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The growing availability of observational databases like electronic health records (EHR) provides unprecedented opportunities for secondary use of such data in biomedical research. However, these data can be error-prone and need to be validated before use. It is usually unrealistic to validate the whole database due to resource constraints. A cost-effective alternative is to implement a two-phase design that validates a subset of patient records that are enriched for information about the research question of interest. Herein, we consider odds ratio estimation under differential outcome and exposure misclassification. We propose optimal designs that minimize the variance of the maximum likelihood odds ratio estimator. We develop a novel adaptive grid search algorithm that can locate the optimal design in a computationally feasible and numerically accurate manner. Because the optimal design requires specification of unknown parameters at the outset and thus is unattainable without prior information, we introduce a multi-wave sampling strategy to approximate it in practice. We demonstrate the efficiency gains of the proposed designs over existing ones through extensive simulations and two large observational studies. We provide an R package and Shiny app to facilitate the use of the optimal designs.

The problem of anticipating human actions is an inherently uncertain one. However, we can reduce this uncertainty if we have a sense of the goal that the actor is trying to achieve. Here, we present an action anticipation model that leverages goal information for the purpose of reducing the uncertainty in future predictions. Since we do not possess goal information or the observed actions during inference, we resort to visual representation to encapsulate information about both actions and goals. Through this, we derive a novel concept called abstract goal which is conditioned on observed sequences of visual features for action anticipation. We design the abstract goal as a distribution whose parameters are estimated using a variational recurrent network. We sample multiple candidates for the next action and introduce a goal consistency measure to determine the best candidate that follows from the abstract goal. Our method obtains impressive results on the very challenging Epic-Kitchens55 (EK55), EK100, and EGTEA Gaze+ datasets. We obtain absolute improvements of +13.69, +11.24, and +5.19 for Top-1 verb, Top-1 noun, and Top-1 action anticipation accuracy respectively over prior state-of-the-art methods for seen kitchens (S1) of EK55. Similarly, we also obtain significant improvements in the unseen kitchens (S2) set for Top-1 verb (+10.75), noun (+5.84) and action (+2.87) anticipation. Similar trend is observed for EGTEA Gaze+ dataset, where absolute improvement of +9.9, +13.1 and +6.8 is obtained for noun, verb, and action anticipation. It is through the submission of this paper that our method is currently the new state-of-the-art for action anticipation in EK55 and EGTEA Gaze+ //competitions.codalab.org/competitions/20071#results Code available at //github.com/debadityaroy/Abstract_Goal

We study the potential of data-driven deep learning methods for separation of two communication signals from an observation of their mixture. In particular, we assume knowledge on the generation process of one of the signals, dubbed signal of interest (SOI), and no knowledge on the generation process of the second signal, referred to as interference. This form of the single-channel source separation problem is also referred to as interference rejection. We show that capturing high-resolution temporal structures (nonstationarities), which enables accurate synchronization to both the SOI and the interference, leads to substantial performance gains. With this key insight, we propose a domain-informed neural network (NN) design that is able to improve upon both "off-the-shelf" NNs and classical detection and interference rejection methods, as demonstrated in our simulations. Our findings highlight the key role communication-specific domain knowledge plays in the development of data-driven approaches that hold the promise of unprecedented gains.

This paper introduces an algorithm for the detection of change-points and the identification of the corresponding subsequences in transient multivariate time-series data (MTSD). The analysis of such data has become more and more important due to the increase of availability in many industrial fields. Labeling, sorting or filtering highly transient measurement data for training condition based maintenance (CbM) models is cumbersome and error-prone. For some applications it can be sufficient to filter measurements by simple thresholds or finding change-points based on changes in mean value and variation. But a robust diagnosis of a component within a component group for example, which has a complex non-linear correlation between multiple sensor values, a simple approach would not be feasible. No meaningful and coherent measurement data which could be used for training a CbM model would emerge. Therefore, we introduce an algorithm which uses a recurrent neural network (RNN) based Autoencoder (AE) which is iteratively trained on incoming data. The scoring function uses the reconstruction error and latent space information. A model of the identified subsequence is saved and used for recognition of repeating subsequences as well as fast offline clustering. For evaluation, we propose a new similarity measure based on the curvature for a more intuitive time-series subsequence clustering metric. A comparison with seven other state-of-the-art algorithms and eight datasets shows the capability and the increased performance of our algorithm to cluster MTSD online and offline in conjunction with mechatronic systems.

Physics-constrained data-driven computing is an emerging computational paradigm that allows simulation of complex materials directly based on material database and bypass the classical constitutive model construction. However, it remains difficult to deal with high-dimensional applications and extrapolative generalization. This paper introduces deep learning techniques under the data-driven framework to address these fundamental issues in nonlinear materials modeling. To this end, an autoencoder neural network architecture is introduced to learn the underlying low-dimensional representation (embedding) of the given material database. The offline trained autoencoder and the discovered embedding space are then incorporated in the online data-driven computation such that the search of optimal material state from database can be performed on a low-dimensional space, aiming to enhance the robustness and predictability with projected material data. To ensure numerical stability and representative constitutive manifold, a convexity-preserving interpolation scheme tailored to the proposed autoencoder-based data-driven solver is proposed for constructing the material state. In this study, the applicability of the proposed approach is demonstrated by modeling nonlinear biological tissues. A parametric study on data noise, data size and sparsity, training initialization, and model architectures, is also conducted to examine the robustness and convergence property of the proposed approach.

Unsupervised domain adaptation has recently emerged as an effective paradigm for generalizing deep neural networks to new target domains. However, there is still enormous potential to be tapped to reach the fully supervised performance. In this paper, we present a novel active learning strategy to assist knowledge transfer in the target domain, dubbed active domain adaptation. We start from an observation that energy-based models exhibit free energy biases when training (source) and test (target) data come from different distributions. Inspired by this inherent mechanism, we empirically reveal that a simple yet efficient energy-based sampling strategy sheds light on selecting the most valuable target samples than existing approaches requiring particular architectures or computation of the distances. Our algorithm, Energy-based Active Domain Adaptation (EADA), queries groups of targe data that incorporate both domain characteristic and instance uncertainty into every selection round. Meanwhile, by aligning the free energy of target data compact around the source domain via a regularization term, domain gap can be implicitly diminished. Through extensive experiments, we show that EADA surpasses state-of-the-art methods on well-known challenging benchmarks with substantial improvements, making it a useful option in the open world. Code is available at //github.com/BIT-DA/EADA.

This paper focuses on the expected difference in borrower's repayment when there is a change in the lender's credit decisions. Classical estimators overlook the confounding effects and hence the estimation error can be magnificent. As such, we propose another approach to construct the estimators such that the error can be greatly reduced. The proposed estimators are shown to be unbiased, consistent, and robust through a combination of theoretical analysis and numerical testing. Moreover, we compare the power of estimating the causal quantities between the classical estimators and the proposed estimators. The comparison is tested across a wide range of models, including linear regression models, tree-based models, and neural network-based models, under different simulated datasets that exhibit different levels of causality, different degrees of nonlinearity, and different distributional properties. Most importantly, we apply our approaches to a large observational dataset provided by a global technology firm that operates in both the e-commerce and the lending business. We find that the relative reduction of estimation error is strikingly substantial if the causal effects are accounted for correctly.

Over the past few years, we have seen fundamental breakthroughs in core problems in machine learning, largely driven by advances in deep neural networks. At the same time, the amount of data collected in a wide array of scientific domains is dramatically increasing in both size and complexity. Taken together, this suggests many exciting opportunities for deep learning applications in scientific settings. But a significant challenge to this is simply knowing where to start. The sheer breadth and diversity of different deep learning techniques makes it difficult to determine what scientific problems might be most amenable to these methods, or which specific combination of methods might offer the most promising first approach. In this survey, we focus on addressing this central issue, providing an overview of many widely used deep learning models, spanning visual, sequential and graph structured data, associated tasks and different training methods, along with techniques to use deep learning with less data and better interpret these complex models --- two central considerations for many scientific use cases. We also include overviews of the full design process, implementation tips, and links to a plethora of tutorials, research summaries and open-sourced deep learning pipelines and pretrained models, developed by the community. We hope that this survey will help accelerate the use of deep learning across different scientific domains.

Small data challenges have emerged in many learning problems, since the success of deep neural networks often relies on the availability of a huge amount of labeled data that is expensive to collect. To address it, many efforts have been made on training complex models with small data in an unsupervised and semi-supervised fashion. In this paper, we will review the recent progresses on these two major categories of methods. A wide spectrum of small data models will be categorized in a big picture, where we will show how they interplay with each other to motivate explorations of new ideas. We will review the criteria of learning the transformation equivariant, disentangled, self-supervised and semi-supervised representations, which underpin the foundations of recent developments. Many instantiations of unsupervised and semi-supervised generative models have been developed on the basis of these criteria, greatly expanding the territory of existing autoencoders, generative adversarial nets (GANs) and other deep networks by exploring the distribution of unlabeled data for more powerful representations. While we focus on the unsupervised and semi-supervised methods, we will also provide a broader review of other emerging topics, from unsupervised and semi-supervised domain adaptation to the fundamental roles of transformation equivariance and invariance in training a wide spectrum of deep networks. It is impossible for us to write an exclusive encyclopedia to include all related works. Instead, we aim at exploring the main ideas, principles and methods in this area to reveal where we are heading on the journey towards addressing the small data challenges in this big data era.