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Histo-genomic multi-modal methods have recently emerged as a powerful paradigm, demonstrating significant potential for improving cancer prognosis. However, genome sequencing, unlike histopathology imaging, is still not widely accessible in underdeveloped regions, limiting the application of these multi-modal approaches in clinical settings. To address this, we propose a novel Genome-informed Hyper-Attention Network, termed G-HANet, which is capable of effectively distilling the histo-genomic knowledge during training to elevate uni-modal whole slide image (WSI)-based inference for the first time. Compared with traditional knowledge distillation methods (i.e., teacher-student architecture) in other tasks, our end-to-end model is superior in terms of training efficiency and learning cross-modal interactions. Specifically, the network comprises the cross-modal associating branch (CAB) and hyper-attention survival branch (HSB). Through the genomic data reconstruction from WSIs, CAB effectively distills the associations between functional genotypes and morphological phenotypes and offers insights into the gene expression profiles in the feature space. Subsequently, HSB leverages the distilled histo-genomic associations as well as the generated morphology-based weights to achieve the hyper-attention modeling of the patients from both histopathology and genomic perspectives to improve cancer prognosis. Extensive experiments are conducted on five TCGA benchmarking datasets and the results demonstrate that G-HANet significantly outperforms the state-of-the-art WSI-based methods and achieves competitive performance with genome-based and multi-modal methods. G-HANet is expected to be explored as a useful tool by the research community to address the current bottleneck of insufficient histo-genomic data pairing in the context of cancer prognosis and precision oncology.

The ability to predict the future trajectories of traffic participants is crucial for the safe and efficient operation of autonomous vehicles. In this paper, a diffusion-based generative model for multi-agent trajectory prediction is proposed. The model is capable of capturing the complex interactions between traffic participants and the environment, accurately learning the multimodal nature of the data. The effectiveness of the approach is assessed on large-scale datasets of real-world traffic scenarios, showing that our model outperforms several well-established methods in terms of prediction accuracy. By the incorporation of differential motion constraints on the model output, we illustrate that our model is capable of generating a diverse set of realistic future trajectories. Through the use of an interaction-aware guidance signal, we further demonstrate that the model can be adapted to predict the behavior of less cooperative agents, emphasizing its practical applicability under uncertain traffic conditions.

Reentrancy vulnerability as one of the most notorious vulnerabilities, has been a prominent topic in smart contract security research. Research shows that existing vulnerability detection presents a range of challenges, especially as smart contracts continue to increase in complexity. Existing tools perform poorly in terms of efficiency and successful detection rates for vulnerabilities in complex contracts. To effectively detect reentrancy vulnerabilities in contracts with complex logic, we propose a tool named SliSE. SliSE's detection process consists of two stages: Warning Search and Symbolic Execution Verification. In Stage I, SliSE utilizes program slicing to analyze the Inter-contract Program Dependency Graph (I-PDG) of the contract, and collects suspicious vulnerability information as warnings. In Stage II, symbolic execution is employed to verify the reachability of these warnings, thereby enhancing vulnerability detection accuracy. SliSE obtained the best performance compared with eight state-of-the-art detection tools. It achieved an F1 score of 78.65%, surpassing the highest score recorded by an existing tool of 9.26%. Additionally, it attained a recall rate exceeding 90% for detection of contracts on Ethereum. Overall, SliSE provides a robust and efficient method for detection of Reentrancy vulnerabilities for complex contracts.

Kernel conditional mean embeddings (CMEs) offer a powerful framework for representing conditional distribution, but they often face scalability and expressiveness challenges. In this work, we propose a new method that effectively combines the strengths of deep learning with CMEs in order to address these challenges. Specifically, our approach leverages the end-to-end neural network (NN) optimization framework using a kernel-based objective. This design circumvents the computationally expensive Gram matrix inversion required by current CME methods. To further enhance performance, we provide efficient strategies to optimize the remaining kernel hyperparameters. In conditional density estimation tasks, our NN-CME hybrid achieves competitive performance and often surpasses existing deep learning-based methods. Lastly, we showcase its remarkable versatility by seamlessly integrating it into reinforcement learning (RL) contexts. Building on Q-learning, our approach naturally leads to a new variant of distributional RL methods, which demonstrates consistent effectiveness across different environments.

We introduce a new class of hardware trojans called interrupt-resilient trojans (IRTs). Our work is motivated by the observation that hardware trojan attacks on CPUs, even under favorable attack scenarios (e.g., an attacker with local system access), are affected by unpredictability due to non-deterministic context switching events. As we confirm experimentally, these events can lead to race conditions between trigger signals and the CPU events targeted by the trojan payloads (e.g., a CPU memory access), thus affecting the reliability of the attacks. Our work shows that interrupt-resilient trojans can successfully address the problem of non-deterministic triggering in CPUs, thereby providing high reliability guarantees in the implementation of sophisticated hardware trojan attacks. Specifically, we successfully utilize IRTs in different attack scenarios against a Linux-capable CPU design and showcase its resilience against context-switching events. More importantly, we show that our design allows for seamless integration during fabrication stage attacks.We evaluate different strategies for the implementation of our attacks on a tape-out ready high-speed RISC-V microarchitecture in a 28nm commercial technology process and successfully implement them with an average overhead delay of only 20 picoseconds, while leaving the sign-off characteristics of the layout intact. In doing so, we challenge the common wisdom regarding the low flexibility of late supply chain stages (e.g., fabrication) for the insertion of powerful trojans. To promote further research on microprocessor trojans, we open-source our designs and provide the accompanying supporting software logic.

The problem of distributed optimization requires a group of networked agents to compute a parameter that minimizes the average of their local cost functions. While there are a variety of distributed optimization algorithms that can solve this problem, they are typically vulnerable to "Byzantine" agents that do not follow the algorithm. Recent attempts to address this issue focus on single dimensional functions, or assume certain statistical properties of the functions at the agents. In this paper, we provide two resilient, scalable, distributed optimization algorithms for multi-dimensional functions. Our schemes involve two filters, (1) a distance-based filter and (2) a min-max filter, which each remove neighborhood states that are extreme (defined precisely in our algorithms) at each iteration. We show that these algorithms can mitigate the impact of up to $F$ (unknown) Byzantine agents in the neighborhood of each regular agent. In particular, we show that if the network topology satisfies certain conditions, all of the regular agents' states are guaranteed to converge to a bounded region that contains the minimizer of the average of the regular agents' functions.

Multi-objective optimization problems can be found in many real-world applications, where the objectives often conflict each other and cannot be optimized by a single solution. In the past few decades, numerous methods have been proposed to find Pareto solutions that represent different optimal trade-offs among the objectives for a given problem. However, these existing methods could have high computational complexity or may not have good theoretical properties for solving a general differentiable multi-objective optimization problem. In this work, by leveraging the smooth optimization technique, we propose a novel and lightweight smooth Tchebycheff scalarization approach for gradient-based multi-objective optimization. It has good theoretical properties for finding all Pareto solutions with valid trade-off preferences, while enjoying significantly lower computational complexity compared to other methods. Experimental results on various real-world application problems fully demonstrate the effectiveness of our proposed method.

Planning a public transit network is a challenging optimization problem, but essential in order to realize the benefits of autonomous buses. We propose a novel algorithm for planning networks of routes for autonomous buses. We first train a graph neural net model as a policy for constructing route networks, and then use the policy as one of several mutation operators in a evolutionary algorithm. We evaluate this algorithm on a standard set of benchmarks for transit network design, and find that it outperforms the learned policy alone by up to 20% and a plain evolutionary algorithm approach by up to 53% on realistic benchmark instances.

Microcanonical gradient descent is a sampling procedure for energy-based models allowing for efficient sampling of distributions in high dimension. It works by transporting samples from a high-entropy distribution, such as Gaussian white noise, to a low-energy region using gradient descent. We put this model in the framework of normalizing flows, showing how it can often overfit by losing an unnecessary amount of entropy in the descent. As a remedy, we propose a mean-field microcanonical gradient descent that samples several weakly coupled data points simultaneously, allowing for better control of the entropy loss while paying little in terms of likelihood fit. We study these models in the context of financial time series, illustrating the improvements on both synthetic and real data.

Knowledge graph embedding, which aims to represent entities and relations as low dimensional vectors (or matrices, tensors, etc.), has been shown to be a powerful technique for predicting missing links in knowledge graphs. Existing knowledge graph embedding models mainly focus on modeling relation patterns such as symmetry/antisymmetry, inversion, and composition. However, many existing approaches fail to model semantic hierarchies, which are common in real-world applications. To address this challenge, we propose a novel knowledge graph embedding model---namely, Hierarchy-Aware Knowledge Graph Embedding (HAKE)---which maps entities into the polar coordinate system. HAKE is inspired by the fact that concentric circles in the polar coordinate system can naturally reflect the hierarchy. Specifically, the radial coordinate aims to model entities at different levels of the hierarchy, and entities with smaller radii are expected to be at higher levels; the angular coordinate aims to distinguish entities at the same level of the hierarchy, and these entities are expected to have roughly the same radii but different angles. Experiments demonstrate that HAKE can effectively model the semantic hierarchies in knowledge graphs, and significantly outperforms existing state-of-the-art methods on benchmark datasets for the link prediction task.