Artificial Intelligence (AI) has become commonplace to solve routine everyday tasks. Because of the exponential growth in medical imaging data volume and complexity, the workload on radiologists is steadily increasing. We project that the gap between the number of imaging exams and the number of expert radiologist readers required to cover this increase will continue to expand, consequently introducing a demand for AI-based tools that improve the efficiency with which radiologists can comfortably interpret these exams. AI has been shown to improve efficiency in medical-image generation, processing, and interpretation, and a variety of such AI models have been developed across research labs worldwide. However, very few of these, if any, find their way into routine clinical use, a discrepancy that reflects the divide between AI research and successful AI translation. To address the barrier to clinical deployment, we have formed MONAI Consortium, an open-source community which is building standards for AI deployment in healthcare institutions, and developing tools and infrastructure to facilitate their implementation. This report represents several years of weekly discussions and hands-on problem solving experience by groups of industry experts and clinicians in the MONAI Consortium. We identify barriers between AI-model development in research labs and subsequent clinical deployment and propose solutions. Our report provides guidance on processes which take an imaging AI model from development to clinical implementation in a healthcare institution. We discuss various AI integration points in a clinical Radiology workflow. We also present a taxonomy of Radiology AI use-cases. Through this report, we intend to educate the stakeholders in healthcare and AI (AI researchers, radiologists, imaging informaticists, and regulators) about cross-disciplinary challenges and possible solutions.
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The growing landscape of emerging wireless applications is a key driver toward the development of novel wireless system designs. Such a design can be based on the metaverse that uses a virtual model of the physical world systems along with other schemes/technologies (e.g., optimization theory, machine learning, and blockchain). A metaverse using a virtual model performs proactive intelligent analytics prior to a user request for efficient management of the wireless system resources. Additionally, a metaverse will enable self-sustainability to operate wireless systems with the least possible intervention from network operators. Although the metaverse can offer many benefits, it faces some challenges as well. Therefore, in this tutorial, we discuss the role of a metaverse in enabling wireless applications. We present an overview, key enablers, design aspects (i.e., metaverse for wireless and wireless for metaverse), and a novel high-level architecture of metaverse-based wireless systems. We discuss metaverse management, reliability, and security of the metaverse-based system. Furthermore, we discuss recent advances and standardization of metaverse-enabled wireless system. Finally, we outline open challenges and present possible solutions.
The absence of transparency and explainability hinders the clinical adoption of Machine learning (ML) algorithms. Although various methods of explainable artificial intelligence (XAI) have been suggested, there is a lack of literature that delves into their practicality and assesses them based on criteria that could foster trust in clinical environments. To address this gap this study evaluates two popular XAI methods used for explaining predictive models in the healthcare context in terms of whether they (i) generate domain-appropriate representation, i.e. coherent with respect to the application task, (ii) impact clinical workflow and (iii) are consistent. To that end, explanations generated at the cohort and patient levels were analysed. The paper reports the first benchmarking of the XAI methods applied to risk prediction models obtained by evaluating the concordance between generated explanations and the trigger of a future clinical deterioration episode recorded by the data collection system. We carried out an analysis using two Electronic Medical Records (EMR) datasets sourced from Australian major hospitals. The findings underscore the limitations of state-of-the-art XAI methods in the clinical context and their potential benefits. We discuss these limitations and contribute to the theoretical development of trustworthy XAI solutions where clinical decision support guides the choice of intervention by suggesting the pattern or drivers for clinical deterioration in the future.
Humankind is entering a novel creative era in which anybody can synthesize digital information using generative artificial intelligence (AI). Text-to-image generation, in particular, has become vastly popular and millions of practitioners produce AI-generated images and AI art online. This chapter first gives an overview of the key developments that enabled a healthy co-creative online ecosystem around text-to-image generation to rapidly emerge, followed by a high-level description of key elements in this ecosystem. A particular focus is placed on prompt engineering, a creative practice that has been embraced by the AI art community. It is then argued that the emerging co-creative ecosystem constitutes an intelligent system on its own - a system that both supports human creativity, but also potentially entraps future generations and limits future development efforts in AI. The chapter discusses the potential risks and dangers of cultivating this co-creative ecosystem, such as the bias inherent in today's training data, potential quality degradation in future image generation systems due to synthetic data becoming common place, and the potential long-term effects of text-to-image generation on people's imagination, ambitions, and development.
Medical artificial general intelligence (AGI) is an emerging field that aims to develop systems specifically designed for medical applications that possess the ability to understand, learn, and apply knowledge across a wide range of tasks and domains. Large language models (LLMs) represent a significant step towards AGI. However, training cross-domain LLMs in the medical field poses significant challenges primarily attributed to the requirement of collecting data from diverse domains. This task becomes particularly difficult due to privacy restrictions and the scarcity of publicly available medical datasets. Here, we propose Medical AGI (MedAGI), a paradigm to unify domain-specific medical LLMs with the lowest cost, and suggest a possible path to achieve medical AGI. With an increasing number of domain-specific professional multimodal LLMs in the medical field being developed, MedAGI is designed to automatically select appropriate medical models by analyzing users' questions with our novel adaptive expert selection algorithm. It offers a unified approach to existing LLMs in the medical field, eliminating the need for retraining regardless of the introduction of new models. This characteristic renders it a future-proof solution in the dynamically advancing medical domain. To showcase the resilience of MedAGI, we conducted an evaluation across three distinct medical domains: dermatology diagnosis, X-ray diagnosis, and analysis of pathology pictures. The results demonstrated that MedAGI exhibited remarkable versatility and scalability, delivering exceptional performance across diverse domains. Our code is publicly available to facilitate further research at //github.com/JoshuaChou2018/MedAGI.
In recent years, online social networks have been the target of adversaries who seek to introduce discord into societies, to undermine democracies and to destabilize communities. Often the goal is not to favor a certain side of a conflict but to increase disagreement and polarization. To get a mathematical understanding of such attacks, researchers use opinion-formation models from sociology, such as the Friedkin--Johnsen model, and formally study how much discord the adversary can produce when altering the opinions for only a small set of users. In this line of work, it is commonly assumed that the adversary has full knowledge about the network topology and the opinions of all users. However, the latter assumption is often unrealistic in practice, where user opinions are not available or simply difficult to estimate accurately. To address this concern, we raise the following question: Can an attacker sow discord in a social network, even when only the network topology is known? We answer this question affirmatively. We present approximation algorithms for detecting a small set of users who are highly influential for the disagreement and polarization in the network. We show that when the adversary radicalizes these users and if the initial disagreement/polarization in the network is not very high, then our method gives a constant-factor approximation on the setting when the user opinions are known. To find the set of influential users, we provide a novel approximation algorithm for a variant of MaxCut in graphs with positive and negative edge weights. We experimentally evaluate our methods, which have access only to the network topology, and we find that they have similar performance as methods that have access to the network topology and all user opinions. We further present an NP-hardness proof, which was an open question by Chen and Racz [IEEE Trans. Netw. Sci. Eng., 2021].
With the widespread use of large artificial intelligence (AI) models such as ChatGPT, AI-generated content (AIGC) has garnered increasing attention and is leading a paradigm shift in content creation and knowledge representation. AIGC uses generative large AI algorithms to assist or replace humans in creating massive, high-quality, and human-like content at a faster pace and lower cost, based on user-provided prompts. Despite the recent significant progress in AIGC, security, privacy, ethical, and legal challenges still need to be addressed. This paper presents an in-depth survey of working principles, security and privacy threats, state-of-the-art solutions, and future challenges of the AIGC paradigm. Specifically, we first explore the enabling technologies, general architecture of AIGC, and discuss its working modes and key characteristics. Then, we investigate the taxonomy of security and privacy threats to AIGC and highlight the ethical and societal implications of GPT and AIGC technologies. Furthermore, we review the state-of-the-art AIGC watermarking approaches for regulatable AIGC paradigms regarding the AIGC model and its produced content. Finally, we identify future challenges and open research directions related to AIGC.
Following unprecedented success on the natural language tasks, Transformers have been successfully applied to several computer vision problems, achieving state-of-the-art results and prompting researchers to reconsider the supremacy of convolutional neural networks (CNNs) as {de facto} operators. Capitalizing on these advances in computer vision, the medical imaging field has also witnessed growing interest for Transformers that can capture global context compared to CNNs with local receptive fields. Inspired from this transition, in this survey, we attempt to provide a comprehensive review of the applications of Transformers in medical imaging covering various aspects, ranging from recently proposed architectural designs to unsolved issues. Specifically, we survey the use of Transformers in medical image segmentation, detection, classification, reconstruction, synthesis, registration, clinical report generation, and other tasks. In particular, for each of these applications, we develop taxonomy, identify application-specific challenges as well as provide insights to solve them, and highlight recent trends. Further, we provide a critical discussion of the field's current state as a whole, including the identification of key challenges, open problems, and outlining promising future directions. We hope this survey will ignite further interest in the community and provide researchers with an up-to-date reference regarding applications of Transformer models in medical imaging. Finally, to cope with the rapid development in this field, we intend to regularly update the relevant latest papers and their open-source implementations at \url{//github.com/fahadshamshad/awesome-transformers-in-medical-imaging}.
Medical Visual Question Answering (VQA) is a combination of medical artificial intelligence and popular VQA challenges. Given a medical image and a clinically relevant question in natural language, the medical VQA system is expected to predict a plausible and convincing answer. Although the general-domain VQA has been extensively studied, the medical VQA still needs specific investigation and exploration due to its task features. In the first part of this survey, we cover and discuss the publicly available medical VQA datasets up to date about the data source, data quantity, and task feature. In the second part, we review the approaches used in medical VQA tasks. In the last part, we analyze some medical-specific challenges for the field and discuss future research directions.
The recent advancements in artificial intelligence (AI) combined with the extensive amount of data generated by today's clinical systems, has led to the development of imaging AI solutions across the whole value chain of medical imaging, including image reconstruction, medical image segmentation, image-based diagnosis and treatment planning. Notwithstanding the successes and future potential of AI in medical imaging, many stakeholders are concerned of the potential risks and ethical implications of imaging AI solutions, which are perceived as complex, opaque, and difficult to comprehend, utilise, and trust in critical clinical applications. Despite these concerns and risks, there are currently no concrete guidelines and best practices for guiding future AI developments in medical imaging towards increased trust, safety and adoption. To bridge this gap, this paper introduces a careful selection of guiding principles drawn from the accumulated experiences, consensus, and best practices from five large European projects on AI in Health Imaging. These guiding principles are named FUTURE-AI and its building blocks consist of (i) Fairness, (ii) Universality, (iii) Traceability, (iv) Usability, (v) Robustness and (vi) Explainability. In a step-by-step approach, these guidelines are further translated into a framework of concrete recommendations for specifying, developing, evaluating, and deploying technically, clinically and ethically trustworthy AI solutions into clinical practice.
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