Machine Learning (ML) has recently shown tremendous success in modeling various healthcare prediction tasks, ranging from disease diagnosis and prognosis to patient treatment. Due to the sensitive nature of medical data, privacy must be considered along the entire ML pipeline, from model training to inference. In this paper, we conduct a review of recent literature concerning Privacy-Preserving Machine Learning (PPML) for healthcare. We primarily focus on privacy-preserving training and inference-as-a-service, and perform a comprehensive review of existing trends, identify challenges, and discuss opportunities for future research directions. The aim of this review is to guide the development of private and efficient ML models in healthcare, with the prospects of translating research efforts into real-world settings.
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A number of deep models trained on high-quality and valuable images have been deployed in practical applications, which may pose a leakage risk of data privacy. Learning differentially private generative models can sidestep this challenge through indirect data access. However, such differentially private generative models learned by existing approaches can only generate images with a low-resolution of less than 128x128, hindering the widespread usage of generated images in downstream training. In this work, we propose learning differentially private probabilistic models (DPPM) to generate high-resolution images with differential privacy guarantee. In particular, we first train a model to fit the distribution of the training data and make it satisfy differential privacy by performing a randomized response mechanism during training process. Then we perform Hamiltonian dynamics sampling along with the differentially private movement direction predicted by the trained probabilistic model to obtain the privacy-preserving images. In this way, it is possible to apply these images to different downstream tasks while protecting private information. Notably, compared to other state-of-the-art differentially private generative approaches, our approach can generate images up to 256x256 with remarkable visual quality and data utility. Extensive experiments show the effectiveness of our approach.
In manufacturing settings, data collection and analysis are often a time-consuming, challenging, and costly process. It also hinders the use of advanced machine learning and data-driven methods which require a substantial amount of offline training data to generate good results. It is particularly challenging for small manufacturers who do not share the resources of a large enterprise. Recently, with the introduction of the Internet of Things (IoT), data can be collected in an integrated manner across the factory in real-time, sent to the cloud for advanced analysis, and used to update the machine learning model sequentially. Nevertheless, small manufacturers face two obstacles in reaping the benefits of IoT: they may be unable to afford or generate enough data to operate a private cloud, and they may be hesitant to share their raw data with a public cloud. Federated learning (FL) is an emerging concept of collaborative learning that can help small-scale industries address these issues and learn from each other without sacrificing their privacy. It can bring together diverse and geographically dispersed manufacturers under the same analytics umbrella to create a win-win situation. However, the widespread adoption of FL across multiple manufacturing organizations remains a significant challenge. This study aims to review the challenges and future directions of applying federated learning in the manufacturing industry, with a specific emphasis on the perspectives of Industry 4.0 and 5.0.
The advancement of Internet and Communication Technologies (ICTs) has led to the era of Industry 4.0. This shift is followed by healthcare industries creating the term Healthcare 4.0. In Healthcare 4.0, the use of IoT-enabled medical imaging devices for early disease detection has enabled medical practitioners to increase healthcare institutions' quality of service. However, Healthcare 4.0 is still lagging in Artificial Intelligence and big data compared to other Industry 4.0 due to data privacy concerns. In addition, institutions' diverse storage and computing capabilities restrict institutions from incorporating the same training model structure. This paper presents a secure multi-party computation-based ensemble federated learning with blockchain that enables heterogeneous models to collaboratively learn from healthcare institutions' data without violating users' privacy. Blockchain properties also allow the party to enjoy data integrity without trust in a centralized server while also providing each healthcare institution with auditability and version control capability.
By interacting, synchronizing, and cooperating with its physical counterpart in real time, digital twin is promised to promote an intelligent, predictive, and optimized modern city. Via interconnecting massive physical entities and their virtual twins with inter-twin and intra-twin communications, the Internet of digital twins (IoDT) enables free data exchange, dynamic mission cooperation, and efficient information aggregation for composite insights across vast physical/virtual entities. However, as IoDT incorporates various cutting-edge technologies to spawn the new ecology, severe known/unknown security flaws and privacy invasions of IoDT hinders its wide deployment. Besides, the intrinsic characteristics of IoDT such as \emph{decentralized structure}, \emph{information-centric routing} and \emph{semantic communications} entail critical challenges for security service provisioning in IoDT. To this end, this paper presents an in-depth review of the IoDT with respect to system architecture, enabling technologies, and security/privacy issues. Specifically, we first explore a novel distributed IoDT architecture with cyber-physical interactions and discuss its key characteristics and communication modes. Afterward, we investigate the taxonomy of security and privacy threats in IoDT, discuss the key research challenges, and review the state-of-the-art defense approaches. Finally, we point out the new trends and open research directions related to IoDT.
Multimodal machine learning is a vibrant multi-disciplinary research field that aims to design computer agents with intelligent capabilities such as understanding, reasoning, and learning through integrating multiple communicative modalities, including linguistic, acoustic, visual, tactile, and physiological messages. With the recent interest in video understanding, embodied autonomous agents, text-to-image generation, and multisensor fusion in application domains such as healthcare and robotics, multimodal machine learning has brought unique computational and theoretical challenges to the machine learning community given the heterogeneity of data sources and the interconnections often found between modalities. However, the breadth of progress in multimodal research has made it difficult to identify the common themes and open questions in the field. By synthesizing a broad range of application domains and theoretical frameworks from both historical and recent perspectives, this paper is designed to provide an overview of the computational and theoretical foundations of multimodal machine learning. We start by defining two key principles of modality heterogeneity and interconnections that have driven subsequent innovations, and propose a taxonomy of 6 core technical challenges: representation, alignment, reasoning, generation, transference, and quantification covering historical and recent trends. Recent technical achievements will be presented through the lens of this taxonomy, allowing researchers to understand the similarities and differences across new approaches. We end by motivating several open problems for future research as identified by our taxonomy.
Causal Machine Learning (CausalML) is an umbrella term for machine learning methods that formalize the data-generation process as a structural causal model (SCM). This allows one to reason about the effects of changes to this process (i.e., interventions) and what would have happened in hindsight (i.e., counterfactuals). We categorize work in \causalml into five groups according to the problems they tackle: (1) causal supervised learning, (2) causal generative modeling, (3) causal explanations, (4) causal fairness, (5) causal reinforcement learning. For each category, we systematically compare its methods and point out open problems. Further, we review modality-specific applications in computer vision, natural language processing, and graph representation learning. Finally, we provide an overview of causal benchmarks and a critical discussion of the state of this nascent field, including recommendations for future work.
Few-shot learning (FSL) has emerged as an effective learning method and shows great potential. Despite the recent creative works in tackling FSL tasks, learning valid information rapidly from just a few or even zero samples still remains a serious challenge. In this context, we extensively investigated 200+ latest papers on FSL published in the past three years, aiming to present a timely and comprehensive overview of the most recent advances in FSL along with impartial comparisons of the strengths and weaknesses of the existing works. For the sake of avoiding conceptual confusion, we first elaborate and compare a set of similar concepts including few-shot learning, transfer learning, and meta-learning. Furthermore, we propose a novel taxonomy to classify the existing work according to the level of abstraction of knowledge in accordance with the challenges of FSL. To enrich this survey, in each subsection we provide in-depth analysis and insightful discussion about recent advances on these topics. Moreover, taking computer vision as an example, we highlight the important application of FSL, covering various research hotspots. Finally, we conclude the survey with unique insights into the technology evolution trends together with potential future research opportunities in the hope of providing guidance to follow-up research.
Federated learning (FL) has been developed as a promising framework to leverage the resources of edge devices, enhance customers' privacy, comply with regulations, and reduce development costs. Although many methods and applications have been developed for FL, several critical challenges for practical FL systems remain unaddressed. This paper provides an outlook on FL development, categorized into five emerging directions of FL, namely algorithm foundation, personalization, hardware and security constraints, lifelong learning, and nonstandard data. Our unique perspectives are backed by practical observations from large-scale federated systems for edge devices.
With the advances of data-driven machine learning research, a wide variety of prediction problems have been tackled. It has become critical to explore how machine learning and specifically deep learning methods can be exploited to analyse healthcare data. A major limitation of existing methods has been the focus on grid-like data; however, the structure of physiological recordings are often irregular and unordered which makes it difficult to conceptualise them as a matrix. As such, graph neural networks have attracted significant attention by exploiting implicit information that resides in a biological system, with interactive nodes connected by edges whose weights can be either temporal associations or anatomical junctions. In this survey, we thoroughly review the different types of graph architectures and their applications in healthcare. We provide an overview of these methods in a systematic manner, organized by their domain of application including functional connectivity, anatomical structure and electrical-based analysis. We also outline the limitations of existing techniques and discuss potential directions for future research.
As data are increasingly being stored in different silos and societies becoming more aware of data privacy issues, the traditional centralized training of artificial intelligence (AI) models is facing efficiency and privacy challenges. Recently, federated learning (FL) has emerged as an alternative solution and continue to thrive in this new reality. Existing FL protocol design has been shown to be vulnerable to adversaries within or outside of the system, compromising data privacy and system robustness. Besides training powerful global models, it is of paramount importance to design FL systems that have privacy guarantees and are resistant to different types of adversaries. In this paper, we conduct the first comprehensive survey on this topic. Through a concise introduction to the concept of FL, and a unique taxonomy covering: 1) threat models; 2) poisoning attacks and defenses against robustness; 3) inference attacks and defenses against privacy, we provide an accessible review of this important topic. We highlight the intuitions, key techniques as well as fundamental assumptions adopted by various attacks and defenses. Finally, we discuss promising future research directions towards robust and privacy-preserving federated learning.
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