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Magnetoencephalography (MEG) recordings of patients with epilepsy exhibit spikes, a typical biomarker of the pathology. Detecting those spikes allows accurate localization of brain regions triggering seizures. Spike detection is often performed manually. However, it is a burdensome and error prone task due to the complexity of MEG data. To address this problem, we propose a 1D temporal convolutional neural network (Time CNN) coupled with a graph convolutional network (GCN) to classify short time frames of MEG recording as containing a spike or not. Compared to other recent approaches, our models have fewer parameters to train and we propose to use a GCN to account for MEG sensors spatial relationships. Our models produce clinically relevant results and outperform deep learning-based state-of-the-art methods reaching a classification f1-score of 76.7% on a balanced dataset and of 25.5% on a realistic, highly imbalanced dataset, for the spike class.

Segmentation of nodules in thyroid ultrasound imaging plays a crucial role in the detection and treatment of thyroid cancer. However, owing to the diversity of scanner vendors and imaging protocols in different hospitals, the automatic segmentation model, which has already demonstrated expert-level accuracy in the field of medical image segmentation, finds its accuracy reduced as the result of its weak generalization performance when being applied in clinically realistic environments. To address this issue, the present paper proposes ASTN, a framework for thyroid nodule segmentation achieved through a new type co-registration network. By extracting latent semantic information from the atlas and target images and utilizing in-depth features to accomplish the co-registration of nodules in thyroid ultrasound images, this framework can ensure the integrity of anatomical structure and reduce the impact on segmentation as the result of overall differences in image caused by different devices. In addition, this paper also provides an atlas selection algorithm to mitigate the difficulty of co-registration. As shown by the evaluation results collected from the datasets of different devices, thanks to the method we proposed, the model generalization has been greatly improved while maintaining a high level of segmentation accuracy.

The task of Question Generation over Knowledge Bases (KBQG) aims to convert a logical form into a natural language question. For the sake of expensive cost of large-scale question annotation, the methods of KBQG under low-resource scenarios urgently need to be developed. However, current methods heavily rely on annotated data for fine-tuning, which is not well-suited for few-shot question generation. The emergence of Large Language Models (LLMs) has shown their impressive generalization ability in few-shot tasks. Inspired by Chain-of-Thought (CoT) prompting, which is an in-context learning strategy for reasoning, we formulate KBQG task as a reasoning problem, where the generation of a complete question is splitted into a series of sub-question generation. Our proposed prompting method KQG-CoT first retrieves supportive logical forms from the unlabeled data pool taking account of the characteristics of the logical form. Then, we write a prompt to explicit the reasoning chain of generating complicated questions based on the selected demonstrations. To further ensure prompt quality, we extend KQG-CoT into KQG-CoT+ via sorting the logical forms by their complexity. We conduct extensive experiments over three public KBQG datasets. The results demonstrate that our prompting method consistently outperforms other prompting baselines on the evaluated datasets. Remarkably, our KQG-CoT+ method could surpass existing few-shot SoTA results of the PathQuestions dataset by 18.25, 10.72, and 10.18 absolute points on BLEU-4, METEOR, and ROUGE-L, respectively.

Simultaneous Localization And Mapping (SLAM) has become a crucial aspect in the fields of autonomous driving and robotics. One crucial component of visual SLAM is the Field-of-View (FoV) of the camera, as a larger FoV allows for a wider range of surrounding elements and features to be perceived. However, when the FoV of the camera reaches the negative half-plane, traditional methods for representing image feature points using [u,v,1]^T become ineffective. While the panoramic FoV is advantageous for loop closure, its benefits are not easily realized under large-attitude-angle differences where loop-closure frames cannot be easily matched by existing methods. As loop closure on wide-FoV panoramic data further comes with a large number of outliers, traditional outlier rejection methods are not directly applicable. To address these issues, we propose LF-VISLAM, a Visual Inertial SLAM framework for cameras with extremely Large FoV with loop closure. A three-dimensional vector with unit length is introduced to effectively represent feature points even on the negative half-plane. The attitude information of the SLAM system is leveraged to guide the feature point detection of the loop closure. Additionally, a new outlier rejection method based on the unit length representation is integrated into the loop closure module. We collect the PALVIO dataset using a Panoramic Annular Lens (PAL) system with an entire FoV of 360{\deg}x(40{\deg}~120{\deg}) and an Inertial Measurement Unit (IMU) for Visual Inertial Odometry (VIO) to address the lack of panoramic SLAM datasets. Experiments on the established PALVIO and public datasets show that the proposed LF-VISLAM outperforms state-of-the-art SLAM methods. Our code will be open-sourced at //github.com/flysoaryun/LF-VISLAM.

Biomarker detection is an indispensable part in the diagnosis and treatment of low-grade glioma (LGG). However, current LGG biomarker detection methods rely on expensive and complex molecular genetic testing, for which professionals are required to analyze the results, and intra-rater variability is often reported. To overcome these challenges, we propose an interpretable deep learning pipeline, a Multi-Biomarker Histomorphology Discoverer (Multi-Beholder) model based on the multiple instance learning (MIL) framework, to predict the status of five biomarkers in LGG using only hematoxylin and eosin-stained whole slide images and slide-level biomarker status labels. Specifically, by incorporating the one-class classification into the MIL framework, accurate instance pseudo-labeling is realized for instance-level supervision, which greatly complements the slide-level labels and improves the biomarker prediction performance. Multi-Beholder demonstrates superior prediction performance and generalizability for five LGG biomarkers (AUROC=0.6469-0.9735) in two cohorts (n=607) with diverse races and scanning protocols. Moreover, the excellent interpretability of Multi-Beholder allows for discovering the quantitative and qualitative correlations between biomarker status and histomorphology characteristics. Our pipeline not only provides a novel approach for biomarker prediction, enhancing the applicability of molecular treatments for LGG patients but also facilitates the discovery of new mechanisms in molecular functionality and LGG progression.

Phase synchrony information plays a crucial role in analyzing functional brain connectivity and identifying brain activities. A widely adopted feature extraction pipeline, composed of preprocessing, selection of EEG acquisition channels, and phase locking value (PLV) calculation, has achieved success in motor imagery classification (MI). However, this pipeline is manual and reliant on expert knowledge, limiting its convenience and adaptability to different application scenarios. Moreover, most studies have employed mediocre data-independent spatial filters to suppress noise, impeding the exploration of more significant phase synchronization phenomena. To address the issues, we propose the concept of phase synchrony component self-organization, which enables the adaptive learning of data-dependent spatial filters for automating both the preprocessing and channel selection procedures. Based on this concept, the first deep learning end-to-end network is developed, which directly extracts phase synchrony-based features from raw EEG signals and perform classification. The network learns optimal filters during training, which are obtained when the network achieves peak classification results. Extensive experiments have demonstrated that our network outperforms state-of-the-art methods. Remarkably, through the learned optimal filters, significant phase synchronization phenomena can be observed. Specifically, by calculating the PLV between a pair of signals extracted from each sample using two of the learned spatial filters, we have obtained an average PLV exceeding 0.87 across all tongue MI samples. This high PLV indicates a groundbreaking discovery in the synchrony pattern of tongue MI.

Recent artificial intelligence (AI) systems have reached milestones in "grand challenges" ranging from Go to protein-folding. The capability to retrieve medical knowledge, reason over it, and answer medical questions comparably to physicians has long been viewed as one such grand challenge. Large language models (LLMs) have catalyzed significant progress in medical question answering; Med-PaLM was the first model to exceed a "passing" score in US Medical Licensing Examination (USMLE) style questions with a score of 67.2% on the MedQA dataset. However, this and other prior work suggested significant room for improvement, especially when models' answers were compared to clinicians' answers. Here we present Med-PaLM 2, which bridges these gaps by leveraging a combination of base LLM improvements (PaLM 2), medical domain finetuning, and prompting strategies including a novel ensemble refinement approach. Med-PaLM 2 scored up to 86.5% on the MedQA dataset, improving upon Med-PaLM by over 19% and setting a new state-of-the-art. We also observed performance approaching or exceeding state-of-the-art across MedMCQA, PubMedQA, and MMLU clinical topics datasets. We performed detailed human evaluations on long-form questions along multiple axes relevant to clinical applications. In pairwise comparative ranking of 1066 consumer medical questions, physicians preferred Med-PaLM 2 answers to those produced by physicians on eight of nine axes pertaining to clinical utility (p < 0.001). We also observed significant improvements compared to Med-PaLM on every evaluation axis (p < 0.001) on newly introduced datasets of 240 long-form "adversarial" questions to probe LLM limitations. While further studies are necessary to validate the efficacy of these models in real-world settings, these results highlight rapid progress towards physician-level performance in medical question answering.

Few-shot Knowledge Graph (KG) completion is a focus of current research, where each task aims at querying unseen facts of a relation given its few-shot reference entity pairs. Recent attempts solve this problem by learning static representations of entities and references, ignoring their dynamic properties, i.e., entities may exhibit diverse roles within task relations, and references may make different contributions to queries. This work proposes an adaptive attentional network for few-shot KG completion by learning adaptive entity and reference representations. Specifically, entities are modeled by an adaptive neighbor encoder to discern their task-oriented roles, while references are modeled by an adaptive query-aware aggregator to differentiate their contributions. Through the attention mechanism, both entities and references can capture their fine-grained semantic meanings, and thus render more expressive representations. This will be more predictive for knowledge acquisition in the few-shot scenario. Evaluation in link prediction on two public datasets shows that our approach achieves new state-of-the-art results with different few-shot sizes.

Bidirectional Encoder Representations from Transformers (BERT) has shown marvelous improvements across various NLP tasks. Recently, an upgraded version of BERT has been released with Whole Word Masking (WWM), which mitigate the drawbacks of masking partial WordPiece tokens in pre-training BERT. In this technical report, we adapt whole word masking in Chinese text, that masking the whole word instead of masking Chinese characters, which could bring another challenge in Masked Language Model (MLM) pre-training task. The model was trained on the latest Chinese Wikipedia dump. We aim to provide easy extensibility and better performance for Chinese BERT without changing any neural architecture or even hyper-parameters. The model is verified on various NLP tasks, across sentence-level to document-level, including sentiment classification (ChnSentiCorp, Sina Weibo), named entity recognition (People Daily, MSRA-NER), natural language inference (XNLI), sentence pair matching (LCQMC, BQ Corpus), and machine reading comprehension (CMRC 2018, DRCD, CAIL RC). Experimental results on these datasets show that the whole word masking could bring another significant gain. Moreover, we also examine the effectiveness of Chinese pre-trained models: BERT, ERNIE, BERT-wwm. We release the pre-trained model (both TensorFlow and PyTorch) on GitHub: //github.com/ymcui/Chinese-BERT-wwm

Object tracking is challenging as target objects often undergo drastic appearance changes over time. Recently, adaptive correlation filters have been successfully applied to object tracking. However, tracking algorithms relying on highly adaptive correlation filters are prone to drift due to noisy updates. Moreover, as these algorithms do not maintain long-term memory of target appearance, they cannot recover from tracking failures caused by heavy occlusion or target disappearance in the camera view. In this paper, we propose to learn multiple adaptive correlation filters with both long-term and short-term memory of target appearance for robust object tracking. First, we learn a kernelized correlation filter with an aggressive learning rate for locating target objects precisely. We take into account the appropriate size of surrounding context and the feature representations. Second, we learn a correlation filter over a feature pyramid centered at the estimated target position for predicting scale changes. Third, we learn a complementary correlation filter with a conservative learning rate to maintain long-term memory of target appearance. We use the output responses of this long-term filter to determine if tracking failure occurs. In the case of tracking failures, we apply an incrementally learned detector to recover the target position in a sliding window fashion. Extensive experimental results on large-scale benchmark datasets demonstrate that the proposed algorithm performs favorably against the state-of-the-art methods in terms of efficiency, accuracy, and robustness.