Recent large language models (LLMs) in the general domain, such as ChatGPT, have shown remarkable success in following instructions and producing human-like responses. However, such language models have not been learned individually and carefully for the medical domain, resulting in poor diagnostic accuracy and inability to give correct recommendations for medical diagnosis, medications, etc. To address this issue, we collected more than 700 diseases and their corresponding symptoms, recommended medications, and required medical tests, and then generated 5K doctor-patient conversations. By fine-tuning models of doctor-patient conversations, these models emerge with great potential to understand patients' needs, provide informed advice, and offer valuable assistance in a variety of medical-related fields. The integration of these advanced language models into healthcare can revolutionize the way healthcare professionals and patients communicate, ultimately improving the overall quality of care and patient outcomes. In addition, we will open all source code, datasets and model weights to advance the further development of dialogue models in the medical field. In addition, the training data, code, and weights of this project are available at: //github.com/Kent0n-Li/ChatDoctor.
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Recent artificial intelligence (AI) systems have reached milestones in "grand challenges" ranging from Go to protein-folding. The capability to retrieve medical knowledge, reason over it, and answer medical questions comparably to physicians has long been viewed as one such grand challenge. Large language models (LLMs) have catalyzed significant progress in medical question answering; Med-PaLM was the first model to exceed a "passing" score in US Medical Licensing Examination (USMLE) style questions with a score of 67.2% on the MedQA dataset. However, this and other prior work suggested significant room for improvement, especially when models' answers were compared to clinicians' answers. Here we present Med-PaLM 2, which bridges these gaps by leveraging a combination of base LLM improvements (PaLM 2), medical domain finetuning, and prompting strategies including a novel ensemble refinement approach. Med-PaLM 2 scored up to 86.5% on the MedQA dataset, improving upon Med-PaLM by over 19% and setting a new state-of-the-art. We also observed performance approaching or exceeding state-of-the-art across MedMCQA, PubMedQA, and MMLU clinical topics datasets. We performed detailed human evaluations on long-form questions along multiple axes relevant to clinical applications. In pairwise comparative ranking of 1066 consumer medical questions, physicians preferred Med-PaLM 2 answers to those produced by physicians on eight of nine axes pertaining to clinical utility (p < 0.001). We also observed significant improvements compared to Med-PaLM on every evaluation axis (p < 0.001) on newly introduced datasets of 240 long-form "adversarial" questions to probe LLM limitations. While further studies are necessary to validate the efficacy of these models in real-world settings, these results highlight rapid progress towards physician-level performance in medical question answering.
While large language models (LLMs) have been successfully applied to various tasks, they still face challenges with hallucinations. Augmenting LLMs with domain-specific tools such as database utilities can facilitate easier and more precise access to specialized knowledge. In this paper, we present GeneGPT, a novel method for teaching LLMs to use the Web APIs of the National Center for Biotechnology Information (NCBI) for answering genomics questions. Specifically, we prompt Codex to solve the GeneTuring tests with NCBI Web APIs by in-context learning and an augmented decoding algorithm that can detect and execute API calls. Experimental results show that GeneGPT achieves state-of-the-art performance on eight tasks in the GeneTuring benchmark with an average score of 0.83, largely surpassing retrieval-augmented LLMs such as the new Bing (0.44), biomedical LLMs such as BioMedLM (0.08) and BioGPT (0.04), as well as GPT-3 (0.16) and ChatGPT (0.12). Our further analyses suggest that: (1) API demonstrations have good cross-task generalizability and are more useful than documentations for in-context learning; (2) GeneGPT can generalize to longer chains of API calls and answer multi-hop questions in GeneHop, a novel dataset introduced in this work; (3) Different types of errors are enriched in different tasks, providing valuable insights for future improvements.
Instruction tuning for large language models (LLMs) has gained attention from researchers due to its ability to unlock the potential of LLMs in following instructions. While instruction tuning offers advantages for facilitating the adaptation of large language models (LLMs) to downstream tasks as a fine-tuning approach, training models with tens of millions or even billions of parameters on large amounts of data results in unaffordable computational costs. To address this, we focus on reducing the data used in LLM instruction tuning to decrease training costs and improve data efficiency, dubbed as Low Training Data Instruction Tuning (LTD Instruction Tuning). Specifically, this paper conducts a preliminary exploration into reducing the data used in LLM training and identifies several observations regarding task specialization for LLM training, such as the optimization of performance for a specific task, the number of instruction types required for instruction tuning, and the amount of data required for task-specific models. The results suggest that task-specific models can be trained using less than 0.5% of the original dataset, with a 2% improvement in performance over those trained on full task-related data.
In this paper, we present ChatPLUG, a Chinese open-domain dialogue system for digital human applications that instruction finetunes on a wide range of dialogue tasks in a unified internet-augmented format. Different from other open-domain dialogue models that focus on large-scale pre-training and scaling up model size or dialogue corpus, we aim to build a powerful and practical dialogue system for digital human with diverse skills and good multi-task generalization by internet-augmented instruction tuning. To this end, we first conduct large-scale pre-training on both common document corpus and dialogue data with curriculum learning, so as to inject various world knowledge and dialogue abilities into ChatPLUG. Then, we collect a wide range of dialogue tasks spanning diverse features of knowledge, personality, multi-turn memory, and empathy, on which we further instruction tune \modelname via unified natural language instruction templates. External knowledge from an internet search is also used during instruction finetuning for alleviating the problem of knowledge hallucinations. We show that \modelname outperforms state-of-the-art Chinese dialogue systems on both automatic and human evaluation, and demonstrates strong multi-task generalization on a variety of text understanding and generation tasks. In addition, we deploy \modelname to real-world applications such as Smart Speaker and Instant Message applications with fast inference. Our models and code will be made publicly available on ModelScope: //modelscope.cn/models/damo/ChatPLUG-3.7B and Github: //github.com/X-PLUG/ChatPLUG .
Automated code generation can be a powerful technique for software development, significantly reducing developers' efforts and time required to create new code by generating it automatically based on requirements. Recently, OpenAI's language model ChatGPT has emerged as a powerful tool for generating human-like responses to a wide range of textual inputs (i.e., prompts), including those related to code generation. However, the effectiveness of ChatGPT for code generation is not well understood, and the generation performance could be heavily influenced by the choice of prompt. To answer these questions, we conducted experiments using the CodeXGlue dataset to evaluate ChatGPT's capabilities for two code generation tasks, including text-to-code and code-to-code generation. We designed prompts by leveraging the chain-of-thought strategy with multi-step optimizations. Our results showed that by carefully designing prompts to guide ChatGPT, the generation performance can be improved substantially. We also analyzed the factors that influenced the prompt design and provided insights that could guide future research.
We present a comprehensive evaluation of Parameter-Efficient Fine-Tuning (PEFT) techniques for diverse medical image analysis tasks. PEFT is increasingly exploited as a valuable approach for knowledge transfer from pre-trained models in natural language processing, vision, speech, and cross-modal tasks, such as vision-language and text-to-image generation. However, its application in medical image analysis remains relatively unexplored. As foundation models are increasingly exploited in the medical domain, it is crucial to investigate and comparatively assess various strategies for knowledge transfer that can bolster a range of downstream tasks. Our study, the first of its kind (to the best of our knowledge), evaluates 16 distinct PEFT methodologies proposed for convolutional and transformer-based networks, focusing on image classification and text-to-image generation tasks across six medical datasets ranging in size, modality, and complexity. Through a battery of more than 600 controlled experiments, we demonstrate performance gains of up to 22% under certain scenarios and demonstrate the efficacy of PEFT for medical text-to-image generation. Further, we reveal the instances where PEFT methods particularly dominate over conventional fine-tuning approaches by studying their relationship with downstream data volume.
There have been growing concerns regarding the out-of-domain generalization ability of natural language processing (NLP) models, particularly in question-answering (QA) tasks. Current synthesized data augmentation methods for QA are hampered by increased training costs. To address this issue, we propose a novel approach that combines prompting methods and linear probing then fine-tuning strategy, which does not entail additional cost. Our method has been theoretically and empirically shown to be effective in enhancing the generalization ability of both generative and discriminative models. Our approach outperforms state-of-the-art baselines, with an average increase in F1 score of 4.5%-7.9%. Furthermore, our method can be easily integrated into any pre-trained models and offers a promising solution to the under-explored cross-domain QA task. We release our source code at GitHub*.
Medical imaging is an essential tool for diagnosing various healthcare diseases and conditions. However, analyzing medical images is a complex and time-consuming task that requires expertise and experience. This article aims to design a decision support system to assist healthcare providers and patients in making decisions about diagnosing, treating, and managing health conditions. The proposed architecture contains three stages: 1) data collection and labeling, 2) model training, and 3) diagnosis report generation. The key idea is to train a deep learning model on a medical image dataset to extract four types of information: the type of image scan, the body part, the test image, and the results. This information is then fed into ChatGPT to generate automatic diagnostics. The proposed system has the potential to enhance decision-making, reduce costs, and improve the capabilities of healthcare providers. The efficacy of the proposed system is analyzed by conducting extensive experiments on a large medical image dataset. The experimental outcomes exhibited promising performance for automatic diagnosis through medical images.
Information retrieval (IR) plays a crucial role in locating relevant resources from vast amounts of data, and its applications have evolved from traditional knowledge bases to modern search engines (SEs). The emergence of large language models (LLMs) has further revolutionized the field by enabling users to interact with search systems in natural language. In this paper, we explore the advantages and disadvantages of LLMs and SEs, highlighting their respective strengths in understanding user-issued queries and retrieving up-to-date information. To leverage the benefits of both paradigms while circumventing their limitations, we propose InteR, a novel framework that facilitates knowledge refinement through interaction between SEs and LLMs. InteR allows SEs to refine knowledge in query using LLM-generated summaries and enables LLMs to enhance prompts using SE-retrieved documents. This iterative refinement process augments the inputs of SEs and LLMs, leading to more accurate retrieval. Experimental evaluations on two large-scale retrieval benchmarks demonstrate that InteR achieves superior zero-shot document retrieval performance compared to state-of-the-art methods, regardless of the use of relevance judgement.
Human doctors with well-structured medical knowledge can diagnose a disease merely via a few conversations with patients about symptoms. In contrast, existing knowledge-grounded dialogue systems often require a large number of dialogue instances to learn as they fail to capture the correlations between different diseases and neglect the diagnostic experience shared among them. To address this issue, we propose a more natural and practical paradigm, i.e., low-resource medical dialogue generation, which can transfer the diagnostic experience from source diseases to target ones with a handful of data for adaptation. It is capitalized on a commonsense knowledge graph to characterize the prior disease-symptom relations. Besides, we develop a Graph-Evolving Meta-Learning (GEML) framework that learns to evolve the commonsense graph for reasoning disease-symptom correlations in a new disease, which effectively alleviates the needs of a large number of dialogues. More importantly, by dynamically evolving disease-symptom graphs, GEML also well addresses the real-world challenges that the disease-symptom correlations of each disease may vary or evolve along with more diagnostic cases. Extensive experiment results on the CMDD dataset and our newly-collected Chunyu dataset testify the superiority of our approach over state-of-the-art approaches. Besides, our GEML can generate an enriched dialogue-sensitive knowledge graph in an online manner, which could benefit other tasks grounded on knowledge graph.
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