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Due to the high human cost of annotation, it is non-trivial to curate a large-scale medical dataset that is fully labeled for all classes of interest. Instead, it would be convenient to collect multiple small partially labeled datasets from different matching sources, where the medical images may have only been annotated for a subset of classes of interest. This paper offers an empirical understanding of an under-explored problem, namely partially supervised multi-label classification (PSMLC), where a multi-label classifier is trained with only partially labeled medical images. In contrast to the fully supervised counterpart, the partial supervision caused by medical data scarcity has non-trivial negative impacts on the model performance. A potential remedy could be augmenting the partial labels. Though vicinal risk minimization (VRM) has been a promising solution to improve the generalization ability of the model, its application to PSMLC remains an open question. To bridge the methodological gap, we provide the first VRM-based solution to PSMLC. The empirical results also provide insights into future research directions on partially supervised learning under data scarcity.

Software model checking is a verification technique which is widely used for checking temporal properties of software systems. Even though it is a property verification technique, its common usage in practice is in "bug finding", that is, finding violations of temporal properties. Motivated by this observation and leveraging the recent progress in fuzzing, we build a greybox fuzzing framework to find violations of Linear-time Temporal Logic (LTL) properties. Our framework takes as input a sequential program written in C/C++, and an LTL property. It finds violations, or counterexample traces, of the LTL property in stateful software systems; however, it does not achieve verification. Our work substantially extends directed greybox fuzzing to witness arbitrarily complex event orderings. We note that existing directed greybox fuzzing approaches are limited to witnessing reaching a location or witnessing simple event orderings like use-after-free. At the same time, compared to model checkers, our approach finds the counterexamples faster, thereby finding more counterexamples within a given time budget. Our LTL-Fuzzer tool, built on top of the AFL fuzzer, is shown to be effective in detecting bugs in well-known protocol implementations, such as OpenSSL and Telnet. We use LTL-Fuzzer to reproduce known vulnerabilities (CVEs), to find 15 zero-day bugs by checking properties extracted from RFCs (for which 12 CVEs have been assigned), and to find violations of both safety as well as liveness properties in real-world protocol implementations. Our work represents a practical advance over software model checkers -- while simultaneously representing a conceptual advance over existing greybox fuzzers. Our work thus provides a starting point for understanding the unexplored synergies between software model checking and greybox fuzzing.

Biomedical research is growing at such an exponential pace that scientists, researchers, and practitioners are no more able to cope with the amount of published literature in the domain. The knowledge presented in the literature needs to be systematized in such a way that claims and hypotheses can be easily found, accessed, and validated. Knowledge graphs can provide such a framework for semantic knowledge representation from literature. However, in order to build a knowledge graph, it is necessary to extract knowledge as relationships between biomedical entities and normalize both entities and relationship types. In this paper, we present and compare a few rule-based and machine learning-based (Naive Bayes, Random Forests as examples of traditional machine learning methods and DistilBERT and T5-based models as examples of modern deep learning transformers) methods for scalable relationship extraction from biomedical literature, and for the integration into the knowledge graphs. We examine how resilient are these various methods to unbalanced and fairly small datasets. Our experiments show that transformer-based models handle well both small (due to pre-training on a large dataset) and unbalanced datasets. The best performing model was the DistilBERT-based model fine-tuned on balanced data, with a reported F1-score of 0.89.

This paper identifies and addresses a serious design bias of existing salient object detection (SOD) datasets, which unrealistically assume that each image should contain at least one clear and uncluttered salient object. This design bias has led to a saturation in performance for state-of-the-art SOD models when evaluated on existing datasets. However, these models are still far from satisfactory when applied to real-world scenes. Based on our analyses, we propose a new high-quality dataset and update the previous saliency benchmark. Specifically, our dataset, called Salient Objects in Clutter~\textbf{(SOC)}, includes images with both salient and non-salient objects from several common object categories. In addition to object category annotations, each salient image is accompanied by attributes that reflect common challenges in common scenes, which can help provide deeper insight into the SOD problem. Further, with a given saliency encoder, e.g., the backbone network, existing saliency models are designed to achieve mapping from the training image set to the training ground-truth set. We, therefore, argue that improving the dataset can yield higher performance gains than focusing only on the decoder design. With this in mind, we investigate several dataset-enhancement strategies, including label smoothing to implicitly emphasize salient boundaries, random image augmentation to adapt saliency models to various scenarios, and self-supervised learning as a regularization strategy to learn from small datasets. Our extensive results demonstrate the effectiveness of these tricks. We also provide a comprehensive benchmark for SOD, which can be found in our repository: //github.com/DengPingFan/SODBenchmark.

In this paper, we consider the challenging task of simultaneously locating and recovering multiple hands from single 2D image. Previous studies either focus on single hand reconstruction or solve this problem in a multi-stage way. Moreover, the conventional two-stage pipeline firstly detects hand areas, and then estimates 3D hand pose from each cropped patch. To reduce the computational redundancy in preprocessing and feature extraction, we propose a concise but efficient single-stage pipeline. Specifically, we design a multi-head auto-encoder structure for multi-hand reconstruction, where each head network shares the same feature map and outputs the hand center, pose and texture, respectively. Besides, we adopt a weakly-supervised scheme to alleviate the burden of expensive 3D real-world data annotations. To this end, we propose a series of losses optimized by a stage-wise training scheme, where a multi-hand dataset with 2D annotations is generated based on the publicly available single hand datasets. In order to further improve the accuracy of the weakly supervised model, we adopt several feature consistency constraints in both single and multiple hand settings. Specifically, the keypoints of each hand estimated from local features should be consistent with the re-projected points predicted from global features. Extensive experiments on public benchmarks including FreiHAND, HO3D, InterHand2.6M and RHD demonstrate that our method outperforms the state-of-the-art model-based methods in both weakly-supervised and fully-supervised manners.

Visual place recognition (VPR) in condition-varying environments is still an open problem. Popular solutions are CNN-based image descriptors, which have been shown to outperform traditional image descriptors based on hand-crafted visual features. However, there are two drawbacks of current CNN-based descriptors: a) their high dimension and b) lack of generalization, leading to low efficiency and poor performance in applications. In this paper, we propose to use a convolutional autoencoder (CAE) to tackle this problem. We employ a high-level layer of a pre-trained CNN to generate features, and train a CAE to map the features to a low-dimensional space to improve the condition invariance property of the descriptor and reduce its dimension at the same time. We verify our method in three challenging datasets involving significant illumination changes, and our method is shown to be superior to the state-of-the-art. For the benefit of the community, we make public the source code.

Correlation acts as a critical role in the tracking field, especially in recent popular Siamese-based trackers. The correlation operation is a simple fusion manner to consider the similarity between the template and the search region. However, the correlation operation itself is a local linear matching process, leading to lose semantic information and fall into local optimum easily, which may be the bottleneck of designing high-accuracy tracking algorithms. Is there any better feature fusion method than correlation? To address this issue, inspired by Transformer, this work presents a novel attention-based feature fusion network, which effectively combines the template and search region features solely using attention. Specifically, the proposed method includes an ego-context augment module based on self-attention and a cross-feature augment module based on cross-attention. Finally, we present a Transformer tracking (named TransT) method based on the Siamese-like feature extraction backbone, the designed attention-based fusion mechanism, and the classification and regression head. Experiments show that our TransT achieves very promising results on six challenging datasets, especially on large-scale LaSOT, TrackingNet, and GOT-10k benchmarks. Our tracker runs at approximatively 50 fps on GPU. Code and models are available at //github.com/chenxin-dlut/TransT.

Applying artificial intelligence techniques in medical imaging is one of the most promising areas in medicine. However, most of the recent success in this area highly relies on large amounts of carefully annotated data, whereas annotating medical images is a costly process. In this paper, we propose a novel method, called FocalMix, which, to the best of our knowledge, is the first to leverage recent advances in semi-supervised learning (SSL) for 3D medical image detection. We conducted extensive experiments on two widely used datasets for lung nodule detection, LUNA16 and NLST. Results show that our proposed SSL methods can achieve a substantial improvement of up to 17.3% over state-of-the-art supervised learning approaches with 400 unlabeled CT scans.

In this paper, we adopt 3D Convolutional Neural Networks to segment volumetric medical images. Although deep neural networks have been proven to be very effective on many 2D vision tasks, it is still challenging to apply them to 3D tasks due to the limited amount of annotated 3D data and limited computational resources. We propose a novel 3D-based coarse-to-fine framework to effectively and efficiently tackle these challenges. The proposed 3D-based framework outperforms the 2D counterpart to a large margin since it can leverage the rich spatial infor- mation along all three axes. We conduct experiments on two datasets which include healthy and pathological pancreases respectively, and achieve the current state-of-the-art in terms of Dice-S{\o}rensen Coefficient (DSC). On the NIH pancreas segmentation dataset, we outperform the previous best by an average of over 2%, and the worst case is improved by 7% to reach almost 70%, which indicates the reliability of our framework in clinical applications.

Recent advances in 3D fully convolutional networks (FCN) have made it feasible to produce dense voxel-wise predictions of volumetric images. In this work, we show that a multi-class 3D FCN trained on manually labeled CT scans of several anatomical structures (ranging from the large organs to thin vessels) can achieve competitive segmentation results, while avoiding the need for handcrafting features or training class-specific models. To this end, we propose a two-stage, coarse-to-fine approach that will first use a 3D FCN to roughly define a candidate region, which will then be used as input to a second 3D FCN. This reduces the number of voxels the second FCN has to classify to ~10% and allows it to focus on more detailed segmentation of the organs and vessels. We utilize training and validation sets consisting of 331 clinical CT images and test our models on a completely unseen data collection acquired at a different hospital that includes 150 CT scans, targeting three anatomical organs (liver, spleen, and pancreas). In challenging organs such as the pancreas, our cascaded approach improves the mean Dice score from 68.5 to 82.2%, achieving the highest reported average score on this dataset. We compare with a 2D FCN method on a separate dataset of 240 CT scans with 18 classes and achieve a significantly higher performance in small organs and vessels. Furthermore, we explore fine-tuning our models to different datasets. Our experiments illustrate the promise and robustness of current 3D FCN based semantic segmentation of medical images, achieving state-of-the-art results. Our code and trained models are available for download: //github.com/holgerroth/3Dunet_abdomen_cascade.