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Road casualties represent an alarming concern for modern societies, especially in poor and developing countries. In the last years, several authors developed sophisticated statistical approaches to help local authorities implement new policies and mitigate the problem. These models are typically developed taking into account a set of socio-economic or demographic variables, such as population density and traffic volumes. However, they usually ignore that the external factors may be suffering from measurement errors, which can severely bias the statistical inference. This paper presents a Bayesian hierarchical model to analyse car crashes occurrences at the network lattice level taking into account measurement error in the spatial covariates. The suggested methodology is exemplified considering all road collisions in the road network of Leeds (UK) from 2011 to 2019. Traffic volumes are approximated at the street segment level using an extensive set of road counts obtained from mobile devices, and the estimates are corrected using a measurement error model. Our results show that omitting measurement error considerably worsens the model's fit and attenuates the effects of imprecise covariates.

We propose a new estimation method for the spatial blind source separation model. The new estimation is based on an eigenanalysis of a positive definite matrix defined in terms of multiple spatial local covariance matrices, and, therefore, can handle moderately high-dimensional random fields. The consistency of the estimated mixing matrix is established with explicit error rates even when the eigen-gap decays to zero slowly. The proposed method is illustrated via both simulation and a real data example.

The goal of regression is to recover an unknown underlying function that best links a set of predictors to an outcome from noisy observations. In nonparametric regression, one assumes that the regression function belongs to a pre-specified infinite-dimensional function space (the hypothesis space). In the online setting, when the observations come in a stream, it is computationally-preferable to iteratively update an estimate rather than refitting an entire model repeatedly. Inspired by nonparametric sieve estimation and stochastic approximation methods, we propose a sieve stochastic gradient descent estimator (Sieve-SGD) when the hypothesis space is a Sobolev ellipsoid. We show that Sieve-SGD has rate-optimal mean squared error (MSE) under a set of simple and direct conditions. The proposed estimator can be constructed with a low computational (time and space) expense: We also formally show that Sieve-SGD requires almost minimal memory usage among all statistically rate-optimal estimators.

Digital image correlation (DIC) has become an industry standard to retrieve accurate displacement and strain measurement in tensile testing and other material characterization. Though traditional DIC offers a high precision estimation of deformation for general tensile testing cases, the prediction becomes unstable at large deformation or when the speckle patterns start to tear. In addition, traditional DIC requires a long computation time and often produces a low spatial resolution output affected by filtering and speckle pattern quality. To address these challenges, we propose a new deep learning-based DIC approach--Deep DIC, in which two convolutional neural networks, DisplacementNet and StrainNet, are designed to work together for end-to-end prediction of displacements and strains. DisplacementNet predicts the displacement field and adaptively tracks a region of interest. StrainNet predicts the strain field directly from the image input without relying on the displacement prediction, which significantly improves the strain prediction accuracy. A new dataset generation method is developed to synthesize a realistic and comprehensive dataset, including the generation of speckle patterns and the deformation of the speckle image with synthetic displacement fields. Though trained on synthetic datasets only, Deep DIC gives highly consistent and comparable predictions of displacement and strain with those obtained from commercial DIC software for real experiments, while it outperforms commercial software with very robust strain prediction even at large and localized deformation and varied pattern qualities. In addition, Deep DIC is capable of real-time prediction of deformation with a calculation time down to milliseconds.

One of the fundamental assumptions in stochastic control of continuous time processes is that the dynamics of the underlying (diffusion) process is known. This is, however, usually obviously not fulfilled in practice. On the other hand, over the last decades, a rich theory for nonparametric estimation of the drift (and volatility) for continuous time processes has been developed. The aim of this paper is bringing together techniques from stochastic control with methods from statistics for stochastic processes to find a way to both learn the dynamics of the underlying process and control in a reasonable way at the same time. More precisely, we study a long-term average impulse control problem, a stochastic version of the classical Faustmann timber harvesting problem. One of the problems that immediately arises is an exploration-exploitation dilemma as is well known for problems in machine learning. We propose a way to deal with this issue by combining exploration and exploitation periods in a suitable way. Our main finding is that this construction can be based on the rates of convergence of estimators for the invariant density. Using this, we obtain that the average cumulated regret is of uniform order $O({T^{-1/3}})$.

CRISPR genome engineering and single-cell RNA sequencing have transformed biological discovery. Single-cell CRISPR screens unite these two technologies, linking genetic perturbations in individual cells to changes in gene expression and illuminating regulatory networks underlying diseases. Despite their promise, single-cell CRISPR screens present substantial statistical challenges. We demonstrate through theoretical and real data analyses that a standard method for estimation and inference in single-cell CRISPR screens -- "thresholded regression" -- exhibits attenuation bias and a bias-variance tradeoff as a function of an intrinsic, challenging-to-select tuning parameter. To overcome these difficulties, we introduce GLM-EIV ("GLM-based errors-in-variables"), a new method for single-cell CRISPR screen analysis. GLM-EIV extends the classical errors-in-variables model to responses and noisy predictors that are exponential family-distributed and potentially impacted by the same set of confounding variables. We develop a computational infrastructure to deploy GLM-EIV across tens or hundreds of nodes on clouds (e.g., Microsoft Azure) and high-performance clusters. Leveraging this infrastructure, we apply GLM-EIV to analyze two recent, large-scale, single-cell CRISPR screen datasets, demonstrating improved performance in challenging problem settings.

This paper proposes a new image-based localization framework that explicitly localizes the camera/robot by fusing Convolutional Neural Network (CNN) and sequential images' geometric constraints. The camera is localized using a single or few observed images and training images with 6-degree-of-freedom pose labels. A Siamese network structure is adopted to train an image descriptor network, and the visually similar candidate image in the training set is retrieved to localize the testing image geometrically. Meanwhile, a probabilistic motion model predicts the pose based on a constant velocity assumption. The two estimated poses are finally fused using their uncertainties to yield an accurate pose prediction. This method leverages the geometric uncertainty and is applicable in indoor scenarios predominated by diffuse illumination. Experiments on simulation and real data sets demonstrate the efficiency of our proposed method. The results further show that combining the CNN-based framework with geometric constraint achieves better accuracy when compared with CNN-only methods, especially when the training data size is small.

This work focuses on combining nonparametric topic models with Auto-Encoding Variational Bayes (AEVB). Specifically, we first propose iTM-VAE, where the topics are treated as trainable parameters and the document-specific topic proportions are obtained by a stick-breaking construction. The inference of iTM-VAE is modeled by neural networks such that it can be computed in a simple feed-forward manner. We also describe how to introduce a hyper-prior into iTM-VAE so as to model the uncertainty of the prior parameter. Actually, the hyper-prior technique is quite general and we show that it can be applied to other AEVB based models to alleviate the {\it collapse-to-prior} problem elegantly. Moreover, we also propose HiTM-VAE, where the document-specific topic distributions are generated in a hierarchical manner. HiTM-VAE is even more flexible and can generate topic distributions with better variability. Experimental results on 20News and Reuters RCV1-V2 datasets show that the proposed models outperform the state-of-the-art baselines significantly. The advantages of the hyper-prior technique and the hierarchical model construction are also confirmed by experiments.

Handling object interaction is a fundamental challenge in practical multi-object tracking, even for simple interactive effects such as one object temporarily occluding another. We formalize the problem of occlusion in tracking with two different abstractions. In object-wise occlusion, objects that are occluded by other objects do not generate measurements. In measurement-wise occlusion, a previously unstudied approach, all objects may generate measurements but some measurements may be occluded by others. While the relative validity of each abstraction depends on the situation and sensor, measurement-wise occlusion fits into probabilistic multi-object tracking algorithms with much looser assumptions on object interaction. Its value is demonstrated by showing that it naturally derives a popular approximation for lidar tracking, and by an example of visual tracking in image space.

Discrete random structures are important tools in Bayesian nonparametrics and the resulting models have proven effective in density estimation, clustering, topic modeling and prediction, among others. In this paper, we consider nested processes and study the dependence structures they induce. Dependence ranges between homogeneity, corresponding to full exchangeability, and maximum heterogeneity, corresponding to (unconditional) independence across samples. The popular nested Dirichlet process is shown to degenerate to the fully exchangeable case when there are ties across samples at the observed or latent level. To overcome this drawback, inherent to nesting general discrete random measures, we introduce a novel class of latent nested processes. These are obtained by adding common and group-specific completely random measures and, then, normalising to yield dependent random probability measures. We provide results on the partition distributions induced by latent nested processes, and develop an Markov Chain Monte Carlo sampler for Bayesian inferences. A test for distributional homogeneity across groups is obtained as a by product. The results and their inferential implications are showcased on synthetic and real data.