers that are most vulnerable to these code that seems right -- They are always novice developers that are not familiar with the APIs that LLMs generate code for them. Therefore, they could hardly tell the misuse in the code generated by LLMs, which further facilitates the incorrect code applied in real-world software. Existing code evaluation benchmark and datasets focus on crafting small tasks such as programming questions in coding interviews, which however deviates from the problem that developers would ask LLM for real-world coding help. To fill the missing piece, in this work, we propose a dataset RobustAPI for evaluating the reliability and robustness of code generated by LLMs. We collect 1208 coding questions from StackOverflow on 24 representative Java APIs. We summarize thecommon misuse patterns of these APIs and evaluate them oncurrent popular LLMs. The evaluation results show that evenfor GPT-4, 62% of the generated code contains API misuses,which would cause unexpected consequences if the code isintroduced into real-world software.
Recent proprietary large language models (LLMs), such as GPT-4, have achieved a milestone in tackling diverse challenges in the biomedical domain, ranging from multiple-choice questions to long-form generations. To address challenges that still cannot be handled with the encoded knowledge of LLMs, various retrieval-augmented generation (RAG) methods have been developed by searching documents from the knowledge corpus and appending them unconditionally or selectively to the input of LLMs for generation. However, when applying existing methods to different domain-specific problems, poor generalization becomes apparent, leading to fetching incorrect documents or making inaccurate judgments. In this paper, we introduce Self-BioRAG, a framework reliable for biomedical text that specializes in generating explanations, retrieving domain-specific documents, and self-reflecting generated responses. We utilize 84k filtered biomedical instruction sets to train Self-BioRAG that can assess its generated explanations with customized reflective tokens. Our work proves that domain-specific components, such as a retriever, domain-related document corpus, and instruction sets are necessary for adhering to domain-related instructions. Using three major medical question-answering benchmark datasets, experimental results of Self-BioRAG demonstrate significant performance gains by achieving a 7.2% absolute improvement on average over the state-of-the-art open-foundation model with a parameter size of 7B or less. Overall, we analyze that Self-BioRAG finds the clues in the question, retrieves relevant documents if needed, and understands how to answer with information from retrieved documents and encoded knowledge as a medical expert does. We release our data and code for training our framework components and model weights (7B and 13B) to enhance capabilities in biomedical and clinical domains.
Large language models have demonstrated remarkable potential in various tasks, however, there remains a significant scarcity of open-source models and data for specific domains. Previous works have primarily focused on manually specifying resources and collecting high-quality data on specific domains, which significantly consume time and effort. To address this limitation, we propose an efficient data collection method~\textit{Query of CC} based on large language models. This method bootstraps seed information through a large language model and retrieves related data from public corpora. It not only collects knowledge-related data for specific domains but unearths the data with potential reasoning procedures. Through the application of this method, we have curated a high-quality dataset called~\textsc{Knowledge Pile}, encompassing four major domains, including stem and humanities sciences, among others. Experimental results demonstrate that~\textsc{Knowledge Pile} significantly improves the performance of large language models in mathematical and knowledge-related reasoning ability tests. To facilitate academic sharing, we open-source our dataset and code, providing valuable support to the academic community.
Large language models (LLMs) exhibit superior performance on various natural language tasks, but they are susceptible to issues stemming from outdated data and domain-specific limitations. In order to address these challenges, researchers have pursued two primary strategies, knowledge editing and retrieval augmentation, to enhance LLMs by incorporating external information from different aspects. Nevertheless, there is still a notable absence of a comprehensive survey. In this paper, we propose a review to discuss the trends in integration of knowledge and large language models, including taxonomy of methods, benchmarks, and applications. In addition, we conduct an in-depth analysis of different methods and point out potential research directions in the future. We hope this survey offers the community quick access and a comprehensive overview of this research area, with the intention of inspiring future research endeavors.
Large language models (LLMs) have significantly advanced the field of natural language processing (NLP), providing a highly useful, task-agnostic foundation for a wide range of applications. The great promise of LLMs as general task solvers motivated people to extend their functionality largely beyond just a ``chatbot'', and use it as an assistant or even replacement for domain experts and tools in specific domains such as healthcare, finance, and education. However, directly applying LLMs to solve sophisticated problems in specific domains meets many hurdles, caused by the heterogeneity of domain data, the sophistication of domain knowledge, the uniqueness of domain objectives, and the diversity of the constraints (e.g., various social norms, cultural conformity, religious beliefs, and ethical standards in the domain applications). To fill such a gap, explosively-increase research, and practices have been conducted in very recent years on the domain specialization of LLMs, which, however, calls for a comprehensive and systematic review to better summarizes and guide this promising domain. In this survey paper, first, we propose a systematic taxonomy that categorizes the LLM domain-specialization techniques based on the accessibility to LLMs and summarizes the framework for all the subcategories as well as their relations and differences to each other. We also present a comprehensive taxonomy of critical application domains that can benefit from specialized LLMs, discussing their practical significance and open challenges. Furthermore, we offer insights into the current research status and future trends in this area.
Machine reading comprehension (MRC) aims to teach machines to read and comprehend human languages, which is a long-standing goal of natural language processing (NLP). With the burst of deep neural networks and the evolution of contextualized language models (CLMs), the research of MRC has experienced two significant breakthroughs. MRC and CLM, as a phenomenon, have a great impact on the NLP community. In this survey, we provide a comprehensive and comparative review on MRC covering overall research topics about 1) the origin and development of MRC and CLM, with a particular focus on the role of CLMs; 2) the impact of MRC and CLM to the NLP community; 3) the definition, datasets, and evaluation of MRC; 4) general MRC architecture and technical methods in the view of two-stage Encoder-Decoder solving architecture from the insights of the cognitive process of humans; 5) previous highlights, emerging topics, and our empirical analysis, among which we especially focus on what works in different periods of MRC researches. We propose a full-view categorization and new taxonomies on these topics. The primary views we have arrived at are that 1) MRC boosts the progress from language processing to understanding; 2) the rapid improvement of MRC systems greatly benefits from the development of CLMs; 3) the theme of MRC is gradually moving from shallow text matching to cognitive reasoning.
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