Automatic identification of clinical trials for which a patient is eligible is complicated by the fact that trial eligibility is stated in natural language. A potential solution to this problem is to employ text classification methods for common types of eligibility criteria. In this study, we focus on seven common exclusion criteria in cancer trials: prior malignancy, human immunodeficiency virus, hepatitis B, hepatitis C, psychiatric illness, drug/substance abuse, and autoimmune illness. Our dataset consists of 764 phase III cancer trials with these exclusions annotated at the trial level. We experiment with common transformer models as well as a new pre-trained clinical trial BERT model. Our results demonstrate the feasibility of automatically classifying common exclusion criteria. Additionally, we demonstrate the value of a pre-trained language model specifically for clinical trials, which yields the highest average performance across all criteria.
Electrical impedance tomography (EIT) is a noninvasive medical imaging modality utilizing the current-density/voltage data measured on the surface of the subject. Calder\'on's method is a relatively recent EIT imaging algorithm that is non-iterative, fast, and capable of reconstructing complex-valued electric impedances. However, due to the regularization via low-pass filtering and linearization, the reconstructed images suffer from severe blurring and under-estimation of the exact conductivity values. In this work, we develop an enhanced version of Calder\'on's method, using {deep} convolution neural networks (i.e., U-net) {as an effective targeted post-processing step, and term the resulting method by deep Calder\'{o}n's method.} Specifically, we learn a U-net to postprocess the EIT images generated by Calder\'on's method so as to have better resolutions and more accurate estimates of conductivity values. We simulate chest configurations with which we generate the current-density/voltage boundary measurements and the corresponding reconstructed images by Calder\'on's method. With the paired training data, we learn the deep neural network and evaluate its performance on real tank measurement data. The experimental results indicate that the proposed approach indeed provides a fast and direct (complex-valued) impedance tomography imaging technique, and substantially improves the capability of the standard Calder\'on's method.
Neural networks are known to exploit spurious artifacts (or shortcuts) that co-occur with a target label, exhibiting heuristic memorization. On the other hand, networks have been shown to memorize training examples, resulting in example-level memorization. These kinds of memorization impede generalization of networks beyond their training distributions. Detecting such memorization could be challenging, often requiring researchers to curate tailored test sets. In this work, we hypothesize -- and subsequently show -- that the diversity in the activation patterns of different neurons is reflective of model generalization and memorization. We quantify the diversity in the neural activations through information-theoretic measures and find support for our hypothesis on experiments spanning several natural language and vision tasks. Importantly, we discover that information organization points to the two forms of memorization, even for neural activations computed on unlabelled in-distribution examples. Lastly, we demonstrate the utility of our findings for the problem of model selection. The associated code and other resources for this work are available at //rachitbansal.github.io/information-measures.
Sequential design of experiments for optimizing a reward function in causal systems can be effectively modeled by the sequential design of interventions in causal bandits (CBs). In the existing literature on CBs, a critical assumption is that the causal models remain constant over time. However, this assumption does not necessarily hold in complex systems, which constantly undergo temporal model fluctuations. This paper addresses the robustness of CBs to such model fluctuations. The focus is on causal systems with linear structural equation models (SEMs). The SEMs and the time-varying pre- and post-interventional statistical models are all unknown. Cumulative regret is adopted as the design criteria, based on which the objective is to design a sequence of interventions that incur the smallest cumulative regret with respect to an oracle aware of the entire causal model and its fluctuations. First, it is established that the existing approaches fail to maintain regret sub-linearity with even a few instances of model deviation. Specifically, when the number of instances with model deviation is as few as $T^\frac{1}{2L}$, where $T$ is the time horizon and $L$ is the longest causal path in the graph, the existing algorithms will have linear regret in $T$. Next, a robust CB algorithm is designed, and its regret is analyzed, where upper and information-theoretic lower bounds on the regret are established. Specifically, in a graph with $N$ nodes and maximum degree $d$, under a general measure of model deviation $C$, the cumulative regret is upper bounded by $\tilde{\mathcal{O}}(d^{L-\frac{1}{2}}(\sqrt{NT} + NC))$ and lower bounded by $\Omega(d^{\frac{L}{2}-2}\max\{\sqrt{T},d^2C\})$. Comparing these bounds establishes that the proposed algorithm achieves nearly optimal $\tilde{\mathcal{O}}(\sqrt{T})$ regret when $C$ is $o(\sqrt{T})$ and maintains sub-linear regret for a broader range of $C$.
As cyclones become more intense due to climate change, the rise of AI-based modelling provides a more affordable and accessible approach compared to traditional methods based on mathematical models. This work leverages diffusion models to forecast cyclone trajectories and precipitation patterns by integrating satellite imaging, remote sensing, and atmospheric data, employing a cascaded approach that incorporates forecasting, super-resolution, and precipitation modelling, with training on a dataset of 51 cyclones from six major basins. Experiments demonstrate that the final forecasts from the cascaded models show accurate predictions up to a 36-hour rollout, with SSIM and PSNR values exceeding 0.5 and 20 dB, respectively, for all three tasks. This work also highlights the promising efficiency of AI methods such as diffusion models for high-performance needs, such as cyclone forecasting, while remaining computationally affordable, making them ideal for highly vulnerable regions with critical forecasting needs and financial limitations. Code accessible at \url{//github.com/nathzi1505/forecast-diffmodels}.
Many problems can be viewed as forms of geospatial search aided by aerial imagery, with examples ranging from detecting poaching activity to human trafficking. We model this class of problems in a visual active search (VAS) framework, which has three key inputs: (1) an image of the entire search area, which is subdivided into regions, (2) a local search function, which determines whether a previously unseen object class is present in a given region, and (3) a fixed search budget, which limits the number of times the local search function can be evaluated. The goal is to maximize the number of objects found within the search budget. We propose a reinforcement learning approach for VAS that learns a meta-search policy from a collection of fully annotated search tasks. This meta-search policy is then used to dynamically search for a novel target-object class, leveraging the outcome of any previous queries to determine where to query next. Through extensive experiments on several large-scale satellite imagery datasets, we show that the proposed approach significantly outperforms several strong baselines. We also propose novel domain adaptation techniques that improve the policy at decision time when there is a significant domain gap with the training data. Code is publicly available.
One of the fundamental cognitive abilities of humans is to quickly resolve uncertainty by generating hypotheses and testing them via active trials. Encountering a novel phenomenon accompanied by ambiguous cause-effect relationships, humans make hypotheses against data, conduct inferences from observation, test their theory via experimentation, and correct the proposition if inconsistency arises. These iterative processes persist until the underlying mechanism becomes clear. In this work, we devise the IVRE (pronounced as "ivory") environment for evaluating artificial agents' reasoning ability under uncertainty. IVRE is an interactive environment featuring rich scenarios centered around Blicket detection. Agents in IVRE are placed into environments with various ambiguous action-effect pairs and asked to determine each object's role. They are encouraged to propose effective and efficient experiments to validate their hypotheses based on observations and actively gather new information. The game ends when all uncertainties are resolved or the maximum number of trials is consumed. By evaluating modern artificial agents in IVRE, we notice a clear failure of today's learning methods compared to humans. Such inefficacy in interactive reasoning ability under uncertainty calls for future research in building human-like intelligence.
Emerging applications of robotics, and concerns about their impact, require the research community to put human-centric objectives front-and-center. To meet this challenge, we advocate an interdisciplinary approach, socially cognizant robotics, which synthesizes technical and social science methods. We argue that this approach follows from the need to empower stakeholder participation (from synchronous human feedback to asynchronous societal assessment) in shaping AI-driven robot behavior at all levels, and leads to a range of novel research perspectives and problems both for improving robots' interactions with individuals and impacts on society. Drawing on these arguments, we develop best practices for socially cognizant robot design that balance traditional technology-based metrics (e.g. efficiency, precision and accuracy) with critically important, albeit challenging to measure, human and society-based metrics.
Estimating conditional average treatment effect from observational data is highly challenging due to the existence of treatment selection bias. Prevalent methods mitigate this issue by aligning distributions of different treatment groups in the latent space. However, there are two critical problems that these methods fail to address: (1) mini-batch sampling effects (MSE), which causes misalignment in non-ideal mini-batches with outcome imbalance and outliers; (2) unobserved confounder effects (UCE), which results in inaccurate discrepancy calculation due to the neglect of unobserved confounders. To tackle these problems, we propose a principled approach named Entire Space CounterFactual Regression (ESCFR), which is a new take on optimal transport in the context of causality. Specifically, based on the framework of stochastic optimal transport, we propose a relaxed mass-preserving regularizer to address the MSE issue and design a proximal factual outcome regularizer to handle the UCE issue. Extensive experiments demonstrate that our proposed ESCFR can successfully tackle the treatment selection bias and achieve significantly better performance than state-of-the-art methods.
The two-hand interaction is one of the most challenging signals to analyze due to the self-similarity, complicated articulations, and occlusions of hands. Although several datasets have been proposed for the two-hand interaction analysis, all of them do not achieve 1) diverse and realistic image appearances and 2) diverse and large-scale groundtruth (GT) 3D poses at the same time. In this work, we propose Re:InterHand, a dataset of relighted 3D interacting hands that achieve the two goals. To this end, we employ a state-of-the-art hand relighting network with our accurately tracked two-hand 3D poses. We compare our Re:InterHand with existing 3D interacting hands datasets and show the benefit of it. Our Re:InterHand is available in //mks0601.github.io/ReInterHand/.
We consider the problem of explaining the predictions of graph neural networks (GNNs), which otherwise are considered as black boxes. Existing methods invariably focus on explaining the importance of graph nodes or edges but ignore the substructures of graphs, which are more intuitive and human-intelligible. In this work, we propose a novel method, known as SubgraphX, to explain GNNs by identifying important subgraphs. Given a trained GNN model and an input graph, our SubgraphX explains its predictions by efficiently exploring different subgraphs with Monte Carlo tree search. To make the tree search more effective, we propose to use Shapley values as a measure of subgraph importance, which can also capture the interactions among different subgraphs. To expedite computations, we propose efficient approximation schemes to compute Shapley values for graph data. Our work represents the first attempt to explain GNNs via identifying subgraphs explicitly and directly. Experimental results show that our SubgraphX achieves significantly improved explanations, while keeping computations at a reasonable level.