Adaptive experiment is widely adopted to estimate conditional average treatment effect (CATE) in clinical trials and many other scenarios. While the primary goal in experiment is to maximize estimation accuracy, due to the imperative of social welfare, it's also crucial to provide treatment with superior outcomes to patients, which is measured by regret in contextual bandit framework. These two objectives often lead to contrast optimal allocation mechanism. Furthermore, privacy concerns arise in clinical scenarios containing sensitive data like patients health records. Therefore, it's essential for the treatment allocation mechanism to incorporate robust privacy protection measures. In this paper, we investigate the tradeoff between loss of social welfare and statistical power in contextual bandit experiment. We propose a matched upper and lower bound for the multi-objective optimization problem, and then adopt the concept of Pareto optimality to mathematically characterize the optimality condition. Furthermore, we propose differentially private algorithms which still matches the lower bound, showing that privacy is "almost free". Additionally, we derive the asymptotic normality of the estimator, which is essential in statistical inference and hypothesis testing.
Musculoskeletal diseases and cognitive impairments in patients lead to difficulties in movement as well as negative effects on their psychological health. Clinical gait analysis, a vital tool for early diagnosis and treatment, traditionally relies on expensive optical motion capture systems. Recent advances in computer vision and deep learning have opened the door to more accessible and cost-effective alternatives. This paper introduces a novel spatio-temporal Transformer network to estimate critical gait parameters from RGB videos captured by a single-view camera. Empirical evaluations on a public dataset of cerebral palsy patients indicate that the proposed framework surpasses current state-of-the-art approaches and show significant improvements in predicting general gait parameters (including Walking Speed, Gait Deviation Index - GDI, and Knee Flexion Angle at Maximum Extension), while utilizing fewer parameters and alleviating the need for manual feature extraction.
LLMs have demonstrated impressive performance in answering medical questions, such as passing scores on medical licensing examinations. However, medical board exam questions or general clinical questions do not capture the complexity of realistic clinical cases. Moreover, the lack of reference explanations means we cannot easily evaluate the reasoning of model decisions, a crucial component of supporting doctors in making complex medical decisions. To address these challenges, we construct two new datasets: JAMA Clinical Challenge and Medbullets. JAMA Clinical Challenge consists of questions based on challenging clinical cases, while Medbullets comprises USMLE Step 2&3 style clinical questions. Both datasets are structured as multiple-choice question-answering tasks, where each question is accompanied by an expert-written explanation. We evaluate four LLMs on the two datasets using various prompts. Experiments demonstrate that our datasets are harder than previous benchmarks. The inconsistency between automatic and human evaluations of model-generated explanations highlights the need to develop new metrics to support future research on explainable medical QA.
Several approaches have recently used automated techniques to generate architecture design alternatives by means of optimization techniques. These approaches aim at improving an initial architecture with respect to quality aspects, such as performance, reliability, or maintainability. In this context, each optimization experiment usually produces a different set of architecture alternatives that is characterized by specific settings. As a consequence, the designer is left with the task of comparing such sets to identify the settings that lead to better solution sets for the problem. To assess the quality of solution sets, multi-objective optimization commonly relies on quality indicators. Among these, the quality indicator for the maximum spread estimates the diversity of the generated alternatives, providing a measure of how much of the solution space has been explored. However, the maximum spread indicator is computed only on the objective space and does not consider architectural information (e.g., components structure, design decisions) from the architectural space. In this paper, we propose a quality indicator for the spread that assesses the diversity of alternatives by taking into account architectural features. To compute the spread, we rely on a notion of distance between alternatives according to the way they were generated during the optimization. We demonstrate how our architectural quality indicator can be applied to a dataset from the literature.
Knowledge distillation has emerged as a highly effective method for bridging the representation discrepancy between large-scale models and lightweight models. Prevalent approaches involve leveraging appropriate metrics to minimize the divergence or distance between the knowledge extracted from the teacher model and the knowledge learned by the student model. Centered Kernel Alignment (CKA) is widely used to measure representation similarity and has been applied in several knowledge distillation methods. However, these methods are complex and fail to uncover the essence of CKA, thus not answering the question of how to use CKA to achieve simple and effective distillation properly. This paper first provides a theoretical perspective to illustrate the effectiveness of CKA, which decouples CKA to the upper bound of Maximum Mean Discrepancy~(MMD) and a constant term. Drawing from this, we propose a novel Relation-Centered Kernel Alignment~(RCKA) framework, which practically establishes a connection between CKA and MMD. Furthermore, we dynamically customize the application of CKA based on the characteristics of each task, with less computational source yet comparable performance than the previous methods. The extensive experiments on the CIFAR-100, ImageNet-1k, and MS-COCO demonstrate that our method achieves state-of-the-art performance on almost all teacher-student pairs for image classification and object detection, validating the effectiveness of our approaches.
Vulnerability to adversarial attacks is one of the principal hurdles to the adoption of deep learning in safety-critical applications. Despite significant efforts, both practical and theoretical, training deep learning models robust to adversarial attacks is still an open problem. In this paper, we analyse the geometry of adversarial attacks in the large-data, overparameterized limit for Bayesian Neural Networks (BNNs). We show that, in the limit, vulnerability to gradient-based attacks arises as a result of degeneracy in the data distribution, i.e., when the data lies on a lower-dimensional submanifold of the ambient space. As a direct consequence, we demonstrate that in this limit BNN posteriors are robust to gradient-based adversarial attacks. Crucially, we prove that the expected gradient of the loss with respect to the BNN posterior distribution is vanishing, even when each neural network sampled from the posterior is vulnerable to gradient-based attacks. Experimental results on the MNIST, Fashion MNIST, and half moons datasets, representing the finite data regime, with BNNs trained with Hamiltonian Monte Carlo and Variational Inference, support this line of arguments, showing that BNNs can display both high accuracy on clean data and robustness to both gradient-based and gradient-free based adversarial attacks.
Adversarial examples in machine learning has emerged as a focal point of research due to their remarkable ability to deceive models with seemingly inconspicuous input perturbations, potentially resulting in severe consequences. In this study, we undertake a thorough investigation into the emergence of adversarial examples, a phenomenon that can, in principle, manifest in a wide range of machine learning models. Through our research, we unveil a new notion termed computational entanglement, with its ability to entangle distant features, display perfect correlations or anti-correlations regardless to their spatial separation, significantly contributes to the emergence of adversarial examples. We illustrate how computational entanglement aligns with relativistic effects such as time dilation and length contraction to feature pair, ultimately resulting in the convergence of their angle differences and distances towards zero, signifying perfect correlation, or towards maximum, indicating perfect anti-correlation.
Objective: For transradial amputees, robotic prosthetic hands promise to regain the capability to perform daily living activities. Current control methods based on physiological signals such as electromyography (EMG) are prone to yielding poor inference outcomes due to motion artifacts, muscle fatigue, and many more. Vision sensors are a major source of information about the environment state and can play a vital role in inferring feasible and intended gestures. However, visual evidence is also susceptible to its own artifacts, most often due to object occlusion, lighting changes, etc. Multimodal evidence fusion using physiological and vision sensor measurements is a natural approach due to the complementary strengths of these modalities. Methods: In this paper, we present a Bayesian evidence fusion framework for grasp intent inference using eye-view video, eye-gaze, and EMG from the forearm processed by neural network models. We analyze individual and fused performance as a function of time as the hand approaches the object to grasp it. For this purpose, we have also developed novel data processing and augmentation techniques to train neural network components. Results: Our results indicate that, on average, fusion improves the instantaneous upcoming grasp type classification accuracy while in the reaching phase by 13.66% and 14.8%, relative to EMG (81.64% non-fused) and visual evidence (80.5% non-fused) individually, resulting in an overall fusion accuracy of 95.3%. Conclusion: Our experimental data analyses demonstrate that EMG and visual evidence show complementary strengths, and as a consequence, fusion of multimodal evidence can outperform each individual evidence modality at any given time.
Understanding causality helps to structure interventions to achieve specific goals and enables predictions under interventions. With the growing importance of learning causal relationships, causal discovery tasks have transitioned from using traditional methods to infer potential causal structures from observational data to the field of pattern recognition involved in deep learning. The rapid accumulation of massive data promotes the emergence of causal search methods with brilliant scalability. Existing summaries of causal discovery methods mainly focus on traditional methods based on constraints, scores and FCMs, there is a lack of perfect sorting and elaboration for deep learning-based methods, also lacking some considers and exploration of causal discovery methods from the perspective of variable paradigms. Therefore, we divide the possible causal discovery tasks into three types according to the variable paradigm and give the definitions of the three tasks respectively, define and instantiate the relevant datasets for each task and the final causal model constructed at the same time, then reviews the main existing causal discovery methods for different tasks. Finally, we propose some roadmaps from different perspectives for the current research gaps in the field of causal discovery and point out future research directions.
When is heterogeneity in the composition of an autonomous robotic team beneficial and when is it detrimental? We investigate and answer this question in the context of a minimally viable model that examines the role of heterogeneous speeds in perimeter defense problems, where defenders share a total allocated speed budget. We consider two distinct problem settings and develop strategies based on dynamic programming and on local interaction rules. We present a theoretical analysis of both approaches and our results are extensively validated using simulations. Interestingly, our results demonstrate that the viability of heterogeneous teams depends on the amount of information available to the defenders. Moreover, our results suggest a universality property: across a wide range of problem parameters the optimal ratio of the speeds of the defenders remains nearly constant.
Due to their increasing spread, confidence in neural network predictions became more and more important. However, basic neural networks do not deliver certainty estimates or suffer from over or under confidence. Many researchers have been working on understanding and quantifying uncertainty in a neural network's prediction. As a result, different types and sources of uncertainty have been identified and a variety of approaches to measure and quantify uncertainty in neural networks have been proposed. This work gives a comprehensive overview of uncertainty estimation in neural networks, reviews recent advances in the field, highlights current challenges, and identifies potential research opportunities. It is intended to give anyone interested in uncertainty estimation in neural networks a broad overview and introduction, without presupposing prior knowledge in this field. A comprehensive introduction to the most crucial sources of uncertainty is given and their separation into reducible model uncertainty and not reducible data uncertainty is presented. The modeling of these uncertainties based on deterministic neural networks, Bayesian neural networks, ensemble of neural networks, and test-time data augmentation approaches is introduced and different branches of these fields as well as the latest developments are discussed. For a practical application, we discuss different measures of uncertainty, approaches for the calibration of neural networks and give an overview of existing baselines and implementations. Different examples from the wide spectrum of challenges in different fields give an idea of the needs and challenges regarding uncertainties in practical applications. Additionally, the practical limitations of current methods for mission- and safety-critical real world applications are discussed and an outlook on the next steps towards a broader usage of such methods is given.