Many neurodegenerative diseases are connected to the spreading of misfolded prionic proteins. In this paper, we analyse the process of misfolding and spreading of both $\alpha$-synuclein and Amyloid-$\beta$, related to Parkinson's and Alzheimer's diseases, respectively. We introduce and analyze a positivity-preserving numerical method for the discretization of the Fisher-Kolmogorov equation, modelling accumulation and spreading of prionic proteins. The proposed approximation method is based on the discontinuous Galerkin method on polygonal and polyhedral grids for space discretization and on $\vartheta-$method time integration scheme. We prove the existence of the discrete solution and a convergence result where the Implicit Euler scheme is employed for time integration. We show that the proposed approach is structure-preserving, in the sense that it guaranteed that the discrete solution is non-negative, a feature that is of paramount importance in practical application. The numerical verification of our numerical model is performed both using a manufactured solution and considering wavefront propagation in two-dimensional polygonal grids. Next, we present a simulation of $\alpha$-synuclein spreading in a two-dimensional brain slice in the sagittal plane. The polygonal mesh for this simulation is agglomerated maintaining the distinction of white and grey matter, taking advantage of the flexibility of PolyDG methods in the mesh construction. Finally, we simulate the spreading of Amyloid-$\beta$ in a patient-specific setting by using a three-dimensional geometry reconstructed from magnetic resonance images and an initial condition reconstructed from positron emission tomography. Our numerical simulations confirm that the proposed method is able to capture the evolution of Parkinson's and Alzheimer's diseases.
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Maintaining factual consistency is a critical issue in abstractive text summarisation, however, it cannot be assessed by traditional automatic metrics used for evaluating text summarisation, such as ROUGE scoring. Recent efforts have been devoted to developing improved metrics for measuring factual consistency using pre-trained language models, but these metrics have restrictive token limits, and are therefore not suitable for evaluating long document text summarisation. Moreover, there is limited research evaluating whether existing automatic evaluation metrics are fit for purpose when applied to long document data sets. In this work, we evaluate the efficacy of automatic metrics at assessing factual consistency in long document text summarisation and propose a new evaluation framework LongDocFACTScore. This framework allows metrics to be extended to any length document. This framework outperforms existing state-of-the-art metrics in its ability to correlate with human measures of factuality when used to evaluate long document summarisation data sets. Furthermore, we show LongDocFACTScore has performance comparable to state-of-the-art metrics when evaluated against human measures of factual consistency on short document data sets. We make our code and annotated data publicly available: //github.com/jbshp/LongDocFACTScore.
Neural networks have become a prominent approach to solve inverse problems in recent years. While a plethora of such methods was developed to solve inverse problems empirically, we are still lacking clear theoretical guarantees for these methods. On the other hand, many works proved convergence to optimal solutions of neural networks in a more general setting using overparametrization as a way to control the Neural Tangent Kernel. In this work we investigate how to bridge these two worlds and we provide deterministic convergence and recovery guarantees for the class of unsupervised feedforward multilayer neural networks trained to solve inverse problems. We also derive overparametrization bounds under which a two-layers Deep Inverse Prior network with smooth activation function will benefit from our guarantees.
The goal of this paper is to detect objects by exploiting their interrelationships. Rather than relying on predefined and labeled graph structures, we infer a graph prior from object co-occurrence statistics. The key idea of our paper is to model object relations as a function of initial class predictions and co-occurrence priors to generate a graph representation of an image for improved classification and bounding box regression. We additionally learn the object-relation joint distribution via energy based modeling. Sampling from this distribution generates a refined graph representation of the image which in turn produces improved detection performance. Experiments on the Visual Genome and MS-COCO datasets demonstrate our method is detector agnostic, end-to-end trainable, and especially beneficial for rare object classes. What is more, we establish a consistent improvement over object detectors like DETR and Faster-RCNN, as well as state-of-the-art methods modeling object interrelationships.
This paper explores a fine-grained version of the Watrous conjecture, including the randomized and quantum algorithms with success probabilities arbitrarily close to $1/2$. Our contributions include the following: i) An analysis of the optimal success probability of quantum and randomized query algorithms of two fundamental partial symmetric Boolean functions given a fixed number of queries. We prove that for any quantum algorithm computing these two functions using $T$ queries, there exist randomized algorithms using $\mathsf{poly}(T)$ queries that achieve the same success probability as the quantum algorithm, even if the success probability is arbitrarily close to 1/2. ii) We establish that for any total symmetric Boolean function $f$, if a quantum algorithm uses $T$ queries to compute $f$ with success probability $1/2+\beta$, then there exists a randomized algorithm using $O(T^2)$ queries to compute $f$ with success probability $1/2+\Omega(\delta\beta^2)$ on a $1-\delta$ fraction of inputs, where $\beta,\delta$ can be arbitrarily small positive values. As a corollary, we prove a randomized version of Aaronson-Ambainis Conjecture for total symmetric Boolean functions in the regime where the success probability of algorithms can be arbitrarily close to 1/2. iii) We present polynomial equivalences for several fundamental complexity measures of partial symmetric Boolean functions. Specifically, we first prove that for certain partial symmetric Boolean functions, quantum query complexity is at most quadratic in approximate degree for any error arbitrarily close to 1/2. Next, we show exact quantum query complexity is at most quadratic in degree. Additionally, we give the tight bounds of several complexity measures, indicating their polynomial equivalence.
Gender bias in education gained considerable relevance in the literature over the years. However, while the problem of gender bias in education has been widely addressed from a student perspective, it is still not fully analysed from an academic point of view. In this work, we study the problem of gender bias in academic promotions (i.e., from Researcher to Associated Professor and from Associated to Full Professor) in the informatics (INF) and software engineering (SE) Italian communities. In particular, we first conduct a literature review to assess how the problem of gender bias in academia has been addressed so far. Next, we describe a process to collect and preprocess the INF and SE data needed to analyse gender bias in Italian academic promotions. Subsequently, we apply a formal bias metric to these data to assess the amount of bias and look at its variation over time. From the conducted analysis, we observe how the SE community presents a higher bias in promotions to Associate Professors and a smaller bias in promotions to Full Professors compared to the overall INF community.
Knitting patterns are a crucial component in the creation and design of knitted materials. Traditionally, these patterns were taught informally, but thanks to advancements in technology, anyone interested in knitting can use the patterns as a guide to start knitting. Perhaps because knitting is mostly a hobby, with the exception of industrial manufacturing utilising specialised knitting machines, the use of Al in knitting is less widespread than its application in other fields. However, it is important to determine whether knitted pattern classification using an automated system is viable. In order to recognise and classify knitting patterns. Using data augmentation and a transfer learning technique, this study proposes a deep learning model. The Inception ResNet-V2 is the main feature extraction and classification algorithm used in the model. Metrics like accuracy, logarithmic loss, F1-score, precision, and recall score were used to evaluate the model. The model evaluation's findings demonstrate high model accuracy, precision, recall, and F1 score. In addition, the AUC score for majority of the classes was in the range (0.7-0.9). A comparative analysis was done using other pretrained models and a ResNet-50 model with transfer learning and the proposed model evaluation results surpassed all others. The major limitation for this project is time, as with more time, there might have been better accuracy over a larger number of epochs.
In this paper, we consider the problem of discovering dynamical system models from noisy data. The presence of noise is known to be a significant problem for symbolic regression algorithms. We combine Gaussian process regression, a nonparametric learning method, with SINDy, a parametric learning approach, to identify nonlinear dynamical systems from data. The key advantages of our proposed approach are its simplicity coupled with the fact that it demonstrates improved robustness properties with noisy data over SINDy. We demonstrate our proposed approach on a Lotka-Volterra model and a unicycle dynamic model in simulation and on an NVIDIA JetRacer system using hardware data. We demonstrate improved performance over SINDy for discovering the system dynamics and predicting future trajectories.
In this paper, we introduce a new, spectral notion of approximation between directed graphs, which we call singular value (SV) approximation. SV-approximation is stronger than previous notions of spectral approximation considered in the literature, including spectral approximation of Laplacians for undirected graphs (Spielman Teng STOC 2004), standard approximation for directed graphs (Cohen et. al. STOC 2017), and unit-circle approximation for directed graphs (Ahmadinejad et. al. FOCS 2020). Further, SV approximation enjoys several useful properties not possessed by previous notions of approximation, e.g., it is preserved under products of random-walk matrices and bounded matrices. We provide a nearly linear-time algorithm for SV-sparsifying (and hence UC-sparsifying) Eulerian directed graphs, as well as $\ell$-step random walks on such graphs, for any $\ell\leq \text{poly}(n)$. Combined with the Eulerian scaling algorithms of (Cohen et. al. FOCS 2018), given an arbitrary (not necessarily Eulerian) directed graph and a set $S$ of vertices, we can approximate the stationary probability mass of the $(S,S^c)$ cut in an $\ell$-step random walk to within a multiplicative error of $1/\text{polylog}(n)$ and an additive error of $1/\text{poly}(n)$ in nearly linear time. As a starting point for these results, we provide a simple black-box reduction from SV-sparsifying Eulerian directed graphs to SV-sparsifying undirected graphs; such a directed-to-undirected reduction was not known for previous notions of spectral approximation.
Model complexity is a fundamental problem in deep learning. In this paper we conduct a systematic overview of the latest studies on model complexity in deep learning. Model complexity of deep learning can be categorized into expressive capacity and effective model complexity. We review the existing studies on those two categories along four important factors, including model framework, model size, optimization process and data complexity. We also discuss the applications of deep learning model complexity including understanding model generalization capability, model optimization, and model selection and design. We conclude by proposing several interesting future directions.
Textual entailment is a fundamental task in natural language processing. Most approaches for solving the problem use only the textual content present in training data. A few approaches have shown that information from external knowledge sources like knowledge graphs (KGs) can add value, in addition to the textual content, by providing background knowledge that may be critical for a task. However, the proposed models do not fully exploit the information in the usually large and noisy KGs, and it is not clear how it can be effectively encoded to be useful for entailment. We present an approach that complements text-based entailment models with information from KGs by (1) using Personalized PageR- ank to generate contextual subgraphs with reduced noise and (2) encoding these subgraphs using graph convolutional networks to capture KG structure. Our technique extends the capability of text models exploiting structural and semantic information found in KGs. We evaluate our approach on multiple textual entailment datasets and show that the use of external knowledge helps improve prediction accuracy. This is particularly evident in the challenging BreakingNLI dataset, where we see an absolute improvement of 5-20% over multiple text-based entailment models.
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