Proteins, as essential biomolecules, play a central role in biological processes, including metabolic reactions and DNA replication. Accurate prediction of their properties and functions is crucial in biological applications. Recent development of protein language models (pLMs) with supervised fine tuning provides a promising solution to this problem. However, the fine-tuned model is tailored for particular downstream prediction task, and achieving general-purpose protein understanding remains a challenge. In this paper, we introduce Structure-Enhanced Protein Instruction Tuning (SEPIT) framework to bridge this gap. Our approach integrates a noval structure-aware module into pLMs to inform them with structural knowledge, and then connects these enhanced pLMs to large language models (LLMs) to generate understanding of proteins. In this framework, we propose a novel two-stage instruction tuning pipeline that first establishes a basic understanding of proteins through caption-based instructions and then refines this understanding using a mixture of experts (MoEs) to learn more complex properties and functional information with the same amount of activated parameters. Moreover, we construct the largest and most comprehensive protein instruction dataset to date, which allows us to train and evaluate the general-purpose protein understanding model. Extensive experimental results on open-ended generation and closed-set answer tasks demonstrate the superior performance of SEPIT over both closed-source general LLMs and open-source LLMs trained with protein knowledge.
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Recently, quadrupedal locomotion has achieved significant success, but their manipulation capabilities, particularly in handling large objects, remain limited, restricting their usefulness in demanding real-world applications such as search and rescue, construction, industrial automation, and room organization. This paper tackles the task of obstacle-aware, long-horizon pushing by multiple quadrupedal robots. We propose a hierarchical multi-agent reinforcement learning framework with three levels of control. The high-level controller integrates an RRT planner and a centralized adaptive policy to generate subgoals, while the mid-level controller uses a decentralized goal-conditioned policy to guide the robots toward these sub-goals. A pre-trained low-level locomotion policy executes the movement commands. We evaluate our method against several baselines in simulation, demonstrating significant improvements over baseline approaches, with 36.0% higher success rates and 24.5% reduction in completion time than the best baseline. Our framework successfully enables long-horizon, obstacle-aware manipulation tasks like Push-Cuboid and Push-T on Go1 robots in the real world.
The advent of AI-Generated Content (AIGC) has spurred research into automated video generation to streamline conventional processes. However, automating storytelling video production, particularly for customized narratives, remains challenging due to the complexity of maintaining subject consistency across shots. While existing approaches like Mora and AesopAgent integrate multiple agents for Story-to-Video (S2V) generation, they fall short in preserving protagonist consistency and supporting Customized Storytelling Video Generation (CSVG). To address these limitations, we propose StoryAgent, a multi-agent framework designed for CSVG. StoryAgent decomposes CSVG into distinct subtasks assigned to specialized agents, mirroring the professional production process. Notably, our framework includes agents for story design, storyboard generation, video creation, agent coordination, and result evaluation. Leveraging the strengths of different models, StoryAgent enhances control over the generation process, significantly improving character consistency. Specifically, we introduce a customized Image-to-Video (I2V) method, LoRA-BE, to enhance intra-shot temporal consistency, while a novel storyboard generation pipeline is proposed to maintain subject consistency across shots. Extensive experiments demonstrate the effectiveness of our approach in synthesizing highly consistent storytelling videos, outperforming state-of-the-art methods. Our contributions include the introduction of StoryAgent, a versatile framework for video generation tasks, and novel techniques for preserving protagonist consistency.
SaSR-Net: Source-Aware Semantic Representation Network for Enhancing Audio-Visual Question Answering
Audio-Visual Question Answering (AVQA) is a challenging task that involves answering questions based on both auditory and visual information in videos. A significant challenge is interpreting complex multi-modal scenes, which include both visual objects and sound sources, and connecting them to the given question. In this paper, we introduce the Source-aware Semantic Representation Network (SaSR-Net), a novel model designed for AVQA. SaSR-Net utilizes source-wise learnable tokens to efficiently capture and align audio-visual elements with the corresponding question. It streamlines the fusion of audio and visual information using spatial and temporal attention mechanisms to identify answers in multi-modal scenes. Extensive experiments on the Music-AVQA and AVQA-Yang datasets show that SaSR-Net outperforms state-of-the-art AVQA methods.
Recurrent Neural Networks (RNNs) are widely recognized for their proficiency in modeling temporal dependencies, making them highly prevalent in sequential data processing applications. Nevertheless, vanilla RNNs are confronted with the well-known issue of gradient vanishing and exploding, posing a significant challenge for learning and establishing long-range dependencies. Additionally, gated RNNs tend to be over-parameterized, resulting in poor computational efficiency and network generalization. To address these challenges, this paper proposes a novel Delayed Memory Unit (DMU). The DMU incorporates a delay line structure along with delay gates into vanilla RNN, thereby enhancing temporal interaction and facilitating temporal credit assignment. Specifically, the DMU is designed to directly distribute the input information to the optimal time instant in the future, rather than aggregating and redistributing it over time through intricate network dynamics. Our proposed DMU demonstrates superior temporal modeling capabilities across a broad range of sequential modeling tasks, utilizing considerably fewer parameters than other state-of-the-art gated RNN models in applications such as speech recognition, radar gesture recognition, ECG waveform segmentation, and permuted sequential image classification.
Existing regression models tend to fall short in both accuracy and uncertainty estimation when the label distribution is imbalanced. In this paper, we propose a probabilistic deep learning model, dubbed variational imbalanced regression (VIR), which not only performs well in imbalanced regression but naturally produces reasonable uncertainty estimation as a byproduct. Different from typical variational autoencoders assuming I.I.D. representations (a data point's representation is not directly affected by other data points), our VIR borrows data with similar regression labels to compute the latent representation's variational distribution; furthermore, different from deterministic regression models producing point estimates, VIR predicts the entire normal-inverse-gamma distributions and modulates the associated conjugate distributions to impose probabilistic reweighting on the imbalanced data, thereby providing better uncertainty estimation. Experiments in several real-world datasets show that our VIR can outperform state-of-the-art imbalanced regression models in terms of both accuracy and uncertainty estimation. Code will soon be available at //github.com/Wang-ML-Lab/variational-imbalanced-regression.
Regression discontinuity design (RDD) is widely adopted for causal inference under intervention determined by a continuous variable. While one is interested in treatment effect heterogeneity by subgroups in many applications, RDD typically suffers from small subgroup-wise sample sizes, which makes the estimation results highly instable. To solve this issue, we introduce hierarchical RDD (HRDD), a hierarchical Bayes approach for pursuing treatment effect heterogeneity in RDD. A key feature of HRDD is to employ a pseudo-model based on a loss function to estimate subgroup-level parameters of treatment effects under RDD, and assign a hierarchical prior distribution to ''borrow strength'' from other subgroups. The posterior computation can be easily done by a simple Gibbs sampling, and the optimal bandwidth can be automatically selected by the Hyv\"{a}rinen scores for unnormalized models. We demonstrate the proposed HRDD through simulation and real data analysis, and show that HRDD provides much more stable point and interval estimation than separately applying the standard RDD method to each subgroup.
Knowledge Graphs (KGs) play a pivotal role in advancing various AI applications, with the semantic web community's exploration into multi-modal dimensions unlocking new avenues for innovation. In this survey, we carefully review over 300 articles, focusing on KG-aware research in two principal aspects: KG-driven Multi-Modal (KG4MM) learning, where KGs support multi-modal tasks, and Multi-Modal Knowledge Graph (MM4KG), which extends KG studies into the MMKG realm. We begin by defining KGs and MMKGs, then explore their construction progress. Our review includes two primary task categories: KG-aware multi-modal learning tasks, such as Image Classification and Visual Question Answering, and intrinsic MMKG tasks like Multi-modal Knowledge Graph Completion and Entity Alignment, highlighting specific research trajectories. For most of these tasks, we provide definitions, evaluation benchmarks, and additionally outline essential insights for conducting relevant research. Finally, we discuss current challenges and identify emerging trends, such as progress in Large Language Modeling and Multi-modal Pre-training strategies. This survey aims to serve as a comprehensive reference for researchers already involved in or considering delving into KG and multi-modal learning research, offering insights into the evolving landscape of MMKG research and supporting future work.
Reasoning is a fundamental aspect of human intelligence that plays a crucial role in activities such as problem solving, decision making, and critical thinking. In recent years, large language models (LLMs) have made significant progress in natural language processing, and there is observation that these models may exhibit reasoning abilities when they are sufficiently large. However, it is not yet clear to what extent LLMs are capable of reasoning. This paper provides a comprehensive overview of the current state of knowledge on reasoning in LLMs, including techniques for improving and eliciting reasoning in these models, methods and benchmarks for evaluating reasoning abilities, findings and implications of previous research in this field, and suggestions on future directions. Our aim is to provide a detailed and up-to-date review of this topic and stimulate meaningful discussion and future work.
With the breakthrough of AlphaGo, deep reinforcement learning becomes a recognized technique for solving sequential decision-making problems. Despite its reputation, data inefficiency caused by its trial and error learning mechanism makes deep reinforcement learning hard to be practical in a wide range of areas. Plenty of methods have been developed for sample efficient deep reinforcement learning, such as environment modeling, experience transfer, and distributed modifications, amongst which, distributed deep reinforcement learning has shown its potential in various applications, such as human-computer gaming, and intelligent transportation. In this paper, we conclude the state of this exciting field, by comparing the classical distributed deep reinforcement learning methods, and studying important components to achieve efficient distributed learning, covering single player single agent distributed deep reinforcement learning to the most complex multiple players multiple agents distributed deep reinforcement learning. Furthermore, we review recently released toolboxes that help to realize distributed deep reinforcement learning without many modifications of their non-distributed versions. By analyzing their strengths and weaknesses, a multi-player multi-agent distributed deep reinforcement learning toolbox is developed and released, which is further validated on Wargame, a complex environment, showing usability of the proposed toolbox for multiple players and multiple agents distributed deep reinforcement learning under complex games. Finally, we try to point out challenges and future trends, hoping this brief review can provide a guide or a spark for researchers who are interested in distributed deep reinforcement learning.
Multi-relation Question Answering is a challenging task, due to the requirement of elaborated analysis on questions and reasoning over multiple fact triples in knowledge base. In this paper, we present a novel model called Interpretable Reasoning Network that employs an interpretable, hop-by-hop reasoning process for question answering. The model dynamically decides which part of an input question should be analyzed at each hop; predicts a relation that corresponds to the current parsed results; utilizes the predicted relation to update the question representation and the state of the reasoning process; and then drives the next-hop reasoning. Experiments show that our model yields state-of-the-art results on two datasets. More interestingly, the model can offer traceable and observable intermediate predictions for reasoning analysis and failure diagnosis, thereby allowing manual manipulation in predicting the final answer.
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