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Early detection of melanoma, a potentially lethal type of skin cancer with high prevalence worldwide, improves patient prognosis. In retrospective studies, artificial intelligence (AI) has proven to be helpful for enhancing melanoma detection. However, there are few prospective studies confirming these promising results. Existing studies are limited by low sample sizes, too homogenous datasets, or lack of inclusion of rare melanoma subtypes, preventing a fair and thorough evaluation of AI and its generalizability, a crucial aspect for its application in the clinical setting. Therefore, we assessed 'All Data are Ext' (ADAE), an established open-source ensemble algorithm for detecting melanomas, by comparing its diagnostic accuracy to that of dermatologists on a prospectively collected, external, heterogeneous test set comprising eight distinct hospitals, four different camera setups, rare melanoma subtypes, and special anatomical sites. We advanced the algorithm with real test-time augmentation (R-TTA, i.e. providing real photographs of lesions taken from multiple angles and averaging the predictions), and evaluated its generalization capabilities. Overall, the AI showed higher balanced accuracy than dermatologists (0.798, 95% confidence interval (CI) 0.779-0.814 vs. 0.781, 95% CI 0.760-0.802; p<0.001), obtaining a higher sensitivity (0.921, 95% CI 0.900- 0.942 vs. 0.734, 95% CI 0.701-0.770; p<0.001) at the cost of a lower specificity (0.673, 95% CI 0.641-0.702 vs. 0.828, 95% CI 0.804-0.852; p<0.001). As the algorithm exhibited a significant performance advantage on our heterogeneous dataset exclusively comprising melanoma-suspicious lesions, AI may offer the potential to support dermatologists particularly in diagnosing challenging cases.

With the emergence and spread of infectious diseases with pandemic potential, such as COVID- 19, the urgency for vaccine development have led to unprecedented compressed and accelerated schedules that shortened the standard development timeline. In a relatively short time, the leading pharmaceutical companies1, received an Emergency Use Authorization (EUA) for vaccine\prime s en-mass deployment To monitor the potential side effect(s) of the vaccine during the (initial) vaccination campaign, we developed an optimal sequential test that allows for the early detection of potential side effect(s). This test employs a rule to stop the vaccination process once the observed number of side effect incidents exceeds a certain (pre-determined) threshold. The optimality of the proposed sequential test is justified when compared with the ({\alpha}, {\beta}) optimality of the non-randomized fixed-sample Uniformly Most Powerful (UMP) test. In the case of a single side effect, we study the properties of the sequential test and derive the exact expressions of the Average Sample Number (ASN) curve of the stopping time (and its variance) via the regularized incomplete beta function. Additionally, we derive the asymptotic distribution of the relative savings in ASN as compared to maximal sample size. Moreover, we construct the post-test parameter estimate and studied its sampling properties, including its asymptotic behavior under local-type alternatives. These limiting behavior results are the consistency and asymptotic normality of the post-test parameter estimator. We conclude the paper with a small simulation study illustrating the asymptotic performance of the point and interval estimation and provide a detailed example, based on COVID-19 side effect data (see Beatty et al. (2021)) of our suggested testing procedure.

Recent medical image reconstruction techniques focus on generating high-quality medical images suitable for clinical use at the lowest possible cost and with the fewest possible adverse effects on patients. Recent works have shown significant promise for reconstructing MR images from sparsely sampled k-space data using deep learning. In this work, we propose a technique that rapidly estimates deep neural networks directly at reconstruction time by fitting them on small adaptively estimated neighborhoods of a training set. In brief, our algorithm alternates between searching for neighbors in a data set that are similar to the test reconstruction, and training a local network on these neighbors followed by updating the test reconstruction. Because our reconstruction model is learned on a dataset that is in some sense similar to the image being reconstructed rather than being fit on a large, diverse training set, it is more adaptive to new scans. It can also handle changes in training sets and flexible scan settings, while being relatively fast. Our approach, dubbed LONDN-MRI, was validated on multiple data sets using deep unrolled reconstruction networks. Reconstructions were performed at four fold and eight fold undersampling of k-space with 1D variable-density random phase-encode undersampling masks. Our results demonstrate that our proposed locally-trained method produces higher-quality reconstructions compared to models trained globally on larger datasets as well as other scan-adaptive methods.

Electrophysiological nature of neuronal networks allows to reveal various interactions between different cell units at a very short time-scales. One of the many challenges in analyzing these signals is to retrieve the morphology and functionality of a given network. In this work we developed a computational model, based on Reservoir Computing Network (RCN) architecture, which decodes the spatio-temporal data from electro-physiological measurements of neuronal cultures and reconstructs the network structure on a macroscopic domain, representing the connectivity between neuronal units. We demonstrate that the model can predict the connectivity map of the network with higher accuracy than the common methods such as Cross-Correlation and Transfer-Entropy. In addition, we experimentally demonstrate the ability of the model to predict a network response to a specific input, such as localized stimulus.

In this study, we investigated the potential of GPT-3 for the anti-cancer drug sensitivity prediction task using structured pharmacogenomics data across five tissue types and evaluated its performance with zero-shot prompting and fine-tuning paradigms. The drug's smile representation and cell line's genomic mutation features were predictive of the drug response. The results from this study have the potential to pave the way for designing more efficient treatment protocols in precision oncology.

Image segmentation in total knee arthroplasty is crucial for precise preoperative planning and accurate implant positioning, leading to improved surgical outcomes and patient satisfaction. The biggest challenges of image segmentation in total knee arthroplasty include accurately delineating complex anatomical structures, dealing with image artifacts and noise, and developing robust algorithms that can handle anatomical variations and pathologies commonly encountered in patients. The potential of using machine learning for image segmentation in total knee arthroplasty lies in its ability to improve segmentation accuracy, automate the process, and provide real-time assistance to surgeons, leading to enhanced surgical planning, implant placement, and patient outcomes. This paper proposes a methodology to use deep learning for robust and real-time total knee arthroplasty image segmentation. The deep learning model, trained on a large dataset, demonstrates outstanding performance in accurately segmenting both the implanted femur and tibia, achieving an impressive mean-Average-Precision (mAP) of 88.83 when compared to the ground truth while also achieving a real-time segmented speed of 20 frames per second (fps). We have introduced a novel methodology for segmenting implanted knee fluoroscopic or x-ray images that showcases remarkable levels of accuracy and speed, paving the way for various potential extended applications.

Accurate segmentation of polyps from colonoscopy videos is of great significance to polyp treatment and early prevention of colorectal cancer. However, it is challenging due to the difficulties associated with modelling long-range spatio-temporal relationships within a colonoscopy video. In this paper, we address this challenging task with a novel Mixture-Attention Siamese Transformer (MAST), which explicitly models the long-range spatio-temporal relationships with a mixture-attention mechanism for accurate polyp segmentation. Specifically, we first construct a Siamese transformer architecture to jointly encode paired video frames for their feature representations. We then design a mixture-attention module to exploit the intra-frame and inter-frame correlations, enhancing the features with rich spatio-temporal relationships. Finally, the enhanced features are fed to two parallel decoders for predicting the segmentation maps. To the best of our knowledge, our MAST is the first transformer model dedicated to video polyp segmentation. Extensive experiments on the large-scale SUN-SEG benchmark demonstrate the superior performance of MAST in comparison with the cutting-edge competitors. Our code is publicly available at //github.com/Junqing-Yang/MAST.

Traditional ear disease diagnosis heavily depends on experienced specialists and specialized equipment, frequently resulting in misdiagnoses, treatment delays, and financial burdens for some patients. Utilizing deep learning models for efficient ear disease diagnosis has proven effective and affordable. However, existing research overlooked model inference speed and parameter size required for deployment. To tackle these challenges, we constructed a large-scale dataset comprising eight ear disease categories and normal ear canal samples from two hospitals. Inspired by ShuffleNetV2, we developed Best-EarNet, an ultrafast and ultralight network enabling real-time ear disease diagnosis. Best-EarNet incorporates the novel Local-Global Spatial Feature Fusion Module which can capture global and local spatial information simultaneously and guide the network to focus on crucial regions within feature maps at various levels, mitigating low accuracy issues. Moreover, our network uses multiple auxiliary classification heads for efficient parameter optimization. With 0.77M parameters, Best-EarNet achieves an average frames per second of 80 on CPU. Employing transfer learning and five-fold cross-validation with 22,581 images from Hospital-1, the model achieves an impressive 95.23% accuracy. External testing on 1,652 images from Hospital-2 validates its performance, yielding 92.14% accuracy. Compared to state-of-the-art networks, Best-EarNet establishes a new state-of-the-art (SOTA) in practical applications. Most importantly, we developed an intelligent diagnosis system called Ear Keeper, which can be deployed on common electronic devices. By manipulating a compact electronic otoscope, users can perform comprehensive scanning and diagnosis of the ear canal using real-time video. This study provides a novel paradigm for ear endoscopy and other medical endoscopic image recognition applications.

Understanding causality helps to structure interventions to achieve specific goals and enables predictions under interventions. With the growing importance of learning causal relationships, causal discovery tasks have transitioned from using traditional methods to infer potential causal structures from observational data to the field of pattern recognition involved in deep learning. The rapid accumulation of massive data promotes the emergence of causal search methods with brilliant scalability. Existing summaries of causal discovery methods mainly focus on traditional methods based on constraints, scores and FCMs, there is a lack of perfect sorting and elaboration for deep learning-based methods, also lacking some considers and exploration of causal discovery methods from the perspective of variable paradigms. Therefore, we divide the possible causal discovery tasks into three types according to the variable paradigm and give the definitions of the three tasks respectively, define and instantiate the relevant datasets for each task and the final causal model constructed at the same time, then reviews the main existing causal discovery methods for different tasks. Finally, we propose some roadmaps from different perspectives for the current research gaps in the field of causal discovery and point out future research directions.

We propose a novel attention gate (AG) model for medical imaging that automatically learns to focus on target structures of varying shapes and sizes. Models trained with AGs implicitly learn to suppress irrelevant regions in an input image while highlighting salient features useful for a specific task. This enables us to eliminate the necessity of using explicit external tissue/organ localisation modules of cascaded convolutional neural networks (CNNs). AGs can be easily integrated into standard CNN architectures such as the U-Net model with minimal computational overhead while increasing the model sensitivity and prediction accuracy. The proposed Attention U-Net architecture is evaluated on two large CT abdominal datasets for multi-class image segmentation. Experimental results show that AGs consistently improve the prediction performance of U-Net across different datasets and training sizes while preserving computational efficiency. The code for the proposed architecture is publicly available.