The introduction of AI and ML technologies into medical devices has revolutionized healthcare diagnostics and treatments. Medical device manufacturers are keen to maximize the advantages afforded by AI and ML by consolidating multiple applications onto a single platform. However, concurrent execution of several AI applications, each with its own visualization components, leads to unpredictable end-to-end latency, primarily due to GPU resource contentions. To mitigate this, manufacturers typically deploy separate workstations for distinct AI applications, thereby increasing financial, energy, and maintenance costs. This paper addresses these challenges within the context of NVIDIA's Holoscan platform, a real-time AI system for streaming sensor data and images. We propose a system design optimized for heterogeneous GPU workloads, encompassing both compute and graphics tasks. Our design leverages CUDA MPS for spatial partitioning of compute workloads and isolates compute and graphics processing onto separate GPUs. We demonstrate significant performance improvements across various end-to-end latency determinism metrics through empirical evaluation with real-world Holoscan medical device applications. For instance, the proposed design reduces maximum latency by 21-30% and improves latency distribution flatness by 17-25% for up to five concurrent endoscopy tool tracking AI applications, compared to a single-GPU baseline. Against a default multi-GPU setup, our optimizations decrease maximum latency by 35% for up to six concurrent applications by improving GPU utilization by 42%. This paper provides clear design insights for AI applications in the edge-computing domain including medical systems, where performance predictability of concurrent and heterogeneous GPU workloads is a critical requirement.
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The 6TiSCH protocol stack was proposed to ensure high-performance communications in the Industrial Internet of Things (IIoT). However, the lack of sufficient time slots for nodes outside the 6TiSCH's Destination Oriented Directed Acyclic Graph (DODAG) to transmit their Destination Advertisement Object (DAO) messages and cell reservation requests significantly hinders their integration into the DODAG. This oversight not only prolongs the device's join time but also increases energy consumption during the network formation phase. Moreover, challenges emerge due to the substantial number of control packets employed by both the 6TiSCH Scheduling Function (SF) and routing protocol (RPL), thus draining more energy resources, increasing medium contention, and decreasing spatial reuse. Furthermore, an SF that overlooks previously allocated slots when assigning new ones to the same node may increase jitter, and more complications ensue when it neglects the state of the TSCH queue, thus leading to packet dropping due to queue saturation. Additional complexity arises when the RPL disregards the new parent's schedule saturation during parent switching, which results in inefficient energy and time usage. To address these issues, we introduce in this paper novel mechanisms, strategically situated at the intersection of SF and RPL that are designed to balance the control packet distribution and adaptively manage parent switching. Our proposal, implemented within the 6TiSCH simulator, demonstrates significant improvements across vital performance metrics, such as node's joining time, jitter, latency, energy consumption, and amount of traffic, in comparison to the conventional 6TiSCH benchmark.
Reconfigurable antenna multiple-input multiple-output (MIMO) is a promising technology for upcoming 6G communication systems. In this paper, we deal with the problem of configuration selection for reconfigurable antenna MIMO by leveraging Coherent Ising Machines (CIMs). By adopting the CIM as a heuristic solver for the Ising problem, the optimal antenna configuration that maximizes the received signal-to-noise ratio is investigated. A mathematical framework that converts the selection problem into a CIM-compatible unconstrained quadratic formulation is presented. Numerical studies show that the proposed CIM-based design outperforms classical counterparts and achieves near-optimal performance (similar to exponentially complex exhaustive searching) while ensuring polynomial complexity.
For minimization problems without 2nd derivative information, methods that estimate Hessian ma- trices can be very effective. However, conventional techniques generate dense matrices that are prohibitive for large problems. Limited-memory compact representations express the dense arrays in terms of a low rank representation and have become the state-of-the-art for software implementations on large deterministic problems. We develop new compact representations that are parameterized by a choice of vectors and that reduce to existing well known formulas for special choices. We demonstrate effectiveness of the compact representations for large eigenvalue computations, tensor factorizations and nonlinear regressions.
Large language models (LLMs) hold immense promise to serve complex health information needs but also have the potential to introduce harm and exacerbate health disparities. Reliably evaluating equity-related model failures is a critical step toward developing systems that promote health equity. In this work, we present resources and methodologies for surfacing biases with potential to precipitate equity-related harms in long-form, LLM-generated answers to medical questions and then conduct an empirical case study with Med-PaLM 2, resulting in the largest human evaluation study in this area to date. Our contributions include a multifactorial framework for human assessment of LLM-generated answers for biases, and EquityMedQA, a collection of seven newly-released datasets comprising both manually-curated and LLM-generated questions enriched for adversarial queries. Both our human assessment framework and dataset design process are grounded in an iterative participatory approach and review of possible biases in Med-PaLM 2 answers to adversarial queries. Through our empirical study, we find that the use of a collection of datasets curated through a variety of methodologies, coupled with a thorough evaluation protocol that leverages multiple assessment rubric designs and diverse rater groups, surfaces biases that may be missed via narrower evaluation approaches. Our experience underscores the importance of using diverse assessment methodologies and involving raters of varying backgrounds and expertise. We emphasize that while our framework can identify specific forms of bias, it is not sufficient to holistically assess whether the deployment of an AI system promotes equitable health outcomes. We hope the broader community leverages and builds on these tools and methods towards realizing a shared goal of LLMs that promote accessible and equitable healthcare for all.
Customization generation techniques have significantly advanced the synthesis of specific concepts across varied contexts. Multi-concept customization emerges as the challenging task within this domain. Existing approaches often rely on training a Low-Rank Adaptations (LoRA) fusion matrix of multiple LoRA to merge various concepts into a single image. However, we identify this straightforward method faces two major challenges: 1) concept confusion, which occurs when the model cannot preserve distinct individual characteristics, and 2) concept vanishing, where the model fails to generate the intended subjects. To address these issues, we introduce LoRA-Composer, a training-free framework designed for seamlessly integrating multiple LoRAs, thereby enhancing the harmony among different concepts within generated images. LoRA-Composer addresses concept vanishing through Concept Injection Constraints, enhancing concept visibility via an expanded cross-attention mechanism. To combat concept confusion, Concept Isolation Constraints are introduced, refining the self-attention computation. Furthermore, Latent Re-initialization is proposed to effectively stimulate concept-specific latent within designated regions. Our extensive testing showcases a notable enhancement in LoRA-Composer's performance compared to standard baselines, especially when eliminating the image-based conditions like canny edge or pose estimations. Code is released at //github.com/Young98CN/LoRA\_Composer.
The paramount obstacle in longitudinal studies for causal inference is the complex "treatment-confounder feedback." Traditional methodologies for elucidating causal effects in longitudinal analyses are primarily based on the assumption that time moves in specific intervals or that changes in treatment occur discretely. This conventional view confines treatment-confounder feedback to a limited, countable scope. The advent of real-time monitoring in modern medical research introduces functional longitudinal data with dynamically time-varying outcomes, treatments, and confounders, necessitating dealing with a potentially uncountably infinite treatment-confounder feedback. Thus, there is an urgent need for a more elaborate and refined theoretical framework to navigate these intricacies. Recently, Ying (2024) proposed a preliminary framework focusing on end-of-study outcomes and addressing the causality in functional longitudinal data. Our paper expands significantly upon his foundation in fourfold: First, we conduct a comprehensive review of existing literature, which not only fosters a deeper understanding of the underlying concepts but also illuminates the genesis of both Ying (2024)'s and ours. Second, we extend Ying (2024) to fully embrace a functional time-varying outcome process, incorporating right censoring and truncation by death, which are both significant and practical concerns. Third, we formalize previously informal propositions in Ying (2024), demonstrating how this framework broadens the existing frameworks in a nonparametric manner. Lastly, we delve into a detailed discussion on the interpretability and feasibility of our assumptions, and outlining a strategy for future numerical studies.
Background and aims Generalizability of AI colonoscopy algorithms is important for wider adoption in clinical practice. However, current techniques for evaluating performance on unseen data require expensive and time-intensive labels. Methods We use a "Masked Siamese Network" (MSN) to identify novel phenomena in unseen data and predict polyp detector performance. MSN is trained to predict masked out regions of polyp images, without any labels. We test MSN's ability to be trained on data only from Israel and detect unseen techniques, narrow-band imaging (NBI) and chromendoscoy (CE), on colonoscopes from Japan (354 videos, 128 hours). We also test MSN's ability to predict performance of Computer Aided Detection (CADe) of polyps on colonoscopies from both countries, even though MSN is not trained on data from Japan. Results MSN correctly identifies NBI and CE as less similar to Israel whitelight than Japan whitelight (bootstrapped z-test, |z| > 496, p < 10-8 for both) using the label-free Frechet distance. MSN detects NBI with 99% accuracy, predicts CE better than our heuristic (90% vs 79% accuracy) despite being trained only on whitelight, and is the only method that is robust to noisy labels. MSN predicts CADe polyp detector performance on in-domain Israel and out-of-domain Japan colonoscopies (r=0.79, 0.37 respectively). With few examples of Japan detector performance to train on, MSN prediction of Japan performance improves (r=0.56). Conclusion Our technique can identify distribution shifts in clinical data and can predict CADe detector performance on unseen data, without labels. Our self-supervised approach can aid in detecting when data in practice is different from training, such as between hospitals or data has meaningfully shifted from training. MSN has potential for application to medical image domains beyond colonoscopy.
Recent artificial intelligence (AI) systems have reached milestones in "grand challenges" ranging from Go to protein-folding. The capability to retrieve medical knowledge, reason over it, and answer medical questions comparably to physicians has long been viewed as one such grand challenge. Large language models (LLMs) have catalyzed significant progress in medical question answering; Med-PaLM was the first model to exceed a "passing" score in US Medical Licensing Examination (USMLE) style questions with a score of 67.2% on the MedQA dataset. However, this and other prior work suggested significant room for improvement, especially when models' answers were compared to clinicians' answers. Here we present Med-PaLM 2, which bridges these gaps by leveraging a combination of base LLM improvements (PaLM 2), medical domain finetuning, and prompting strategies including a novel ensemble refinement approach. Med-PaLM 2 scored up to 86.5% on the MedQA dataset, improving upon Med-PaLM by over 19% and setting a new state-of-the-art. We also observed performance approaching or exceeding state-of-the-art across MedMCQA, PubMedQA, and MMLU clinical topics datasets. We performed detailed human evaluations on long-form questions along multiple axes relevant to clinical applications. In pairwise comparative ranking of 1066 consumer medical questions, physicians preferred Med-PaLM 2 answers to those produced by physicians on eight of nine axes pertaining to clinical utility (p < 0.001). We also observed significant improvements compared to Med-PaLM on every evaluation axis (p < 0.001) on newly introduced datasets of 240 long-form "adversarial" questions to probe LLM limitations. While further studies are necessary to validate the efficacy of these models in real-world settings, these results highlight rapid progress towards physician-level performance in medical question answering.
Human-in-the-loop aims to train an accurate prediction model with minimum cost by integrating human knowledge and experience. Humans can provide training data for machine learning applications and directly accomplish some tasks that are hard for computers in the pipeline with the help of machine-based approaches. In this paper, we survey existing works on human-in-the-loop from a data perspective and classify them into three categories with a progressive relationship: (1) the work of improving model performance from data processing, (2) the work of improving model performance through interventional model training, and (3) the design of the system independent human-in-the-loop. Using the above categorization, we summarize major approaches in the field, along with their technical strengths/ weaknesses, we have simple classification and discussion in natural language processing, computer vision, and others. Besides, we provide some open challenges and opportunities. This survey intends to provide a high-level summarization for human-in-the-loop and motivates interested readers to consider approaches for designing effective human-in-the-loop solutions.
Incorporating knowledge graph into recommender systems has attracted increasing attention in recent years. By exploring the interlinks within a knowledge graph, the connectivity between users and items can be discovered as paths, which provide rich and complementary information to user-item interactions. Such connectivity not only reveals the semantics of entities and relations, but also helps to comprehend a user's interest. However, existing efforts have not fully explored this connectivity to infer user preferences, especially in terms of modeling the sequential dependencies within and holistic semantics of a path. In this paper, we contribute a new model named Knowledge-aware Path Recurrent Network (KPRN) to exploit knowledge graph for recommendation. KPRN can generate path representations by composing the semantics of both entities and relations. By leveraging the sequential dependencies within a path, we allow effective reasoning on paths to infer the underlying rationale of a user-item interaction. Furthermore, we design a new weighted pooling operation to discriminate the strengths of different paths in connecting a user with an item, endowing our model with a certain level of explainability. We conduct extensive experiments on two datasets about movie and music, demonstrating significant improvements over state-of-the-art solutions Collaborative Knowledge Base Embedding and Neural Factorization Machine.
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