Individualized treatment rules (ITRs) have been widely applied in many fields such as precision medicine and personalized marketing. Beyond the extensive studies on ITR for binary or multiple treatments, there is considerable interest in applying combination treatments. This paper introduces a novel ITR estimation method for combination treatments incorporating interaction effects among treatments. Specifically, we propose the generalized $\psi$-loss as a non-convex surrogate in the residual weighted learning framework, offering desirable statistical and computational properties. Statistically, the minimizer of the proposed surrogate loss is Fisher-consistent with the optimal decision rules, incorporating interaction effects at any intensity level - a significant improvement over existing methods. Computationally, the proposed method applies the difference-of-convex algorithm for efficient computation. Through simulation studies and real-world data applications, we demonstrate the superior performance of the proposed method in recommending combination treatments.
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Technological advances in medical data collection such as high-resolution histopathology and high-throughput genomic sequencing have contributed to the rising requirement for multi-modal biomedical modelling, specifically for image, tabular, and graph data. Most multi-modal deep learning approaches use modality-specific architectures that are trained separately and cannot capture the crucial cross-modal information that motivates the integration of different data sources. This paper presents the Hybrid Early-fusion Attention Learning Network (HEALNet): a flexible multi-modal fusion architecture, which a) preserves modality-specific structural information, b) captures the cross-modal interactions and structural information in a shared latent space, c) can effectively handle missing modalities during training and inference, and d) enables intuitive model inspection by learning on the raw data input instead of opaque embeddings. We conduct multi-modal survival analysis on Whole Slide Images and Multi-omic data on four cancer cohorts of The Cancer Genome Atlas (TCGA). HEALNet achieves state-of-the-art performance, substantially improving over both uni-modal and recent multi-modal baselines, whilst being robust in scenarios with missing modalities.
We illustrate use of nonparametric statistical methods to compare alternative treatments for a particular disease or condition on both their relative effectiveness and their relative cost. These Incremental Cost Effectiveness (ICE) methods are based upon Bootstrapping, i.e. Resampling with Replacement from observational or clinical-trial data on individual patients. We first show how a reasonable numerical value for the "Shadow Price of Health" can be chosen using functions within the ICEinfer R-package when effectiveness is not measured in "QALY"s. We also argue that simple histograms are ideal for communicating key findings to regulators, while our more detailed graphics may well be more informative and compelling for other health-care stakeholders.
With the increasing amount of data available to scientists in disciplines as diverse as bioinformatics, physics, and remote sensing, scientific workflow systems are becoming increasingly important for composing and executing scalable data analysis pipelines. When writing such workflows, users need to specify the resources to be reserved for tasks so that sufficient resources are allocated on the target cluster infrastructure. Crucially, underestimating a task's memory requirements can result in task failures. Therefore, users often resort to overprovisioning, resulting in significant resource wastage and decreased throughput. In this paper, we propose a novel online method that uses monitoring time series data to predict task memory usage in order to reduce the memory wastage of scientific workflow tasks. Our method predicts a task's runtime, divides it into k equally-sized segments, and learns the peak memory value for each segment depending on the total file input size. We evaluate the prototype implementation of our method using workflows from the publicly available nf-core repository, showing an average memory wastage reduction of 29.48% compared to the best state-of-the-art approach
Force perception on medical instruments is critical for understanding the mechanism between surgical tools and tissues for feeding back quantized force information, which is essential for guidance and supervision in robotic autonomous surgery. Especially for continuous curvilinear capsulorhexis (CCC), it always lacks a force measuring method, providing a sensitive, accurate, and multi-dimensional measurement to track the intraoperative force. Furthermore, the decoupling matrix obtained from the calibration can decorrelate signals with acceptable accuracy, however, this calculating method is not a strong way for thoroughly decoupling under some sensitive measuring situations such as the CCC. In this paper, a three-dimensional force perception method on capsulorhexis forceps by installing Fiber Bragg Grating sensors (FBGs) on prongs and a signal decoupling method combined with FASTICA is first proposed to solve these problems. According to experimental results, the measuring range is up to 1 N (depending on the range of wavelength shifts of sensors) and the resolution on x, y, and z axial force is 0.5, 0.5, and 2 mN separately. To minimize the coupling effects among sensors on measuring multi-axial forces, by unitizing the particular parameter and scaling the corresponding vector in the mixing matrix and recovered signals from FastICA, the signals from sensors can be decorrelated and recovered with the errors on axial forces decreasing up to 50% least. The calibration and calculation can also be simplified with half the parameters involved in the calculation. Experiments on thin sheets and in vitro porcine eyes were performed, and it was found that the tearing forces were stable and the time sequence of tearing forceps was stationary or first-order difference stationary during roughly circular crack propagating.
Infertility is a global health problem, and an increasing number of couples are seeking medical assistance to achieve reproduction, at least half of which are caused by men. The success rate of assisted reproductive technologies depends on sperm assessment, in which experts determine whether sperm can be used for reproduction based on morphology and motility of sperm. Previous sperm assessment studies with deep learning have used datasets comprising images that include only sperm heads, which cannot consider motility and other morphologies of sperm. Furthermore, the labels of the dataset are one-hot, which provides insufficient support for experts, because assessment results are inconsistent between experts, and they have no absolute answer. Therefore, we constructed the video dataset for sperm assessment whose videos include sperm head as well as neck and tail, and its labels were annotated with soft-label. Furthermore, we proposed the sperm assessment framework and the neural network, RoSTFine, for sperm video recognition. Experimental results showed that RoSTFine could improve the sperm assessment performances compared to existing video recognition models and focus strongly on important sperm parts (i.e., head and neck).
Path reasoning methods over knowledge graphs have gained popularity for their potential to improve transparency in recommender systems. However, the resulting models still rely on pre-trained knowledge graph embeddings, fail to fully exploit the interdependence between entities and relations in the KG for recommendation, and may generate inaccurate explanations. In this paper, we introduce PEARLM, a novel approach that efficiently captures user behaviour and product-side knowledge through language modelling. With our approach, knowledge graph embeddings are directly learned from paths over the KG by the language model, which also unifies entities and relations in the same optimisation space. Constraints on the sequence decoding additionally guarantee path faithfulness with respect to the KG. Experiments on two datasets show the effectiveness of our approach compared to state-of-the-art baselines. Source code and datasets: AVAILABLE AFTER GETTING ACCEPTED.
A peculiarity of conversational search systems is that they involve mixed-initiatives such as system-generated query clarifying questions. Evaluating those systems at a large scale on the end task of IR is very challenging, requiring adequate datasets containing such interactions. However, current datasets only focus on either traditional ad-hoc IR tasks or query clarification tasks, the latter being usually seen as a reformulation task from the initial query. The only two datasets known to us that contain both document relevance judgments and the associated clarification interactions are Qulac and ClariQ. Both are based on the TREC Web Track 2009-12 collection, but cover a very limited number of topics (237 topics), far from being enough for training and testing conversational IR models. To fill the gap, we propose a methodology to automatically build large-scale conversational IR datasets from ad-hoc IR datasets in order to facilitate explorations on conversational IR. Our methodology is based on two processes: 1) generating query clarification interactions through query clarification and answer generators, and 2) augmenting ad-hoc IR datasets with simulated interactions. In this paper, we focus on MsMarco and augment it with query clarification and answer simulations. We perform a thorough evaluation showing the quality and the relevance of the generated interactions for each initial query. This paper shows the feasibility and utility of augmenting ad-hoc IR datasets for conversational IR.
Decision-making algorithms are being used in important decisions, such as who should be enrolled in health care programs and be hired. Even though these systems are currently deployed in high-stakes scenarios, many of them cannot explain their decisions. This limitation has prompted the Explainable Artificial Intelligence (XAI) initiative, which aims to make algorithms explainable to comply with legal requirements, promote trust, and maintain accountability. This paper questions whether and to what extent explainability can help solve the responsibility issues posed by autonomous AI systems. We suggest that XAI systems that provide post-hoc explanations could be seen as blameworthy agents, obscuring the responsibility of developers in the decision-making process. Furthermore, we argue that XAI could result in incorrect attributions of responsibility to vulnerable stakeholders, such as those who are subjected to algorithmic decisions (i.e., patients), due to a misguided perception that they have control over explainable algorithms. This conflict between explainability and accountability can be exacerbated if designers choose to use algorithms and patients as moral and legal scapegoats. We conclude with a set of recommendations for how to approach this tension in the socio-technical process of algorithmic decision-making and a defense of hard regulation to prevent designers from escaping responsibility.
Human doctors with well-structured medical knowledge can diagnose a disease merely via a few conversations with patients about symptoms. In contrast, existing knowledge-grounded dialogue systems often require a large number of dialogue instances to learn as they fail to capture the correlations between different diseases and neglect the diagnostic experience shared among them. To address this issue, we propose a more natural and practical paradigm, i.e., low-resource medical dialogue generation, which can transfer the diagnostic experience from source diseases to target ones with a handful of data for adaptation. It is capitalized on a commonsense knowledge graph to characterize the prior disease-symptom relations. Besides, we develop a Graph-Evolving Meta-Learning (GEML) framework that learns to evolve the commonsense graph for reasoning disease-symptom correlations in a new disease, which effectively alleviates the needs of a large number of dialogues. More importantly, by dynamically evolving disease-symptom graphs, GEML also well addresses the real-world challenges that the disease-symptom correlations of each disease may vary or evolve along with more diagnostic cases. Extensive experiment results on the CMDD dataset and our newly-collected Chunyu dataset testify the superiority of our approach over state-of-the-art approaches. Besides, our GEML can generate an enriched dialogue-sensitive knowledge graph in an online manner, which could benefit other tasks grounded on knowledge graph.
Few-shot Knowledge Graph (KG) completion is a focus of current research, where each task aims at querying unseen facts of a relation given its few-shot reference entity pairs. Recent attempts solve this problem by learning static representations of entities and references, ignoring their dynamic properties, i.e., entities may exhibit diverse roles within task relations, and references may make different contributions to queries. This work proposes an adaptive attentional network for few-shot KG completion by learning adaptive entity and reference representations. Specifically, entities are modeled by an adaptive neighbor encoder to discern their task-oriented roles, while references are modeled by an adaptive query-aware aggregator to differentiate their contributions. Through the attention mechanism, both entities and references can capture their fine-grained semantic meanings, and thus render more expressive representations. This will be more predictive for knowledge acquisition in the few-shot scenario. Evaluation in link prediction on two public datasets shows that our approach achieves new state-of-the-art results with different few-shot sizes.
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