Supervised deep learning methods have achieved considerable success in medical image analysis, owing to the availability of large-scale and well-annotated datasets. However, creating such datasets for whole slide images (WSIs) in histopathology is a challenging task due to their gigapixel size. In recent years, self-supervised learning (SSL) has emerged as an alternative solution to reduce the annotation overheads in WSIs, as it does not require labels for training. These SSL approaches, however, are not designed for handling multi-resolution WSIs, which limits their performance in learning discriminative image features. In this paper, we propose a Dual-branch SSL Framework for WSI tumour segmentation (DSF-WSI) that can effectively learn image features from multi-resolution WSIs. Our DSF-WSI connected two branches and jointly learnt low and high resolution WSIs in a self-supervised manner. Moreover, we introduced a novel Context-Target Fusion Module (CTFM) and a masked jigsaw pretext task to align the learnt multi-resolution features. Furthermore, we designed a Dense SimSiam Learning (DSL) strategy to maximise the similarity of different views of WSIs, enabling the learnt representations to be more efficient and discriminative. We evaluated our method using two public datasets on breast and liver cancer segmentation tasks. The experiment results demonstrated that our DSF-WSI can effectively extract robust and efficient representations, which we validated through subsequent fine-tuning and semi-supervised settings. Our proposed method achieved better accuracy than other state-of-the-art approaches. Code is available at //github.com/Dylan-H-Wang/dsf-wsi.
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Self-supervised facial representation has recently attracted increasing attention due to its ability to perform face understanding without relying on large-scale annotated datasets heavily. However, analytically, current contrastive-based self-supervised learning (SSL) still performs unsatisfactorily for learning facial representation. More specifically, existing contrastive learning (CL) tends to learn pose-invariant features that cannot depict the pose details of faces, compromising the learning performance. To conquer the above limitation of CL, we propose a novel Pose-disentangled Contrastive Learning (PCL) method for general self-supervised facial representation. Our PCL first devises a pose-disentangled decoder (PDD) with a delicately designed orthogonalizing regulation, which disentangles the pose-related features from the face-aware features; therefore, pose-related and other pose-unrelated facial information could be performed in individual subnetworks and do not affect each other's training. Furthermore, we introduce a pose-related contrastive learning scheme that learns pose-related information based on data augmentation of the same image, which would deliver more effective face-aware representation for various downstream tasks. We conducted linear evaluation on four challenging downstream facial understanding tasks, ie, facial expression recognition, face recognition, AU detection and head pose estimation. Experimental results demonstrate that our method significantly outperforms state-of-the-art SSL methods. Code is available at //github.com/DreamMr/PCL}{//github.com/DreamMr/PCL
Image/video denoising in low-light scenes is an extremely challenging problem due to limited photon count and high noise. In this paper, we propose a novel approach with contrastive learning to address this issue. Inspired by the success of contrastive learning used in some high-level computer vision tasks, we bring in this idea to the low-level denoising task. In order to achieve this goal, we introduce a new denoising contrastive regularization (DCR) to exploit the information of noisy images and clean images. In the feature space, DCR makes the denoised image closer to the clean image and far away from the noisy image. In addition, we build a new feature embedding network called Wnet, which is more effective to extract high-frequency information. We conduct the experiments on a real low-light dataset that captures still images taken on a moonless clear night in 0.6 millilux and videos under starlight (no moon present, <0.001 lux). The results show that our method can achieve a higher PSNR and better visual quality compared with existing methods
Instance segmentation is a form of image detection which has a range of applications, such as object refinement, medical image analysis, and image/video editing, all of which demand a high degree of accuracy. However, this precision is often beyond the reach of what even state-of-the-art, fully automated instance segmentation algorithms can deliver. The performance gap becomes particularly prohibitive for small and complex objects. Practitioners typically resort to fully manual annotation, which can be a laborious process. In order to overcome this problem, we propose a novel approach to enable more precise predictions and generate higher-quality segmentation masks for high-curvature, complex and small-scale objects. Our human-assisted segmentation model, HAISTA-NET, augments the existing Strong Mask R-CNN network to incorporate human-specified partial boundaries. We also present a dataset of hand-drawn partial object boundaries, which we refer to as human attention maps. In addition, the Partial Sketch Object Boundaries (PSOB) dataset contains hand-drawn partial object boundaries which represent curvatures of an object's ground truth mask with several pixels. Through extensive evaluation using the PSOB dataset, we show that HAISTA-NET outperforms state-of-the art methods such as Mask R-CNN, Strong Mask R-CNN, and Mask2Former, achieving respective increases of +36.7, +29.6, and +26.5 points in AP-Mask metrics for these three models. We hope that our novel approach will set a baseline for future human-aided deep learning models by combining fully automated and interactive instance segmentation architectures.
Deep learning on graphs has attracted significant interests recently. However, most of the works have focused on (semi-) supervised learning, resulting in shortcomings including heavy label reliance, poor generalization, and weak robustness. To address these issues, self-supervised learning (SSL), which extracts informative knowledge through well-designed pretext tasks without relying on manual labels, has become a promising and trending learning paradigm for graph data. Different from SSL on other domains like computer vision and natural language processing, SSL on graphs has an exclusive background, design ideas, and taxonomies. Under the umbrella of graph self-supervised learning, we present a timely and comprehensive review of the existing approaches which employ SSL techniques for graph data. We construct a unified framework that mathematically formalizes the paradigm of graph SSL. According to the objectives of pretext tasks, we divide these approaches into four categories: generation-based, auxiliary property-based, contrast-based, and hybrid approaches. We further conclude the applications of graph SSL across various research fields and summarize the commonly used datasets, evaluation benchmark, performance comparison and open-source codes of graph SSL. Finally, we discuss the remaining challenges and potential future directions in this research field.
To date, most existing self-supervised learning methods are designed and optimized for image classification. These pre-trained models can be sub-optimal for dense prediction tasks due to the discrepancy between image-level prediction and pixel-level prediction. To fill this gap, we aim to design an effective, dense self-supervised learning method that directly works at the level of pixels (or local features) by taking into account the correspondence between local features. We present dense contrastive learning, which implements self-supervised learning by optimizing a pairwise contrastive (dis)similarity loss at the pixel level between two views of input images. Compared to the baseline method MoCo-v2, our method introduces negligible computation overhead (only <1% slower), but demonstrates consistently superior performance when transferring to downstream dense prediction tasks including object detection, semantic segmentation and instance segmentation; and outperforms the state-of-the-art methods by a large margin. Specifically, over the strong MoCo-v2 baseline, our method achieves significant improvements of 2.0% AP on PASCAL VOC object detection, 1.1% AP on COCO object detection, 0.9% AP on COCO instance segmentation, 3.0% mIoU on PASCAL VOC semantic segmentation and 1.8% mIoU on Cityscapes semantic segmentation. Code is available at: //git.io/AdelaiDet
Deep supervised learning has achieved great success in the last decade. However, its deficiencies of dependence on manual labels and vulnerability to attacks have driven people to explore a better solution. As an alternative, self-supervised learning attracts many researchers for its soaring performance on representation learning in the last several years. Self-supervised representation learning leverages input data itself as supervision and benefits almost all types of downstream tasks. In this survey, we take a look into new self-supervised learning methods for representation in computer vision, natural language processing, and graph learning. We comprehensively review the existing empirical methods and summarize them into three main categories according to their objectives: generative, contrastive, and generative-contrastive (adversarial). We further investigate related theoretical analysis work to provide deeper thoughts on how self-supervised learning works. Finally, we briefly discuss open problems and future directions for self-supervised learning. An outline slide for the survey is provided.
A key requirement for the success of supervised deep learning is a large labeled dataset - a condition that is difficult to meet in medical image analysis. Self-supervised learning (SSL) can help in this regard by providing a strategy to pre-train a neural network with unlabeled data, followed by fine-tuning for a downstream task with limited annotations. Contrastive learning, a particular variant of SSL, is a powerful technique for learning image-level representations. In this work, we propose strategies for extending the contrastive learning framework for segmentation of volumetric medical images in the semi-supervised setting with limited annotations, by leveraging domain-specific and problem-specific cues. Specifically, we propose (1) novel contrasting strategies that leverage structural similarity across volumetric medical images (domain-specific cue) and (2) a local version of the contrastive loss to learn distinctive representations of local regions that are useful for per-pixel segmentation (problem-specific cue). We carry out an extensive evaluation on three Magnetic Resonance Imaging (MRI) datasets. In the limited annotation setting, the proposed method yields substantial improvements compared to other self-supervision and semi-supervised learning techniques. When combined with a simple data augmentation technique, the proposed method reaches within 8% of benchmark performance using only two labeled MRI volumes for training, corresponding to only 4% (for ACDC) of the training data used to train the benchmark.
Hashing has been widely used in approximate nearest search for large-scale database retrieval for its computation and storage efficiency. Deep hashing, which devises convolutional neural network architecture to exploit and extract the semantic information or feature of images, has received increasing attention recently. In this survey, several deep supervised hashing methods for image retrieval are evaluated and I conclude three main different directions for deep supervised hashing methods. Several comments are made at the end. Moreover, to break through the bottleneck of the existing hashing methods, I propose a Shadow Recurrent Hashing(SRH) method as a try. Specifically, I devise a CNN architecture to extract the semantic features of images and design a loss function to encourage similar images projected close. To this end, I propose a concept: shadow of the CNN output. During optimization process, the CNN output and its shadow are guiding each other so as to achieve the optimal solution as much as possible. Several experiments on dataset CIFAR-10 show the satisfying performance of SRH.
This paper presents SimCLR: a simple framework for contrastive learning of visual representations. We simplify recently proposed contrastive self-supervised learning algorithms without requiring specialized architectures or a memory bank. In order to understand what enables the contrastive prediction tasks to learn useful representations, we systematically study the major components of our framework. We show that (1) composition of data augmentations plays a critical role in defining effective predictive tasks, (2) introducing a learnable nonlinear transformation between the representation and the contrastive loss substantially improves the quality of the learned representations, and (3) contrastive learning benefits from larger batch sizes and more training steps compared to supervised learning. By combining these findings, we are able to considerably outperform previous methods for self-supervised and semi-supervised learning on ImageNet. A linear classifier trained on self-supervised representations learned by SimCLR achieves 76.5% top-1 accuracy, which is a 7% relative improvement over previous state-of-the-art, matching the performance of a supervised ResNet-50. When fine-tuned on only 1% of the labels, we achieve 85.8% top-5 accuracy, outperforming AlexNet with 100X fewer labels.
In this paper, we adopt 3D Convolutional Neural Networks to segment volumetric medical images. Although deep neural networks have been proven to be very effective on many 2D vision tasks, it is still challenging to apply them to 3D tasks due to the limited amount of annotated 3D data and limited computational resources. We propose a novel 3D-based coarse-to-fine framework to effectively and efficiently tackle these challenges. The proposed 3D-based framework outperforms the 2D counterpart to a large margin since it can leverage the rich spatial infor- mation along all three axes. We conduct experiments on two datasets which include healthy and pathological pancreases respectively, and achieve the current state-of-the-art in terms of Dice-S{\o}rensen Coefficient (DSC). On the NIH pancreas segmentation dataset, we outperform the previous best by an average of over 2%, and the worst case is improved by 7% to reach almost 70%, which indicates the reliability of our framework in clinical applications.
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