The process of matching patients with suitable clinical trials is essential for advancing medical research and providing optimal care. However, current approaches face challenges such as data standardization, ethical considerations, and a lack of interoperability between Electronic Health Records (EHRs) and clinical trial criteria. In this paper, we explore the potential of large language models (LLMs) to address these challenges by leveraging their advanced natural language generation capabilities to improve compatibility between EHRs and clinical trial descriptions. We propose an innovative privacy-aware data augmentation approach for LLM-based patient-trial matching (LLM-PTM), which balances the benefits of LLMs while ensuring the security and confidentiality of sensitive patient data. Our experiments demonstrate a 7.32% average improvement in performance using the proposed LLM-PTM method, and the generalizability to new data is improved by 12.12%. Additionally, we present case studies to further illustrate the effectiveness of our approach and provide a deeper understanding of its underlying principles.
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Machine learning models have become increasingly popular for predicting the results of soccer matches, however, the lack of publicly-available benchmark datasets has made model evaluation challenging. The 2023 Soccer Prediction Challenge required the prediction of match results first in terms of the exact goals scored by each team, and second, in terms of the probabilities for a win, draw, and loss. The original training set of matches and features, which was provided for the competition, was augmented with additional matches that were played between 4 April and 13 April 2023, representing the period after which the training set ended, but prior to the first matches that were to be predicted (upon which the performance was evaluated). A CatBoost model was employed using pi-ratings as the features, which were initially identified as the optimal choice for calculating the win/draw/loss probabilities. Notably, deep learning models have frequently been disregarded in this particular task. Therefore, in this study, we aimed to assess the performance of a deep learning model and determine the optimal feature set for a gradient-boosted tree model. The model was trained using the most recent five years of data, and three training and validation sets were used in a hyperparameter grid search. The results from the validation sets show that our model had strong performance and stability compared to previously published models from the 2017 Soccer Prediction Challenge for win/draw/loss prediction.
Understanding the fundamental principles behind the success of deep neural networks is one of the most important open questions in the current literature. To this end, we study the training problem of deep neural networks and introduce an analytic approach to unveil hidden convexity in the optimization landscape. We consider a deep parallel ReLU network architecture, which also includes standard deep networks and ResNets as its special cases. We then show that pathwise regularized training problems can be represented as an exact convex optimization problem. We further prove that the equivalent convex problem is regularized via a group sparsity inducing norm. Thus, a path regularized parallel ReLU network can be viewed as a parsimonious convex model in high dimensions. More importantly, since the original training problem may not be trainable in polynomial-time, we propose an approximate algorithm with a fully polynomial-time complexity in all data dimensions. Then, we prove strong global optimality guarantees for this algorithm. We also provide experiments corroborating our theory.
This study explores the problem solving capabilities of ChatGPT and its prospective applications in standardized test preparation, focusing on the GRE quantitative exam. Prior research has shown great potential for the utilization of ChatGPT for academic purposes in revolutionizing the approach to studying across various disciplines. We investigate how ChatGPT performs across various question types in the GRE quantitative domain, and how modifying question prompts impacts its accuracy. More specifically this study addressed two research questions: 1. How does ChatGPT perform in answering GRE-based quantitative questions across various content areas? 2. How does the accuracy of ChatGPT vary with modifying the question prompts? The dataset consisting of 100 randomly selected GRE quantitative questions was collected from the ETS official guide to GRE test preparation. We used quantitative evaluation to answer our first research question, and t-test to examine the statistical association between prompt modification and ChatGPT's accuracy. Results show a statistical improvement in the ChatGPT's accuracy after applying instruction priming and contextual prompts to the original questions. ChatGPT showed 84% accuracy with the modified prompts compared to 69% with the original data. The study discusses the areas where ChatGPT struggled with certain questions and how modifications can be helpful for preparing for standardized tests like GRE and provides future directions for prompt modifications.
The theory underlying robust distributed learning algorithms, designed to resist adversarial machines, matches empirical observations when data is homogeneous. Under data heterogeneity however, which is the norm in practical scenarios, established lower bounds on the learning error are essentially vacuous and greatly mismatch empirical observations. This is because the heterogeneity model considered is too restrictive and does not cover basic learning tasks such as least-squares regression. We consider in this paper a more realistic heterogeneity model, namely (G,B)-gradient dissimilarity, and show that it covers a larger class of learning problems than existing theory. Notably, we show that the breakdown point under heterogeneity is lower than the classical fraction 1/2. We also prove a new lower bound on the learning error of any distributed learning algorithm. We derive a matching upper bound for a robust variant of distributed gradient descent, and empirically show that our analysis reduces the gap between theory and practice.
Quantifying the heterogeneity of treatment effect is important for understanding how a commercial product or medical treatment affects different subgroups in a population. Beyond the overall impact reflected parameters like the average treatment effect, the analysis of treatment effect heterogeneity further reveals details on the importance of different covariates and how they lead to different treatment impacts. One relevant parameter that addresses such heterogeneity is the variance of treatment effect across different covariate groups, however the treatment effect is defined. One can also derive variable importance parameters that measure (and rank) how much of treatment effect heterogeneity is explained by a targeted subset of covariates. In this article, we propose a new targeted maximum likelihood estimator for a treatment effect variable importance measure. This estimator is a pure plug-in estimator that consists of two steps: 1) the initial estimation of relevant components to plug in and 2) an iterative updating step to optimize the bias-variance tradeoff. The simulation results show that this TMLE estimator has competitive performance in terms of lower bias and better confidence interval coverage compared to the simple substitution estimator and the estimating equation estimator. The application of this method also demonstrates the advantage of a substitution estimator, which always respects the global constraints on the data distribution and that the estimand is a particular function of the distribution.
Semantic reasoning and dynamic planning capabilities are crucial for an autonomous agent to perform complex navigation tasks in unknown environments. It requires a large amount of common-sense knowledge, that humans possess, to succeed in these tasks. We present SayNav, a new approach that leverages human knowledge from Large Language Models (LLMs) for efficient generalization to complex navigation tasks in unknown large-scale environments. SayNav uses a novel grounding mechanism, that incrementally builds a 3D scene graph of the explored environment as inputs to LLMs, for generating feasible and contextually appropriate high-level plans for navigation. The LLM-generated plan is then executed by a pre-trained low-level planner, that treats each planned step as a short-distance point-goal navigation sub-task. SayNav dynamically generates step-by-step instructions during navigation and continuously refines future steps based on newly perceived information. We evaluate SayNav on a new multi-object navigation task, that requires the agent to utilize a massive amount of human knowledge to efficiently search multiple different objects in an unknown environment. SayNav outperforms an oracle based Point-nav baseline, achieving a success rate of 95.35% (vs 56.06% for the baseline), under the ideal settings on this task, highlighting its ability to generate dynamic plans for successfully locating objects in large-scale new environments. In addition, SayNav also enables efficient generalization of learning to navigate from simulation to real novel environments.
Time series anomaly detection has applications in a wide range of research fields and applications, including manufacturing and healthcare. The presence of anomalies can indicate novel or unexpected events, such as production faults, system defects, or heart fluttering, and is therefore of particular interest. The large size and complex patterns of time series have led researchers to develop specialised deep learning models for detecting anomalous patterns. This survey focuses on providing structured and comprehensive state-of-the-art time series anomaly detection models through the use of deep learning. It providing a taxonomy based on the factors that divide anomaly detection models into different categories. Aside from describing the basic anomaly detection technique for each category, the advantages and limitations are also discussed. Furthermore, this study includes examples of deep anomaly detection in time series across various application domains in recent years. It finally summarises open issues in research and challenges faced while adopting deep anomaly detection models.
Face recognition technology has advanced significantly in recent years due largely to the availability of large and increasingly complex training datasets for use in deep learning models. These datasets, however, typically comprise images scraped from news sites or social media platforms and, therefore, have limited utility in more advanced security, forensics, and military applications. These applications require lower resolution, longer ranges, and elevated viewpoints. To meet these critical needs, we collected and curated the first and second subsets of a large multi-modal biometric dataset designed for use in the research and development (R&D) of biometric recognition technologies under extremely challenging conditions. Thus far, the dataset includes more than 350,000 still images and over 1,300 hours of video footage of approximately 1,000 subjects. To collect this data, we used Nikon DSLR cameras, a variety of commercial surveillance cameras, specialized long-rage R&D cameras, and Group 1 and Group 2 UAV platforms. The goal is to support the development of algorithms capable of accurately recognizing people at ranges up to 1,000 m and from high angles of elevation. These advances will include improvements to the state of the art in face recognition and will support new research in the area of whole-body recognition using methods based on gait and anthropometry. This paper describes methods used to collect and curate the dataset, and the dataset's characteristics at the current stage.
The existence of representative datasets is a prerequisite of many successful artificial intelligence and machine learning models. However, the subsequent application of these models often involves scenarios that are inadequately represented in the data used for training. The reasons for this are manifold and range from time and cost constraints to ethical considerations. As a consequence, the reliable use of these models, especially in safety-critical applications, is a huge challenge. Leveraging additional, already existing sources of knowledge is key to overcome the limitations of purely data-driven approaches, and eventually to increase the generalization capability of these models. Furthermore, predictions that conform with knowledge are crucial for making trustworthy and safe decisions even in underrepresented scenarios. This work provides an overview of existing techniques and methods in the literature that combine data-based models with existing knowledge. The identified approaches are structured according to the categories integration, extraction and conformity. Special attention is given to applications in the field of autonomous driving.
We propose a novel attention gate (AG) model for medical imaging that automatically learns to focus on target structures of varying shapes and sizes. Models trained with AGs implicitly learn to suppress irrelevant regions in an input image while highlighting salient features useful for a specific task. This enables us to eliminate the necessity of using explicit external tissue/organ localisation modules of cascaded convolutional neural networks (CNNs). AGs can be easily integrated into standard CNN architectures such as the U-Net model with minimal computational overhead while increasing the model sensitivity and prediction accuracy. The proposed Attention U-Net architecture is evaluated on two large CT abdominal datasets for multi-class image segmentation. Experimental results show that AGs consistently improve the prediction performance of U-Net across different datasets and training sizes while preserving computational efficiency. The code for the proposed architecture is publicly available.
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