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We study the robust mean estimation problem in high dimensions, where less than half of the datapoints can be arbitrarily corrupted. Motivated by compressive sensing, we formulate the robust mean estimation problem as the minimization of the $\ell_0$-`norm' of an \emph{outlier indicator vector}, under a second moment constraint on the datapoints. We further relax the $\ell_0$-`norm' to the $\ell_p$-norm ($0<p\leq 1$) in the objective and prove that the global minima for each of these objectives are order-optimal for the robust mean estimation problem. Then we propose a computationally tractable iterative $\ell_p$-minimization and hard thresholding algorithm that outputs an order-optimal robust estimate of the population mean. Both synthetic and real data experiments demonstrate that the proposed algorithm outperforms state-of-the-art robust mean estimation methods. The source code will be made available at GitHub.

In this article, we aim to provide a general and complete understanding of semi-supervised (SS) causal inference for treatment effects. Specifically, we consider two such estimands: (a) the average treatment effect and (b) the quantile treatment effect, as prototype cases, in an SS setting, characterized by two available data sets: (i) a labeled data set of size $n$, providing observations for a response and a set of high dimensional covariates, as well as a binary treatment indicator; and (ii) an unlabeled data set of size $N$, much larger than $n$, but without the response observed. Using these two data sets, we develop a family of SS estimators which are ensured to be: (1) more robust and (2) more efficient than their supervised counterparts based on the labeled data set only. Beyond the 'standard' double robustness results (in terms of consistency) that can be achieved by supervised methods as well, we further establish root-n consistency and asymptotic normality of our SS estimators whenever the propensity score in the model is correctly specified, without requiring specific forms of the nuisance functions involved. Such an improvement of robustness arises from the use of the massive unlabeled data, so it is generally not attainable in a purely supervised setting. In addition, our estimators are shown to be semi-parametrically efficient as long as all the nuisance functions are correctly specified. Moreover, as an illustration of the nuisance estimators, we consider inverse-probability-weighting type kernel smoothing estimators involving unknown covariate transformation mechanisms, and establish in high dimensional scenarios novel results on their uniform convergence rates, which should be of independent interest. Numerical results on both simulated and real data validate the advantage of our methods over their supervised counterparts with respect to both robustness and efficiency.

We study the problem of inferring heterogeneous treatment effects from time-to-event data. While both the related problems of (i) estimating treatment effects for binary or continuous outcomes and (ii) predicting survival outcomes have been well studied in the recent machine learning literature, their combination -- albeit of high practical relevance -- has received considerably less attention. With the ultimate goal of reliably estimating the effects of treatments on instantaneous risk and survival probabilities, we focus on the problem of learning (discrete-time) treatment-specific conditional hazard functions. We find that unique challenges arise in this context due to a variety of covariate shift issues that go beyond a mere combination of well-studied confounding and censoring biases. We theoretically analyse their effects by adapting recent generalization bounds from domain adaptation and treatment effect estimation to our setting and discuss implications for model design. We use the resulting insights to propose a novel deep learning method for treatment-specific hazard estimation based on balancing representations. We investigate performance across a range of experimental settings and empirically confirm that our method outperforms baselines by addressing covariate shifts from various sources.

Consider estimation of average treatment effects with multi-valued treatments using augmented inverse probability weighted (IPW) estimators, depending on outcome regression and propensity score models in high-dimensional settings. These regression models are often fitted by regularized likelihood-based estimation, while ignoring how the fitted functions are used in the subsequent inference about the treatment parameters. Such separate estimation can be associated with known difficulties in existing methods. We develop regularized calibrated estimation for fitting propensity score and outcome regression models, where sparsity-including penalties are employed to facilitate variable selection but the loss functions are carefully chosen such that valid confidence intervals can be obtained under possible model misspecification. Unlike in the case of binary treatments, the usual augmented IPW estimator is generalized by allowing different copies of coefficient estimators in outcome regression to ensure just-identification. For propensity score estimation, the new loss function and estimating functions are directly tied to achieving covariate balance between weighted treatment groups. We develop practical numerical algorithms for computing the regularized calibrated estimators with group Lasso by innovatively exploiting Fisher scoring, and provide rigorous high-dimensional analysis for the resulting augmented IPW estimators under suitable sparsity conditions, while tackling technical issues absent or overlooked in previous analyses. We present simulation studies and an empirical application to estimate the effects of maternal smoking on birth weights. The proposed methods are implemented in the R package mRCAL.

To assess whether there is some signal in a big database, aggregate tests for the global null hypothesis of no effect are routinely applied in practice before more specialized analysis is carried out. Although a plethora of aggregate tests is available, each test has its strengths but also its blind spots. In a Gaussian sequence model, we study whether it is possible to obtain a test with substantially better consistency properties than the likelihood ratio (i.e., Euclidean norm based) test. We establish an impossibility result, showing that in the high-dimensional framework we consider, the set of alternatives for which a test may improve upon the likelihood ratio test -- that is, its superconsistency points -- is always asymptotically negligible in a relative volume sense.

The rapid development of high-throughput technologies has enabled the generation of data from biological or disease processes that span multiple layers, like genomic, proteomic or metabolomic data, and further pertain to multiple sources, like disease subtypes or experimental conditions. In this work, we propose a general statistical framework based on Gaussian graphical models for horizontal (i.e. across conditions or subtypes) and vertical (i.e. across different layers containing data on molecular compartments) integration of information in such datasets. We start with decomposing the multi-layer problem into a series of two-layer problems. For each two-layer problem, we model the outcomes at a node in the lower layer as dependent on those of other nodes in that layer, as well as all nodes in the upper layer. We use a combination of neighborhood selection and group-penalized regression to obtain sparse estimates of all model parameters. Following this, we develop a debiasing technique and asymptotic distributions of inter-layer directed edge weights that utilize already computed neighborhood selection coefficients for nodes in the upper layer. Subsequently, we establish global and simultaneous testing procedures for these edge weights. Performance of the proposed methodology is evaluated on synthetic and real data.

Multilevel regression and poststratification (MRP) is a flexible modeling technique that has been used in a broad range of small-area estimation problems. Traditionally, MRP studies have been focused on non-causal settings, where estimating a single population value using a nonrepresentative sample was of primary interest. In this manuscript, MRP-style estimators will be evaluated in an experimental causal inference setting. We simulate a large-scale randomized control trial with a stratified cluster sampling design, and compare traditional and nonparametric treatment effect estimation methods with MRP methodology. Using MRP-style estimators, treatment effect estimates for areas as small as 1.3$\%$ of the population have lower bias and variance than standard causal inference methods, even in the presence of treatment effect heterogeneity. The design of our simulation studies also requires us to build upon a MRP variant that allows for non-census covariates to be incorporated into poststratification.

Statistical inference on the explained variation of an outcome by a set of covariates is of particular interest in practice. When the covariates are of moderate to high-dimension and the effects are not sparse, several approaches have been proposed for estimation and inference. One major problem with the existing approaches is that the inference procedures are not robust to the normality assumption on the covariates and the residual errors. In this paper, we propose an estimating equation approach to the estimation and inference on the explained variation in the high-dimensional linear model. Unlike the existing approaches, the proposed approach does not rely on the restrictive normality assumptions for inference. It is shown that the proposed estimator is consistent and asymptotically normally distributed under reasonable conditions. Simulation studies demonstrate better performance of the proposed inference procedure in comparison with the existing approaches. The proposed approach is applied to studying the variation of glycohemoglobin explained by environmental pollutants in a National Health and Nutrition Examination Survey data set.

Counterfactual explanations are usually generated through heuristics that are sensitive to the search's initial conditions. The absence of guarantees of performance and robustness hinders trustworthiness. In this paper, we take a disciplined approach towards counterfactual explanations for tree ensembles. We advocate for a model-based search aiming at "optimal" explanations and propose efficient mixed-integer programming approaches. We show that isolation forests can be modeled within our framework to focus the search on plausible explanations with a low outlier score. We provide comprehensive coverage of additional constraints that model important objectives, heterogeneous data types, structural constraints on the feature space, along with resource and actionability restrictions. Our experimental analyses demonstrate that the proposed search approach requires a computational effort that is orders of magnitude smaller than previous mathematical programming algorithms. It scales up to large data sets and tree ensembles, where it provides, within seconds, systematic explanations grounded on well-defined models solved to optimality.

This paper focuses on the expected difference in borrower's repayment when there is a change in the lender's credit decisions. Classical estimators overlook the confounding effects and hence the estimation error can be magnificent. As such, we propose another approach to construct the estimators such that the error can be greatly reduced. The proposed estimators are shown to be unbiased, consistent, and robust through a combination of theoretical analysis and numerical testing. Moreover, we compare the power of estimating the causal quantities between the classical estimators and the proposed estimators. The comparison is tested across a wide range of models, including linear regression models, tree-based models, and neural network-based models, under different simulated datasets that exhibit different levels of causality, different degrees of nonlinearity, and different distributional properties. Most importantly, we apply our approaches to a large observational dataset provided by a global technology firm that operates in both the e-commerce and the lending business. We find that the relative reduction of estimation error is strikingly substantial if the causal effects are accounted for correctly.