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Locally Decodable Codes (LDCs) are error-correcting codes $C:\Sigma^n\rightarrow \Sigma^m$ with super-fast decoding algorithms. They are important mathematical objects in many areas of theoretical computer science, yet the best constructions so far have codeword length $m$ that is super-polynomial in $n$, for codes with constant query complexity and constant alphabet size. In a very surprising result, Ben-Sasson et al. showed how to construct a relaxed version of LDCs (RLDCs) with constant query complexity and almost linear codeword length over the binary alphabet, and used them to obtain significantly-improved constructions of Probabilistically Checkable Proofs. In this work, we study RLDCs in the standard Hamming-error setting, and introduce their variants in the insertion and deletion (Insdel) error setting. Insdel LDCs were first studied by Ostrovsky and Paskin-Cherniavsky, and are further motivated by recent advances in DNA random access bio-technologies, in which the goal is to retrieve individual files from a DNA storage database. Our first result is an exponential lower bound on the length of Hamming RLDCs making 2 queries, over the binary alphabet. This answers a question explicitly raised by Gur and Lachish. Our result exhibits a "phase-transition"-type behavior on the codeword length for constant-query Hamming RLDCs. We further define two variants of RLDCs in the Insdel-error setting, a weak and a strong version. On the one hand, we construct weak Insdel RLDCs with with parameters matching those of the Hamming variants. On the other hand, we prove exponential lower bounds for strong Insdel RLDCs. These results demonstrate that, while these variants are equivalent in the Hamming setting, they are significantly different in the insdel setting. Our results also prove a strict separation between Hamming RLDCs and Insdel RLDCs.

We construct quantum algorithms to compute the solution and/or physical observables of nonlinear ordinary differential equations (ODEs) and nonlinear Hamilton-Jacobi equations (HJE) via linear representations or exact mappings between nonlinear ODEs/HJE and linear partial differential equations (the Liouville equation and the Koopman-von Neumann equation). The connection between the linear representations and the original nonlinear system is established through the Dirac delta function or the level set mechanism. We compare the quantum linear systems algorithms based methods and the quantum simulation methods arising from different numerical approximations, including the finite difference discretisations and the Fourier spectral discretisations for the two different linear representations, with the result showing that the quantum simulation methods usually give the best performance in time complexity. We also propose the Schr\"odinger framework to solve the Liouville equation for the HJE, since it can be recast as the semiclassical limit of the Wigner transform of the Schr\"odinger equation. Comparsion between the Schr\"odinger and the Liouville framework will also be made.

In data science, vector autoregression (VAR) models are popular in modeling multivariate time series in the environmental sciences and other applications. However, these models are computationally complex with the number of parameters scaling quadratically with the number of time series. In this work, we propose a so-called neighborhood vector autoregression (NVAR) model to efficiently analyze large-dimensional multivariate time series. We assume that the time series have underlying neighborhood relationships, e.g., spatial or network, among them based on the inherent setting of the problem. When this neighborhood information is available or can be summarized using a distance matrix, we demonstrate that our proposed NVAR method provides a computationally efficient and theoretically sound estimation of model parameters. The performance of the proposed method is compared with other existing approaches in both simulation studies and a real application of stream nitrogen study.

Motivated by increasing pressure for decision makers to shorten the time required to evaluate the efficacy of a treatment such that treatments deemed safe and effective can be made publicly available, there has been substantial recent interest in using an earlier or easier to measure surrogate marker, $S$, in place of the primary outcome, $Y$. To validate the utility of a surrogate marker in these settings, a commonly advocated measure is the proportion of treatment effect on the primary outcome that is explained by the treatment effect on the surrogate marker (PTE). Model based and model free estimators for PTE have also been developed. While this measure is very intuitive, it does not directly address the important questions of how $S$ can be used to make inference of the unavailable $Y$ in the next phase clinical trials. In this paper, to optimally use the information of surrogate S, we provide a framework for deriving an optimal transformation of $S$, $g_{opt}(S)$, such that the treatment effect on $g_{opt}(S)$ maximally approximates the treatment effect on $Y$ in a certain sense. Based on the optimally transformed surrogate, $g_{opt}(S)$, we propose a new measure to quantify surrogacy, the relative power (RP), and demonstrate how RP can be used to make decisions with $S$ instead of $Y$ for next phase trials. We propose nonparametric estimation procedures, derive asymptotic properties, and compare the RP measure with the PTE measure. Finite sample performance of our estimators is assessed via a simulation study. We illustrate our proposed procedures using an application to the Diabetes Prevention Program (DPP) clinical trial to evaluate the utility of hemoglobin A1c and fasting plasma glucose as surrogate markers for diabetes.

The continuous quadratures of a single mode of the light field present a promising avenue to encode quantum information. By virtue of the infinite dimensionality of the associated Hilbert space, quantum states of these continuous variables (CV) can enable higher communication rates compared to single photon-based qubit encodings. Quantum repeater protocols that are essential to extend the range of quantum communications at enhanced rates over direct transmission have also been recently proposed for CV quantum encodings. Here we present a quantum repeating switch for CV quantum encodings that caters to multiple communication flows. The architecture of the switch is based on quantum light sources, detectors, memories, and switching fabric, and the routing protocol is based on a Max-Weight scheduling policy that is throughput optimal. We present numerical results on an achievable bipartite entanglement request rate region for multiple CV entanglement flows that can be stably supported through the switch. We elucidate our results with the help of exemplary 3-flow networks.

Tanner codes are long error correcting codes obtained from short codes and a graph, with bits on the edges and parity-check constraints from the short codes enforced at the vertices of the graph. Combining good short codes together with a spectral expander graph yields the celebrated expander codes of Sipser and Spielman, which are asymptotically good classical LDPC codes. In this work we apply this prescription to the left-right Cayley complex that lies at the heart of the recent construction of a $c^3$ locally testable code by Dinur et al. Specifically, we view this complex as two graphs that share the same set of edges. By defining a Tanner code on each of those graphs we obtain two classical codes that together define a quantum code. This construction can be seen as a simplified variant of the Panteleev and Kalachev asymptotically good quantum LDPC code, with improved estimates for its minimum distance. This quantum code is closely related to the Dinur et al. code in more than one sense: indeed, we prove a theorem that simultaneously gives a linearly growing minimum distance for the quantum code and recovers the local testability of the Dinur et al. code.

Deep Reinforcement Learning (RL) has considerably advanced over the past decade. At the same time, state-of-the-art RL algorithms require a large computational budget in terms of training time to converge. Recent work has started to approach this problem through the lens of quantum computing, which promises theoretical speed-ups for several traditionally hard tasks. In this work, we examine a class of hybrid quantum-classical RL algorithms that we collectively refer to as variational quantum deep Q-networks (VQ-DQN). We show that VQ-DQN approaches are subject to instabilities that cause the learned policy to diverge, study the extent to which this afflicts reproduciblity of established results based on classical simulation, and perform systematic experiments to identify potential explanations for the observed instabilities. Additionally, and in contrast to most existing work on quantum reinforcement learning, we execute RL algorithms on an actual quantum processing unit (an IBM Quantum Device) and investigate differences in behaviour between simulated and physical quantum systems that suffer from implementation deficiencies. Our experiments show that, contrary to opposite claims in the literature, it cannot be conclusively decided if known quantum approaches, even if simulated without physical imperfections, can provide an advantage as compared to classical approaches. Finally, we provide a robust, universal and well-tested implementation of VQ-DQN as a reproducible testbed for future experiments.

We give an efficient algorithm that transforms any bounded degree expander graph into another that achieves almost optimal (namely, near-quadratic, $d \leq 1/\lambda^{2+o(1)}$) trade-off between (any desired) spectral expansion $\lambda$ and degree $d$. Furthermore, the algorithm is local: every vertex can compute its new neighbors as a subset of its original neighborhood of radius $O(\log(1/\lambda))$. The optimal quadratic trade-off is known as the Ramanujan bound, so our construction gives almost Ramanujan expanders from arbitrary expanders. The locality of the transformation preserves structural properties of the original graph, and thus has many consequences. Applied to Cayley graphs, our transformation shows that any expanding finite group has almost Ramanujan expanding generators. Similarly, one can obtain almost optimal explicit constructions of quantum expanders, dimension expanders, monotone expanders, etc., from existing (suboptimal) constructions of such objects. Another consequence is a "derandomized" random walk on the original (suboptimal) expander with almost optimal convergence rate. Our transformation also applies when the degree is not bounded or the expansion is not constant. We obtain our results by a generalization of Ta-Shma's technique in his breakthrough paper [STOC 2017], used to obtain explicit almost optimal binary codes. Specifically, our spectral amplification extends Ta-Shma's analysis of bias amplification from scalars to matrices of arbitrary dimension in a very natural way. Curiously, while Ta-Shma's explicit bias amplification derandomizes a well-known probabilistic argument (underlying the Gilbert--Varshamov bound), there seems to be no known probabilistic (or other existential) way of achieving our explicit ("high-dimensional") spectral amplification.

I survey, for a general scientific audience, three decades of research into which sorts of problems admit exponential speedups via quantum computers -- from the classics (like the algorithms of Simon and Shor), to the breakthrough of Yamakawa and Zhandry from April 2022. I discuss both the quantum circuit model, which is what we ultimately care about in practice but where our knowledge is radically incomplete, and the so-called oracle or black-box or query complexity model, where we've managed to achieve a much more thorough understanding that then informs our conjectures about the circuit model. I discuss the strengths and weaknesses of switching attention to sampling tasks, as was done in the recent quantum supremacy experiments. I make some skeptical remarks about widely-repeated claims of exponential quantum speedups for practical machine learning and optimization problems. Through many examples, I try to convey the "law of conservation of weirdness," according to which every problem admitting an exponential quantum speedup must have some unusual property to allow the amplitude to be concentrated on the unknown right answer(s).